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GB2384779A - Method - Google Patents

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Publication number
GB2384779A
GB2384779A GB0306057A GB0306057A GB2384779A GB 2384779 A GB2384779 A GB 2384779A GB 0306057 A GB0306057 A GB 0306057A GB 0306057 A GB0306057 A GB 0306057A GB 2384779 A GB2384779 A GB 2384779A
Authority
GB
United Kingdom
Prior art keywords
proteins
arrays
tagged
terminus
domains
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB0306057A
Other versions
GB2384779B (en
GB0306057D0 (en
Inventor
Roland Kozlowski
Jonathan Michael Blackburn
Michelle Anne Mulder
Mitali Samaddar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sense Proteomic Ltd
Original Assignee
Sense Proteomic Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0020357A external-priority patent/GB0020357D0/en
Application filed by Sense Proteomic Ltd filed Critical Sense Proteomic Ltd
Publication of GB0306057D0 publication Critical patent/GB0306057D0/en
Publication of GB2384779A publication Critical patent/GB2384779A/en
Application granted granted Critical
Publication of GB2384779B publication Critical patent/GB2384779B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)

Abstract

The present invention relates to novel methods of producing proteins in which one or more domains are full length and correctly folded and which are each tagged at either the N- or C-terminus with one or more marker moieties and arrays containing such proteins, as well as the use of such proteins in arrays for rapid screening.

Description

(72) Inventor(s) Roland Koziowski Jonathan Michael Blackburn Michelle Anne
Mulder Mitali Samaddar (74) Agent and/or Address for Service Kilburn & Strode 20 Red Lion Street, LONDON, WC1R 4PJ, United Kingdom
GB0306057A 2000-08-17 2001-08-17 Method for the production of tagged proteins Expired - Fee Related GB2384779B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0020357A GB0020357D0 (en) 2000-08-17 2000-08-17 Method
US24799500P 2000-11-14 2000-11-14
PCT/GB2001/003693 WO2002027327A2 (en) 2000-08-17 2001-08-17 Rapid profiling of the interactions between a chemical entity and proteins in a given proteome

Publications (3)

Publication Number Publication Date
GB0306057D0 GB0306057D0 (en) 2003-04-23
GB2384779A true GB2384779A (en) 2003-08-06
GB2384779B GB2384779B (en) 2004-09-29

Family

ID=26244855

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0306057A Expired - Fee Related GB2384779B (en) 2000-08-17 2001-08-17 Method for the production of tagged proteins

Country Status (10)

Country Link
EP (1) EP1326970A2 (en)
JP (1) JP2004509645A (en)
KR (1) KR20030043933A (en)
CN (1) CN1494589A (en)
AU (1) AU2001279948A1 (en)
BR (1) BR0113330A (en)
CA (1) CA2420415A1 (en)
GB (1) GB2384779B (en)
IL (1) IL154486A0 (en)
WO (1) WO2002027327A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0202018D0 (en) 2002-01-29 2002-03-13 Sense Proteomic Ltd Tag and method
US20060194715A1 (en) * 2002-10-25 2006-08-31 Blackburn Jonathan M Proteins encoded by ble genes and antibiotics from the bleomycin family
US20060094059A1 (en) * 2004-09-22 2006-05-04 Odyssey Thera, Inc. Methods for identifying new drug leads and new therapeutic uses for known drugs
GB2460717A (en) 2008-06-11 2009-12-16 Sense Proteomic Ltd Autoantibodies for the detection of a predisposition to Lupus
GB2478734A (en) 2010-03-15 2011-09-21 Sense Proteomic Ltd Auto-antibody biomarkers of prostate cancer
GB201017520D0 (en) 2010-10-15 2010-12-01 Sense Proteomic Ltd Biomarkers

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999011777A1 (en) * 1997-09-03 1999-03-11 Biovation Limited Methods for protein screening
WO1999039210A1 (en) * 1998-01-29 1999-08-05 Miller, Samuel High density arrays for proteome analysis and methods and compositions therefor
WO1999051773A1 (en) * 1998-04-03 1999-10-14 Phylos, Inc. Addressable protein arrays
WO2000004382A1 (en) * 1998-07-14 2000-01-27 Zyomyx, Inc. Arrays of proteins and methods of use thereof
WO2000009654A2 (en) * 1998-08-12 2000-02-24 Zycos Inc. Profiling and cataloging expressed protein tags
WO2001004265A2 (en) * 1999-07-12 2001-01-18 Phylos, Inc. C-terminal protein tagging
WO2001057198A2 (en) * 2000-01-31 2001-08-09 Sense Proteomic Limited Methods of generating protein expression arrays and the use thereof in rapid screening

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999011777A1 (en) * 1997-09-03 1999-03-11 Biovation Limited Methods for protein screening
WO1999039210A1 (en) * 1998-01-29 1999-08-05 Miller, Samuel High density arrays for proteome analysis and methods and compositions therefor
WO1999051773A1 (en) * 1998-04-03 1999-10-14 Phylos, Inc. Addressable protein arrays
WO2000004382A1 (en) * 1998-07-14 2000-01-27 Zyomyx, Inc. Arrays of proteins and methods of use thereof
WO2000009654A2 (en) * 1998-08-12 2000-02-24 Zycos Inc. Profiling and cataloging expressed protein tags
WO2001004265A2 (en) * 1999-07-12 2001-01-18 Phylos, Inc. C-terminal protein tagging
WO2001057198A2 (en) * 2000-01-31 2001-08-09 Sense Proteomic Limited Methods of generating protein expression arrays and the use thereof in rapid screening

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Chemistry & Biology, Vol. 8, No. 10, October 2001, pages 951-965 *
Nature, Vol 405, No. 6788, June 2000, pages 837-846 *
Physiological Genomics, Vol. 1, No. 1, 1999, pages 25-32 *

Also Published As

Publication number Publication date
WO2002027327A3 (en) 2003-04-17
KR20030043933A (en) 2003-06-02
GB2384779B (en) 2004-09-29
EP1326970A2 (en) 2003-07-16
BR0113330A (en) 2003-12-30
IL154486A0 (en) 2003-09-17
CA2420415A1 (en) 2002-04-04
AU2001279948A1 (en) 2002-04-08
CN1494589A (en) 2004-05-05
GB0306057D0 (en) 2003-04-23
WO2002027327A2 (en) 2002-04-04
JP2004509645A (en) 2004-04-02

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Legal Events

Date Code Title Description
732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20130817