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GB2504424A - Synthesis and use of glycoside pro-drug analogs - Google Patents

Synthesis and use of glycoside pro-drug analogs Download PDF

Info

Publication number
GB2504424A
GB2504424A GB1319845.2A GB201319845A GB2504424A GB 2504424 A GB2504424 A GB 2504424A GB 201319845 A GB201319845 A GB 201319845A GB 2504424 A GB2504424 A GB 2504424A
Authority
GB
United Kingdom
Prior art keywords
pro
synthesis
glycoside
drug analogs
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB1319845.2A
Other versions
GB201319845D0 (en
Inventor
Brian Shull
Ramesh Gopalaswamy
John Baldwin
Zishan Haroon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NuTek Pharma Ltd
Original Assignee
NuTek Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NuTek Pharma Ltd filed Critical NuTek Pharma Ltd
Priority claimed from PCT/US2012/033098 external-priority patent/WO2012142141A1/en
Publication of GB201319845D0 publication Critical patent/GB201319845D0/en
Publication of GB2504424A publication Critical patent/GB2504424A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/04—Disaccharides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to methods and compositions for the synthesis, production, and use of pro-drug analogs. This invention relates to a method for the production of a broad group of glycosylated drugs, including but not limited to propofol, acetaminophen, and camptothecin carbohydrate derivatives.
GB1319845.2A 2012-04-11 2012-04-11 Synthesis and use of glycoside pro-drug analogs Withdrawn GB2504424A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2012/033098 WO2012142141A1 (en) 2011-04-13 2012-04-11 Synthesis and use of glycoside pro-drug analogs

Publications (2)

Publication Number Publication Date
GB201319845D0 GB201319845D0 (en) 2013-12-25
GB2504424A true GB2504424A (en) 2014-01-29

Family

ID=49818607

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1319845.2A Withdrawn GB2504424A (en) 2012-04-11 2012-04-11 Synthesis and use of glycoside pro-drug analogs

Country Status (1)

Country Link
GB (1) GB2504424A (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4293503A (en) * 1980-01-10 1981-10-06 Ppg Industries, Inc. Synthesis of polyol bis(allyl carbonate) utilizing reagent recovery and recycle
US6720307B2 (en) * 1996-03-27 2004-04-13 The University Of Michigan Glycosylated analogs of fusidic acid
US7538092B2 (en) * 2002-10-08 2009-05-26 Fresenius Kabi Deutschland Gmbh Pharmaceutically active oligosaccharide conjugates

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4293503A (en) * 1980-01-10 1981-10-06 Ppg Industries, Inc. Synthesis of polyol bis(allyl carbonate) utilizing reagent recovery and recycle
US6720307B2 (en) * 1996-03-27 2004-04-13 The University Of Michigan Glycosylated analogs of fusidic acid
US7538092B2 (en) * 2002-10-08 2009-05-26 Fresenius Kabi Deutschland Gmbh Pharmaceutically active oligosaccharide conjugates

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LEENDERS et al. A novel b-D-glycosyl carbamate forming reaction, Tetrahedron Letters, 2000, Vol. 41, pp 9173-9175. pg 9174, para 3 *

Also Published As

Publication number Publication date
GB201319845D0 (en) 2013-12-25

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)