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GB2527879B - Using theoretical collision cross section ("CCS") in sample identification - Google Patents

Using theoretical collision cross section ("CCS") in sample identification

Info

Publication number
GB2527879B
GB2527879B GB1504071.0A GB201504071A GB2527879B GB 2527879 B GB2527879 B GB 2527879B GB 201504071 A GB201504071 A GB 201504071A GB 2527879 B GB2527879 B GB 2527879B
Authority
GB
United Kingdom
Prior art keywords
ccs
section
sample identification
collision cross
theoretical collision
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB1504071.0A
Other versions
GB2527879A (en
GB201504071D0 (en
Inventor
Raymond Green Martin
George Richardson Keith
Lee Wildgoose Jason
Giles Kevin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micromass UK Ltd
Original Assignee
Micromass UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd
Publication of GB201504071D0 publication Critical patent/GB201504071D0/en
Publication of GB2527879A publication Critical patent/GB2527879A/en
Application granted granted Critical
Publication of GB2527879B publication Critical patent/GB2527879B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0036—Step by step routines describing the handling of the data generated during a measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/623—Ion mobility spectrometry combined with mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/005—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by collision with gas, e.g. by introducing gas or by accelerating ions with an electric field

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Electrochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
GB1504071.0A 2014-03-10 2015-03-10 Using theoretical collision cross section ("CCS") in sample identification Active GB2527879B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB201404195A GB201404195D0 (en) 2014-03-10 2014-03-10 Confirmation using multiple CCS measurements

Publications (3)

Publication Number Publication Date
GB201504071D0 GB201504071D0 (en) 2015-04-22
GB2527879A GB2527879A (en) 2016-01-06
GB2527879B true GB2527879B (en) 2018-09-12

Family

ID=50554805

Family Applications (5)

Application Number Title Priority Date Filing Date
GB201404195A Ceased GB201404195D0 (en) 2014-03-10 2014-03-10 Confirmation using multiple CCS measurements
GB1504033.0A Active GB2527876B (en) 2014-03-10 2015-03-10 Confirmation using multiple collision cross section ("CCS") Measurements
GB1504069.4A Active GB2527878B (en) 2014-03-10 2015-03-10 Theoretical collision cross section ("CCS") in experimental design
GB1504071.0A Active GB2527879B (en) 2014-03-10 2015-03-10 Using theoretical collision cross section ("CCS") in sample identification
GB1504070.2A Active GB2527632B (en) 2014-03-10 2015-03-10 Unknown identification using theroretical collision cross section

Family Applications Before (3)

Application Number Title Priority Date Filing Date
GB201404195A Ceased GB201404195D0 (en) 2014-03-10 2014-03-10 Confirmation using multiple CCS measurements
GB1504033.0A Active GB2527876B (en) 2014-03-10 2015-03-10 Confirmation using multiple collision cross section ("CCS") Measurements
GB1504069.4A Active GB2527878B (en) 2014-03-10 2015-03-10 Theoretical collision cross section ("CCS") in experimental design

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB1504070.2A Active GB2527632B (en) 2014-03-10 2015-03-10 Unknown identification using theroretical collision cross section

Country Status (1)

Country Link
GB (5) GB201404195D0 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020212877A1 (en) * 2019-04-15 2020-10-22 Waters Technologies Ireland Limited Techniques for predicting collision cross-section values in ion mobility spectrometry
GB202001249D0 (en) * 2020-01-29 2020-03-11 Waters Technologies Ireland Ltd Techniques for sample analysis using product ion collision-cross section information

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100127166A1 (en) * 2008-02-05 2010-05-27 Excellims Corporation Method and apparatus for chemical and biological sample separation
WO2011128703A1 (en) * 2010-04-15 2011-10-20 Micromass Uk Limited Ion mobility method and apparatus for identifying and/or characterising a sample compound

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495824B1 (en) * 2000-03-13 2002-12-17 Bechtel Bwxt Idaho, Llc Ion mobility spectrometer, spectrometer analyte detection and identification verification system, and method
EP1539333B1 (en) * 2002-07-25 2014-10-15 Dh Technologies Development Pte. Ltd. Method and apparatus for control of mobility-based ion species identification
US6831273B2 (en) * 2002-07-31 2004-12-14 General Electric Company Ion mobility spectrometers with improved resolution
GB0508239D0 (en) * 2005-04-23 2005-06-01 Smiths Group Plc Detection apparatus
US20070114382A1 (en) * 2005-11-23 2007-05-24 Clemmer David E Ion mobility spectrometer
US9523657B2 (en) * 2006-02-14 2016-12-20 Excellims Corporation Practical ion mobility spectrometer apparatus and methods for chemical and/or biological detection
WO2008005283A2 (en) * 2006-06-29 2008-01-10 Sionex Corporation Tandem differential mobility spectrometers and mass spectrometer for enhanced analysis
US20100224770A1 (en) * 2009-03-06 2010-09-09 Ensco, Inc. Method for configuring an ion mobility spectrometer system
US8278620B2 (en) * 2010-05-03 2012-10-02 Thermo Finnigan Llc Methods for calibration of usable fragmentation energy in mass spectrometry
US8525106B2 (en) * 2011-05-09 2013-09-03 Bruker Daltonics, Inc. Method and apparatus for transmitting ions in a mass spectrometer maintained in a sub-atmospheric pressure regime

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100127166A1 (en) * 2008-02-05 2010-05-27 Excellims Corporation Method and apparatus for chemical and biological sample separation
WO2011128703A1 (en) * 2010-04-15 2011-10-20 Micromass Uk Limited Ion mobility method and apparatus for identifying and/or characterising a sample compound

Also Published As

Publication number Publication date
GB201504069D0 (en) 2015-04-22
GB2527878B (en) 2018-02-28
GB2527879A (en) 2016-01-06
GB201504070D0 (en) 2015-04-22
GB201404195D0 (en) 2014-04-23
GB2527632A (en) 2015-12-30
GB2527632B (en) 2018-05-30
GB2527876B (en) 2018-05-23
GB2527878A (en) 2016-01-06
GB2527876A (en) 2016-01-06
GB201504033D0 (en) 2015-04-22
GB201504071D0 (en) 2015-04-22

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