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GB2641646A - Tensioning mechanisms for peeling a sheet from a blister strip for use in dry powder inhalers - Google Patents

Tensioning mechanisms for peeling a sheet from a blister strip for use in dry powder inhalers

Info

Publication number
GB2641646A
GB2641646A GB2511642.7A GB202511642A GB2641646A GB 2641646 A GB2641646 A GB 2641646A GB 202511642 A GB202511642 A GB 202511642A GB 2641646 A GB2641646 A GB 2641646A
Authority
GB
United Kingdom
Prior art keywords
hub
take
spring
dry powder
powder inhaler
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB2511642.7A
Other versions
GB202511642D0 (en
Inventor
Alexander Earwaker Thomas
Georgina Armstrong Zoe
Ray Nicholson-Lewis Michael
meredith jones Matthew
Wang Jianye
Alexander Senior James
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Transpire Bio Inc
Original Assignee
Transpire Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transpire Bio Inc filed Critical Transpire Bio Inc
Publication of GB202511642D0 publication Critical patent/GB202511642D0/en
Publication of GB2641646A publication Critical patent/GB2641646A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0043—Non-destructive separation of the package, e.g. peeling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/003—Particle size control by passing the aerosol trough sieves or filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0003—Details of inhalators; Constructional features thereof with means for dispensing more than one drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A61M15/0026—Hinged caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0053—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal
    • A61M15/0055—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal the used dosages being coiled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A61M15/0075—Mechanical counters having a display or indicator on a disc
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Inhaler devices for delivering dry powdered medicament from at least one blister strip. The inhaler device includes an actuator for operating a dispensing mechanism of the inhaler device. Tensioning mechanisms for use in the inhaler devices are configured to maintain consistent tension in the blister strip over a lifetime of the device.

Claims (41)

1. CLAIMS
2. 1. A tensioning mechanism for peeling a sheet from a blister strip for use in a dry powder inhaler device, the tensioning mechanism comprising: a base; a nut that includes at least one rib that engages with a cam surface; a compression spring longitudinally axially adjacent to the nut; and a take-up hub disposed about the nut and the compression spring, wherein the nut is disposed between and coupled to each of the take-up hub and the base, and wherein the take-up hub is rotationally constrained to the nut, and wherein the take-up hub is configured to rotate relative to the base, and wherein when the base is rotationally driven the nut is configured to interact with the compression spring and the cam surface to apply a torque onto the take-up hub, and wherein when the take-up hub applies an opposing torque onto the nut, the nut moves along the cam surface and axially compresses the compression spring.
3. 2. The tensioning mechanism of claim 1, wherein the take-up hub includes a hook on an outer surface thereof, the hook being configured to attach to an end of the sheet of the blister strip such that rotation of the take-up hub results in winding of the sheet of the blister strip around the takeup hub.
4. 3. The tensioning mechanism of claim 1, wherein the take-up hub is axially constrained relative to the base.
5. 4. The tensioning mechanism of claim 3, wherein the take-up hub is axially constrained relative to the base via a bayonet connection between the base and the take-up hub.
6. 5. The tensioning mechanism of claim 4, wherein the bayonet connection includes a radial extension on the base and an internal flange in the take-up hub, the internal flange including an axial slot that is configured to allow passage of the radial extension therethrough.
7. 6. The tensioning mechanism of claim 1, wherein the base includes a plurality of gear teeth integrally formed with or fixed to an outer circumferential surface of the base.
8. 7. The tensioning mechanism of claim 1, wherein the cam surface includes alternating sections of vertical surfaces and inclined surfaces.
9. 8. The tensioning mechanism of claim 7, wherein the at least one rib includes a plurality of ribs circumferentially spaced apart.
10. 9. The tensioning mechanism of claim 1, wherein the cam surface is integrally formed with or fixed to a portion of the base, and wherein the at least one rib projects radially inwards from an inner circumferential surface of the nut, and wherein the take-up hub is rotationally locked to the nut.
11. 10. The tensioning mechanism of claim 9, wherein the compression spring extends between the take-up hub and the nut.
12. 11. The tensioning mechanism of claim 9, wherein the take-up hub is rotationally locked to the nut via an outwardly-extending rib which projects radially outwards from an outer circumferential surface of the nut and is received within an axial slot of the take-up hub.
13. 12. The tensioning mechanism of claim 9, wherein the cam surface has a first outer diameter, and the compression spring has a second outer diameter, the first outer diameter being greater than the second outer diameter.
14. 13. The tensioning mechanism of claim 1, wherein the cam surface is integrally formed with or fixed to a portion of the take-up hub, and wherein the at least one rib projects radially outwards from an outer circumferential surface of the nut, and wherein the base is rotationally locked to the nut.
15. 14. The tensioning mechanism of claim 13, wherein a shaft extends from the base, the shaft being integrally formed with or fixed to the base, and wherein the base is rotationally locked to the nut via an inwardly-extending rib which projects radially inwards from an inner circumferential surface of the nut and is received within an axial slot of the shaft.
16. 15. The tensioning mechanism of claim 1, wherein the compression spring extends between the nut and the base.
17. 16. A dry powder inhaler device comprising: a housing for receiving at least one blister strip for use in the dry powder inhaler device, the blister strip including a bottom sheet and a top sheet releasably secured to the bottom sheet; the tensioning mechanism of claim 1 disposed within the housing; and, an index spool which is rotationally driven in a first direction, wherein an outer surface of the index spool receives the bottom sheet of the blister strip, wherein an outer surface of the take-up hub is attached to an end of the top sheet and rotation of the take-up hub in a second opposing direction causes the top sheet to wind around the outer surface of the take-up hub, and wherein increased tension along the top sheet of the blister strip results in rotation of the take-up hub relative to the base in the first direction to reduce tension along the top sheet of the blister strip, and wherein axial compression of the compression spring is transferred to torque applied to the take-up hub.
18. 17. A dry powder inhaler device comprising: a housing for receiving at least one blister strip for use in the dry powder inhaler device, the blister strip including a bottom sheet and a top sheet releasably secured to the bottom sheet; an index spool which is rotationally driven in a first direction, wherein an outer surface of the index spool receives the bottom sheet of the blister strip; a take-up hub which is rotationally driven in the first direction or a second opposing direction, wherein an outer surface of the take-up hub is attached to an end of the top sheet and rotation of the take-up hub causes the top sheet to wind around the outer surface of the take-up hub; and a tensioning mechanism including a slider and at least one spring attached to the slider, wherein the tensioning mechanism is coupled to the housing so as to permit axial movement of the slider relative to the housing along a predetermined path, wherein the slider is configured to receive an intermediate portion of the top sheet of the blister strip, the intermediate portion of the top sheet disposed between the index spool and the take-up hub, and wherein increased tension along the top sheet of the blister strip results in axial movement of the slider along the predetermined path, and wherein axial movement of the slider axially compresses or extends the spring to reduce tension along the top sheet of the blister strip.
19. 18. The dry powder inhaler device of claim 17, wherein a first end of the spring is attached to the slider and a second end of the spring is attached to the housing.
20. 19. The dry powder inhaler device of claim 17, wherein the predetermined path is formed by a recess in an inner surface of the housing.
21. 20. The dry powder inhaler device of claim 17, wherein the spring is a compression spring, and the compression spring is biased to push the slider away from each of the index spool and the take-up hub.
22. 21. The dry powder inhaler device of claim 20, wherein axial compression of the compression spring moves the slider closer to the each of the index spool and the take-up hub.
23. 22. The dry powder inhaler device of claim 17, wherein the predetermined path is linear.
24. 23. The dry powder inhaler device of claim 17, wherein the at least one spring includes a single spring.
25. 24. The dry powder inhaler device of claim 17, wherein the at least one spring includes two springs.
26. 25. The dry powder inhaler device of claim 17, wherein the take-up hub is rotationally driven in the first direction.
27. 26. The dry powder inhaler device of claim 17, wherein the take-up hub is rotationally driven in the second opposing direction.
28. 27. The dry powder inhaler device of claim 17, wherein the at least one spring is a compression spring and axial movement of the slider axially compresses the spring to reduce the tension along the top sheet of the blister strip.
29. 28. The dry powder inhaler device of claim 17, wherein the at least one spring is an extension spring and axial movement of the slider axially extends the spring to reduce the tension along the top sheet of the blister strip.
30. 29. A dry powder inhaler device comprising: a housing for receiving at least one blister strip for use in the dry powder inhaler device, the blister strip including a bottom sheet and a top sheet releasably secured to the bottom sheet, wherein the housing includes a curved slot on an inner surface thereof and a pin radially extending from the inner surface of the housing, the pin disposed adjacent to a first end of the curved slot and fixed to the housing; an index spool which is rotationally driven in a first direction, wherein an outer surface of the index spool receives the bottom sheet of the blister strip; a take-up hub which is rotationally driven in a second opposing direction, wherein an outer surface of the take-up hub is attached to an end of the top sheet and rotation of the take-up hub causes the top sheet to wind around the outer surface of the take-up hub, and wherein the take-up hub is coupled to the housing so as to permit movement of the take-up hub relative to the housing along the curved slot; and a tensioning mechanism including at least one spring coupled to the take-up hub, wherein a first end of the spring is fixed to the housing and a second end of the spring is coupled to the take-up hub, wherein the pin is configured to receive an intermediate portion of the top sheet of the blister strip, the intermediate portion of the top sheet extending between the index spool and the take-up hub, and wherein increased tension along the top sheet of the blister strip results in movement of the take-up hub along the curved slot of the housing, and wherein movement of the take-up hub axially deforms the spring to reduce the tension along the top sheet of the blister strip.
31. 30. The dry powder inhaler device of claim 29, wherein the at least one spring is an extension spring.
32. 31. The dry powder inhaler device of claim 29, wherein the tensioning mechanism includes a bracket, the bracket having a first end coupled to permit relative rotation of the index spool relative to the bracket, a second end attached to the second end of the spring, and an intermediate portion coupled to the take-up hub to permit relative rotation of the take-up hub relative to the bracket.
33. 32. The dry powder inhaler device of claim 31, wherein the bracket is permitted to rotate relative to the housing.
34. 33. The dry powder inhaler device of claim 32, wherein the spring is biased to position the takeup hub at a second end of the curved slot which is opposite from the first end of the curved slot and the pin and wherein movement of the take-up hub in a direction towards the pin axially extends the extension spring to reduce the tension along the top sheet of the blister strip.
35. 34. The dry powder inhaler device of claim 29, wherein the spring is disposed in line with a centerline of the top sheet.
36. 35. The dry powder inhaler device of claim 29, wherein the curved slot is concentric with an axis of rotation of the index spool.
37. 36. The dry powder inhaler device of claim 29, wherein the at least one spring is a torsion spring.
38. 37. The dry powder inhaler device of claim 36, wherein the at least one spring includes a first torsion spring and a second torsion spring, the first torsion spring configured to act on a first side of the take-up hub and the second torsion spring configured to act on a second opposing side of the take-up hub.
39. 38. The dry powder inhaler device of claim 36, wherein a first leg of the torsion spring is fixed to the inner surface of the housing and a second leg of the torsion spring is coupled to the take-up hub to move in conjunction with the take-up hub along the curved slot.
40. 39. The dry powder inhaler device of claim 38, wherein a body of the torsion spring is disposed concentric to an axis of rotation of the index spool.
41. 40. The dry powder inhaler device of claim 38, wherein the torsion spring is biased to position the take-up hub at a second end of the curved slot which is opposite from the first end of the curved slot and the pin and movement of the take-up hub in a direction towards the pin twists the torsion spring to reduce tension along the top sheet of the blister strip.
GB2511642.7A 2023-02-06 2024-02-01 Tensioning mechanisms for peeling a sheet from a blister strip for use in dry powder inhalers Pending GB2641646A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363483383P 2023-02-06 2023-02-06
PCT/US2024/014004 WO2024167762A2 (en) 2023-02-06 2024-02-01 Tensioning mechanisms for peeling a sheet from a blister strip for use in dry powder inhalers

Publications (2)

Publication Number Publication Date
GB202511642D0 GB202511642D0 (en) 2025-09-03
GB2641646A true GB2641646A (en) 2025-12-10

Family

ID=92263377

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2511642.7A Pending GB2641646A (en) 2023-02-06 2024-02-01 Tensioning mechanisms for peeling a sheet from a blister strip for use in dry powder inhalers

Country Status (6)

Country Link
EP (1) EP4661941A2 (en)
JP (1) JP2026503722A (en)
CN (1) CN120641156A (en)
AU (1) AU2024216557A1 (en)
GB (1) GB2641646A (en)
WO (1) WO2024167762A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6536427B2 (en) * 1990-03-02 2003-03-25 Glaxo Group Limited Inhalation device
US20100059052A1 (en) * 2006-11-15 2010-03-11 Glaxo Group Limited Sheet driver for use in a drug dispenser
US10376662B2 (en) * 2009-05-18 2019-08-13 Adamis Pharmaceuticals Corporation Dry powder inhalers
US11065403B2 (en) * 2015-04-10 2021-07-20 Microdose Therapeutx, Inc. Blister strip advance mechanism
WO2021195353A1 (en) * 2020-03-25 2021-09-30 Lupin Inc. Multi-carrier medicament dispensers

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6536427B2 (en) * 1990-03-02 2003-03-25 Glaxo Group Limited Inhalation device
US20100059052A1 (en) * 2006-11-15 2010-03-11 Glaxo Group Limited Sheet driver for use in a drug dispenser
US10376662B2 (en) * 2009-05-18 2019-08-13 Adamis Pharmaceuticals Corporation Dry powder inhalers
US11065403B2 (en) * 2015-04-10 2021-07-20 Microdose Therapeutx, Inc. Blister strip advance mechanism
WO2021195353A1 (en) * 2020-03-25 2021-09-30 Lupin Inc. Multi-carrier medicament dispensers

Also Published As

Publication number Publication date
WO2024167762A3 (en) 2024-10-24
JP2026503722A (en) 2026-01-29
CN120641156A (en) 2025-09-12
GB202511642D0 (en) 2025-09-03
WO2024167762A2 (en) 2024-08-15
AU2024216557A1 (en) 2025-08-28
EP4661941A2 (en) 2025-12-17

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