GB2412315A - Peroxide tooth whitening composition - Google Patents
Peroxide tooth whitening composition Download PDFInfo
- Publication number
- GB2412315A GB2412315A GB0406392A GB0406392A GB2412315A GB 2412315 A GB2412315 A GB 2412315A GB 0406392 A GB0406392 A GB 0406392A GB 0406392 A GB0406392 A GB 0406392A GB 2412315 A GB2412315 A GB 2412315A
- Authority
- GB
- United Kingdom
- Prior art keywords
- gum
- peroxide
- teeth
- composition
- oral care
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 77
- 150000002978 peroxides Chemical class 0.000 title claims abstract description 21
- 230000002087 whitening effect Effects 0.000 title claims description 21
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 24
- 229920001285 xanthan gum Polymers 0.000 claims abstract description 17
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 13
- 235000011187 glycerol Nutrition 0.000 claims abstract description 12
- 235000010493 xanthan gum Nutrition 0.000 claims abstract description 12
- 239000000230 xanthan gum Substances 0.000 claims abstract description 12
- 229940082509 xanthan gum Drugs 0.000 claims abstract description 12
- 239000003906 humectant Substances 0.000 claims abstract description 10
- 239000000227 bioadhesive Substances 0.000 claims abstract description 9
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229920001206 natural gum Polymers 0.000 claims abstract description 8
- 150000001875 compounds Chemical class 0.000 claims abstract description 7
- 229940078916 carbamide peroxide Drugs 0.000 claims abstract description 5
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000004343 Calcium peroxide Substances 0.000 claims abstract description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims abstract description 4
- LHJQIRIGXXHNLA-UHFFFAOYSA-N calcium peroxide Chemical compound [Ca+2].[O-][O-] LHJQIRIGXXHNLA-UHFFFAOYSA-N 0.000 claims abstract description 4
- 235000019402 calcium peroxide Nutrition 0.000 claims abstract description 4
- 244000215068 Acacia senegal Species 0.000 claims abstract description 3
- 229920000084 Gum arabic Polymers 0.000 claims abstract description 3
- 235000010489 acacia gum Nutrition 0.000 claims abstract description 3
- 239000000205 acacia gum Substances 0.000 claims abstract description 3
- 229920000615 alginic acid Polymers 0.000 claims abstract description 3
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 3
- 239000001814 pectin Substances 0.000 claims abstract description 3
- 235000010987 pectin Nutrition 0.000 claims abstract description 3
- 229920001277 pectin Polymers 0.000 claims abstract description 3
- 229920000591 gum Polymers 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- -1 percarbonates Substances 0.000 claims description 4
- MJYQFWSXKFLTAY-OVEQLNGDSA-N (2r,3r)-2,3-bis[(4-hydroxy-3-methoxyphenyl)methyl]butane-1,4-diol;(2r,3r,4s,5s,6r)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O.C1=C(O)C(OC)=CC(C[C@@H](CO)[C@H](CO)CC=2C=C(OC)C(O)=CC=2)=C1 MJYQFWSXKFLTAY-OVEQLNGDSA-N 0.000 claims description 2
- 244000106483 Anogeissus latifolia Species 0.000 claims description 2
- 235000011514 Anogeissus latifolia Nutrition 0.000 claims description 2
- 241000416162 Astragalus gummifer Species 0.000 claims description 2
- 239000001879 Curdlan Substances 0.000 claims description 2
- 229920002558 Curdlan Polymers 0.000 claims description 2
- 239000001922 Gum ghatti Substances 0.000 claims description 2
- 229920000161 Locust bean gum Polymers 0.000 claims description 2
- 244000090599 Plantago psyllium Species 0.000 claims description 2
- 235000010451 Plantago psyllium Nutrition 0.000 claims description 2
- 239000004373 Pullulan Substances 0.000 claims description 2
- 229920001218 Pullulan Polymers 0.000 claims description 2
- 229920001615 Tragacanth Polymers 0.000 claims description 2
- 244000250129 Trigonella foenum graecum Species 0.000 claims description 2
- 235000001484 Trigonella foenum graecum Nutrition 0.000 claims description 2
- 229920002310 Welan gum Polymers 0.000 claims description 2
- 235000019316 curdlan Nutrition 0.000 claims description 2
- 229940078035 curdlan Drugs 0.000 claims description 2
- 235000004426 flaxseed Nutrition 0.000 claims description 2
- 150000004676 glycans Chemical class 0.000 claims description 2
- 235000019314 gum ghatti Nutrition 0.000 claims description 2
- 235000010420 locust bean gum Nutrition 0.000 claims description 2
- 239000000711 locust bean gum Substances 0.000 claims description 2
- 238000010422 painting Methods 0.000 claims description 2
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 239000005017 polysaccharide Substances 0.000 claims description 2
- 235000019423 pullulan Nutrition 0.000 claims description 2
- 235000001019 trigonella foenum-graecum Nutrition 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- 229960001631 carbomer Drugs 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 229920001519 homopolymer Polymers 0.000 claims 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract description 6
- 150000004760 silicates Chemical class 0.000 abstract description 5
- 229920001223 polyethylene glycol Polymers 0.000 abstract description 4
- 229910000323 aluminium silicate Inorganic materials 0.000 abstract description 3
- 235000012211 aluminium silicate Nutrition 0.000 abstract description 3
- 239000003349 gelling agent Substances 0.000 abstract description 3
- 239000005995 Aluminium silicate Substances 0.000 abstract description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 abstract description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract description 2
- 229920000569 Gum karaya Polymers 0.000 abstract description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract description 2
- 229930006000 Sucrose Natural products 0.000 abstract description 2
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 abstract description 2
- 239000008103 glucose Substances 0.000 abstract description 2
- 235000010494 karaya gum Nutrition 0.000 abstract description 2
- NEMFQSKAPLGFIP-UHFFFAOYSA-N magnesiosodium Chemical compound [Na].[Mg] NEMFQSKAPLGFIP-UHFFFAOYSA-N 0.000 abstract description 2
- 239000011777 magnesium Substances 0.000 abstract description 2
- 229910052749 magnesium Inorganic materials 0.000 abstract description 2
- 239000000391 magnesium silicate Substances 0.000 abstract description 2
- 229910052919 magnesium silicate Inorganic materials 0.000 abstract description 2
- 235000019792 magnesium silicate Nutrition 0.000 abstract description 2
- 239000000600 sorbitol Substances 0.000 abstract description 2
- 235000010356 sorbitol Nutrition 0.000 abstract description 2
- 239000005720 sucrose Substances 0.000 abstract description 2
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- 229920002907 Guar gum Polymers 0.000 abstract 1
- 235000010418 carrageenan Nutrition 0.000 abstract 1
- 239000000679 carrageenan Substances 0.000 abstract 1
- 229920001525 carrageenan Polymers 0.000 abstract 1
- 229940113118 carrageenan Drugs 0.000 abstract 1
- 235000010417 guar gum Nutrition 0.000 abstract 1
- 239000000665 guar gum Substances 0.000 abstract 1
- 229960002154 guar gum Drugs 0.000 abstract 1
- 239000000377 silicon dioxide Substances 0.000 abstract 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 22
- 239000004615 ingredient Substances 0.000 description 15
- 238000009472 formulation Methods 0.000 description 11
- 230000000694 effects Effects 0.000 description 8
- 229940094522 laponite Drugs 0.000 description 8
- XCOBTUNSZUJCDH-UHFFFAOYSA-B lithium magnesium sodium silicate Chemical compound [Li+].[Li+].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 XCOBTUNSZUJCDH-UHFFFAOYSA-B 0.000 description 8
- 210000003298 dental enamel Anatomy 0.000 description 7
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 6
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 6
- 210000000214 mouth Anatomy 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000008367 deionised water Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- 239000000654 additive Substances 0.000 description 3
- 238000004061 bleaching Methods 0.000 description 3
- 239000004202 carbamide Substances 0.000 description 3
- 235000013877 carbamide Nutrition 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 238000001311 chemical methods and process Methods 0.000 description 2
- 238000002845 discoloration Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000007800 oxidant agent Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- NNRXCKZMQLFUPL-WBMZRJHASA-N (3r,4s,5s,6r,7r,9r,11r,12r,13s,14r)-6-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione;(2r,3 Chemical compound OC(=O)[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O.O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 NNRXCKZMQLFUPL-WBMZRJHASA-N 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 239000004150 EU approved colour Substances 0.000 description 1
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Natural products O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 241000871495 Heeria argentea Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 229920000604 Polyethylene Glycol 200 Polymers 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 241000934878 Sterculia Species 0.000 description 1
- 241001415849 Strigiformes Species 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000016674 enamel mineralization Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 229940098008 erythrocin Drugs 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000013022 formulation composition Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 description 1
- 229910000271 hectorite Inorganic materials 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 239000000231 karaya gum Substances 0.000 description 1
- 229940039371 karaya gum Drugs 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000010297 mechanical methods and process Methods 0.000 description 1
- 230000005226 mechanical processes and functions Effects 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229940006093 opthalmologic coloring agent diagnostic Drugs 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 230000007505 plaque formation Effects 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000005204 segregation Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 159000000008 strontium salts Chemical class 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 239000002966 varnish Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/737—Galactomannans, e.g. guar; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
An oral care composition comprising a peroxide containing compound dispersed in an orally acceptable carrier, wherein the carrier comprises a humectant and a combination of bioadhesive agents consisting essentially of at least one natural gum and a silicate. Preferred peroxide sources include hydrogen peroxide, carbamide peroxide, calcium peroxide and percarbonates. Preferred humectants include glycerine, sorbitol, propylene glycol, glucose, sucrose and low molecular weight polyethylene glycols. Preferred gums include xanthan gum, carrageenan, alginates, gum karaya, guar gum, gum Arabic and pectins. Preferred silicates include synthetic layered silicates, sodium magnesium silicate, hydrated aluminium silicates and magnesium aluminium silicate. Compositions comprising carabamide peroxide, glycerine, xanthan gum and a layered silica are exemplified. Such compositions show excellent substantivity to the teeth as a result of a synergistic interation between the gelling agents.
Description
ORAL COMPOSITION
The present invention relates to an oral care composition containing a peroxide containing compound. Specifically the present invention relates to a stable tooth whitening composition comprising synergistic gelling agents. Said composition shows excellent substantivity to the teeth.
White teeth have long been considered cosmetically desirable. Unfortunately, teeth almost invariably become discoloured in the absence of intervention. The tooth structure which is generally responsible for presenting a stained appearance is the enamel layer. Several factors contribute to enamel discoloration, but the three main factors are believed to be: (i) formation of plaque and tartar matrices on the tooth surface which then entraps stains; (ii) ingestion of certain drugs during gestational tooth formation; and (iii) discoloration due to oral cavity traumatization following which blood break-down products seep into the mineralized area of the teeth during enamel formation.
Over-the-counter teeth whitening preparations have been developed to address the cosmetic preference of many to restore luster to tooth enamel discolored by surface entrapped materials. There are various approaches to enamel whitening currently in general use. One approach is a physical abrading of the stain to effect stain removal, however this can be seen as potentially harmful to the teeth. This mechanical process may therefore be supplemented or even replaced by a chemical process which may involve an oxidative or enzymatic step to effect stain removal.
The chemical process generally utilizes a tooth whitening or bleaching formulation applied to a stained tooth surface for a specified period, after which the formulation is removed. Oxidizing agents represent one of the most widely distributed and utilized active agents in commercially available tooth whitening or bleaching products. Peroxide-containing agents such as carbamide peroxide, hydrogen peroxide and calcium peroxide are the most commonly used oxidizing agents, and are typically formulated into a liquid, solution, gel or paste. However it is known that products containing such agents may lose their whitening efficacy with time and retaining these types of formulations in the oral cavity, particularly in contact with the teeth has proved a problem. Moreover low viscosities of aqueous peroxide solutions do not allow the peroxide whitening agent to remain in contact with the teeth for the necessary time period to effect substantive whitening because of constant flushing effects of salivary secretions. The prior art indicates that viscous formulations show good substantivity when used in the oral cavity. EP-B-1 161 198 (Procter & Gamble Company) disloses a tacky or sticky aqueous tooth whitening substance suitable for application to the oral cavity via a thin film strip. However there remains a need for alternatives that do not suffer the drawbacks encountered with known formulations. It has therefore become desirable to provide simple formulations that do not require extensive stabilization, that are easy to manufacture and have excellent substantivity when applied directly to the oral cavity.
It has since been shown that viscosity is not directly related to substantivity and it is possible for a highly viscous formulation to show poor substantivity. The present invention therefore shows that substantivity effects can be increased synergistically by combining certain gelling agents.
It is an object of the present invention to provide a composition that meets these requirements. According to the invention there is provided an oral care composition comprising a peroxide containing compound dispersed in an orally acceptable carrier, wherein the carrier comprises a humectant and a bioadhesive agent consisting essentially of at least one natural gum and a silicate.
Peroxide containing compounds used as whitening agents in the present invention include the following compounds and mixtures thereof: hydrogen peroxide e.g. as a or 35%w/w aqueous solution, carbamide peroxide, calcium peroxide and percarbonates.
Suitably the total amount of peroxide present in the liquid whitening composition of the invention is in the range of 1 to 40% w/w, preferably in the range 10 to 30%w/w, more preferably in the range 5 to 20%w/w.
A humectant is a key component of a composition of the invention. Suitable humectants include the following and mixtures thereof: glycerin, sorbitol, propylene glycol, sugars, such as glucose or sucrose, and low molecular weight polyethylene glycols (PEGs) i.e. in the range 200-600 e. g. PEG 200, 300, 400, and 600, available from Dow Chemicals USA, PO Box 1206, Midland MI48642. Glycerin is available from Albion Chemical Distributers, 215, Tunnel Ave., Greenwich, London SE10 OQW. Preferred humectants include glycerin and PEG's.
Suitably the humectant is present in an amount ranging from 30 to 95 %w/w, preferably in the range 50 to 75%w/w, more preferably from 40% to 60%w/w.
A combination of bioadhesive agents are included in a composition of the invention.
In the present invention the bioadhesive agents will exhibit excellent adhesive properties i.e. have a strong affinity for biological surfaces such as teeth.
The combination of bioadhesive agents will include a natural gum and a silicate material. Natural gums useful in the present invention include Xanthan Gum, Gum Karaya, Carragenan, Alginates, Guar Gum, Gum Arabic, Gum Ghatti, Locust Bean Gum, Tara Gum, Fenugreek Gum, Gum Tragacanth, Tamarind Gum, Gellan Gum, Succinoglucan Gum, Welan Gum, Rhamsan Gum, Aloe Polysaccharides, Chia Gum, Flaxseed Gum, Okra Gum, Psyllium Seed Gum, Quince Seed Gum, Curdlan, Pullulan, Pectins and mixtures thereof. Xanthan gum is also known by the tradname Keltrol and is available from Nutrasweet Kelco Co Ltd.,Penrhyn Road, Knowsley Industrial Estate, Prescot, Merseyside. L34 9HY, England. The preferred natural gum for use in the invention is either xanthan or karaya gum. The most preferred is xanthan.
The term silicate refers to both synthetic and natural silicates. Examples of synthetic silicates include Laponite, a layered silicate available from Rockwood Specialities Inc., Princeton, NJ, USA and Hectorite, sodium magnesium silicate, available from Sud-Chemie Inc., PO Box 32370, Louisville, KY, USA. Other suitable silicates include Bentonite, a natural hydrated aluminium silicate and magnesium aluminium silicate.
Most preferably the bioadhesive agents are a mixture of a natural gum ea. Xanthan gum and a synthetic silicate e.g.Laponite.
Suitably the total amount of bioadhesive agents present are in an amount ranging from 0.1 to 20% w/w, preferably from 0.5 to 15%w/w, more preferably 1 to 10%w/w.
The composition may also comprise water, preferably deionised water. Water is an optional ingredient but if present it may be from 15 to 60%w/w, preferably 20 to 40% by weight of the composition (including the contribution from the aqueous peroxide ingredients, if used in this form).
Alcohol may also be present in the compositions disclosed herein. Alcohol may be used as an additional carrier, will increase the stability of the composition and will allow easy application of the composition to the teeth. Once the composition is applied to the teeth the alcohol will rapidly evaporate leaving the active ingredients firmly adhered to the teeth. Suitably 96% (pharmaceutical grade) ethanol is used.
Suitably alcohol may be used in the range 1 to 70%w/w, prefereably 5 to 40%w/w and more preferably 7.5 to 20%w/w.
Additionally, compositions of the present invention will suitably contain acceptable additives or excipients conventional in the field of oral care products including for example chelating agents such as ethylenediaminetetraacetic acid and/or citric acid, antisensitivity agents such as potassium and strontium salts, colouring agents, a fluoride source such as sodium fluoride or sodium monoflurophosphate, flavouring agents and sweetening agents. The additives or excipients used in any given composition will be compatible both with each other and with the essential ingredients of the composition such that there is no interaction which would impair the performance of the active ingredients. All additives or excipients must of course be non-toxic and of sufficient purity to render them suitable for human use.
The oral care composition of the invention is a highly viscous liquid or gel that may be presented in any form that is suitable for application to the oral cavity. It may conveniently be applied to one or all of the teeth. On application to teeth, the composition forms a protective barrier which adheres firmly to the teeth and retains the components of the formulation in a matrix-type environment.
The composition adheres sufficiently to remain on the teeth for a period of time e.g. up to a few hours. Suitably the composition is applied at night time, allowing peroxide activity to take place during sleep periods. During use, the peroxide is released slowly from the gel, in an amount and at such a rate as required to effect stain removal. The gel may be removed from the user's teeth by any convenient means e.g. brushing and/or by rinsing with a mouthwash.
The term "painted onto the teeth" above is intended to encompass all manner of applying the whitening composition to the teeth and includes sponging, coating, daubing, spraying, wiping and rubbing. Preferably the composition is applied to the teeth with a soft applicator brush. Suitably the composition is housed in a container such as a bottle or tube, and the composition is applied with a soft applicator brush.
If the composition is to be supplied in a bottle and brush this may be provided in a kit form e.g. as may be used with a conventional nail varnish kit. Alternatively the composition may be housed in a dispensing device such as a pen with an applicator brush attached thereto e.g. generally of the type used with the Brite Smile To Go'M Whitening pen.
The whitening compositions of the present invention are prepared by adding and mixing the ingredients of the composition in a suitable vessel such as a stainless steel tank provided with a mixer. In the preparation of the composition the silicate was slowly added to the water to allow dispersion and full hydration. The humectant is then added to the mixture. The natural gum was then dispersed separately in a further carrier (if necessary) and added to the mixture in the vessel.
The mixture was mixed until homogeneity was achieved. The final whitening product prepared is then suitably packaged and stored as required.
Advantageously the composition of the invention is suitably prepared as a single or one component system i.e. it does not require segregation and then mixing of ingredients just prior to use. In a second aspect of the invention there is provided a kit of parts comprising an anhydrous liquid tooth whitening composition as hereinbefore described, a container for housing the composition and an applicator for applying the composition to teeth to be whitened.
In an alternative aspect there is provided a method of whitening teeth comprising: a. preparing a tooth whitening composition as hereinbefore described; b. painting the composition onto teeth to be whitened, suitably at night-time c. maintaining the composition in contact with the teeth for a plurality of hours per day.
d. repeating steps b and c for multiple days e.g. up to fourteen days, to thereby whiten the teeth.
The present invention is illustrated by the following examples but is not limited thereby.
Examples
I. A composition was prepared having the following ingredients: Ingredient %w/w Glycerin 20.00 Keltrol 2.00 Laponite 4.50 Hydrogen peroxide(30%) 12.00 Deionised water 49.00 Ethanol 12.5 Total 100.00 Keltrol is a tradename for Xanthan gum II. A composition was prepared having the following ingredients: Ingredient Owls Glycerin 70.00 Keltrol 2.00 Laponite 4.50 Carbamide peroxide 11.00 Ethanol 12.50 Total 100.00 *Keltrol is a tradename for Xanthan gum III. A composition was prepared having the following ingredients: Ingredient %w/w Glycerin 69.00 Keltrol 2.00 Laponite 4.50 Ethanol 12.50 Hydrogen peroxide (30%) 12.00 Total 100.00 *Keltrol is a tradename for Xanthan gum IV. A composition was prepared having the following ingredients: Ingredient %w/w Glycerin 74.00 Keltrol 1.00 Ethanol 13.00 Hydrogen peroxide (30%) 12.00 Total 100.00 *Keltrol is a tradename for Xanthan gum V. A composition was prepared having the following ingredients: Ingredient %w/w Glycerin 78.00 Keltrol 1.00 Laponite 9.00 Hydrogen peroxide (30%) 12.00 Total 100.00 *Keltrol is a tradename for Xanthan gum Determination of Gel Substantivity Method A thin layer of the test formulations coloured with erythrocin is applied to the tiles.
The tiles are mounted in the spray fermenter and sprayed with water at a rate of approximately lml/min for 30 minutes. The rate of flow is then increased to approximately 33ml/min. The substantivity is visually assessed (time for removal of formulation).
Results Formulation Composition %w/w Substantivity (mine) Peroxide | Water | Glycerin | Ethanol | Xanthan | Laponite Low | High 11 (carbarnide 70 12.5 4.5 30 12 peroxide) 11(carbamide 72.5 13 2 5 30 4 peroxide) 11(carbamide 70 12.5 2 4 5 30 21 peroxide) 11 (carbamide 72.5 13 2.5 30 12 peroxide) 12(30%H2O2) 0 69 12.5 2 4 5 30 20 1 2(30%H2O2) 0 72 12.5 1 2.5 30 10
Conclusion
Addition of xanthan to the system enhances the substantivity.
Determination of bleaching effect Method Stained Pellicle Cleaning Ratio (PCR) enamel blocks were hydrated for at least one hour in deionised water and then dried by vacuum for 20 minutes. L*a*b* measurements were then taken using a HunterLab Spectrocolorimeter and recorded for each PCR enamel block.
The blocks were then treated and placed into the spray fermenter. Tap water was used to spray onto the blocks at a rate of approximately [ml/minute for 30 minutes, followed by 330ml/minute for 30 minutes. After this time the enamel blocks were removed from the spray fermenter, rinsed by immersing in deionised water for approximately 2 minutes, dried under vacuum for 20 minutes and then the L*a*b* was remeasured.
Results A graph showing the change in L after 60 minutes treatment (hydrogen peroxide samples) is shown below in Figure 1.
Conclusion
The results indicate that after 60 minutes treatment the change in L was higher for the Laponite/xanthan combination (Example V) than for the xanthan formulation (Example IV) or the untreated control. -1D
Claims (6)
- Claims 1. An oral care composition comprising a peroxide contaningcompound dispersed in an orally acceptable carrier, wherein the carrier comprises a humectant and a combination of bioadhesive agents consisting essentially of at least one natural gum and a silicate.
- 2. An oral care composition according to claim 1 wherein the peroxide containing compound is selected from hydrogen peroxide, carbamide peroxide, calcium peroxide, percarbonates, and mixtures thereof.
- 3. An oral care composition according to claim 1 or claim 2 wherein the humectant is glycerin.
- 4. An oral care composition according to any one of claims 1 to 3 wherein the bioadhesive agents are selected from Xanthan Gum, Gum Karaya, Carragenan, Alginates, Guar Gum, Gum Arabic, Gum Ghatti, Locust Bean Gum, Tara Gum, Fenugreek Gum, Gum Tragacanth, Tamarind Gum, Gellan Gum, Succinoglucan Gum, Welan Gum, Rhamsan Gum, Aloe Polysaccharides, Chia Gum, Flaxseed Gum, Okra Gum, Psyllium Seed Gum, Quince Seed Gum, Curdlan, Pullulan, Pectins and mixtures thereof plus a carbomer homopolymer or copolymer.
- 5. A kit of parts comprising a tooth whitening composition according to any one of claims 1 to 4, a container for housing the composition and an applicator for applying the composition to teeth to be whitened.
- 6. A method of whitening teeth comprising: a. preparing a tooth whitening composition according to any one of claims 1 to 4; b. painting the composition onto teeth to be whitened; c. maintaining the composition in contact with the teeth for a plurality of hours per day; and then d. repeating steps b and c for multiple days to thereby whiten the teeth.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0406392A GB2412315A (en) | 2004-03-22 | 2004-03-22 | Peroxide tooth whitening composition |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0406392A GB2412315A (en) | 2004-03-22 | 2004-03-22 | Peroxide tooth whitening composition |
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| Publication Number | Publication Date |
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| GB0406392D0 GB0406392D0 (en) | 2004-04-21 |
| GB2412315A true GB2412315A (en) | 2005-09-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| GB0406392A Withdrawn GB2412315A (en) | 2004-03-22 | 2004-03-22 | Peroxide tooth whitening composition |
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| GB (1) | GB2412315A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022207843A3 (en) * | 2021-03-31 | 2022-12-15 | G. Pohl-Boskamp Gmbh & Co. Kg | Composition for topical application to a subject |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0424020A1 (en) * | 1989-10-13 | 1991-04-24 | The Procter & Gamble Company | Oral compositions containing monoperoxy acids |
| CN1189334A (en) * | 1996-12-30 | 1998-08-05 | 美国Basf公司 | Dentifrice formulations containing liquid polyoxyalkylene compounds miscible in liquid, polyalkylene glycol carrier |
| US5939052A (en) * | 1996-11-21 | 1999-08-17 | The Procter & Gamble Company | Dentifrice compositions containing polyphosphate and fluoride |
| US6106812A (en) * | 1998-10-05 | 2000-08-22 | Colgate-Palmolive Company | Dual component antiplaque and tooth whitening composition |
| US6365134B1 (en) * | 1999-07-07 | 2002-04-02 | Scientific Pharmaceuticals, Inc. | Process and composition for high efficacy teeth whitening |
-
2004
- 2004-03-22 GB GB0406392A patent/GB2412315A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0424020A1 (en) * | 1989-10-13 | 1991-04-24 | The Procter & Gamble Company | Oral compositions containing monoperoxy acids |
| US5939052A (en) * | 1996-11-21 | 1999-08-17 | The Procter & Gamble Company | Dentifrice compositions containing polyphosphate and fluoride |
| CN1189334A (en) * | 1996-12-30 | 1998-08-05 | 美国Basf公司 | Dentifrice formulations containing liquid polyoxyalkylene compounds miscible in liquid, polyalkylene glycol carrier |
| US6106812A (en) * | 1998-10-05 | 2000-08-22 | Colgate-Palmolive Company | Dual component antiplaque and tooth whitening composition |
| US6365134B1 (en) * | 1999-07-07 | 2002-04-02 | Scientific Pharmaceuticals, Inc. | Process and composition for high efficacy teeth whitening |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022207843A3 (en) * | 2021-03-31 | 2022-12-15 | G. Pohl-Boskamp Gmbh & Co. Kg | Composition for topical application to a subject |
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| Publication number | Publication date |
|---|---|
| GB0406392D0 (en) | 2004-04-21 |
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