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GB2471800B - Preparation of N-alkylated morphinans by reduction of an iminium group - Google Patents

Preparation of N-alkylated morphinans by reduction of an iminium group

Info

Publication number
GB2471800B
GB2471800B GB1017988A GB201017988A GB2471800B GB 2471800 B GB2471800 B GB 2471800B GB 1017988 A GB1017988 A GB 1017988A GB 201017988 A GB201017988 A GB 201017988A GB 2471800 B GB2471800 B GB 2471800B
Authority
GB
United Kingdom
Prior art keywords
reduction
preparation
iminium group
morphinans
alkylated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB1017988A
Other versions
GB2471800A (en
GB201017988D0 (en
Inventor
Audun Heggelund
Harald Halvorsen
Ole Heine Kvernenes
Anne Mette Nyg Rd
Original Assignee
Alpharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alpharma filed Critical Alpharma
Priority to GB1017988A priority Critical patent/GB2471800B/en
Publication of GB201017988D0 publication Critical patent/GB201017988D0/en
Publication of GB2471800A publication Critical patent/GB2471800A/en
Application granted granted Critical
Publication of GB2471800B publication Critical patent/GB2471800B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB1017988A 2006-05-25 2006-05-25 Preparation of N-alkylated morphinans by reduction of an iminium group Expired - Fee Related GB2471800B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1017988A GB2471800B (en) 2006-05-25 2006-05-25 Preparation of N-alkylated morphinans by reduction of an iminium group

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0610386A GB2438399A (en) 2006-05-25 2006-05-25 Preparation of N-alkylated morphinans by reduction of an iminium group
GB1017988A GB2471800B (en) 2006-05-25 2006-05-25 Preparation of N-alkylated morphinans by reduction of an iminium group

Publications (3)

Publication Number Publication Date
GB201017988D0 GB201017988D0 (en) 2010-12-08
GB2471800A GB2471800A (en) 2011-01-12
GB2471800B true GB2471800B (en) 2011-03-09

Family

ID=36687715

Family Applications (2)

Application Number Title Priority Date Filing Date
GB1017988A Expired - Fee Related GB2471800B (en) 2006-05-25 2006-05-25 Preparation of N-alkylated morphinans by reduction of an iminium group
GB0610386A Withdrawn GB2438399A (en) 2006-05-25 2006-05-25 Preparation of N-alkylated morphinans by reduction of an iminium group

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB0610386A Withdrawn GB2438399A (en) 2006-05-25 2006-05-25 Preparation of N-alkylated morphinans by reduction of an iminium group

Country Status (1)

Country Link
GB (2) GB2471800B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102227433B (en) 2008-09-30 2015-01-07 马林克罗特有限公司 Processes for synthesis of tertiary amines

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3717643A (en) * 1967-05-04 1973-02-20 Sterling Drug Inc N-substituted-norapomorphines
US3793329A (en) * 1971-02-19 1974-02-19 H Merz N-(furyl-methyl)-3-oxy-morphinans and salts thereof
WO2006035195A1 (en) * 2004-09-30 2006-04-06 Johnson Matthey Public Limited Company Preparation of opiate analgesics by reductive alkylation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3717643A (en) * 1967-05-04 1973-02-20 Sterling Drug Inc N-substituted-norapomorphines
US3793329A (en) * 1971-02-19 1974-02-19 H Merz N-(furyl-methyl)-3-oxy-morphinans and salts thereof
WO2006035195A1 (en) * 2004-09-30 2006-04-06 Johnson Matthey Public Limited Company Preparation of opiate analgesics by reductive alkylation

Also Published As

Publication number Publication date
GB2471800A (en) 2011-01-12
GB0610386D0 (en) 2006-07-05
GB2438399A (en) 2007-11-28
GB201017988D0 (en) 2010-12-08

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20120525