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GB2593091B - Solid-phase N-terminal peptide capture and release - Google Patents

Solid-phase N-terminal peptide capture and release Download PDF

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Publication number
GB2593091B
GB2593091B GB2106350.8A GB202106350A GB2593091B GB 2593091 B GB2593091 B GB 2593091B GB 202106350 A GB202106350 A GB 202106350A GB 2593091 B GB2593091 B GB 2593091B
Authority
GB
United Kingdom
Prior art keywords
release
solid
phase
terminal peptide
peptide capture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB2106350.8A
Other versions
GB2593091A (en
GB202106350D0 (en
Inventor
Anslyn Eric
Marcotte Edward
J Ii Howard Cecil
Swaminathan Jagannath
M Bardo Angela
Reuther James
M Floyd Brendan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
University of Texas at Austin
Original Assignee
University of Texas System
University of Texas at Austin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System, University of Texas at Austin filed Critical University of Texas System
Priority to GB2216622.7A priority Critical patent/GB2614128B/en
Publication of GB202106350D0 publication Critical patent/GB202106350D0/en
Publication of GB2593091A publication Critical patent/GB2593091A/en
Application granted granted Critical
Publication of GB2593091B publication Critical patent/GB2593091B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6818—Sequencing of polypeptides
    • G01N33/6824—Sequencing of polypeptides involving N-terminal degradation, e.g. Edman degradation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/06—Peptides being immobilised on, or in, an organic carrier attached to the carrier via a bridging agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/14—Peptides being immobilised on, or in, an inorganic carrier
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/265—Adsorption chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/0203—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of metals not provided for in B01J20/04
    • B01J20/0225—Compounds of Fe, Ru, Os, Co, Rh, Ir, Ni, Pd, Pt
    • B01J20/0229—Compounds of Fe
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3285—Coating or impregnation layers comprising different type of functional groups or interactions, e.g. different ligands in various parts of the sorbent, mixed mode, dual zone, bimodal, multimodal, ionic or hydrophobic, cationic or anionic, hydrophilic or hydrophobic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3291—Characterised by the shape of the carrier, the coating or the obtained coated product
    • B01J20/3293—Coatings on a core, the core being particle or fiber shaped, e.g. encapsulated particles, coated fibers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/161—Modifications characterised by incorporating target specific and non-target specific sites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/179—Nucleic acid detection characterized by the use of physical, structural and functional properties the label being a nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/50—Detection characterised by immobilisation to a surface
    • C12Q2565/514—Detection characterised by immobilisation to a surface characterised by the use of the arrayed oligonucleotides as identifier tags, e.g. universal addressable array, anti-tag or tag complement array
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
GB2106350.8A 2018-10-05 2019-10-04 Solid-phase N-terminal peptide capture and release Active GB2593091B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2216622.7A GB2614128B (en) 2018-10-05 2019-10-04 Solid-phase N-terminal peptide capture and release

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862741833P 2018-10-05 2018-10-05
US201962879735P 2019-07-29 2019-07-29
PCT/US2019/054702 WO2020072907A1 (en) 2018-10-05 2019-10-04 Solid-phase n-terminal peptide capture and release

Publications (3)

Publication Number Publication Date
GB202106350D0 GB202106350D0 (en) 2021-06-16
GB2593091A GB2593091A (en) 2021-09-15
GB2593091B true GB2593091B (en) 2023-12-20

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Family Applications (2)

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GB2106350.8A Active GB2593091B (en) 2018-10-05 2019-10-04 Solid-phase N-terminal peptide capture and release
GB2216622.7A Active GB2614128B (en) 2018-10-05 2019-10-04 Solid-phase N-terminal peptide capture and release

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB2216622.7A Active GB2614128B (en) 2018-10-05 2019-10-04 Solid-phase N-terminal peptide capture and release

Country Status (8)

Country Link
US (1) US12498379B2 (en)
EP (1) EP3861009A4 (en)
JP (1) JP2022504225A (en)
CN (1) CN113015740A (en)
AU (1) AU2019355579A1 (en)
CA (1) CA3117476A1 (en)
GB (2) GB2593091B (en)
WO (1) WO2020072907A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11435358B2 (en) 2011-06-23 2022-09-06 Board Of Regents, The University Of Texas System Single molecule peptide sequencing
CN112513269A (en) 2018-07-12 2021-03-16 德克萨斯大学系统董事会 Molecular neighborhood detection by oligonucleotides
GB2593091B (en) 2018-10-05 2023-12-20 Univ Texas Solid-phase N-terminal peptide capture and release
KR20250162948A (en) 2018-11-15 2025-11-19 퀀텀-에스아이 인코포레이티드 Methods and compositions for protein sequencing
US20210139973A1 (en) * 2019-10-28 2021-05-13 Quantum-Si Incorporated Methods of single-cell polypeptide sequencing
WO2021236716A2 (en) * 2020-05-19 2021-11-25 Board Of Regents, The University Of Texas System Methods, systems and kits for polypeptide processing and analysis
US12065466B2 (en) 2020-05-20 2024-08-20 Quantum-Si Incorporated Methods and compositions for protein sequencing
JP7710028B2 (en) * 2021-03-23 2025-07-17 デンカ株式会社 Insoluble particles, kit for measuring target antigen or target antibody, method for measuring target antigen or target antibody, and method for producing insoluble particles
EP4348266A1 (en) * 2021-05-26 2024-04-10 Board of Regents, The University of Texas System Methods and systems for single cell protein analysis
CN117813506A (en) * 2021-05-26 2024-04-02 德克萨斯大学系统董事会 Compositions, methods and utility of conjugated biomolecule barcodes
WO2024076928A1 (en) 2022-10-03 2024-04-11 Erisyon Inc. Fluorophore-polymer conjugates and uses thereof
WO2025072368A1 (en) * 2023-09-28 2025-04-03 Illumina, Inc. Capture and selective release of biological material

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326136B1 (en) * 1988-04-01 2001-12-04 Digene Corporation Macromolecular conjugate made using unsaturated aldehydes
US20020137045A1 (en) * 1999-07-29 2002-09-26 Lukhtanov Eugeny Alexander Attachment of oligonucleotides to solid supports through schiff base type linkages for capture and detection of nucleic acids
US20090215635A1 (en) * 2005-05-02 2009-08-27 Basf Se Labelling strategies for the sensitive detection of analytes
WO2012071428A2 (en) * 2010-11-22 2012-05-31 Solulink, Inc. Methods and/or use of oligonucleotide conjugates for assays and detections
US9580736B2 (en) * 2013-12-30 2017-02-28 Atreca, Inc. Analysis of nucleic acids associated with single cells using nucleic acid barcodes
US20180112212A1 (en) * 2015-03-11 2018-04-26 The Broad Institute, Inc. Proteomic analysis with nucleic acid identifiers
WO2019168164A1 (en) * 2018-03-02 2019-09-06 国立大学法人大阪大学 Molecule for protein and/or peptide design

Family Cites Families (137)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02114180A (en) * 1988-09-06 1990-04-26 Eastman Kodak Co Analytic reagent, element and latex particle for method
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5279954A (en) 1989-06-30 1994-01-18 Board Of Regents Of The University Of Nebraska And Bionebraska Exopeptidase catalyzed site-specific bonding of supports, labels and bioactive agents to proteins
US5914313A (en) 1991-10-17 1999-06-22 Merck & Co., Inc. 1- 4-hydroxy-5-aminoethyloxy-N2 -(10,12-dimethyl-1-oxotetradecyl)ornithine!-5-(3-hydroxyglutamine)-6-(3-hydroxyproline)echinocandin B, other aminoalkyl derivatives and salts thereof
WO1993012234A1 (en) 1991-12-13 1993-06-24 Sri International Antiviral reagents based on rna-binding proteins
US5591646A (en) 1992-09-02 1997-01-07 Arris Pharmaceutical Method and apparatus for peptide synthesis and screening
US5605809A (en) 1994-10-28 1997-02-25 Oncoimmunin, Inc. Compositions for the detection of proteases in biological samples and methods of use thereof
US6660233B1 (en) 1996-01-16 2003-12-09 Beckman Coulter, Inc. Analytical biochemistry system with robotically carried bioarray
ATE247173T1 (en) 1997-01-23 2003-08-15 Xzillion Gmbh & Co Kg CHARACTERIZATION OF POLYPEPTIDES
KR20020021779A (en) 1999-03-23 2002-03-22 바이오베이션 리미티드 Protein isolation and analysis
US6783929B1 (en) 1999-11-02 2004-08-31 Chiron Corporation Biological sample component purification and differential display
US7351540B1 (en) 2000-03-17 2008-04-01 Merck Patent Gmbh Protein isolation and analysis
AU4338502A (en) 2000-10-23 2002-06-24 Genetics Inst Acid-labile isotope-coded extractant (alice) and its use in quantitative mass spectrometric analysis of protein mixtures
DE10117430A1 (en) 2001-04-06 2002-10-10 Nicole Marme Highly sensitive and highly specific enzyme detection with a detection limit down to the femtomolar range
US6829539B2 (en) 2001-04-13 2004-12-07 The Institute For Systems Biology Methods for quantification and de novo polypeptide sequencing by mass spectrometry
IL159857A0 (en) 2001-07-16 2004-06-20 Hk Pharmaceuticals Inc Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
EP1451207B1 (en) 2001-11-05 2009-08-26 Irm Llc Labeling reagent and methods of use
US20040053356A1 (en) 2001-12-28 2004-03-18 Mds Proteomics Inc. Enzyme/chemical reactor based protein processing method for proteomics analysis by mass spectrometry
WO2003087839A1 (en) * 2002-04-04 2003-10-23 Xzillion Gmbh & Co. Kg Method for characterising analytes
JP4186532B2 (en) 2002-07-12 2008-11-26 株式会社島津製作所 Novel metal complex and method for determining amino acid sequence of protein using the same
KR100491666B1 (en) 2002-09-23 2005-05-27 학교법인 인하학원 Method for partitioned layout of protein interaction networks
ATE474851T1 (en) 2002-10-02 2010-08-15 Hoffmann La Roche METHOD FOR IDENTIFYING ANTIGEN PEPTIDES
NZ540889A (en) 2002-11-25 2008-09-26 Attenuon Llc Peptides which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, compositions and uses thereof
US7041472B2 (en) 2002-12-25 2006-05-09 Shimadzu Corporation Method for selectively collecting N-terminal peptide fragment of protein
DE10305050A1 (en) 2003-02-07 2004-08-19 Roche Diagnostics Gmbh Analytical test element and method for blood tests
JP2007528870A (en) * 2003-05-23 2007-10-18 アプラーゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング Peptide synthesis
US7524925B2 (en) 2004-11-18 2009-04-28 Washington State University Protein interaction reporter agents and methods for using same
NO20053354D0 (en) 2005-07-11 2005-07-11 Amersham Health As Optical imaging contrast agent.
DK1957644T3 (en) 2005-12-01 2011-03-28 Nuevolution As Enzymatic coding methods for efficient synthesis of large libraries
WO2007070021A1 (en) 2005-12-09 2007-06-21 Nanobac Pharmaceuticals Incorporated Detection of calcifying nano-particles, and associated proteins thereon
US20100047170A1 (en) 2006-01-05 2010-02-25 Denmeade Samuel R Peptide Prodrugs
US20080044405A1 (en) 2006-02-25 2008-02-21 President And Fellows Of Harvard College Noble metal complex-mediated immunosuppression
US7468258B2 (en) 2006-03-07 2008-12-23 Wake Forest University Health Sciences Self-quenching homofluorophore compositions for detecting enzyme activity
CN100347175C (en) 2006-03-14 2007-11-07 深圳市海滨制药有限公司 Preparation method of beta-methyl carbon penicillenic intermediate
DE102006015001A1 (en) 2006-03-31 2007-10-11 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Method for detecting and / or enriching analyte proteins and / or analyte peptides from a complex protein mixture
CN101432626B (en) 2006-04-04 2013-06-19 神谷来克斯公司 Highly sensitive systems and methods for troponin analysis
US20080076680A1 (en) 2006-04-13 2008-03-27 Ozone Research Frontier Ltd. System and apparatus for automated protein analysis priority
US7848848B2 (en) 2006-04-28 2010-12-07 Freeslate, Inc. Robotic station for capturing both image and weight of a sample
US20090087873A1 (en) 2006-07-21 2009-04-02 Invitrogen Corporation Sharply resolving labeled protein molecular weight standards
JP2008059703A (en) 2006-08-31 2008-03-13 Toshiba Corp Optical disc recording / reproducing apparatus
US20080090238A1 (en) 2006-10-12 2008-04-17 Dan-Hui Dorothy Yang Increased sensitivity of proximity ligation assays
US9029085B2 (en) 2007-03-07 2015-05-12 President And Fellows Of Harvard College Assays and other reactions involving droplets
JP2010528268A (en) 2007-05-18 2010-08-19 ライフ テクノロジーズ コーポレーション Rapid protein labeling and analysis
WO2009090651A2 (en) 2008-01-15 2009-07-23 Technion Research And Development Foundation Ltd. Major histocompatibility complex hla-b2705 ligands useful for therapy and diagnosis
EP2090584A1 (en) 2008-02-13 2009-08-19 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Identification of a novel cysteine-rich cell penetrating peptide
EP2626703B1 (en) 2008-03-27 2017-05-03 Promega Corporation Protein labeling with cyanobenzothiazole conjugates
JP2011525990A (en) 2008-06-26 2011-09-29 ライフ テクノロジーズ コーポレーション Method and apparatus for detecting molecular interactions using FET arrays
CA2766828A1 (en) 2008-07-08 2010-01-14 Cure Kids Methods and compositions for promoting bone growth
WO2010044892A1 (en) 2008-10-17 2010-04-22 President And Fellows Of Harvard College Diagnostic method based on large scale identification of post-translational modification of proteins
JP5203132B2 (en) 2008-10-21 2013-06-05 古河電気工業株式会社 Method for producing silica particle having crosslinkable functional group on particle surface, silica particle having crosslinkable functional group on particle surface, colloid of silica particle, composite particle using silica particle, and method for producing composite particle
US8268977B2 (en) 2008-11-20 2012-09-18 The Board Of Trustees Of The Leland Stanford Junior University Strongly quenching oligomeric excimer/quencher pairs for detection schemes
WO2010065322A1 (en) 2008-12-01 2010-06-10 Research Triangle Institute Concurrent identification of multitudes of polypeptides
WO2010065531A1 (en) 2008-12-01 2010-06-10 Robi David Mitra Single molecule protein screening
CA2750409C (en) 2009-01-30 2019-03-05 Adlyfe, Inc. Peptide probes for amyloid beta protein
EP2226637A1 (en) * 2009-03-04 2010-09-08 Centre National de la Recherche Scientifique (CNRS) Cross-linking agents on solid medium
EP2253635B1 (en) 2009-04-28 2014-03-19 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Novel hydrophilic and lipophilic rhodamines for labelling and imaging
GB2473868A (en) 2009-09-28 2011-03-30 Invitrogen Dynal As Apparatus and method of automated processing of biological samples
US8778685B2 (en) 2009-08-25 2014-07-15 Life Technologies Corporation Quantitative fluorescent protein standards
US9566335B1 (en) 2009-09-25 2017-02-14 The Governing Council Of The University Of Toronto Protein sequencing method and reagents
US8603828B2 (en) 2009-11-18 2013-12-10 Bio-Rad Laboratories, Inc. Multiplex immunoassays for hemoglobin, hemoglobin variants, and glycated forms
US9073990B2 (en) 2010-04-05 2015-07-07 Bar-Llan University Protease-activatable pore-forming polypeptides
WO2012019765A1 (en) 2010-08-10 2012-02-16 European Molecular Biology Laboratory (Embl) Methods and systems for tracking samples and sample combinations
WO2012083261A1 (en) 2010-12-16 2012-06-21 Human Biomolecular Research Institute Blood brain barrier-penetrating oximes for cholistenerases reactivation
US10494671B2 (en) 2011-01-17 2019-12-03 Life Technologies Corporation Enzymatic ligation of nucleic acids
JP5066615B2 (en) 2011-01-31 2012-11-07 株式会社日立製作所 Oligopeptide sequences that bind specifically to phenylboronic acid groups
US20140024124A1 (en) 2011-02-16 2014-01-23 National University Corporation Hokkaido University Labeling agent for analyzing post-translational modifications of serine and threonine
US9470680B2 (en) 2011-02-28 2016-10-18 The Trustees Of Columbia University In The City Of New York Fluorescence-based approach to monitor release factor-catalyzed termination of protein synthesis
EP2518514B1 (en) 2011-04-29 2014-06-18 F. Hoffmann-La Roche AG A method for operating an automated sample workcell
US20200123593A1 (en) 2011-05-20 2020-04-23 Quantum-Si Incorporated Systems and methods for sample preparation
US20200123594A1 (en) 2011-05-20 2020-04-23 Quantum-Si Incorporated Methods and devices for sequencing
CA2839702C (en) 2011-06-23 2021-04-20 Board Of Regents, The University Of Texas System Identifying peptides at the single molecule level
US11435358B2 (en) 2011-06-23 2022-09-06 Board Of Regents, The University Of Texas System Single molecule peptide sequencing
WO2016069124A1 (en) 2014-09-15 2016-05-06 Board Of Regents, The University Of Texas System Improved single molecule peptide sequencing
WO2013112745A1 (en) 2012-01-24 2013-08-01 The Regents Of The University Of Colorado, A Body Corporate Peptide identification and sequencing by single-molecule detection of peptides undergoing degradation
NL2009191C2 (en) 2012-07-16 2014-01-20 Univ Delft Tech Single molecule protein sequencing.
JP6197039B2 (en) 2012-08-24 2017-09-13 イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔｙ High-throughput multiplex detection system, apparatus and method
EP2749653A1 (en) 2012-12-28 2014-07-02 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Molecular coding for analysis of composition of macromolecules and molecular complexes
JP6351511B2 (en) 2013-01-07 2018-07-04 国立大学法人 東京大学 Synthesis of asymmetric Si rhodamine and rhodol
WO2014124336A2 (en) 2013-02-08 2014-08-14 10X Technologies, Inc. Partitioning and processing of analytes and other species
US9435810B2 (en) 2013-03-15 2016-09-06 Washington University Molecules and methods for iterative polypeptide analysis and processing
CA2915499A1 (en) 2013-06-27 2014-12-31 10X Genomics, Inc. Compositions and methods for sample processing
NL2011101C2 (en) 2013-07-04 2014-06-23 Maxi Miliaan Bv Stroller.
US9567645B2 (en) 2013-08-28 2017-02-14 Cellular Research, Inc. Massively parallel single cell analysis
US9186391B2 (en) 2013-08-29 2015-11-17 Musc Foundation For Research Development Cyclic peptide inhibitors of lysine-specific demethylase 1
CN111979229A (en) 2013-09-05 2020-11-24 杰克逊实验室 Compositions for RNA-chromatin interaction analysis and uses thereof
WO2015042506A1 (en) 2013-09-23 2015-03-26 The Trustees Of Columbia University In The City Of New York High-throughput single molecule protein identification
MX2016012055A (en) 2014-03-20 2017-04-13 Bio Rad Laboratories Inc Glycated protein assay.
SG11201608188QA (en) 2014-04-04 2016-10-28 Univ Princeton Decarboxylative cross-coupling and applications thereof
US9568404B2 (en) 2014-05-16 2017-02-14 Junyu Mai Method and apparatus for biomolecule analysis
ES2770634T3 (en) 2014-06-06 2020-07-02 Herlev Hospital Determination of antigen recognition through MHC multimer bar coding
MX2016016902A (en) 2014-06-26 2017-03-27 10X Genomics Inc Methods of analyzing nucleic acids from individual cells or cell populations.
KR101631371B1 (en) * 2014-07-18 2016-06-17 경북대학교 산학협력단 A biochip comprising covalently immobilized bioactive molecules through organic couplers thereon
WO2016114970A1 (en) 2015-01-12 2016-07-21 10X Genomics, Inc. Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same
EP3766988B1 (en) 2015-02-19 2024-02-14 Becton, Dickinson and Company High-throughput single-cell analysis combining proteomic and genomic information
WO2016145416A2 (en) 2015-03-11 2016-09-15 The Broad Institute, Inc. Proteomic analysis with nucleic acid identifiers
WO2016164530A1 (en) 2015-04-07 2016-10-13 University Of Maryland, College Park Compositions and methods for high throughput protein sequencing
GB201509640D0 (en) 2015-06-03 2015-07-15 Sphere Fluidics Ltd Systems and methods
WO2016196931A1 (en) 2015-06-05 2016-12-08 The Trustees Of Princeton University Decarboxylative conjugate additions and applications thereof
JP6873103B2 (en) 2015-08-27 2021-05-19 エルジー ハウスホールド アンド ヘルスケア リミテッド Composition for surface modification
EP3371194B1 (en) 2015-10-16 2020-12-30 Andrew Emili Protein sequencing method
WO2017075265A1 (en) 2015-10-28 2017-05-04 The Broad Institute, Inc. Multiplex analysis of single cell constituents
WO2017079606A1 (en) 2015-11-04 2017-05-11 The Procter & Gamble Company Thin and flexible absorbent articles
EP3371309B1 (en) 2015-11-04 2023-07-05 Atreca, Inc. Combinatorial sets of nucleic acid barcodes for analysis of nucleic acids associated with single cells
ITUA20161706A1 (en) 2016-03-15 2017-09-15 Cyanagen S R L NEW CUMARIN DYES AND RELATED CONJUGES
WO2017180904A1 (en) 2016-04-13 2017-10-19 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods and systems for detecting or monitoring aggregation related to proteopathies
SG10201911917WA (en) 2016-05-02 2020-01-30 Encodia Inc Macromolecule analysis employing nucleic acid encoding
CN109642231A (en) 2016-06-17 2019-04-16 博德研究所 Type VI CRISPR orthologs and systems
WO2018005559A1 (en) 2016-06-27 2018-01-04 Juno Therapeutics, Inc. Method of identifying peptide epitopes, molecules that bind such epitopes and related uses
CN116840465A (en) 2016-06-28 2023-10-03 文塔纳医疗系统公司 New colors dyed with chromogenic IHC and ISH of multi-dye quinone methide and tyramide conjugates
US11339434B2 (en) 2016-07-29 2022-05-24 The Regents Of The University Of California Methods for determining gene functions
SG11201903519UA (en) 2016-10-19 2019-05-30 10X Genomics Inc Methods and systems for barcoding nucleic acid molecules from individual cells or cell populations
DK3548652T3 (en) 2016-12-01 2024-07-08 Nautilus Subsidiary Inc METHODS FOR PROTEIN ANALYSIS
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP4628582A3 (en) 2017-01-30 2025-12-24 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
US11072816B2 (en) 2017-05-03 2021-07-27 The Broad Institute, Inc. Single-cell proteomic assay using aptamers
GB201715684D0 (en) 2017-09-28 2017-11-15 Univ Gent Means and methods for single molecule peptide sequencing
EP3704246A4 (en) 2017-10-31 2021-08-11 Encodia, Inc. PROCEDURES AND KITS USING NUCLEIC ACID ENCODING AND / OR MARKING
CA3081441C (en) 2017-10-31 2023-08-29 Encodia, Inc. Kits for analysis using nucleic acid encoding and/or label
CA3081446A1 (en) 2017-10-31 2019-05-09 Encodia, Inc. Methods and compositions for polypeptide analysis
SG11202004906QA (en) 2017-12-18 2020-07-29 Janssen Biotech Inc Radiolabeling of polypeptides
WO2019178033A1 (en) 2018-03-12 2019-09-19 Arbor Biotechnologies, Inc. Ultrahigh throughput protein discovery
CN112513269A (en) 2018-07-12 2021-03-16 德克萨斯大学系统董事会 Molecular neighborhood detection by oligonucleotides
CN112469832A (en) 2018-07-23 2021-03-09 德克萨斯大学系统董事会 Single molecule sequencing identification of post-translational modifications on proteins
EP3837271A4 (en) 2018-08-14 2022-06-15 Board of Regents, The University of Texas System SINGLE MOLECULE SEQUENCING PEPTIDES RELATED TO MAJOR HISTOCOMPATIBILITY COMPLEX
CN113286893A (en) 2018-08-28 2021-08-20 10X基因组学股份有限公司 Method of generating an array
GB2593091B (en) 2018-10-05 2023-12-20 Univ Texas Solid-phase N-terminal peptide capture and release
KR20250162948A (en) 2018-11-15 2025-11-19 퀀텀-에스아이 인코포레이티드 Methods and compositions for protein sequencing
US20200284807A1 (en) 2019-03-05 2020-09-10 Victor Manneh Saturation binding ratiometric assay
US20220227889A1 (en) 2019-04-30 2022-07-21 Encodia, Inc. Methods and reagents for cleavage of the n-terminal amino acid from a polypeptide
CN115485563A (en) 2020-02-18 2022-12-16 德克萨斯大学系统董事会 Peptide and protein C-terminal labeling
GB2610078A (en) 2020-04-13 2023-02-22 Erisyon Inc Single molecule N-terminal sequencing using electrical signals
WO2021236716A2 (en) 2020-05-19 2021-11-25 Board Of Regents, The University Of Texas System Methods, systems and kits for polypeptide processing and analysis
CN117083391A (en) 2021-02-24 2023-11-17 德克萨斯大学系统董事会 Peptide processing and analysis methods
EP4348266A1 (en) 2021-05-26 2024-04-10 Board of Regents, The University of Texas System Methods and systems for single cell protein analysis
CN117813506A (en) 2021-05-26 2024-04-02 德克萨斯大学系统董事会 Compositions, methods and utility of conjugated biomolecule barcodes
WO2023019163A1 (en) 2021-08-11 2023-02-16 Board Of Regents, The University Of Texas System Methods and compositions for edman-like reactions
WO2023091961A2 (en) 2021-11-17 2023-05-25 Erisyon Inc. Methods and systems for automated sample processing

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326136B1 (en) * 1988-04-01 2001-12-04 Digene Corporation Macromolecular conjugate made using unsaturated aldehydes
US20020137045A1 (en) * 1999-07-29 2002-09-26 Lukhtanov Eugeny Alexander Attachment of oligonucleotides to solid supports through schiff base type linkages for capture and detection of nucleic acids
US20090215635A1 (en) * 2005-05-02 2009-08-27 Basf Se Labelling strategies for the sensitive detection of analytes
WO2012071428A2 (en) * 2010-11-22 2012-05-31 Solulink, Inc. Methods and/or use of oligonucleotide conjugates for assays and detections
US9580736B2 (en) * 2013-12-30 2017-02-28 Atreca, Inc. Analysis of nucleic acids associated with single cells using nucleic acid barcodes
US20180112212A1 (en) * 2015-03-11 2018-04-26 The Broad Institute, Inc. Proteomic analysis with nucleic acid identifiers
WO2019168164A1 (en) * 2018-03-02 2019-09-06 国立大学法人大阪大学 Molecule for protein and/or peptide design

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Bioconjugate Chemistry, Vol. 30(9), 2019 [publication date 22 August 2019], (Nozomu Inoue; Onoda Akira; Hayashi Takashi), pages 2427 2434, ISSN 1043-1802, DOI:10.1021/acs.bioconjchem.9b00515. *
Biomacromolecules, Vol. 19(7), 2018 [publication date 11 April 2018], (Kimio Sumaru; Toshiyuki Takagi; Kana Morishita; Toshiyuki Kanamori), pages 2913-2922, ISSN 1525-7797, DOI: 10.1021/acs.biomac.8b00470. *
Nature Chemical Biology, Vol. 11(5), 2015, (Macdonald James I; Munch Henrik K; Moore Troy; Francis Matthew B), pages 326-331, ISSN 1552-4450, DOI:10.1038/nchembio.1792. *
Solulink, http://www.ulab360.com/files/prod/manuals/201305/23/394817001.pdf, 2012, MagnaLink 4FB Magnetic Beads , Cat. No. M-104, pages 1-19. *

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