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GB729967A - Isonicotinic acid derivatives and process for the manufacture thereof - Google Patents

Isonicotinic acid derivatives and process for the manufacture thereof

Info

Publication number
GB729967A
GB729967A GB6225/53A GB622553A GB729967A GB 729967 A GB729967 A GB 729967A GB 6225/53 A GB6225/53 A GB 6225/53A GB 622553 A GB622553 A GB 622553A GB 729967 A GB729967 A GB 729967A
Authority
GB
United Kingdom
Prior art keywords
hydrazine
isonicotinyl
aralkyl
alkyl
dimethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB6225/53A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Products Ltd
Original Assignee
Roche Products Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Products Ltd filed Critical Roche Products Ltd
Publication of GB729967A publication Critical patent/GB729967A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises compounds of the general formula <FORM:0729967/IV (b)/1> wherein R1 and R2 each stand for a hydrogen atom or an alkyl, aralkyl or alkenyl group and R3 stands for an alkyl, aralkyl or alkenyl group, and their acid salts. They are prepared by reacting an isonicotinyl halide or a hydrohalide thereof with mono-, di-, or tri-substituted hydrazine, the substituents being alkyl, aralkyl or alkenyl groups, and in the case when an N1,N1-disubstituted hydrazine is used, treating the N2,N2-disubstituted isonicotinyl hydrazine obtained with an alkali metal dissolved in a lower alkanol and subsequently with an alkyl, aralkyl or alkenyl halide. Examples disclose the preparation of (1) N1-isonicotinyl - N1,N2 - diisopropyl - hydrazine and its hydrochloride; (2) N1-isonicotinyl-N1,N2-dibenzyl-hydrazine and its hydrochloride; (3) N1 - isonicotinyl - N1 - n - butyl - N2,N2-dimethyl - hydrazine; (4) N1 - isonicotinyl-N1 - benzyl - N2,N2 - dimethyl - hydrazine; (5) N1 - isonicotinyl - N1 - allyl - N2,N2 - dimethyl - hydrazine; (6) N1 - isonicotinyl - N1-allyl-N2,N2-diethyl-hydrazine.
GB6225/53A 1952-03-07 1953-03-06 Isonicotinic acid derivatives and process for the manufacture thereof Expired GB729967A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US729967XA 1952-03-07 1952-03-07

Publications (1)

Publication Number Publication Date
GB729967A true GB729967A (en) 1955-05-11

Family

ID=22111051

Family Applications (1)

Application Number Title Priority Date Filing Date
GB6225/53A Expired GB729967A (en) 1952-03-07 1953-03-06 Isonicotinic acid derivatives and process for the manufacture thereof

Country Status (1)

Country Link
GB (1) GB729967A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2951846A (en) * 1957-10-29 1960-09-06 Hoffmann La Roche 1-(4-methyl-thiazole-5-carbonyl)-1, 2-dhsopropyl-hydrazine and certain salts
US3073819A (en) * 1959-04-30 1963-01-15 Hoffmann La Roche Hydrazine derivatives
US4137067A (en) 1975-05-14 1979-01-30 Ciba-Geigy Corporation Pyridine-4-carboxylic acid hydrazides for combatting phytopathogenic microorganisms and for regulating plant growth

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2951846A (en) * 1957-10-29 1960-09-06 Hoffmann La Roche 1-(4-methyl-thiazole-5-carbonyl)-1, 2-dhsopropyl-hydrazine and certain salts
US3073819A (en) * 1959-04-30 1963-01-15 Hoffmann La Roche Hydrazine derivatives
US4137067A (en) 1975-05-14 1979-01-30 Ciba-Geigy Corporation Pyridine-4-carboxylic acid hydrazides for combatting phytopathogenic microorganisms and for regulating plant growth

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