[go: up one dir, main page]

GB766246A - Phenyl-ethyl-acetyl methionine and the process of preparing same - Google Patents

Phenyl-ethyl-acetyl methionine and the process of preparing same

Info

Publication number
GB766246A
GB766246A GB8797/55A GB879755A GB766246A GB 766246 A GB766246 A GB 766246A GB 8797/55 A GB8797/55 A GB 8797/55A GB 879755 A GB879755 A GB 879755A GB 766246 A GB766246 A GB 766246A
Authority
GB
United Kingdom
Prior art keywords
phenyl
ethyl
methionine
acetyl
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8797/55A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chimie et Atomistique SA
Original Assignee
Chimie et Atomistique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chimie et Atomistique SA filed Critical Chimie et Atomistique SA
Publication of GB766246A publication Critical patent/GB766246A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention comprises phenyl-ethyl-acetyl methionine of the formula <FORM:0766246/IV(b)/1> and its preparation of reaction of methionine with a phenyl-ethyl-acetyl halide under alkaline conditions. Suitably the reaction is carried out in the presence of a strong base such as sodium hydroxide, to maintain a pH of at least 9, at a temperature which does not exceed 15-20 DEG C. In an example, phenyl-ethyl-acetyl chloride is reacted with methionine in aqueous sodium hydroxide and the resulting phenyl-ethylacetyl methionine is recrystallized from benzene or acetone.ALSO:Therapeutic compositions for the treatment of hypercholesterolemia comprise phenyl - ethyl - acetyl methionine of the formula:- <FORM:0766246/VI/1> (see Group IV(b)) in tablets containing 0.40 gm. of the compound with an excipient consisting for example of a mixture of starch, magnesium stearate and talc.
GB8797/55A 1954-03-25 1955-03-25 Phenyl-ethyl-acetyl methionine and the process of preparing same Expired GB766246A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR766246X 1954-03-25

Publications (1)

Publication Number Publication Date
GB766246A true GB766246A (en) 1957-01-16

Family

ID=9183198

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8797/55A Expired GB766246A (en) 1954-03-25 1955-03-25 Phenyl-ethyl-acetyl methionine and the process of preparing same

Country Status (1)

Country Link
GB (1) GB766246A (en)

Similar Documents

Publication Publication Date Title
ES280377A1 (en) A procedure to sinter an aluminosilicate crystalline zeolite (Machine-translation by Google Translate, not legally binding)
NO822705L (en) PROCEDURE FOR PREPARING 4-METHYL-6-PHENYL-PYRIDAZINE DERIVATIVES
ES413266A1 (en) Indenyl compounds
GB735408A (en) Chlorotoloxy-ethyl sulphates
GB766246A (en) Phenyl-ethyl-acetyl methionine and the process of preparing same
GB981286A (en) Sulphonamides and a process for the manufacture thereof
GB853783A (en) New piperazine derivatives and process for the preparation thereof
GB974408A (en) Preparation of allyloxybenzenesulfonates
ES413742A1 (en) A PROCEDURE FOR THE PREPARATION OF ACIDOL-ALPHA-HYDRAZINE-BETAF-PHENYLPROPIONIC COMPOUNDS.
GB1001704A (en) Process for the production of water soluble derivatives of ªÐ-amino-salicylic acid
ES282422A1 (en) Procedure for obtaining dialcohyl alkaline aluminum compounds (Machine-translation by Google Translate, not legally binding)
GB633459A (en) A process for the manufacture of n-(p-arsenosobenzyl)-glycine-amide and salts thereof
GB672164A (en) A process for the manufacture of pentaenes
GB1467225A (en) 7-alkoxy-4,6-dihydroxy-quinoline derivatives and pharmaceuti cal compositions thereof
GB1336350A (en) Choline derivatives and process for producing the same
GB740130A (en) Derivatives of 4-cyclohexyl-cyclohexanone and process for the manufacture thereof
GB669016A (en) N-benzhydryl-n-acyl-ureas and process for the manufacture of same
GB850479A (en) Acylated amino-acids and amino-sugars
GB728968A (en) Process for the preparation of piperazides of the lysergic acid series
ES267018A1 (en) Procedure for preparing fluorate-acetic acid derivatives as pesticides (Machine-translation by Google Translate, not legally binding)
ES386294A1 (en) Chemical synthesis procedure for the preparation of 2,6-dietanolamino 4,8-dipiperidino-pirimidino- (5,4 d) -pirimidina. (Machine-translation by Google Translate, not legally binding)
GB746051A (en) S:s-diethyldithioterephthalate and therapeutic compositions containing the same
GB948882A (en) Process for preparing borazoles
ES281030A1 (en) Procedure for the preparation of new derivatives of the cumarina (Machine-translation by Google Translate, not legally binding)
ES243711A1 (en) A procedure for preparing new therapeutic compounds in the form of free base or acidal salts of non-toxic addiction (Machine-translation by Google Translate, not legally binding)