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GB2494741B - A method for diagnosing or determining the prognosis of colorectal cancer (crc) using novel autoantigens: gene expression guided autoantigen discovery - Google Patents

A method for diagnosing or determining the prognosis of colorectal cancer (crc) using novel autoantigens: gene expression guided autoantigen discovery

Info

Publication number
GB2494741B
GB2494741B GB1211395.7A GB201211395A GB2494741B GB 2494741 B GB2494741 B GB 2494741B GB 201211395 A GB201211395 A GB 201211395A GB 2494741 B GB2494741 B GB 2494741B
Authority
GB
United Kingdom
Prior art keywords
gene expression
colorectal cancer
prognosis
crc
diagnosing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB1211395.7A
Other versions
GB201211395D0 (en
GB2494741A (en
Inventor
Mark Jq Lim
Christopher Sears
Kenneth J Rothschild
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ambergen Inc
Original Assignee
Ambergen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/533,036 external-priority patent/US20130022987A1/en
Application filed by Ambergen Inc filed Critical Ambergen Inc
Publication of GB201211395D0 publication Critical patent/GB201211395D0/en
Publication of GB2494741A publication Critical patent/GB2494741A/en
Application granted granted Critical
Publication of GB2494741B publication Critical patent/GB2494741B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • G01N33/57535—
    • G01N33/5758—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/65—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to a method of detecting autoantibodies related to colorectal cancer in an individual comprising contacting a test sample from an individual with one or more target antigens selected from MAP4K4 and IGFBP3 and detecting any antibodies that bind to said antigens. The sample may also be contacted with target antigens selected from p53 or IGF2BP2 to detect autoantibodies to said antigens. Also provided in a further embodiment is a method for identifying antibodies related to cancer by comparing gene expression levels of cancer cells compared to normal cells, assaying body fluid from an individual with cancer for antibodies to the genes only activated in the cancer cells and identifying an antibody.
GB1211395.7A 2011-06-27 2012-06-27 A method for diagnosing or determining the prognosis of colorectal cancer (crc) using novel autoantigens: gene expression guided autoantigen discovery Expired - Fee Related GB2494741B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161501466P 2011-06-27 2011-06-27
US13/533,036 US20130022987A1 (en) 2011-06-27 2012-06-26 Method for Diagnosing or Determining the Prognosis of Colorectal Cancer (CRC) Using Novel Autoantigens: Gene Expression Guided Autoantigen Discovery

Publications (3)

Publication Number Publication Date
GB201211395D0 GB201211395D0 (en) 2012-08-08
GB2494741A GB2494741A (en) 2013-03-20
GB2494741B true GB2494741B (en) 2013-11-06

Family

ID=46704290

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1211395.7A Expired - Fee Related GB2494741B (en) 2011-06-27 2012-06-27 A method for diagnosing or determining the prognosis of colorectal cancer (crc) using novel autoantigens: gene expression guided autoantigen discovery

Country Status (1)

Country Link
GB (1) GB2494741B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021358002A1 (en) * 2020-10-05 2023-06-08 Freenome Holdings, Inc. Markers for the early detection of colon cell proliferative disorders
CN120559235A (en) * 2025-02-13 2025-08-29 浙江大学 A biomarker for early colorectal cancer detection and its application

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009114836A1 (en) * 2008-03-14 2009-09-17 Genomic Health, Inc. Gene expression markers for prediction of patient response to chemotherapy
WO2010042228A2 (en) * 2008-10-10 2010-04-15 Cornell University Methods for predicting disease outcome in patients with colon cancer
US20100297014A1 (en) * 2007-10-10 2010-11-25 Paul Jenkins Method of detecting the risk of cancer using genetic markers

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100297014A1 (en) * 2007-10-10 2010-11-25 Paul Jenkins Method of detecting the risk of cancer using genetic markers
WO2009114836A1 (en) * 2008-03-14 2009-09-17 Genomic Health, Inc. Gene expression markers for prediction of patient response to chemotherapy
WO2010042228A2 (en) * 2008-10-10 2010-04-15 Cornell University Methods for predicting disease outcome in patients with colon cancer

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Cancer Epidemiol; Vol 12, pp 136-143 (2003). Zhang et al. "Enhancement of antibody detection in cancer using panel of recombinant tumor-associated antigens" *
Clin Cancer Res; Vol 9, pp 5120-5126 (2003). Koziol et al. "Recursive partitioning as an approach to selection of immune markers for tumour diagnosis" *
Hepato-Gastroenterology; Vol 54, pp 1422-1425 (2007). Nozoe et al. "Clinicopathologic significance in serum presence of anti-p53 antibody in patients with colorectal cancer" *
Int J Oncology; Vol 26, pp 311-317. Himoto et al "Significance of autoantibodies against insulin-like growth factor II mRNA-binding proteins in patients with hepatocellular carcinoma" *
J Pathol; Vol 220, pp 475-489 (2009). Hao et al. "A five gene signature as a potential predictor of metastasis and survival in colorectal cancer" *
Scandinavian J Immunol; Vol 69, pp 57-63 (2008). Liu et al. "Evaluation of tumour-associated antigen (TAA) miniarray in immunodiagnosis of colon cancer" *

Also Published As

Publication number Publication date
GB201211395D0 (en) 2012-08-08
GB2494741A (en) 2013-03-20

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20160627