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GB2314334A - Improved production of antibodies through the use of antigen antibody complexes - Google Patents

Improved production of antibodies through the use of antigen antibody complexes

Info

Publication number
GB2314334A
GB2314334A GB9721432A GB9721432A GB2314334A GB 2314334 A GB2314334 A GB 2314334A GB 9721432 A GB9721432 A GB 9721432A GB 9721432 A GB9721432 A GB 9721432A GB 2314334 A GB2314334 A GB 2314334A
Authority
GB
United Kingdom
Prior art keywords
antibodies
improved production
antibody complexes
antigen antibody
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB9721432A
Other versions
GB9721432D0 (en
Inventor
Arthur Randell Bradwell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Binding Site Ltd
Original Assignee
Binding Site Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Binding Site Ltd filed Critical Binding Site Ltd
Publication of GB9721432D0 publication Critical patent/GB9721432D0/en
Publication of GB2314334A publication Critical patent/GB2314334A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

We have been able to make high affinity and high titre antibodies by administering not only antigen to an animal, but also a relatively low dose of antibodies to that antigen. These high affinity antibodies can then be used to make better immunological diagnostic test kits, or in the preparation of therapeutic substance or in the treatment of patients. High affinity antibodies are administered to an antibody source in order to make even higher affinity antibodies.
GB9721432A 1996-03-27 1997-03-26 Improved production of antibodies through the use of antigen antibody complexes Withdrawn GB2314334A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9606425.8A GB9606425D0 (en) 1996-03-27 1996-03-27 Improvements in and relating to the production of antibodies and test kits incorporating antibodies
PCT/GB1997/000855 WO1997035884A1 (en) 1996-03-27 1997-03-26 Improved production of antibodies through the use of combinations of antigen and antibody, test kits incorporating said antibodies, and medical uses of said antibodies

Publications (2)

Publication Number Publication Date
GB9721432D0 GB9721432D0 (en) 1997-12-10
GB2314334A true GB2314334A (en) 1997-12-24

Family

ID=10791102

Family Applications (2)

Application Number Title Priority Date Filing Date
GBGB9606425.8A Pending GB9606425D0 (en) 1996-03-27 1996-03-27 Improvements in and relating to the production of antibodies and test kits incorporating antibodies
GB9721432A Withdrawn GB2314334A (en) 1996-03-27 1997-03-26 Improved production of antibodies through the use of antigen antibody complexes

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GBGB9606425.8A Pending GB9606425D0 (en) 1996-03-27 1996-03-27 Improvements in and relating to the production of antibodies and test kits incorporating antibodies

Country Status (4)

Country Link
AU (1) AU2169797A (en)
DE (1) DE19780326T1 (en)
GB (2) GB9606425D0 (en)
WO (1) WO1997035884A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU756349B2 (en) * 1997-07-25 2003-01-09 Altana Pharma Ag Substituted 6-phenylphenanthridines
EP1981535A2 (en) 2005-12-22 2008-10-22 IQ Corporation Compositions and methods of modulating the immune response
WO2008142483A2 (en) * 2006-12-14 2008-11-27 Plant Research International B.V. Vaccine compositions and methods of use thereof
AU2017238168B2 (en) * 2016-03-21 2024-06-13 Sarah Elliott DNA antibody constructs and method of using same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0153871A2 (en) * 1984-03-01 1985-09-04 Centocor, Inc. Antibody enhancement of immunogenicity of antigen
EP0251065A2 (en) * 1986-06-20 1988-01-07 Neorx Corporation Enhanced production of antibodies utilizing insolubilized immune complexes
US5332665A (en) * 1991-12-18 1994-07-26 The General Hospital Corporation Species specific, high affinity monoclonal antibodies

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0153871A2 (en) * 1984-03-01 1985-09-04 Centocor, Inc. Antibody enhancement of immunogenicity of antigen
EP0251065A2 (en) * 1986-06-20 1988-01-07 Neorx Corporation Enhanced production of antibodies utilizing insolubilized immune complexes
US5332665A (en) * 1991-12-18 1994-07-26 The General Hospital Corporation Species specific, high affinity monoclonal antibodies

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Infection and Immunity 1974,10(3)437-442 *
Nature 1983,302,256-258 *

Also Published As

Publication number Publication date
WO1997035884A8 (en) 2001-04-26
DE19780326T1 (en) 1998-04-23
GB9606425D0 (en) 1996-06-05
GB9721432D0 (en) 1997-12-10
WO1997035884A1 (en) 1997-10-02
AU2169797A (en) 1997-10-17

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)