GB2568061A - Apparatus for delivering a composition for a vascular embolisation - Google Patents
Apparatus for delivering a composition for a vascular embolisation Download PDFInfo
- Publication number
- GB2568061A GB2568061A GB1718180.1A GB201718180A GB2568061A GB 2568061 A GB2568061 A GB 2568061A GB 201718180 A GB201718180 A GB 201718180A GB 2568061 A GB2568061 A GB 2568061A
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- United Kingdom
- Prior art keywords
- piston
- pressure transducer
- displaying data
- mount
- catheter
- Prior art date
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- 230000002792 vascular Effects 0.000 title claims abstract description 19
- 239000000203 mixture Substances 0.000 title claims abstract description 11
- 210000003813 thumb Anatomy 0.000 claims abstract description 36
- 230000008878 coupling Effects 0.000 claims abstract description 21
- 238000010168 coupling process Methods 0.000 claims abstract description 21
- 238000005859 coupling reaction Methods 0.000 claims abstract description 21
- 125000006850 spacer group Chemical group 0.000 claims abstract description 13
- 239000012530 fluid Substances 0.000 claims abstract description 12
- 238000004891 communication Methods 0.000 claims abstract description 3
- 238000000034 method Methods 0.000 claims description 13
- 238000012544 monitoring process Methods 0.000 claims description 7
- 230000000007 visual effect Effects 0.000 claims description 5
- 210000004204 blood vessel Anatomy 0.000 claims description 4
- 238000012546 transfer Methods 0.000 claims description 4
- 230000002706 hydrostatic effect Effects 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000463 material Substances 0.000 description 7
- 230000003073 embolic effect Effects 0.000 description 6
- 210000003811 finger Anatomy 0.000 description 5
- 206010028980 Neoplasm Diseases 0.000 description 4
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 206010003694 Atrophy Diseases 0.000 description 1
- 208000005189 Embolism Diseases 0.000 description 1
- 206010046798 Uterine leiomyoma Diseases 0.000 description 1
- 208000009443 Vascular Malformations Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 201000010260 leiomyoma Diseases 0.000 description 1
- 230000036244 malformation Effects 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/48—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for varying, regulating, indicating or limiting injection pressure
- A61M5/486—Indicating injection pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
- A61B17/12186—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices liquid materials adapted to be injected
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00778—Operations on blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/06—Measuring instruments not otherwise provided for
- A61B2090/064—Measuring instruments not otherwise provided for for measuring force, pressure or mechanical tension
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
- A61M2205/502—User interfaces, e.g. screens or keyboards
- A61M2205/507—Head Mounted Displays [HMD]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Anesthesiology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Apparatus for delivering a composition for vascular embolisation comprising a syringe 1, the syringe comprising a piston 2 and a barrel 5 having an outlet 6, wherein the apparatus further comprises a pressure transducer 7 arranged to measure force applied to the piston and means 11b for operatively coupling the pressure transducer to a device 12 for displaying data. The pressure transducer 7 may be releasably mounted to a thumb engaging portion of the piston 2 via a mount. There may be a spacer between the piston and transducer to ensure force is uniformly transferred. The system may also include a device to display the force applied to the piston as a function of time in real time, there may be a catheter in fluid communication with the outlet, a camera to display contents of the catheter, and means for measuring fluid pressure or flow rates in the system.
Description
This invention relates to an apparatus for monitoring the progress of a vascular embolisation procedure.
Embolisation of blood vessels (blocking the blood flow) is an important medical procedure in the treatment of tumours, fibroids and vascular malformations, in which an embolus, or blockage is introduced into a blood vessel to reduce blood flow and induce atrophy of tumours and malformations.
Embolisation procedure is carried out as an endovascular procedure whereby embolic preparation is delivered to the target site via a catheter, a syringe is used to administer the embolic preparation. It is not normal practice to use an automated syringe driver in this procedure because clinicians prefer to monitor the progress of embolisation by tactile feel by operating the syringe themselves. It is however not easy for the clinician to determine when the embolisation procedure has reached completion or where a blockage has occurred. It is also necessary to deliver the embolic preparation at a slow rate to avoid off target embolisation events however if the delivery rate is too slow there is a risk that the embolic particles will fall out of suspension and start to aggreggate. There therefore exists a need to provide an improved apparatus for monitoring the progress of a vascular embolisation.
The present inventors have therefore identified that it is desirable to be able to measure force applied to the piston of the syringe being used to deliver a composition for a vascular embolisation in order to better understand the progress of the embolisation procedure.
Accordingly, in a first aspect, the present invention provides an apparatus for delivering a composition for vascular embolisation comprising a syringe, the syringe comprising a piston and a barrel having an outlet, wherein the apparatus further comprises a pressure transducer arranged to measure force applied to the piston and
- 1 means for operatively coupling the pressure transducer to a device for displaying data.
The syringe can be any syringe capable of delivering a pharmaceutical composition, the syringe typically comprises a piston (sometimes referred to as the plunger) and a barrel having an outlet. The barrel is preferably cylindrical and has an outlet at the distal end (the distal end being defined as the end furthest from the operator during normal use) and an opening at the proximate end of the barrel to receive a piston. The distal end of the barrel typically terminates in an end section including the outlet, the end section may be a wall perpendicular to the barrel wall or it may be a conical section.
The piston comprises an elongate rod portion terminating, distally, in a head piece having a cross-sectional profile matching that of the interior barrel wall and being sized to form a liquid tight seal with the interior barrel wall. Preferably the barrel is cylindrical and the head piece of the piston has a circular cross section. A piston ring may be provided around the outer edge of the head piece and to form the liquid tight seal with the interior wall of the barrel. The distal end of the piston rod is that which terminates in the head piece and is closest to the outlet of the barrel.
The piston is capable of reciprocal movement in the longitudinal direction within the barrel while still forming a liquid tight seal with the interior wall of the barrel. Moving the piston within the barrel towards the outlet forces any fluids within the barrel towards the outlet and ultimately expelled. Typically the barrel will be held static with the operator pushing on the piston in order to expel the fluid through the outlet. Alternatively the piston may be held static and instead the barrel is moved to expel fluid. For example the operator may place a thumb of the end of the piston while holding the barrel between two fingers and will expel the fluid by pulling on the barrel. A further possibility exits where the fluid is expelled from the outlet by a combination of pushing on the piston and pulling on the barrel.
The outlet of the syringe is capable of being connected to other components such as hypodermic needles, nozzles, connectors or tubing. When the outlet is connected to other components in a system, the connection to those components must be suitable to
-2 withstand the pressure in the system. Where the syringe is being used for the delivery of embolic particles the outlet is ideally adapted to be able to connect to a catheter, typically via a Luer® connector.
In an embodiment of the invention the syringe piston has a thumb engaging portion provided on the proximate end of the piston rod. The thumb engaging portion facilitates moving the piston within the barrel and towards the outlet by pushing on the thumb engaging portion. Typically the thumb engaging portion has a T shaped cross section; in use the operator’s thumb engages with the top of the T to apply pressure to drive the piston within the barrel towards the outlet. While the end portion of the piston is described here as the thumb engaging portion it is not limited to being operated by the users thumb, the user may prefer to push on the thumb engaging portion of the piston with a finger instead for example. In the case of use of the syringe in a vascular embolisation procedure the clinician will often prefer to hold the thumb engaging portion of the piston between the thumb and first finger, this is particularly the case where is it necessary to administer the pharmaceutical preparation slowly and in a controlled manner.
The pressure transducer can be any device that is capable of measuring force applied to it. Preferably the pressure transducer is capable of measuring forces up to 200 Newtons.
Preferably the pressure transducer is a load cell. A load cell is a transducer whereby a signal is produced whose magnitude is directly proportional to the force being measured. Typically the signal is in the form of an electrical signal such as current, voltage or an electromagnetic waveform. Load cells include, but are not limited to hydraulic load cells, pneumatic loads cells and strain gauge load cells. More preferably the load cell is a compression load cell (sometimes also known as a canister load cell), a type of strain gauge load cell.
In an embodiment of the invention the pressure transducer includes a piezoelectric element containing piezoelectric material. When force is applied to the piston this causes mechanical stress in the piezoelectric material, this in turn leads to an accumulation of electric charge in the piezoelectric material and the generation of -3 voltage. The voltage produced is a function of the pressure applied to the piezoelectric material in the pressure transducer. Suitable piezoelectric materials include but are not limited to naturally occurring crystals, synthetic crystals and piezoelectric ceramics.
The pressure transducer is arranged to measure force applied to the piston to drive the piston within the barrel towards the outlet. Preferably the pressure transducer is provided on the proximal portion of the piston and is arranged to measure the amount of force required to move the piston within the barrel towards the outlet. More preferably the piston has a thumb engaging portion and the pressure transducer is configured to measure the pressure applied to the thumb engaging port, for example by being provided on the thumb engaging portion.
The means for operatively coupling the pressure transducer to a device for displaying data can be any means that is capable of conveying data relating to the measured force from the pressure transducer. Data is conveyed as a signal, typically electronic signal, electromagnetic waves or radio waves. The signal may be converted from one form of signal into another as it is conveyed from the pressure transducer. In one embodiment of the invention the means for operatively coupling the pressure transducer to the device for displaying data does so via a processor which is capable of converting signal from one form into another suitable for being displayed on a device for displaying data.
In one embodiment the means for operatively coupling is a cable, for example an electric cable for conveying electrical signal. In an alternative embodiment the means for operatively coupling is a wireless connection, typically this involves conveying data via radio or electromagnetic waves.
In a further embodiment of the invention the pressure transducer is adapted to be releasably mounted on the piston. Means for releasably mounting the pressure transducer include clips, clamps and touch fasteners such as double sided adhesive fasteners and hook and loop fasteners, for example Velcro®. In an alternative embodiment the pressure transducer may be permanently fixed to the piston, for example by a permanent adhesive.
-4 In a further embodiment of the invention the pressure transducer is located between the piston and a mount, wherein the mount is arranged to transfer force to the piston via the pressure transducer. In a preferred embodiment the mount has a top portion and an elongate skirt. The mount is capable of fitting on top of the piston at the proximal end of the piston. Where the piston has a thumb engaging portion the top portion of the mount is arranged to transfer force to the piston via the thumb engaging portion. In a preferred arrangement the piston has a thumb engaging portion and the mount has a top portion and elongate skirt extending from the periphery of the top portion, wherein the profile of the top portion of the mount matches that of the thumb engaging portion and is sized such that the thumb engaging portion fits closely within the mount. In this embodiment the top portion of the mount is preferably circular and the skirt is cylindrical. Typically thumb engaging portions of syringes are in the size range 10mm to 20mm in diameter and so the mount will have a slightly larger internal diameter such that the thumb engaging portion fits closely within the mount.
Preferably the mount has an elongate skirt, the skirt being sufficiently long to allow the operator to hold the skirt between the thumb and first finger. This arrangement is particularly advantageous for use in vascular embolisation procedures because the operator is better able to control the delivery when holding the skirt between their thumb and first finger. This arrangement efficiently transfers the force applied to the piston. Preferably the skirt has ridges or grooves or a combination of both ridges and grooves on the surface to aid gripping.
Where the means for coupling the pressure transducer to a device for displaying data is a cable, the mount is adapted so as to provide an exit point from the mount for the cable, for example in the form of a slit or a hole. In the embodiment of the invention where the means for coupling the pressure transducer to a device for displaying data is a wireless connection, the transducer will require a means for transmitting data via a wireless connection and a power source, for example a battery.
Preferably the apparatus further comprises means for securing the mount to the piston. In an embodiment of the invention the means for securing the mount to the piston is a clip which engages with both the piston and the mount. Alternatively the - 5 mount may be attached to the piston by an adhesive or a fastener. The advantage for having means for securing the mount to the piston is that the position of the pressure transducer relative to the piston shaft is fixed. This ensures that upon applying force to the piston, the pressure transducer is able to accurately measure the force applied to the piston.
In an alternative embodiment of the invention the mount is integrally formed with the piston, and may for example be integrally formed with the thumb engaging portion. In this embodiment the apparatus does not require means for securing the mount to the piston and the mount and piston are together configured so as to ensure force is transferred to the piston via the pressure transducer. This configuration also ensures that the pressure transducer is able to accurately measure force applied to the piston. . In one arrangement, the transducer is positioned within a gap or pocket within the thumb engaging portion of the piston and the top portion of the mount is formed of flexible material.
In some instances the surface of the piston which engages with the pressure traducer does not have a uniformly flat surface and so force is not efficiently transferred from the pressure transducer to the piston. It is therefore preferable that the apparatus further comprises a spacer provided between the piston and the pressure transducer, such as to ensure force is uniformly transferred from the pressure transducer to the piston. The spacer may include recesses or protrusions on the surface of the spacer which engages with the piston which are complimentary to the surface profile of the piston. Preferably the spacer has the same diameter as the thumb engaging portion of the syringe and has the same profile, for example if the thumb engaging portion has a circular profile it is preferable that the spacer is also circular.
A further aspect of the invention provides a system for monitoring the progress of a vascular embolisation comprising a syringe, pressure transducer and means for operatively coupling the pressure transducer to the device for displaying data as described above, the system further comprising a device for displaying data. The device for displaying data may, for example, be a screen. Alternatively the device for displaying data may be an analogue device such as a meter having a needle which indicates the force being measured by the pressure transducer.
-6In a further embodiment of the invention, the device for displaying data is capable of representing force applied to the piston as a function of time. In this embodiment of the invention it is preferable that the device for displaying data is able to represent data in two dimensions such that force applied to the piston is capable of being plotted against time. Preferably force applied to the syringe piston is displayed as a function of time, in real time, which facilitates the operator in monitoring the progress of the vascular embolisation.
Preferably the device for displaying data will also be capable of representing other data relating to the embolisation procedure, examples include catheter flow rates and intra-vessel hydrostatic pressure.
The system may also include one or more processors. In the embodiment of the invention where the means for operatively coupling the transducer to the device for displaying data is a wireless connection, the system further comprises a transmitter and a receiver. In this embodiment the transmitter may incorporate a processor for converting signal received from the pressure transducer into a form suitable for transmitting via a wireless connection and the receiver may incorporate an additional processor for converting wireless signal into a form suitable for displaying on the means for displaying data. The processor incorporated in the transmitter may, for example, convert electronic signal into electromagnetic waves for transmission by a wireless connection. The processor incorporated the receiver may, for example, convert electromagnetic waves received via the wireless connection into a digital, optical or analogue image for displaying on the means for displaying data.
Preferably the system further comprises a catheter with the catheter being in fluid communication with the outlet in the syringe.
Preferably the system further comprises a camera and the device for displaying data is configured to represent a visual image provided by the camera of the contents of the catheter. Preferably the device for displaying data is capable of representing force applied to the piston as a function of time at the same time as representing a visual image provided by the camera. Preferably the camera is a video camera capable of -7capturing images in real time and the device for displaying data will represent visual images in real time.
Preferably the catheter further comprises a catheter hub and the camera is configured to visualise the contents of the catheter hub. The catheter hub is typically provided at the end of the catheter which connects with the outlet of the syringe. When the system is in use during a vascular embolisation procedure, microparticles will pass through the catheter hub and the operator will be able to see a visual image of this on the means for displaying data.
Preferably the system further comprises means for measuring fluid pressure and/or flow rates within the system. In one embodiment of the invention the system is capable of measuring fluid pressure and/or flow rates at various points along the length of the catheter.
Preferably the system further comprises means for measuring intra-vessel hydrostatic pressure in blood vessels proximate to the catheter.
In a further embodiment of the invention the system further comprises apparatus capable of visualising and mapping tumours and the surrounding vasculature, such apparatus include flow dynamic programs such as FlightPlan™ or EmboGuide™ Flow dynamic programs are capable of producing two and three dimension images of the tumour site by processing and manipulating images obtained through conventional imaging techniques, for example visualising radiopaque contrast agent which is injected as a composition with embolic particles. The system of the present invention is therefore capable of being incorporated into a global suite for characterising and monitoring the progress of a vascular embolisation on a means for displaying data such as a screen where the data output from both the flow dynamic program and the apparatus of the present invention is displayed.
A further aspect of the invention provides a pressure transducer capable of being mounted and arranged on a syringe piston to measure force applied to the syringe piston and means for operatively coupling the pressure transducer to a device for displaying data. Preferably the pressure transducer according to this aspect of the
- 8 invention is secured within a mount for attaching to the thumb engaging portion of a piston.
Figures
Figures la and lb represent side views of an embodiment of the invention where the pressure transducer is arranged to measure force applied to the thumb engaging portion.
Figure 2a shows a close up view of the end of the piston and represents an embodiment of the invention where the pressure transducer is located between the piston and a mount and the apparatus further comprises means for securing the mount to the piston and a spacer.
Figure 2b represents a side view of an embodiment of the invention where the pressure transducer is located between the piston and a mount and the apparatus further comprises means for securing the mount to the piston and a spacer.
Figures 3a and 3b represent perspective views of an embodiment of the invention where the mount has an exit point for a cable.
Figures 4a, 4b and 4c show an embodiment of the invention where the mount is integrally formed with the piston.
Figure 5a is a schematic representation of an embodiment of the invention where the system comprises apparatus delivering a composition for vascular embolisation and a device for displaying data where the means for operatively coupling the pressure transducer to the device for displaying data is a cable.
Figure 5b is a schematic representation of an embodiment of the invention where the system comprises apparatus for delivering a composition for vascular embolisation, a device for displaying data and a processor where the means for operatively coupling the pressure transducer to the device for displaying data is a wireless connection.
Figures la and lb shows an embodiment of the invention where the pressure transducer is arranged to measure force applied to the thumb engaging portion. The syringe (1) comprises a piston (2) having a rod or shaft (3) and an end portion (4), the syringe further comprises a barrel (5) having an outlet (6). The apparatus further comprises a pressure transducer (7) arranged to measure force applied to the piston and in the embodiment of the invention represented in Figures la and lb the pressure transducer (7) is arranged to measure force applied to the thumb engaging portion
-9(15). In the embodiment of the invention shown in Figures la and lb the thumb engaging (15) portion has a T shaped cross section.
Figures 2a and 2b show a close up view of the end of the piston and represent an embodiment of the invention where the apparatus comprises a mount (8) and the pressure transducer (7) is located between the piston (2) and the mount (8). The mount (8) has a top portion (8a) and a skirt (8b). The pressure transducer (7) shown in Figures 2a and 2b has a circular profile however other profile shapes are possible. In the embodiment of the invention shown in Figures 2a and 2b the means for operatively coupling the pressure transducer to the device for displaying data is a wireless connection and the mount (8) does not include an exit point for a cable. In the embodiment of the invention shown in Figures 2a and 2b the apparatus further comprises means for securing the mount to the piston (9), in this case a fixture clip, and a spacer (10). It can be seen from Figure 2a that the thumb engaging portion (15) of the piston (2) has a T shaped cross section having an uneven surface on the surface that interfaces the spacer (10). By providing the spacer (10) between the piston and the pressure transducer, this ensures force is uniformly transferred from the pressure transducer to the piston because the spacer has a surface which is substantially flat no both sides.
Figure 3a and 3b shows perspective views of an embodiment of the invention where the mount (8) has an exit point (8c) for a cable (11a) which provides the means for operatively coupling the pressure transducer to a device for displaying data. Figure 3a shows the mount (8) without the pressure transducer being located within it. In the embodiment of the invention shown in Figure 3a the skirt (8b) has ridges (8d) for improved grip. Figure 3b shows the mount (8) with the pressure transducer (7) located within.
Figures 4a, 4b and 4c show an embodiment of the invention where the mount (8) is integrally formed with the piston (2). Figure 4a shows the integrally formed mount (8) and piston (2) having a gap between the piston (2) and the top portion (8a) of the mount (8), the mount (8) further comprises a slot (8e) for receiving the pressure transducer (7). Figure 4b shows the integrally formed mount (8) and piston (2) where the transducer (7) has been inserted into the slot (8e) and is positioned in the gap
- 10 between the piston (2) and the top portion (8a) of the mount (8). In this embodiment of the invention the top portion (8a) of the mount is formed of flexible material to ensure that force is transferred to the piston (2) via the pressure transducer (7). In the embodiment of the invention show in Figure 4b the means for operatively coupling the pressure transducer to the device for displaying data is a cable (11a). Figure 4c shows a side view of the embodiment of the invention where the mount (8) is integrally formed with the piston (2).
Figure 5a is a schematic representation of an embodiment of the invention where the system comprises apparatus for delivering a composition for vascular embolisation comprising a syringe (1), the syringe comprising a piston (2) and a barrel (5) having an outlet (6), a pressure transducer (7) arranged to measure force applied to the piston (2), means for operatively coupling the pressure transducer to a device for displaying data (11) and a device for displaying data (12). In this embodiment of the invention the means for operatively coupling the pressure transducer to a device for displaying data (11) is a cable (11a).
Figure 5b is a schematic representation of an embodiment of the invention where the system comprises apparatus for delivering a composition for vascular embolisation comprising a syringe (1), the syringe comprising a piston (2) and a barrel (5) having an outlet (6), a pressure transducer (7) arranged to measure force applied to the piston (2), means for operatively coupling the pressure transducer to a device for displaying data (12), a device for displaying data (12). In this embodiment of the invention the means for operatively coupling the pressure transducer to a device for displaying data (11) is a wireless connection (1 lb). The embodiment of the invention shown in Figure 5b further comprises a transmitter (13) comprising a processor for converting signal received from the pressure transducer into a form suitable for transmitting via a wireless connection and a receiver (14) comprising a processor for converting wireless signal into a form suitable for displaying on the means for displaying data.
Claims (15)
1. Apparatus for delivering a composition for vascular embolisation comprising a syringe, the syringe comprising a piston and a barrel having an outlet, wherein the apparatus further comprises a pressure transducer arranged to measure force applied to the piston and means for operatively coupling the pressure transducer to a device for displaying data.
2. Apparatus according to claim 1, wherein the piston has a thumb engaging portion and the pressure transducer is arranged to measure force applied to the thumb engaging portion.
3. Apparatus according to either claims 1 or 2, wherein the pressure transducer is releasably mounted on the piston.
4. Apparatus according to any of claims 1 to 3, wherein the pressure transducer is located between the piston and a mount and wherein the mount is arranged is transfer force to the piston via the pressure transducer.
5. Apparatus according to claim 4, wherein the apparatus further comprises means for securing the mount to the piston.
6. Apparatus according to any of the preceding claims, wherein the apparatus further comprises a spacer provided between the piston and the pressure transducer, such as to ensure force is uniformly transferred from the pressure transducer to the piston.
7. A system for monitoring the progress of a vascular embolisation procedurere comprising the apparatus of any of the preceding claims, and a device for displaying data.
8. A system according to claim 7, wherein the device for displaying data is capable of representing force applied to the piston as a function of time.
9. A system according to claim 8, wherein the device for displaying data is capable of representing force applied to the piston as a function of time, in real time.
10. A system according to any of claims 7 to 9, wherein the system further comprises a catheter in fluid communication with the outlet.
11. A system according to claim 10, further comprising a camera and wherein the device for displaying data is configured to represent a visual image provided by the camera of the contents of the catheter.
12. A system according to claim 11, wherein the catheter comprises a catheter hub and the camera is configured to visualise the contents of the catheter hub.
13. A system according to claims 10 or 11, further comprising means for measuring fluid pressure and/or flow rates in the system.
14. A system for delivering pharmaceutical composition according to any of claims 10 to 12, further comprising means for measuring intra-vessel hydrostatic pressure in blood vessels proximate to the catheter.
15. A method of treatment by embolisation comprising the steps of using the apparatus of claim 1 to deliver a composition for vascular embolisation, measuring the force applied to the piston and monitoring the progress of the embolisation procedure on a device for displaying data.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1718180.1A GB2568061A (en) | 2017-11-02 | 2017-11-02 | Apparatus for delivering a composition for a vascular embolisation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1718180.1A GB2568061A (en) | 2017-11-02 | 2017-11-02 | Apparatus for delivering a composition for a vascular embolisation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB201718180D0 GB201718180D0 (en) | 2017-12-20 |
| GB2568061A true GB2568061A (en) | 2019-05-08 |
Family
ID=60664668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1718180.1A Withdrawn GB2568061A (en) | 2017-11-02 | 2017-11-02 | Apparatus for delivering a composition for a vascular embolisation |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2568061A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040260238A1 (en) * | 2003-05-05 | 2004-12-23 | Call Evan W. | Infusion syringe |
| WO2016162298A1 (en) * | 2015-04-07 | 2016-10-13 | Albert Sinfreu Alay | Portable module for detecting an infusion of the contents of a syringe |
| WO2017070391A2 (en) * | 2015-10-20 | 2017-04-27 | Truinject Medical Corp. | Injection system |
| WO2017189153A1 (en) * | 2016-04-29 | 2017-11-02 | Verily Life Sciences Llc | Pressure sensor in plunger head to wake up electronics |
-
2017
- 2017-11-02 GB GB1718180.1A patent/GB2568061A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040260238A1 (en) * | 2003-05-05 | 2004-12-23 | Call Evan W. | Infusion syringe |
| WO2016162298A1 (en) * | 2015-04-07 | 2016-10-13 | Albert Sinfreu Alay | Portable module for detecting an infusion of the contents of a syringe |
| WO2017070391A2 (en) * | 2015-10-20 | 2017-04-27 | Truinject Medical Corp. | Injection system |
| WO2017189153A1 (en) * | 2016-04-29 | 2017-11-02 | Verily Life Sciences Llc | Pressure sensor in plunger head to wake up electronics |
Also Published As
| Publication number | Publication date |
|---|---|
| GB201718180D0 (en) | 2017-12-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |