GB736816A - A new trypanocidal substance and its acid addition salts - Google Patents
A new trypanocidal substance and its acid addition saltsInfo
- Publication number
- GB736816A GB736816A GB31705/52A GB3170552A GB736816A GB 736816 A GB736816 A GB 736816A GB 31705/52 A GB31705/52 A GB 31705/52A GB 3170552 A GB3170552 A GB 3170552A GB 736816 A GB736816 A GB 736816A
- Authority
- GB
- United Kingdom
- Prior art keywords
- addition salt
- acid
- diamino
- oxide
- trypanocidal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/66—Arsenic compounds
- C07F9/70—Organo-arsenic compounds
- C07F9/80—Heterocyclic compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
4 - (2 : 6 - Diamino - 4 - pyrimidylamino)-phenylarsine oxide <FORM:0736816/IV (b)/1> is prepared by (a) reduction of 4-(2 : 6-diamino-4-pyrimidylamino)-phenyl arsonic acid with sulphur dioxide and hydrochloric acid in the presence of potassium iodide, and hydrolysing the dichloride so formed without purification and isolating the arsine oxide as its carbonate addition salt by passage of CO2 into the alkaline solution; or (b) reacting p-aminophenylarsine oxide with 2 : 6-diamino-4-chloropyrimidine and isolating the required product as its carbonate addition salt. Reaction (b) may be carried out in an acid medium, e.g. aqueous hydrochloric acid. The arsine oxide carbonate addition salt may be converted to the isethionate addition salt by reaction with isethionic acid (see Group VI) in an aqueous medium. Detailed examples are given. U.S.A. Specification 2,435,393 is referred to.ALSO:4 - (2:6 - diamino - 4 - pyrmiidylamino)-phenylarsine oxide <FORM:0736816/VI/1> and is acid addition salts (see Group IV (b)) may be used in trypanocidal compositions. In particular, the isethionate addition salt may be used in aqueous solution. U.S.A. Specification 2,435,393 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB326011X | 1952-12-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB736816A true GB736816A (en) | 1955-09-14 |
Family
ID=10341163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB31705/52A Expired GB736816A (en) | 1952-12-15 | 1952-12-15 | A new trypanocidal substance and its acid addition salts |
Country Status (4)
| Country | Link |
|---|---|
| CH (1) | CH326011A (en) |
| DE (1) | DE1003214B (en) |
| FR (1) | FR1096246A (en) |
| GB (1) | GB736816A (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2435393A (en) * | 1943-06-19 | 1948-02-03 | Parke Davis & Co | Arsenic derivatives and process of preparing same |
-
1952
- 1952-12-15 GB GB31705/52A patent/GB736816A/en not_active Expired
-
1953
- 1953-12-11 CH CH326011D patent/CH326011A/en unknown
- 1953-12-12 FR FR1096246D patent/FR1096246A/en not_active Expired
- 1953-12-14 DE DEI8045A patent/DE1003214B/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE1003214B (en) | 1957-02-28 |
| FR1096246A (en) | 1955-06-16 |
| CH326011A (en) | 1957-11-30 |
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