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GB2440081A - A method of measuring the glomerular filtration rate of a human or animal patient a self-use kit for providing blood samples - Google Patents

A method of measuring the glomerular filtration rate of a human or animal patient a self-use kit for providing blood samples Download PDF

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Publication number
GB2440081A
GB2440081A GB0721595A GB0721595A GB2440081A GB 2440081 A GB2440081 A GB 2440081A GB 0721595 A GB0721595 A GB 0721595A GB 0721595 A GB0721595 A GB 0721595A GB 2440081 A GB2440081 A GB 2440081A
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GB
United Kingdom
Prior art keywords
patient
human
filtration rate
glomerular filtration
measuring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB0721595A
Other versions
GB0721595D0 (en
GB2440081B (en
Inventor
Richard Henry Sammons
David John Newman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epsom & St Helier University H
JANE NEWMAN
Original Assignee
Epsom & St Helier University H
JANE NEWMAN
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epsom & St Helier University H, JANE NEWMAN filed Critical Epsom & St Helier University H
Priority to GB1005968A priority Critical patent/GB2466737B/en
Publication of GB0721595D0 publication Critical patent/GB0721595D0/en
Publication of GB2440081A publication Critical patent/GB2440081A/en
Application granted granted Critical
Publication of GB2440081B publication Critical patent/GB2440081B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/14—Devices for taking samples of blood ; Measuring characteristics of blood in vivo, e.g. gas concentration within the blood, pH-value of blood
    • A61B5/1405—Devices for taking blood samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/14—Devices for taking samples of blood ; Measuring characteristics of blood in vivo, e.g. gas concentration within the blood, pH-value of blood
    • A61B5/1405—Devices for taking blood samples
    • A61B5/1411—Devices for taking blood samples by percutaneous method, e.g. by lancet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/14—Devices for taking samples of blood ; Measuring characteristics of blood in vivo, e.g. gas concentration within the blood, pH-value of blood
    • A61B5/1405—Devices for taking blood samples
    • A61B5/1427—Multiple blood sampling, e.g. at periodic or pre-established intervals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150305—Packages specially adapted for piercing devices or blood sampling devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150358—Strips for collecting blood, e.g. absorbent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15142—Devices intended for single use, i.e. disposable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15146—Devices loaded with multiple lancets simultaneously, e.g. for serial firing without reloading, for example by use of stocking means.
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/155—Devices specially adapted for continuous or multiple sampling, e.g. at predetermined intervals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15103—Piercing procedure
    • A61B5/15107—Piercing being assisted by a triggering mechanism

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Physiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Manufacturing & Machinery (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A method of measuring glomerular filtration rate in a human or animal patient comprising: (i) intravenously administering a known amount of filtration marker to the patient at a known time; (ii) taking a sample of capillary blood from the patient at a known time after administration and absorbing a droplet of blood on an absorbent substrate to form a blood spot on the substrate; (iii) causing or allowing the blood spot to dry on the substrate; (iv) removing a portion of said substrate, said portion having a predetermined, substantially constant volume, and being substantially uniformly impregnated with the blood spot; (v) extracting an analyte from the portion; (vi) quantitating the amount of said filtration marker in said analyte; and (vii) determining the glomerular filtration rate of the patient from the quantitated amount of said filtration marker.
GB0721595A 2005-04-18 2006-04-18 A method of measuring the glomerular filtration rate of a patient and a self-use kit for providing blood samples Active GB2440081B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1005968A GB2466737B (en) 2005-04-18 2006-04-18 A self use kit for providing blood samples for use in measuring glomerular filtration rate of a patient

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0507838.1A GB0507838D0 (en) 2005-04-18 2005-04-18 A method of measuring the glomerular filtration rate of an human or animal patient, a self-use kit for providing blood samples for use in measuring glomerular
PCT/GB2006/001426 WO2006111741A1 (en) 2005-04-18 2006-04-18 A method of measuring the glomerular filtration rate of a human or animal patient, a self-use kit for providing blood samples for use in measuring the glomerular filtration rate of a patient, and a method of collecting timed samples of capillary blood from a patient

Publications (3)

Publication Number Publication Date
GB0721595D0 GB0721595D0 (en) 2007-12-12
GB2440081A true GB2440081A (en) 2008-01-16
GB2440081B GB2440081B (en) 2010-08-25

Family

ID=34630888

Family Applications (3)

Application Number Title Priority Date Filing Date
GBGB0507838.1A Ceased GB0507838D0 (en) 2005-04-18 2005-04-18 A method of measuring the glomerular filtration rate of an human or animal patient, a self-use kit for providing blood samples for use in measuring glomerular
GB1005968A Active GB2466737B (en) 2005-04-18 2006-04-18 A self use kit for providing blood samples for use in measuring glomerular filtration rate of a patient
GB0721595A Active GB2440081B (en) 2005-04-18 2006-04-18 A method of measuring the glomerular filtration rate of a patient and a self-use kit for providing blood samples

Family Applications Before (2)

Application Number Title Priority Date Filing Date
GBGB0507838.1A Ceased GB0507838D0 (en) 2005-04-18 2005-04-18 A method of measuring the glomerular filtration rate of an human or animal patient, a self-use kit for providing blood samples for use in measuring glomerular
GB1005968A Active GB2466737B (en) 2005-04-18 2006-04-18 A self use kit for providing blood samples for use in measuring glomerular filtration rate of a patient

Country Status (2)

Country Link
GB (3) GB0507838D0 (en)
WO (1) WO2006111741A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2681792A1 (en) * 2007-03-26 2008-10-02 Novartis Ag Predictive renal safety biomarkers and biomarker signatures to monitor kidney function
EP2408372B1 (en) 2009-03-02 2019-01-09 Seventh Sense Biosystems, Inc. Devices associated with blood sampling
WO2012018486A2 (en) 2010-07-26 2012-02-09 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
US20110125058A1 (en) * 2009-11-24 2011-05-26 Seven Sense Biosystems, Inc. Patient-enacted sampling technique
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
WO2011094573A1 (en) 2010-01-28 2011-08-04 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
US8775095B2 (en) 2010-06-18 2014-07-08 Roche Diagnostics Operations, Inc. Methods and apparatus for decentralized diabetes monitoring
EP2593014B1 (en) 2010-07-16 2015-11-04 Seventh Sense Biosystems, Inc. Low-pressure environment for fluid transfer devices
US20120039809A1 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
US8808202B2 (en) 2010-11-09 2014-08-19 Seventh Sense Biosystems, Inc. Systems and interfaces for blood sampling
JP6121400B2 (en) 2011-04-29 2017-04-26 セブンス センス バイオシステムズ，インコーポレーテッド Delivery and / or receipt of fluid
WO2012149134A1 (en) 2011-04-29 2012-11-01 Seventh Sense Biosystems, Inc. Devices and methods for collection and/or manipulation of blood spots or other bodily fluids
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
EP2701598A1 (en) 2011-04-29 2014-03-05 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
WO2016025429A1 (en) * 2014-08-15 2016-02-18 The Johns Hopkins University Precise estimation of glomerular filtration rate from multiple biomarkers

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4908202A (en) * 1988-02-02 1990-03-13 Cassella Aktiengesellschaft Use of 2-oxo-1-pyrrolidineacetamide for the determination of the glomerular filtration rate in humans
WO2004064637A1 (en) * 2003-01-23 2004-08-05 Epsom & St Helier University Hospitals Nhs Trust A lancet holding device

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US4731726A (en) * 1986-05-19 1988-03-15 Healthware Corporation Patient-operated glucose monitor and diabetes management system
US5518006A (en) * 1994-08-09 1996-05-21 International Technidyne Corp. Blood sampling device
US5951492A (en) * 1996-05-17 1999-09-14 Mercury Diagnostics, Inc. Methods and apparatus for sampling and analyzing body fluid
US5989198A (en) * 1997-05-30 1999-11-23 Mayo Foundation For Medical Education And Research Use of capillary electrophoresis to determine glomerular filtration rate using iothalamate
US20020055176A1 (en) * 2000-11-08 2002-05-09 Ray Robert A. Diagnostic assay system
US6474694B1 (en) * 2001-06-05 2002-11-05 Moore North America, Inc. Medical test form
US20030195435A1 (en) * 2002-04-12 2003-10-16 Williams Arthur G. Method and apparatus for collecting and transporting capillary blood samples for diagnostic and research evaluation

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US4908202A (en) * 1988-02-02 1990-03-13 Cassella Aktiengesellschaft Use of 2-oxo-1-pyrrolidineacetamide for the determination of the glomerular filtration rate in humans
WO2004064637A1 (en) * 2003-01-23 2004-08-05 Epsom & St Helier University Hospitals Nhs Trust A lancet holding device

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Acta Paediatrica (2005), Vol 94, pp 19-23, "Measurement of renal function in patients...", Kleinert et al *
Clinical Chemistry (1987), Vol 33, pp 1643-1644, "Capillary blood, dried on filter paper,...", Lampe et al *
Diabetic Medicine (2001), Vol 18, pp 116-120, "Iohexol as a marker of glomerular...", Pucci et al *
Kidney International (2006), Vol 69, pp 1272-1275, "Development of an outpatient...", Niculescu-Duvaz et al *
Renal Failure (1998), Vol 20, pp 277-284, "Iohexol plasma clearance in determining...", Pucci et al *

Also Published As

Publication number Publication date
GB2466737A (en) 2010-07-07
GB0721595D0 (en) 2007-12-12
GB0507838D0 (en) 2005-05-25
GB2466737B (en) 2010-10-13
GB2440081B (en) 2010-08-25
GB201005968D0 (en) 2010-05-26
WO2006111741A1 (en) 2006-10-26

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PCNP Patent ceased through non-payment of renewal fee

Effective date: 20170418

S28 Restoration of ceased patents (sect. 28/pat. act 1977)

Free format text: APPLICATION FILED

S28 Restoration of ceased patents (sect. 28/pat. act 1977)

Free format text: RESTORATION ALLOWED

Effective date: 20180511