GB2632418A - Oral compositions - Google Patents

Abstract

An oral care or like composition comprises an oxygenator, to be used in a method of treatment of the human or animal body by therapy practised on the body by using the oxygenator as a medicament acting through the oral tissue in order to reach the bloodstream. The oxygenator may comprise an essential oil, e.g. 1% to 5% w/w, e.g. of one or more citrus and/or berry fruits, and/or CBD, e.g. 1% to 5% w/w, and may comprise one or more members of a minerals group, e.g. 1% to 5% w/w. The composition may also comprise an elemental metal, such as gold. The method may be a method to ameliorate inflammation other than in the mouth.

Description

TITLE: ORAL COMPOSITIONS

BACKGROUND

This invention relates to oral compositions, more particularly but not exclusively oral care compositions comprising a source of cannabinoid, more particularly of cannabidiol (CBD).

For some years, at least as early as 2017, toothpastes have been known comprising CBD for its beneficial effects. (I) For example the "CBD TEETH WHITENING TOOTHPASTE" on the 2017 South African website: httos://puresmile.co./a/producUebd-toeff-whitening-toothpastei which states the following: Main Benefits: * Gum regeneration * Bone stimulating properties * Anti-inflammatory * Fights bad breath * Antioxidant properties * Relieves toothache * Reduces sensitivity * Fights plaque * Prevents decay * Anti -Bacterial Common oral care products like fluoride toothpaste do not do nearly enough to protect your mouth. In fact, their ingredients are known to compromise the health of your mouth instead! And that is why we have come CO up with a product that still whitens the teeth, and is also healthy, natural and has protective properties such as CBD oil! 00 CBD Oil has the power to restore, strengthen and enhance oral health as it is an anti-inflammatory, antibacterial, antifungal and bone stimulant substance. Even if it only prevents the variables that cause C) 25 cavities, decay, and gum disease; it accelerates the healing process for existing damage mid rebalances your 0 vulnerable oral microbiome.

If you wear dentures or other dental prosthetics, being vulnerable to inflammation, gum disease, and other complications, the CBD toothpaste penetrates through the tissue of your gums to slow, stop and prevent inflammation-causing destruction to your jawbone.

CBD has antioxidant properties. Antioxidants are natural chemicals known to prevent and delay cell damage by balancing free radicals and blocking the damage they cause. Free radicals exist in so many forms that it's impossible to shield your mouth or body from their dangers: * Environmental toxins like tobacco, pollution and pesticides * Ultraviolet rays * Substances found in processed and relined foods * Chemicals that your body produces * These unstable molecules interrupt cell function and cause significant damage to the body. CBD strengthens cell protection against free radicals and supports healthier gum tissue in the mouth.

This website page has at the bottom "Copyright 2017 it Pure Smile".

(2) Another example is the Certificate of Analysis on the website page: https://cbddent.comicertificate-of-analysis/ Certificate of Analysis Sample ID: CW35884S01 -Verify Sample Name: CBD Toothpaste Submitted On: 2019-06-03 Expiration Date: 2020-06-03 Sample Type: Other Non-inhalable Product Weight(s): No. Tests: 28.46 g Profiling by Liquid Chromatography 1 Cannabinoid % mg/g Total mgA LOQ (mg/g) LOD (mg/g) L.C.A1 Status d9-THC ND1 ND1 ND1 0.05 0.02 Pass d8-THC ND1 ND1 ND1 0.05 0.02 Pass THCA ND1 ND1 ND1 0.05 0.02 Pass THCV ND1 ND1 ND1 0.05 0.02 Pass CBG 0.02 0.21 5.86 0.05 0.02 Pass CBGA ND1 ND1 ND1 0.05 0.02 Pass CBN ND1 ND1 ND1 0.05 0.02 Pass CBD 0.07 0.70 19.99 0.05 0.02 Pass CBDV ND1 ND1 ND1 0.05 0.02 Pass CBDA ND1 ND1 ND1 0.05 0.02 - Pass Total 0.09 0.91 25.85 NA NA NA Total THC ND1 ND1 ND1 - Pass Total CBD 0.07 0.70 19.99 - Pass C\I 25 (3) Another example is the patent document W02021071867A1, published 15 April 2021, entitled "ORAL CO CARE COMPOSITION COMPRISING A CANNABINOLD". Since this has a large amount of background and 0 relevant information, in the public domain at this date, it is as a matter of convenience hereby imported in its entirety into the present description, actually and/or by reference.

O THE INVENTION.

The present inventor has noted that there are disorders of the body, particularly associated with the body not taking up enough oxygen, and has found that these can be ameliorated by enhancing the ability of the body to take up oxygen. Thus, such disorders constitute a group, the characteristic of which is that they can be ameliorated by enhancing the ability of the body to lake up oxygen. This is to be done by supplying, essentially to the bloodstream, a substance to enhance the ability of the body to take up oxygen, herein and/or in the claims called an oxygen-enhancer, or supplying to the body a source substance from which the body may derive such an oxygen-enhancer. Such oxygen-enhancer and such source substance are both termed herein and/or in the claims an oxygenator. Accordingly, 'an oxygenator as herein defined' is hereby defined as a substance which can be supplied to the body, usually to the bloodstream, to enhance the ability of the body to take up oxygen, or a source from which the body may derive such a substance. The term 'oxygenator' where used herein and in the claims has this meaning. Such oxygen-enhancing action of any such oxygenator, supplied via the digestive tract, has been found by the inventor to be largely negated by actions of the digestive tract or following from them, for example, the oxygenator having to pass through the liver. The inventor has found that a convenient and more direct method of introducing such a substance to the bloodstream gives a greatly enhanced effect.

This method is to introduce the oxygenator via an oral care or like composition e.g. toothpaste, mouthwash or chewing gum, which has the effect that the oxygenator is mainly introduced directly, e.g. through the gums or under the tongue, i.e. through the skin of the mouth (or the oral membrane or oral mucosa), into the bloodstream. For the avoidance of doubt, a 'like composition' is hereby defined as one which, like oral care compositions, is intended to remain in the mouth for a while (in contrast to being immediately swallowed), e.g. like food or drink, (e.g. a minimum of 5, 10, 20 or 30 seconds, or more, e.g. chewing gum) which will give time for the oxygenator to penetrate through oral skin (skin of the mouth) etc into the bloodstream, avoiding the need ND1 = Not Detected L.C.A1 = Lable Claim in mg/g Percent Decarboxylated: -0% Total THC: ((THCA*0.877)+ d9-THC) rye Total CBD: ((CBDA*0.877)+ CBD) Results arc not moisture normalized. (i.c., percent of total weight) to go through the digestive tract, and not requiring to be injected into the body.

While, for example, said oxygenator may be synthetic, better and more body-friendly mechanisms for such oxygenation take-up result from using natural sources. For example, a composition comprising one or more so-called berry fruits can provide said oxygenator. Again, an indirect oxygenator can be provided by a source of vitamin C or a substance which enhances the body's ability to take up vitamin C. it is found that the enhanced vitamin C leads to enhanced take-up by the body of oxygen. Thus, anything that can provide enhanced vitamin C, essentially direct to the bloodstream, is an oxygenator. The inventor has found that a composition comprising one or more citrus fruits can provide a vitamin C oxygenator. The following references indicate that all or most citrus fruits can provide a vitamin C oxygenator: hfips://www.vervwcilhealtlicom/citrus-fruits-7498754 https://www. nhs.uk/conditi ons/vitami n s-and-mi nera skitamin-c/ Said composition preferably comprises an essential oil of one or more said fruits. The inventor considers, and has confirmed by trials, that use of one or more of both citrus fruits and berry fruits can act synergistically, i.e. more than simply the sums of the enhancements due to either the citrus fruits group or the berry fruits group used without the other.

Reference is directed to the online article in Wikipedia entitled "Essential Oil" (and references therein and their various precautions) to indicate which essential oils can safely be used (herein referred to as 'safe'), e.g. GRAS substances. Further reference is made to the papers by Dr Mestri mentioned herein. These references also indicate the compositions, or likely compositions, or standard compositions, of essential oils, that may be used in embodiments of the invention.

Further, the inventor has found that use of CBD in an oral care or like preparation greatly enhances the efficacy CO of such a mechanism. This is in spite of references in prior examples (1) and (2) to CBD having anti-oxidant properties to enhance oral health. For example, the present inventor has found that a toothpaste combining CBD and fruit juice helps the body's uptake of oxygen, synergistically, i.e. more than simply the addition of the CO 25 uptakes due to using fruit juice and CBD separately.

0 Again, the present inventor has found that the addition of preparations of one or more of what is herein termed a 0 minerals group, namely, a group comprising precious metals, precious stones, precious minerals, crystals, semiprecious stones, semiprecious crystals and monatomic molecular materials, can have an anti-inflammatory effect, as exemplified below, but particularly can enhance the said mechanisms synergistically, i.e. more than simply the sums of the enhancements due to one or more of either or both of said fruit groups and any one or more of said minerals group alone. Members of this group can also serve as an abrasive, e.g. in a toothpaste. They can usefully be included in the compositions in a weight-in-weight proportion in the range of from half a percent to 1°A, singly, or those which are used taken together.

One aspect of the present invention provides an oral care or like composition that comprises an oxygenator as herein defined, to be used in a method of treatment of the human or animal body by therapy practised on the body. This is preferably to be done by using the oxygenator as a medicament acting through the oral tissue (which term is used herein to include any one or more of the skin of the mouth, the oral membranes, the oral mucosa, any of which terms may overlap or be identical in extent). This is in order to reach the bloodstream, to achieve a systemic effect (in contrast to simply a local or topical effect, e.g. within the oral cavity) and/or to enhance the body's ability to take up vitamin C and/or oxygen.

Another aspect of the present invention provides an oral care or like composition that comprises an oxygenator as herein defined, to be used in a method of treatment of the human or animal body by therapy practised on the human or animal body to enhance the body's ability to take up vitamin C and/or oxygen.

Embodiments of the invention may have any one or more of the following features: * in which said oxygenator comprises essential oil.

* in which said oxygenator comprises essential oil of one or more fruits.

* in which said essential oil comprises essential oil of one or more citrus fruits. * * * * * * of NM 25

O O tr 30

in which said citrus fruits comprise one or more of the group comprising orange, mandarin orange, tangerine, blood orange, tangelo, bitter orange, yuzu, grapefruit, pomelo, ugli fmit, ktunquat, citron, calamondin, lemon, key lime, finger lime and persian lime, all excluding those which are poisonous or poisonous when unripe.

in which said one or more fruits comprise one or more berry fruits.

in which said berry fruits comprise one or more of the group comprising acai berry, barberry, bilberry, blackberry, blackcurrant, blueberry, boysenberries, chokeberry, cloudberryt, cranberry, elderberry, gooseberry, huckleberry, juneberry, kiwi berry, lingonberry, loganberry mulberry, raspberry, redcurrant, salmonberry, sea buckthorn berry, strawberry, tayberry, bananas, grapes, cucumbers, tomatoes, oranges, watermelons, pumpkins and pineapples, all excluding those which are poisonous or poisonous when unripe.

comprising CBD.

comprising one or more of what is hereby termed a minerals group, namely, the group comprising gold, gold dust, gold salts, silver, silver dust, silver salts, diamonds and other precious stones, crystals and semiprecious crystals, quartz, rose quartz, e.g. all being suitable for use as au abrasive, and mono-atomic molecular nmterials.

comprising one or more of what is hereby termed a minerals group, namely, the group comprising gold, gold dust, gold salts, silver, silver dust, silver salts, diamonds and other precious stones, crystals and semiprecious crystals, quartz, rose quartz and mono-atomic molecular materials, e.g. the subgroup thereof herein mentioned, to be used in a method of treatment of the human or animal body by surgery or therapy or of diagnosis practised on the human or animal body to enhance the body's ability to take up vitamin C and/or oxygen via the mouth skin * in which the weight-in-weight proportion of said minerals group in the composition is in the range of preferably from 1% to 5% but may usefully be in an extension to the range of from 0.5% to 1%.

* in which said oxygenator comprises essential oil of one or more fruits and the weight-in-weight proportion of said essential oil in the composition is in the range of from 1% to 5% * such preferred proportions are fruit substantially 2% and mineral substantially 1%.

* in which the weight-in-weight proportion of said CBD in the composition is in the range of from 1% to 5% Another aspect of the invention provides an oral composition comprising CBD and essential oil of one or more fruits of the group comprising citrus Mats and berry fruits, to be used in a method of treatment of the hum n or animal body by surgery or therapy or of diagnosis practised on the human or animal body to enhance the body's ability to take up vitamin C and/or oxygen.

Embodiments may have any of the features: * to be used in said method to ameliorate inflammation.

Another aspect of the invention provides a method to improve the health of the body comprising applying an effective amount of the composition to the oral cavity of a subject in need thereof.

Embodiments may have any of the features: * applied to enhance the body's ability to take up vitamin C and/or oxygen.

* applied to ameliorate inflammation or the likelihood of inflammation.

Another aspect of the invention provides a method to improve the health of the body comprising applying to the oral cavity a safe and effective amount of any composition embodying the invention.

Another aspect of the invention provides the use of fruit or a fruit product in the manufacture of a composition embodying the invention.

Another aspect of the invention provides the use of fruit or a fruit product in the manufacture of a composition embodying the invention, for use in any such method as mentioned above.

Another aspect of the invention provides an oral care or like composition that comprises an oxygenator as herein defined, to be used in a method of treatment of the human or animal body by therapy practised on the body by using die oxygenator as a medicament acting through the oral tissue in order to reach the bloodstream Another aspect of the invention provides an oral care or like composition, that comprises an oxygenator as herein defined, to be used in a method of treatment of the human or animal body by therapy practised on the body by using the oxygenator as a medicament acting through the oral tissue in order to reach the bloodstream, to achieve a systemic effect and/or to enhance the body's ability to take up vitamin C and/or oxygen.

Embodiments may have any of the features: * said oxygenator comprises essential oil.

* said oxygenator comprises essential oil of one or more fruits.

* said one or more fruits comprise one or more citrus fruits.

* said citrus fruits comprise one or more of the group comprising orange, mandarin orange, tangerine, blood orange, tangelo, bitter orange, yuzu, grapefruit, pomelo, ugh fruit, kumquat, citron, calamondin, lemon, key lime, finger lime and persian lime, all excluding those which are poisonous or poisonous when unripe.

* said one or more fruits comprise one or more berry fruits.

* said berry fruits comprise one or more of the group comprising Kai berry, barberry, bilberry, blackberry, blackcurrant, blueberry, boysenberries, chokeberry, cloudberry, cranberry, elderberry, gooseberry, huckleberry, jumberry, kiwi berry, lingonberry, loganberry mulberry, raspberry, redcurrant, salmonberiy, sea buckthorn berry, strawberry, taybeny, bananas, grapes cucumbers, tomatoes, oranges, watermelons.

pumpkins and pineapples, all excluding those which are poisonous or poisonous when unripe.

* the oxygenator comprises CBD.

CO* comprising one or more of what is hereby termed a minerals group, namely, the group comprising gold, gold dust, gold salts, silver, silver dust, silver salts, diamonds and other precious stones, crystals and semiprecious crystals, quartz, rose quartz and a subgroup of mono-atomic molecular materials comprising M 25 gold, platinum, silver, carbon, calcium, copper, iron, magnesium, manganese, sodium, nickel, zinc, all 0 excluding those which are poisonous.

* the weight-in-weight proportion of said minerals group in the composition is in the range of from 1% to 0 5%.

* the oxygenator comprises CBD, in which the weight-in-weight proportion of the CBD in the composition is in the range of from 1% to 5°/0.

* said oxygenator comprises essential oil and the weight-in-weight proportion of said essential oil in the composition is in the range of from 1% to 5%.

* comprising CBD and essential oil of one or more fruits of the group comprising citrus fruits and berry fruits.

* to be used in said method to ameliorate inflammation other than in the mouth.

Another aspect of the invention provides a method to improve the health of the body comprising applying an effective amount of any such composition to the oral cavity of a subject in need thereof.

Embodiments may have any of the features: * applied to enhance the body's ability to take up vitamin C and/or oxygen.

* applied to ameliorate inflammation or the likelihood of inflammation.

Another aspect of the invention provides a method to improve the health of the body comprising applying to the oral cavity a safe and effective amount of any such composition.

Another aspect of the invention provides the use of fruit or a fruit product in the manufacture of any such composition.

Another aspect of the invention provides the use of fruit or a fruit product in the manufacture of any such composition, for use in any such method to improve the health of the body The text of the accompanying abstract is hereby imported into the present description.

Embodiments of the invention may comprise any suitable feature or suitable combination of features as given in the aforesaid imported text of the aforesaid patent document W02021071867A1, including (but not limited to) compositions and forms thereof, and ingredients, and forms, quantities and ranges of quantities of ingredients. Use of an oxygenator in embodiments of the invention to enhance the body's ability to take up vitamin C and/or oxygen does not preclude use of the same at the same time for other purposes, mentioned generally or specifically in said patent document W02021071867A1, e.g. flavouring.

Compositions and methods embodying the invention (e.g., the compositions mentioned herein directly or by reference) can be incorporated into oral compositions for the care of the mouth and teeth such as dentifrices, toothpastes, transparent pastes, gels, mouth rinses, sprays and chewing gum, and uses thereof.

As used throughout ranges are used as shorthand for describing each and even' value that is within the range.

Any value within the range can be selected as the terminus of the range. In addition, all references cited herein are hereby incorporated by reference in their entireties. In the event of a conflict in a definition in the present disclosure and that of a cited reference, the present disclosure controls. It is understood that when formulations are described, they may be described in terms of their ingredients, as is common in the art, notwithstanding that these ingredients may react with one another in the actual formulation as it is made, stored and used, and such products are intended to be covered by the formulations described.

The present inventor has long and extensive experience as a clinical nutritional therapist, majoring in biochemistry, and, apart from having a series of certified investigations carried out externally and independently as part of a trial, has carried out many tests and investigations in-house (with and without one or more of the said ingredients and quantities, including placebos) to obtain more generally each of the results mentioned herein, including each of the fruits mentioned below under the heading "Fruit / berry based composition Cr) includes the following".

CONDITIONS AND ILLNESSES THAT APPEAR TO BE HELPED BY USE OF THE INVENTION

HV The inventor has found in trials what appears to be improvement due to use of the invention in the following CO 25 conditions and illnesses: Common inflammatory diseases, namely diabetes, cardiovascular disease (CVD), 0 arthritis and other joint diseases, allergies of various common kinds, chronic obstructive pulmonary disease 0 (COPD), psoriasis, rheumatoid arthritis, irritable bowel syndrome (IBS). These all appear to have a commonality regarding their amelioration due to improved oxygen uptake in the bloodstream consequent upon use of the invention. Reference is made to the web page: https://www.nature.com/articles/pr200951/.

Further, the inventor has found in trials what appears to be improvement due to use of the invention in conditions arising from treatment of cancer, e.g. IBS.

The inventor has trialled the following compositions and found similar improvements due to their use. It is to be noted that they all include CBD and fruit and/or mineral and/or the group comprising the mint family (including mint and peppermint), menthol and the calendula family (including calendula officinalis) and any other 'safe' substances as mentioned above.

* MINT CHARCOAL (MCCBD) Sorbitol, water, hydrated silica, glycerin, sodium lauroyl sarcosinate, cellulose gum, xanthan gum, potassium sorbate, sodium phytate, tetrasodium pyrophosphate, xylitol, calendula officinalis extract, citric acid, cannabis sativa leaf extract CBD, charcoal powder, menthol, peppermint ( MENTHA ARVENSIS extract), Flavor * LEMON (LCBD) Sorbitol, water, hydrated silica, glycerin, sodium lauroyl sarcosinate, cellulose gum, xanthan gum, potassium sorbate, sodium phytate, tetrasodium pyrophosphate, xylitol, calendula officinalis extract, citric acid, cannabis sativa leaf extract CBD, menthol, citrus limon fruit extract, flavour * STRAWBERRY (SCBD) Sorbitol, water, hydrated silica, glycerin, sodium lauroyl sarcosinate, cellulose gum, xanthan gum, potassium sorbate, sodium phytate, tetrasodium pyrophosphate, xylitol, calendula officinalis extract, citric acid, cannabis sativa leaf extract CBD, charcoal powder, menthol, strawberry extract * ORANGE (OCBD) Sorbitol, water, hydrated silica, glycerin, sodium lauroyl sarcosinate, cellulose gum, xanthan gum, potassium sorbate, sodium phytate, tetrasodium pyrophosphate, xylitol, calendula officinalis extract, citric acid, cannabis sativa leaf extract CBD, menthol, citrus orange fruit extract, flavour MINT (MCBD) Sorbitol, water, hydrated silica, glycerin, sodium lauroyl sarcosinate, cellulose gum, xanthan gum, potassium sorbate, sodium phytate, tetrasodium pyrophosphate, xylitol, calendula officinalis extract, citric acid, cannabis sativa leaf extract CBD, menthol, peppermint ( MENTHA ARVENSIS extract), Flavor BLUEBERRY (BBCBD) Sorbitol, water, hydrated silica, glycerin, sodium lauroyl sarcosinate, cellulose gum, xanthan gum, potassium sorbate, sodium phytate, tetrasodium pyrophosphate, xylitol, calendula officinalis extract, citric acid, cannabis sativa leaf extract CBD, menthol, blueberry fruit extract, flavour BLACKCURRENT (BCCBD) Sorbitol, water, hydrated silica, glycerin, sodium lauroyl sarcosinate, cellulose gum, xanthan gum, potassium sorbate, sodium phytate, tetrasodium pyrophosphate, xylitol, calendula officinalis extract, citric acid, cannabis sativa leaf extract CBD, charcoal powder, menthol, blackcurrent extract RASPBERRY (RCBD) Sorbitol, water, hydrated silica, glycerin, sodium lauroyl sarcosinate, cellulose gum, xanthan gum, potassium sorbate, sodium phytate, tetrasodium pyrophosphate, xylitol, calendula officinalis extract, citric acid, cannabis sativa leaf extract CBD, menthol, raspberry fruit extract, flavor GRAPE (GCBD) Sorbitol, water, hydrated silica, glycerin, sodium lauroyl sarcosinate, cellulose gum, xanthan gum, potassium sorbate, sodium phytate, tetrasodium pyrophosphate, xylitol, calendula officinalis extract, citric acid, cannabis sativa leaf extract CBD, menthol, grape fruit extract, flavour BANANA (BNCBD) Sorbitol, water, hydrated silica, glycerin, sodium lauroyl sarcosinate, cellulose gum, xanthan gum, potassium sorbate, sodium phytate, tetrasodium pyrophosphate, xylitol, calendula officinalis extract, citric acid, cannabis sativa leaf extract CBD, charcoal powder, menthol, banana extract NATURAL (NCBD) Sorbitol, water, hydrated silica, glycerin, sodium lauroyl sarcosinate, cellulose gum, xanthan gum, potassium sorbate, sodium phytate, tetrasodium pyrophosphate, xylitol, calendula officinalis extract, citric acid, cannabis sativa leaf extract CBD, menthol, MINT CHARCOAL (MCCBDG) Sorbitol, water, hydrated silica, glycerin, sodium lauroyl sarcosinate, cellulose gum, xanthan gum, potassium sorbate, sodium phytate, tetrasodium pyrophosphate, xylitol, calendula officinalis extract, citric acid, cannabis sativa leaf extract CBD, charcoal powder, menthol, peppermint ( MENTHA ARVENSIS rye extract), Flavor GOLD SALT 0.5% C\I * LEMON (LCBDG) Sorbitol, water, hydrated silica, glycerin, sodium lauroyl sarcosinate, cellulose gum, xanthan gum, potassium sorbate, sodium phytate, tetrasodium pyrophosphate, xylitol, calendula officinalis 0 extract, citric acid, cannabis sativa leaf extract CBD, menthol, citrus limon fruit extract, flavour GOLD SALT 0.5% O* STRAWBERRY (SCBDG) Sorbitol, water, hydrated silica, glycerin, sodium lauroyl sarcosinate, cellulose gum, xanthan gum, potassium sorbate, sodium phytate, tetrasodium pyrophosphate. xylitol, calendula officinalis extract, 0 40 citric acid, cannabis sativa leaf extract CBD, charcoal powder, menthol, strawberry extract GOLD SALT 0.5% * ORANGE (OCBDG) Sorbitol, water, hydrated silica, glycerin, sodium lauroyl sarcosinate, cellulose gum, xanthan gum, potassium sorbate, sodium phytate, tetrasodium pyrophosphate, xylitol, calendula officinalis extract, citric acid, cannabis sativa leaf extract CBD, menthol, citrus orange fruit extract, flavour GOLD SALT 0.5% * MINT (MCBDG) Sorbitol, water, hydrated silica, glycerin, sodium lauroyl sarcosinate, cellulose gum, xanthan gum, potassium sorbate, sodium phytate, tetrasodium pyrophosphate, xylitol, calendula officinalis extract, citric acid, cannabis sativa leaf extract CBD, menthol, peppermint ( MENTHA ARVENSIS extract), Flavor GOLD SALT 0.5% * BLUEBERRY (BBCBDG) Sorbitol, water, hydrated silica, glycerin, sodium lauroyl sarcosinate, cellulose gum, xanthan gum, potassium sorbate, sodium phytate, tetrasodium pyrophosphate, xylitol, calendula officinalis extract, citric acid, cannabis sativa leaf extract CBD, menthol, blueberry fruit extract, flavour GOLD SALT 0.5% * BLACKCURRENT (BCCBDG) Sorbitol, water, hydrated silica, glycerin, sodium lauroyl sarcosinate, cellulose gum, xanthan gum, potassium sorbate, sodium phytate, tetrasodium pyrophosphate, xylitol, calendula officinalis extract, citric acid, cannabis sativa leaf extract CBD, charcoal powder, menthol, blackcurrent extract GOLD SALT 0.5% * RASPBERRY Sorbitol, water, hydrated silica, glycerin, sodium lauroyl sarcosinate, cellulose gum, xanthan gum, potassium sorbate, sodium phytate, tetrasodium pyrophosphate, xylitol, calendula officinalis extract, citric acid, cannabis sativa leaf extract CBD, menthol, raspberry fruit extract, flavour GOLD SALT 0.5% * GRAPE (GCBDG) Sorbitol, water, hydrated silica, glycerin, sodium lauroyl sarcosinate, cellulose gum, xanthan gum, potassium sorbate, sodium phytate, tetrasodium pyrophosphate, xylitol, calendula officinalis extract, citric acid, cannabis sativa leaf extract CBD, menthol, grape fruit extract, flavour GOLD SALT 0.5% * BANANA (BNCBDG) Sorbitol, water, hydrated silica, glycerin, sodium lauroyl sarcosinate, cellulose gum, xanthan gum, potassium sorbate, sodium phytate, tetrasodium pyrophosphate, xylitol, calendula officinalis extract, citric acid, cannabis sativa leaf extract CBD, charcoal powder, menthol, banana extract GOLD SALT 0.5% * NATURAL (NCBDG) Sorbitol, water, hydrated silica, glycerin, sodium lauroyl sarcosinate, cellulose gum, xanthan gum, potassium sorbate, sodium phytate, tetrasodium pyrophosphate, xylitol, calendula officinalis extract, citric acid, cannabis sativa leaf extract CBD, menthol, GOLD SALT 0.5% * * * * * * * * The inventor has found the following references which indicate minerals that produce increased oxygenation, and disclose generally accepted details (which ones, amounts of minerals, increases of oxygenation, references): * https://dailyhcalthpost.com/nutrients-improve-oxygen-uptake/ * https://www.livestrong. com/article/517541-what-are-the-benefits-of-cellfood-supplement/ * https://www.nhs.ik/conditions/vitamins-and-minerals/ The inventor has also successfully trialled CBD in the range of proportions from 1 g to 10 g in 75 g of the toothpaste, in trials increasing by 1 g of CBD, preferring 2 g to 5 g, in relation to the embodiments referred to herein comprising CBD.

In spite of comments in prior examples (1) and (2), as mentioned above, CBD is a known oxygenator, as may bc seen at: * httuis://mvw.vetywel health.com/cbd-and-congestive-heart-failure-5197 34#toc-cbd-and-heart-health * https://www.ncbtnIminh.gov/pinc/articles/PMC8159073/ The working of CBD at cellular level (mitochondria) can be seen at * https://www.altemetorg/2016/12/cbd-science-mitochondria-myster es-homeostas s-renewal-endocannabinoid-system * https://www.medicalnewstoday.com/articles/cbd-for-energy#comparison In relation to the embodiments referred to herein mentioning minerals and trialled by the inventor, gold can be in the range of up to 1%, preferably 0.5% to 1%, weight-in-weight in the total composition. Other minerals in suitable compounds (of course, excluding toxic compounds thereof), can be used similarly, including silver, copper and platinum.

Cr) Regarding the essential oils mentioned herein, their purity is 100()/0, meaning that an unadulterated distillation or extraction is used and no important constituents are removed.

This link relating to COPD speaks of how increased oxygen reduces symptoms: * https://www.nhs. uldconditions/chronic-obstructive-pulmoninv-disease-copd/treatment/ C) 25 This link talks about the relationship between low (systemic) oxygen levels and inflammation: 0 https://www.britaimica.com/science/inflammation This link relates to uses of essential oils and their purity: https://www.linkedin. com/pulse/adulteration-essential-oils-detection-techniques-dr-sudhir-mestr i It discusses adulteration of essential oils, their degree of purity (the present inventor prefers to use substantially pure essential oils) and the standards for use in dental compositions.

Another useful article by Dr Mestri in this connection is at https://wwwlinkedin.com/pul se/oil-pulling-boonoral-hygiene-dr-sudhir-mestriArk=article-ssr-frontend-p ulse more-articles related-content-card These links relate to consuming gold: * littps://brightstuffs.com/7-benefits-of-eating-gold-can-vou-eat-real-gold/ * https://healthyhuemans.com/11-ormus-gold-health-benefits/

PARTICULAR EXAMPLES EMBODYING THE INVENTION

INDEPENDENT EXTERNAL (CERTIFIED) TRIALS PROTOCOL TITLE. A trial to see if the addition of [a] Citrus fruit and/or [b] Berry fruit, to a cannabinoid oral care composition with a xanthan gum, can increase the oxygen levels in its users.

ABSTRACT. The purpose of this study is to evaluate a relationship that might exist between increased oxygenation via the use of an oral care composition containing (i) cannabinoid (ii) xanthan gum (iii) a citrus and/or (iv) a berry.

BACKGROUND AND SIGNIFICANCE OF PRELIMINARY STUDIES.

I. For the purpose of this study, lemon will bc used with the assumption that all citrus fruits have the same identified benefit of increased oxygen uptake. It is common general knowledge that all citrus fruits have similar benefits in relation to vitamin C. 2. For the purpose of this study, strawberry will be used with the assumption that all berry fruits (including banana, pineapple, pumpkin, tomato) have the same identified benefit of increased oxygen uptake. It is common general knowledge that all berry fruits have similar benefits in relation to vitamins C.

STUDY AIMS

The research is required to see if the addition of [a] Citrus fnUt and/or [b] Berry fruit, to a cannabinoid oral care composition with xanthan gum, can increase the oxygen levels in its users. (The answer is, yes, but for details see the internal tests below, particularly regarding synergistic increase.) The measurement of oxygen levels will be determined by use of a clinical oximeter.

ADMINISTRATION

The method of testing will be undertaken over an 8 week period, home visits and use of a clinical oximeter.

STUDY DESIGN

The study will be using 10 participants aged between 18 -60.

STUDY PROCEDURES

The two testers will visit 5 participants each once a week for 2 successive weeks, 3 times, to measure their respective oxygen levels before using the products and 1 hour after using the products. The information will be recorded and be published to! the Client I at the end of the study.

SAFETY MONITORING PLAN co 20

All participants have confirmed that they are not allergic to any of the composition ingredients and no contraindications are present.

00 FRUIT / BERRY BASED COMPOSITION INCLUDES THE FOLLOWING (Excluding poisonous / poisonous when unripe)

O

Orange, Mandarin, Orange, Tangerine, Blood Orange, Tangelo, Bitter Orange, 0 Yuzu, Grapefruit, Pomelo, Ugh Fruit, Kumquat, Citron, Calamondin, Lemon, Key Lime, Finger Lime, Persian Lime, Acai Berry, Barberry Bilberry, Blackberry, Blackcurrant, Blueberry, Boysenberries, Chokeberry, Cloudberry Cranberry, Elderberry, Gooseberry, Huckleberry, Juneberry, Kiwi berry, Lingonberry Loganberry Mulberry, Raspberry, Redcurrant, Salmonberry, Sea buckthorn berry Strawberry, Taybcrry, Banana, Pumpkin, Pineapple (The following results are a typical example taken from the full trial results.) Specifically, for each of the following results, the compositions used were: for NCBD and for LCBD products: (the lists of ingredients and proportions of key ones are the same as given below in the corresponding internal trials.

TABLE I (First trial, using NCBD and LCBD) This external trial was performed with CBD (= NCBD) and lemon citrus CBD (= LCBD) compositions NCBD CBD+Fruit = LCBD Ref Age Sex Tester Week 1 Before After +(/-) Week 2 Before After +(/-) AX/234098 18 M AP 14/08/22 90 91 1 21/08/22 92 95 3 BG/976554 22 M AP 14/08/22 87 89 2 21/08/22 89 91 2 DD/937420 46 F AP 14/08/22 86 87 1 21/08/22 88 92 4 KM/735293 47 F AP 14/08/22 92 93 1 21/08/22 94 95 1 FG/037462 54 M AP 14/08/22 88 90 2 21/08/22 90 93 3

CO

C

CO O

O

-10 -M N/209457 60 F RD 14/08/22 89 90 1 21/08/22 91 94 3 E M/053866 32 F RD 14/08/22 85 87 2 21/08/22 87 90 3 M P/563921 23 F RD 14/08/22 95 95 0 21/08/22 97 98 1 P1/258495 19 M RD 14/08/22 93 94 1 21/08/22 95 97 2 YY/141991 40 M RD 14/08/22 93 94 1 21/08/22 95 98 3 NC BD C BD+F ruit = LCBD Ref Age Sex Tester Week 4 Before After +(/-) Week 5 Before After +(/-) AX/234098 18 M AP 04/09/22 88 91 3 11/09/22 90 94 4 86/976554 22 M AP 04/09/22 88 89 1 11/09/22 90 92 2 DD/937420 46 F AP 04/09/22 87 89 2 11/09/22 91 91 0 KM/735293 47 F AP 04/09/22 91 93 2 11/09/22 93 95 2 FG/037462 54 M AP 04/09/22 87 90 3 11/09/22 89 92 3 M N/209457 60 F RD 04/09/22 90 91 1 11/09/22 92 93 1 E M/053866 32 F RD 04/09/22 86 87 1 11/09/22 88 89 1 M P/563921 23 F RD 04/09/22 93 95 2 11/09/22 95 97 2 P1/258495 19 M RD 04/09/22 90 91 1 11/09/22 90 96 6 YY/141991 40 M RD 04/09/22 92 94 2 04/09/22 92 96 4 NCBD CBD+Fru it = LC BD Ref Age Sex Tester Week 7 Before After +(/-) Week 8 Before After +(/-) AX/234098 18 M AP 25/09/22 93 94 1 02/10/22 95 97 2 B6/976554 22 M AP 25/09/22 90 90 0 02/10/22 92 94 2 DD/937420 46 F AP 25/09/22 93 94 1 02/10/22 95 96 1 KM/735293 47 F AP 25/09/22 87 89 2 02/10/22 89 93 4 FG/037462 54 M AP 25/09/22 89 90 1 02/10/22 91 92 1 M N/209457 60 F RD 25/09/22 91 93 2 02/10/22 93 97 4 E M/053866 32 F RD 25/09/22 90 92 2 02/10/22 92 94 4 M P/563921 23 F RD 25/09/22 94 95 1 02/10/22 96 97 1 P1/258495 19 M RD 25/09/22 93 94 1 02/10/22 95 96 1 YY/141991 40 M RD 25/09/22 91 92 1 02/10/22 93 95 2 (i) All resul s gathered using a MD300052 PULSE OXIMETER (ii) All participants measured 60 minutes between the 'before' and 'after' of each weekly test.

(iii) CBD in toothpaste= 75mg in 75m1

CONCLUSION, TABLE I

Based on the testing group and the parameters, it appears that there is a relationship between the oral care composition and the increase in oxygen levels, namely, a consistent increase in the oxygenation when using LCBD compared with using NCBD.

There is an assumption is that a composition containing any [a] citrus and/or any [b] berry fruit will achieve the same results as any other of these, based on the facts that the respective fruits have similar properties in terms of increasing oxygen levels. (For the basis of this assumption, see the above references.) TABLE 2 (second trial usin LCBD) The participant had mucositis inflammation and IBS resulting from treatment for cancer.

The trial results given below in Table 2, unlike those in Table 1 above, which show the comparative effects of using different components for the composition, arc included because they show an interesting conclusion, see note (iv).

Tested daily for a week using the same composition as above, except with variable amounts of fruit: Ref Age Sex Tester Day Date % Before After + (-) 1 DC/048574 48 M AP Day 1 0.50 89 89 0 Day 2 0.8 91 92 1 Day 3 1.00 88 92 4 Day 4 1.25 90 94 4 Day 5 1.50 93 94 1 Day 6 1.8 92 94 2 Day 7 2.00 90 93 3 NB: (i) All results gathered using an MD300052 PULSE OX1METER (ii) Participant measured 60 minutes between each daily (Before and After) pair of tests %_ % amount of fruit in composition (iv) From this it was possible to deduce that the body was building up its blood-oxygen level, which evened out from Day 4 (sec "After" = 94, 94, 94, 93) and was responding to oxygenation increase due to the fruit.

The participant confirmed that, from Day 4, mouth ulcers and IBS (together with pains in the stomach) had practically ceased. (IBS is inflammation of the gastro-intestinal tract.)

CONCLUSION, TABLE 2

CO

NM 15

O

Based on the testing parameters, it appears that there is a relationship between the concentration of fruit in the oral care composition and the increase in oxygen levels, between concentration levels of %O.5-%1.25.

There is an assumption that a composition containing any [a] citrus and/or any [b] berry fruit will achieve the same results as any other of these, based on the facts that the respective fruits have similar properties in terms of ability to increase oxygen levels.

1N-HOUSE TRIALS Using the above external trials as a model, similar in-house clinical trials (using a urine strip test) showed that with each of the citrus fruits there was a significant increased uptake of vitamin C. Similar in-house clinical trials (using an oximeter) showed that with each of the berry fruits there was a significant increased systemic uptake of oxygen.

Similar in-house clinical trials (using an oximeter) showed that with each of the minerals there was a significant increased systemic uptake of oxygen.

The aforesaid monatomic molecular materials are elements and, as a subgroup, comprise gold, platinum, silver, carbon, calcium, copper, iron, magnesium, manganese, sodium, nickel, zinc. Similar in-house clinical trials (using an oximeter) showed that with each of the minerals of this subgroup as, or as part of, the oxygenator there was a significant increased systemic uptake of oxygen, moreover this (in conjunction with the use of fruit) was -12 -found to be a synergistic increase compared with that due to the fruit alone or these minerals alone, all excluding those which are poisonous.

The trials were conducted multiply, using 1%, 3% and 5% of the oxygenator and again of each (or each combination) of the essential oils and/or minerals where two or more were used together in the oxygenator, with and without CBD, all in respective trials.

Embodiments of this invention have been found to produce in the body an increased systemic uptake of oxygen. Thus, embodiments of the invention comprise: respective oral care or like compositions comprising as an oxygenator each one of the following citrus fruits, namely, orange, mandarin orange; tangerine, blood orange, tangelo, bitter orange, yuzu, grapefruit, pomelo, ugh fruit, kumquat, citron, calamondin, lemon, key lime, finger lime and persian lime; all excluding those which are poisonous or poisonous when unripe; respective oral care or like compositions comprising as an oxygenator each one of the following berry fruits, namely, acai berry, barberry, bilberry, blackberry, blackcurrant, blueberry, boysenberries, chokeberry, cloudberry, cranberry, elderberry, gooseberry, huckleberry, juneberry, kiwi berry, lingonberry, loganberry, mulberry, raspberry, redcurrant, salmonberry, sea buckthorn berry, strawberry, tayberry, bananas, grapes, cucumbers, tomatoes, oranges, watermelons, pumpkins and pineapples; all excluding those which are poisonous or poisonous when unripe; respective oral care or like compositions comprising as an oxygenator each one of the following other sources of essential oils, namely, rose, mint, menthol, peppermint, other common members of the mint family, and others mentioned in the articles by Dr Mestri; all excluding those which are poisonous or Cr) poisonous when unripe or over ripe; respective oral care or like compositions comprising as an oxygenator each one of the following minerals, namely, gold, gold dust, gold salts, silver, silver dust, silver salts, diamonds and other 00 precious stones, crystals and semiprecious crystals, quartz, rose quartz, and monoatomic molecular 0 25 materials, namely, gold, platinum, silver, carbon, calcium, copper, iron, magmesium, manganese, sodium, nickel, zinc; all excluding those which are poisonous. Such oxygenator may additionally act O as an abrasive.

Most of the foregoing have been very successfully trialled, with and without CBD, all in respective trials.

Regarding the essential oil purity, the inventor has noted the above-mentioned online article by Dr Mestri; and from his own in-house trials that the percentage of fruit (essential oil) is preferred to be roughly the same for single fruit or multiple fruits used together. The inventor notes that too much fruit (it will be clear That references herein to "fruit" should be read as references to "fruit essential oil" and so on as the case may be), say, >5%, will imbalance the flavour and also change the viscosity of the composition to being too watery and concludes from his in-house trials that the preferred range of total essential oil should be 1% to 5%, though the range could still be useful down to 0.5% or even to 0.1%. Percentages stated herein are to be understood as substantially those percentages.

Some examples are now given in the following tables of a selection of many similar in-house clinical trials which were carried out, all using one of the 'COMPOSITIONS' listed below, apart from an added ingredient of one or more of CBI), essential oil (usually fruit) and mineral (preferably gold salt). A large number of in-house trials were conducted along the same lines as the certified trial described above; but no further details are given here because to do so would be unduly burdensome: it is considered that any competent skilled person can trial similarly from the above-given external trial details and a note of the parameters to be Mailed.

The fruits and other essential oils would not normally be expected to be mixed except as required by flavour or marketing. Trials are still ongoing but are believed to be only confirmatory.

-13 -

TABLE 3

Using NCBD = 'NATURAL' CBD; then LCBD = CBD + Emit CBD COMPOSITION (NCBD) CBD + FRUIT COMPOSITION (LCBD) Ref Age Sex Tester TEST 1 Before After + (-) TEST 2 Before After + (-) 1 AY/234102 20 F AP 17/04/2023 92 94 2 24/04/2023 90 94 4 2 BJ/976558 24 F RD 17/04/2023 89 91 2 24/04/2023 90 93 3 3 DP/937424 28 M AP 17/04/2023 88 90 2 24/04/2023 91 94 3 4 KG/735297 49 M RD 17/04/2023 92 93 1 24/04/2023 93 97 4 FF/037466 56 F AP 17/04/2023 90 91 1 24/04/2023 90 92 2 6 MN/209461 62 IVI AP 17/04/2023 91 92 1 24/04/2023 92 96 4 7 1M/053870 34 M RD 17/04/2023 87 89 2 24/04/2023 88 92 4 8 TP/563925 25 IVI RD 17/04/2023 93 93 0 24/04/2023 94 97 3 9 P1/258499 21 F AP 17/04/2023 91 93 2 24/04/2023 92 95 3 YY/141995 42 F RD 17/04/2023 90 91 1 24/04/2023 93 96 3 (NATURAL) CBD COMPOSITION (= NCBD) = Sorbitol, water hydrated silica, glycerin, sodium lauroy sarcosinate, cellulose gum, xanthan gum, potassium sorbate, sodium phytate, tetrasodium pyrophosphate xylitol, calendula officinalis extract, citric acid, cannabis sativa leaf extract CBD, menthol.

CBD + FRUIT (LEMON) COMPOSITION (= LCBD) = Sorbitol, water, hydrated silica, glycerin, sodium Cle) lauroyl sarcosinate, cellulose gum, xanthan gum, potassium sorbate, sodium phytate, tetrasodium Cpyrophosphate, xylitol, calendula officinalis extract, dirk acid, cannabis sativa leaf extract CBD, menthol, citrus limon fruit extract (essential oil), flavour.

CO 10 NB: (a) All results gathered using an MD300052 PULSE OXIMETER (ii) Participant measured 60 minutes between the pair of (Before and After) tests on each weekly date (iii) CBD in toothpaste = 75mg in 75m1

TABLE 4

Using LCBD. then CBDG, then LCBDG CBD & FRUIT (LCBD) CBD & MINERAL (CBDG) CBD & FRUIT & MINERAL (LCBDG) Ref Age Sex Tester TEST 1 Before After + (-) TEST 2 Before After + (-) TEST 3 Before After + (-) 1 AY/234102 20 F AP 01/05/2023 90 91 1 08/05/2023 91 93 2 15/05/2023 91 95 4 2 BJ/976558 24 F RD 01/05/2023 88 89 1 08/05/2023 90 92 2 15/05/2023 90 95 5 3 DP/937424 28 M AP 01/05/2023 88 89 1 08/05/2023 91 94 3 15/05/2023 91 96 5 4 KG/735297 49 M RD 01/05/2023 91 93 2 08/05/2023 92 95 3 15/05/2023 92 98 6 FF/037466 56 F AP 01/05/2023 90 92 2 08/05/2023 91 95 4 15/05/2023 91 98 7 6 MN/209461 62 M AP 01/05/2023 91 93 2 08/05/2023 89 91 2 15/05/2023 89 95 6 7 JM/053870 34 M RD 01/05/2023 87 88 1 08/05/2023 92 94 2 15/05/2023 92 96 4 8 TP/563925 25 M RD 01/05/2023 93 94 1 08/05/2023 92 94 2 15/05/2023 92 99 7 9 PJ/258499 21 F AP 01/05/2023 91 92 1 08/05/2023 91 93 2 15/05/2023 91 95 4 YY/141995 42 F RD 01/05/2023 90 92 2 08/05/2023 90 93 3 15/05/2023 90 96 6 -14 -LCBD = CBD FRUIT COMPOSITION = LEMON (LCBD) = Sorbitol, water, hydrated silica, glycerin, sodium lauroyl sarcosinate, cellulose gum, xanthan gum, potassium sorbate, sodium phytate tetrasodium pyrophosphate, xylitol, calendula oflicinalis extract, citric acid, cannabis sativa leaf extract CBD, menthol, citrus limon fruit extract, flavour CBD MINERAL (GOLD SALT) COMPOSITION = (CBDG) = MINERAL (CBDG) Sorbitol, water, hydrated silica, glycerin, sodium lauroyl sarcosinate, cellulose gum, Nathan gum, potassium sorbate, sodium phytate, tetrasodium pyrophosphate, xylitol, calendula officinalis extract, citric acid, cannabis saliva leant extract CBD, menthol, gold salt CBD FRUIT & MINERAL COMPOSITION = GOLD (LCBDG) = LEMON (LCBDG) Sorbitol, water.

hydrated silica, glycerin, sodium lauroyl sarcosinate, cellulose gum, xanthan gum, potassium sorbate, sodium phytate, tetrasodium pyrophosphate, xylitol, calendula officinalis extract, citric acid, cannabis sativa leaf extract CBD, menthol, citrus limon fruit extract, flavour, gold salt CO N25

O

NB: (i) All results gathered using an MD300052 PULSE OXIMETER (ii) Participant measured 60 minutes between the pair of (Before and After) tests on each weeldy date In these last three examples used for trialling, the respective proportions (roughly equal to % w/w) were substantially: CBD 2 Sorbitol 30 Water 15.1 PAP 18 Propylene Glycol 10 Glycerol 5 Potassium Nitrate 5 Polyethylene Glycol-8 3 Hydroxyapatite 1 Cellulose Gum 1 Hydroxyethyl Cellulose 0.5 Xanthan Gum 0.35 Saccharin Sodium 0.2 Menthol 0.2 Methyl paraben 0.15 Aloe Leaf Juice 0. I Chamomilla Recutita Extract 0.1 Pomegranate Seed Extract 0.1 Sodium Bicarbonate 0.1 Propylparaben 0.05 Trans-Anethole 0.015 Cineole 0.005 Isomenthone 0.005 Trans-menthone 0.005 Carvone 0.005 Dipentene 0.005 Pin-2(3)-ene 0.005 Pin-2(10)-ene 0.005 with substantially the proportions, likewise, of citrus limon fruit extract (citrus essential oil) 0.5 and gold salt 0.5 where included.

The examples given herein describe and demonstrate illustrative embodiments within the scope of the present invention. The examples are given solely for illustration and are not to be construed as limitations of this invention as many variations are possible without departing from the spirit and scope thereof. Various modifications of the invention in addition to those shown and described herein should be apparent to those skilled in the art and are intended to fall within the appended claims.

-15 -References herein to websites are to be taken as importing the whole of the content of each such website into the present description; and features thereof are to be considered as being able to be combined with any other features hereof to adduce further examples of embodiments of the invention, including for example values and ranges and alternatives of ingredients.

The text of the accompanying claims is hereby imported into this description as aspects of the invention and/or embodiments of the invention.

It will be apparent to one skilled in the art, that features of the different embodiments disclosed or otherwise mentioned herein may be omitted, selected, combined or exchanged and the invention is considered to extend to any new and inventive combination thus formed, taking into account the following. Where a preference or particularisation is stated, there is implied die possibility of its negative, i.e. a case in which that preference or particularisation is absent.

Many variations of the invention and embodiments hereinbeforc described or otherwise mentioned will bc apparent to people skilled in the art and all such variations are to bc considered as falling within the scope of the invention.

CO C

CO O

O

Claims (21)

1. CLAIMS1. An oral care or like composition that comprises an oxygenator as herein defined, to be used in a method of treatment of the human or animal body by therapy practised on the body by using the oxygenator as a medicament acting through the oral tissue in order to reach the bloodstream.
2. 2. An oral care or like composition as claimed in any preceding claim, that comprises an oxygenator as herein defined, to be used in a method of treatment of the human or animal body by therapy practised on the body by using the oxygenator as a medicament acting through the oral tissue in order to reach the bloodstream, to achieve a systemic effect and/or to enhance the body's ability to take up vitamin C and/or oxygen.
3. 3. A composition as claimed in any preceding claim, in which said oxygenator comprises essential oil.
4. 4. A composition as claimed in any preceding claim, in which said oxygenator comprises essential oil of one or more fruits.
5. S. A composition as claimed in claim 4 in which said one or more fruits comprise one or more citrus fruits.
6. 6. A composition as claimed in claim 5, in which said citrus fruits comprise one or more of the group comprising orange, mandarin orange, tangerine, blood orange, tangelo, bitter orange, yuzu, grapefruit, pomelo, ugh fruit, kumquat, citron, calamondin, lemon, key lime finger lime and persian lime, all excluding those which are poisonous or poisonous when unripe.
7. 7. A composition as claimed in claim 4, 5 or 6, in which said one or more fruits comprise one or more berry fruits.
8. 8. A composition as claimed in claim 7, in which said berry fruits comprise one or more of the group comprising nal berry, barberry, bilberry, blackberry, blackcurrant, blueberry, boysenberries, chokeberry, cloudberry, cranberry, elderberry, gooseberry, huckleberry, Juneberry, kiwi berry, lingonberry, loganberry, mulberry, raspberry, redcurrant, salmonberry, sea buckthorn berry, strawberry, tayberry, bananas, grapes, cucumbers, tomatoes, oranges, watermelons, pumpkins and pineapples, all excluding those which are poisonous or poisonous when unripe.
9. 9. A composition as claimed in any preceding claim, in which the oxygenator comprises CBD.
10. 10. A composition as claimed in any preceding claim, comprising one or more of what is hereby termed a minerals group, namely, the group comprising gold, gold dust, gold salts, silver, silver dust, silver salts, diamonds and other precious stones, crystals and semiprecious crystals, quartz, rose quartz and a subgroup of mono-atomic molecular materials comprising gold, platinum, silver, carbon, calcium, copper, iron, magnesium, manganese, sodium, nickel, zinc, all excluding those which are poisonous.
11. I1. A composition as claimed in claim 10, in which the weight-in-weight proportion of said minerals group in the composition is in the range of from 1% to 5%.
12. 12. A composition as claimed in any preceding claim, in which the oxygenator comprises CBD, in which the weight-in-weight proportion of the CBD in the composition is in the range of from I% to 5%.
13. 13. A composition as claimed in any preceding claim, in which said oxygenator comprises essential oil and the weight-in-weight proportion of said essential oil in the composition is in the range of from 1% to 5%.
14. 14. A composition as claimed in any preceding claim, comprising CBD and essential oil of one or more fruits of the group comprising citrus fruits and berry fruits.
15. 15. A composition as claimed in any preceding claim, to be used in said method to ameliorate inflammation other than in the mouth.
16. 16. A method to improve the health of the body comprising applying an effective amount of the composition as claimed in any preceding claim to the oral cavity of a subject in need thereof.
17. 17. A method as claimed in claim 16, applied to enhance the body's ability to take up vitamin C and/or oxygen.
18. 18. A method as claimed in claim 17, applied to ameliorate inflammation or the likelihood of inflammation.
19. 19. A method to improve the health of the body comprising applying to the oral cavity a safe and effective amount of a composition as claimed in any one of claims 1 to 15.
20. 20. The use of fruit or a fruit product in the manufacture of a composition as claimed in any one of claims 1 to 15.
21. 21. The use of fruit or a fruit product in the manufacture of a composition as claimed in any one of claims 1 to 15, for use in a method as claimed in any one of claims 16 to 19.