[go: up one dir, main page]

GB2311781B - Piperazine 2,5 dione derivatives as modulators of multi-drug resistance - Google Patents

Piperazine 2,5 dione derivatives as modulators of multi-drug resistance

Info

Publication number
GB2311781B
GB2311781B GB9712184A GB9712184A GB2311781B GB 2311781 B GB2311781 B GB 2311781B GB 9712184 A GB9712184 A GB 9712184A GB 9712184 A GB9712184 A GB 9712184A GB 2311781 B GB2311781 B GB 2311781B
Authority
GB
United Kingdom
Prior art keywords
modulators
piperazine
drug resistance
dione derivatives
dione
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB9712184A
Other versions
GB2311781A (en
GB9712184D0 (en
Inventor
Philip Anthony Ashworth
Sukhjit Hunjan
Ian Andrew Pretswell
Hamish Ryder
Stephen James Brocchini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xenova Ltd
Original Assignee
Xenova Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9426224.3A external-priority patent/GB9426224D0/en
Application filed by Xenova Ltd filed Critical Xenova Ltd
Priority to GB9712184A priority Critical patent/GB2311781B/en
Publication of GB9712184D0 publication Critical patent/GB9712184D0/en
Publication of GB2311781A publication Critical patent/GB2311781A/en
Application granted granted Critical
Publication of GB2311781B publication Critical patent/GB2311781B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB9712184A 1994-12-23 1995-12-22 Piperazine 2,5 dione derivatives as modulators of multi-drug resistance Expired - Fee Related GB2311781B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9712184A GB2311781B (en) 1994-12-23 1995-12-22 Piperazine 2,5 dione derivatives as modulators of multi-drug resistance

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9426224.3A GB9426224D0 (en) 1994-12-23 1994-12-23 Pharmaceutical compounds
PCT/GB1995/003027 WO1996020190A1 (en) 1994-12-23 1995-12-22 Piperazine 2,5 dione derivatives as modulators of multi-drug resistance
GB9712184A GB2311781B (en) 1994-12-23 1995-12-22 Piperazine 2,5 dione derivatives as modulators of multi-drug resistance

Publications (3)

Publication Number Publication Date
GB9712184D0 GB9712184D0 (en) 1997-08-13
GB2311781A GB2311781A (en) 1997-10-08
GB2311781B true GB2311781B (en) 1998-09-16

Family

ID=26306264

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9712184A Expired - Fee Related GB2311781B (en) 1994-12-23 1995-12-22 Piperazine 2,5 dione derivatives as modulators of multi-drug resistance

Country Status (1)

Country Link
GB (1) GB2311781B (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994001408A1 (en) * 1992-07-10 1994-01-20 Laboratoires Glaxo S.A. Anilide derivatives
WO1994004512A1 (en) * 1992-08-14 1994-03-03 Xenova Limited Pharmaceutically active diketopiperazines

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994001408A1 (en) * 1992-07-10 1994-01-20 Laboratoires Glaxo S.A. Anilide derivatives
WO1994004512A1 (en) * 1992-08-14 1994-03-03 Xenova Limited Pharmaceutically active diketopiperazines
WO1994004513A1 (en) * 1992-08-14 1994-03-03 Xenova Limited Pharmaceutically active diketopiperazines

Also Published As

Publication number Publication date
GB2311781A (en) 1997-10-08
GB9712184D0 (en) 1997-08-13

Similar Documents

Publication Publication Date Title
AU4310096A (en) Piperazine 2,5 dione derivatives as modulators of multi-drug resistance
GB2319250B (en) Derivatives of 6,8-Difluoro-7-Hydroxycoumarin
PL327406A1 (en) 1-(1,2-disubstituted-piperidinyl)-4-substituted derivatives of piperazine
AU4400796A (en) New piperazine derivatives and methods for the preparation thereof and compositions containing the same
ZA962817B (en) Novel substituted piperazine derivatives
AU2349395A (en) Morpholine derivatives and their use as antagonists of tachikinins
PL338563A1 (en) Substituted derivatives of 1,2,3,4-tetrahydronaphtalene
PL329121A1 (en) Substituted derivatives of 1,2,3,4-tetrahydronaphtalene
PL324992A1 (en) Novel derivatives of 2,3-dioxotetrahydoquinoxaline
AP9500731A0 (en) 1,5 benzodiazepine derivatives
AU2565795A (en) Carbazole derivatives as agents against multi-drug resistance
GB9509474D0 (en) Piperazine derivatives
AU1636297A (en) Novel 2,3-benzodiazepine derivatives
PL312692A1 (en) New derivatives of dialkoxy-pyridinol-benzimidazole
AU4991797A (en) Piperazino derivatives as neurokinin antagonists
AU3467697A (en) 3'-oximino-2',3'-dideoxynucleosides and derivatives of the same
GB9512479D0 (en) Substituted benzene derivatives
AU4310196A (en) Piperazine-2,5-dione derivatives as modulators of multi-drug resistance
GR3035910T3 (en) Derivatives of 10,11-dihydro-10-oxo-5h-dibenz/b,f/azepine-5-carboxamide
GB2311781B (en) Piperazine 2,5 dione derivatives as modulators of multi-drug resistance
HK1002196A (en) Piperazine2,5 dione derivatives as modulators of multi-drug resistance
HK1002196B (en) Piperazine2,5 dione derivatives as modulators of multi-drug resistance
GB9815066D0 (en) Piperazine 2, 5-dione derivatives as modulators of multidrug resistance
GB2310854B (en) Piperazine-2,5-dione derivatives as modulators of multi-drug resistance
PL304971A1 (en) Novel derivatives of n'-oxy-2,2'-bipyridilamine

Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19991222