GB2362320A

GB2362320A - Liquid bactericidal cleaning composition based on alkyl polyglycoside surfactant, surface active quaternary ammonium salt, halogen-free arylphenol & Dichlosan

Info

Publication number: GB2362320A
Application number: GB0012037A
Authority: GB
Inventors: Els Quintyn; Dirk Veryser
Original assignee: Yplon S A
Current assignee: Yplon S A
Priority date: 2000-05-16
Filing date: 2000-05-16
Publication date: 2001-11-21
Also published as: GB0012037D0

Abstract

Liquid bactericidal cleaning composition comprises an alkyl (C<SB>8-22</SB>) polyglycoside surfactant, a surface active quaternary ammonium salt, a non halogenated phenyl-phenol compound and Dichlosan [2-chloro-6-(4-chlorophenoxy)phenol] in a liquid vehicle, and is useful for surface cleaning and the washing of dishes and textiles. The alkyl polyglycoside acts with the quaternary ammonium salt so that a lower quantity of the aryl-phenol compound and Dichlosan is required. The latter two components provide short and long term bacteriocidal/bacteriostatic activity. The composition may be provided as a concentrate for dilution on use.

Description

2362320 1 BACTERICIDAL CLEANER The present invention relates to a

bactericidal cleaner for use in cleaning operations, particularly but not exclusively for surface cleaning.

In recent years there has been a trend to the use of cleaning compositions that are not only able to perform as a cleaner but that are also bactericidal. Such cleaners are able to perform the same task as before with the added advantage that the material being cleaned is also at least partially sterilised. This effect is obviously beneficial, particularly on surfaces / items involved in the preparation / consumption of food or that come into contact with skin, leading to a reduction in infections caused by microorganisms.

Such cleaners typically comprise a surfactant composition together with a bactericidal agent. The bactericidal agent can be based on an oxidising agent such as chlorine bleach or peroxides. Alternatively other chemical agents may be used such as natural oils, strong acids, quaternary surfactants, known biocides or aldehyde derivatives.

For each of these agents it is typically necessary that they are soluble in / compatible with water, non-toxic, compatible with the item to be cleaned and, of course, adequately bactericidal. Usually they are applied in an aqueous medium to an item, left for a period of time and then rinsed / wiped away.

Each of the bactericidal agents mentioned has its own advantages and disadvantages. Having said that, generally all of the household compositions available must comply with European regulation EN 1276 which stipulates the effect that the bactericidal composition should have upon a range of microbes (Escherichia Coli, Staphylococcus Aureus, Pseudomonas Aeruginosa and so on) at a specified dilution and having had a certain contact time.

2 Agents that have been used in such household bactericidal cleaning compositions include non-halogenated phenyl-phenols, such as ortho-phenylphenol (OPP) and its salts. OPP is an effective bactericidal agent at relatively low concentrations having regard to certain micro-organisms. Also OPP is chlorine free and thus is ecologically friendly. A further advantage of OPP is that (at low concentrations) it has a good dermatological profile.

However, some micro-organisms display a higher resilience to OPP, requiring that a higher concentration of the compound is applied. The higher concentration of OPP required is disadvantageous, not only from an economic point of view but also having regard to toxicity, since at the required concentration OPP can become toxic.

Also although OPP is known to be an effective bactericidal agent in the short term it is not known to have a long lasting effect. Therefore in order to obtain the long-lasting efficacy of other anti-bactericidal agents, bactericidal compositions containing OPP must be used more frequently.

In order to have the short term bactericidal effect of OPP together with a longer term effect the use of a mixture of OPP with a longer term bactericide has been contemplated. However, these formulations have been dismissed for the reasons that the mixture of bactericides has often been found to be no more effective than the use of two separate bactericidal compositions, that is to say that there are no synergistic effects. Thus, such mixtures require high concentrations of each agent to reach the desired activity, which can cause the same economic and toxicity problems as outlined above.

It is an object of the present invention to overcome / mitigate the problems associated with the prior art.

According to the present invention there is provided a liquid bactericidal cleaning composition comprising an alkyl (C8-22) polyglycoside surfactant, a surface 3 active quaternary ammonium salt, a non halogenated phenyl-phenol compound and Dichlosan in a liquid vehicle.

We have found that improvements in the bactericidal action of cleaning compositions may be provided by using the cleaning composition according to the present invention. More particularly the addition of an alkyl (C822) polyglycoside surfactant has been found to enhance the bactericidal activity of aryl-phenol compounds and Dichlosan in comparison to fatty acid ethoxylate surfactants which have been found to be detrimental to these compositions. The alkyl (C8-22) polyglycoside acts together with the bactericidal quaternary ammonium salt, such that a lower concentration of the aryl-phenol compounds and Dichlosan is required. Without these additives the full benefits of the non-halogenated phenyl- phenol and the Dichlosan, namely the short and long term bactericidal / bacteriostatic activity, are not realised.

Also the cleaning composition has been found to provide excellent short term bactericidal action and long term bacteriostatic activity at high dilution, whilst providing excellent primary and secondary cleaning performance and complying with European Regulation EN 1276.

The liquid bactericidal cleaning composition may be produced simply by adding the specific components as separate additions to an appropriate mixing device and thoroughly mixing. Whilst it is preferred that the composition is produced in the form that it is to be used, alternatively a concentrate containing the active ingredients and a lower amount of the liquid vehicle, which may be diluted for use, may be produced.

Dichlosan is represented by the following formula:- OH cl Ir 0 cl ) r 4 It is preferred that the Dichlosan is present in the composition according to the invention at between O.Olwt% to O.Iwt%, more particularly between 0.02 and 0.06wt% and most particularly 0.0375wt%.

Dichlosan is available under the trade name Tinosan HP 100 (a 30% solution of Dichlosan).

It is preferred that the cleaning composition includes a compatibiliser to aid the homogeneity of the composition, particularly having regard to obtaining a homogeneous dispersion of Dichlosan. Preferably the compatibiliser constitutes 5wtO/o of the cleaning composition. A preferred compatibiliser is sodium cumene sulphonate.

The non halogenated phenyl-phenol compound may have the following formula:- Oz I Ph where Z = H or an alkali metal We do not preclude the presence of substituents on the non halogenated phenyl-phenol compound provided that the bacteriocidal / bacteriostatic properties are not affected.

Most preferably the non halogenated phenyl-phenol compound is orthophenylphenol:- 1 ox 1 where X = H or an alkali metal (preferably sodium).

The non halogenated phenyl-phenol compound in which X=H is available under the trade name Preventol 0 extra and that in which X=Na is available under the trade name Preventol ON extra.

It is preferred that the non halogenated phenyl-phenol compound constitutes from 0.001 to 0.50wt% of the weight of the composition. More preferably the non 3 halogenated phenyl-phenol compound constitutes from 0.1 to O.)5wt% and even more preferably about 0.35wt%.

Examples of quaternary ammonium salts which may be used in the formulation are of the formula:

0 R 3 1 + Y - where: W= C8-C20 alkyl, more preferably C8-CI5 alkyl and most preferably C9-CI3 alkyl. R2 = H or C I -C4 alkyl. R 3-5 = Cl-C4 alkyl (the same or different). Y = Counterbalancing anion, e.g. halogen (F, Cl, Br, 1), Sulphate or Cl-C4 Alkylsulphate.

A suitable quaternary ammonium salt is available under the trade name Rewocid UTM 188 (available from Witco). Rewocid UTM 188 has the following formula:- 6 Me + N-Me CH30S03 1 0 M e It is preferred that the quaternary ammonium salts constitutes from 0.01 to 0.4wt% of the weight of the composition. More preferably the aryl- phenol compound constitutes from 0. 0 5 to 0. 3 wt% and even more preferably about 0. 1 Owt%.

The preferred glycoside employed in the present invention is a glucoside (i.e. based on glucose), functionalised with a primary alcohol (e.g. C12CI4). More preferably the glucoside is in the form of a polyglucoside, with a preferred degree of polymerisation of between 1-2, most preferably about 1.4.

A suitable polYglycoside is available under the name Glucopan (Henkel).

It is preferred that the alkyl (C8-22) polyglycoside constitutes from 0. 1 to 5Wt% of the weight of the composition. More preferably the alkyl (C822) polyglycoside compound constitutes from 1 to 4wt% and even more preferably about 2wt%.

It is particularly preferred that the formulation comprises an additional detergent material which may be a non-ionic, cationic, anionic or zwitterionic surfactant.

Preferred examples of anionic surfactants are chosen from the group comprising monoethanol ammonium lauryl sulphate, sodium lauryl sulphate, sodium lauryl ether sulphate, triethyl ammonium lauryl sulphate, Empicol ESB TM and Texapon MLSTM (supplied by Albright & Wilson and Henkel respectively).

7 It is particularly preferred that the additional detergent material comprises an anionic surface active agent (particularly an alkyl sulphate) in an amount of 1% to 5% by weight (preferably about 3%).

The liquid vehicle of the formulation is preferably aqueous but we do not preclude the use of organic liquid vehicles.

Where an aqueous solvent is used the preferred pH of the composition is in the range of 8-11, more preferably from 9 to 10.

The cleaning composition according to the invention may include a coagent. The co-agent may be any co-agent as recognised by those skilled in the art. Preferred examples of such may be chosen from the following group of materials: - (1) (2) (3) (4) (5) (6) (7) (8) Sequestering agents including sodium citrate and Trilon (available from BASF). Hydrotropes including sodium xylene sulphonate. Sources of alkalinity including sodium hydroxide, carbonate and silicates. Perfumes. Dyes. Preservatives including Bronopol. Solvents to increase the homogeneity of the cleaning composition including alcohols, ethers, ethoxylated alcohols, esters and mixtures thereof. Fillers including sodium chloride and sodium sulphate.

Cleaning compositions in accordance with the invention have a variety of end uses, including: - (1) Textile washing. (2) Dish washing.

8 (3) Hard surface cleaning. (4) Kitchen cleaning.

The invention will now be described further with reference to the following non-limiting examples.

9 Examples

In each of the following examples the following all-purpose-cleaner (APC) was used as a base formulation.

Component Trade Narne Product Weight % Active Matter Concentration (%) Water - 100 To 100 To 100 Anionic Surfactant (Sodium Hostapur SAS 60 5 3 parafinesulphonate) (Clariant) 1 Non-ionic Surfactant (fatty Neodol 91-8 100 4 4 alcohol ethoxylate C9-11 E08) (Shell) Soap (Sodium Cocosoap) 100 0.5 0.5 Solvent (dipropropylene glycol Dowanol DPM 100 2 2 methyl ether) (DOW) Sequesterant (EDTA) Trilon B 87 0.17 0.148 (BASF) Sequesterant (Sodium Citrate) 100 2.0 2 Perfume 0.2-0.5 ye 0.002-0.005 Preservative Bronopol Myacide BT 99 0.015 0.015 Total active matter 11.5 Comparative Example 1 The APC formulation including 0.4wt% Preventol 0 extra (orthophenylphenol) was tested against several microbes (contact time 10 minutes). The microbes and the logarithmic reduction in their concentration is shown in Table 1.

Table 1

Microbe Scale of reduction (logarithmic scale) Staph. Aureus 2 Escherichia Coli 5 Pseudomonas Aerugmosa 5 Enterococcus Hirae Although composition was effective against Escherichia Coli and Pseudomonas Aeruginosa, it was not so effective against Staphylococcus Aureus.

Comparative Example 2 The APC formulation including 0.35wt% Preventol ON extra (sodium- orthophenyl-phenol) was tested against several microbes, 2TC, 0.3% bovine albumin (contact time 10 minutes). The microbes and the logarithmic reduction in their concentration is shown in Table 2.

Table 2

Microbe Scale of reduction (logarithmic scale) Escherichia Coli 5 Pseudomonas Aeruginosa 5 1 ___j The composition was highly effective against Escherichia Coli and Pseudomonas Aeruginosa.

Comparative Example 3 Following the relatively poor result of OPP against Staphylococcus Aureus, the composition of Comparative Example I was tested against Staphylococcus Aureus using different non-ionic surfactant in the APC (contact time 15 minutes). The nonionic surfactants and the efficacy of the compositions are shown in Table 3.

Table 3

Type of Non-ionic Surfactant Chain Distribution / Res It Ethoxylation Grade Fatty Alcohol Ethoxylate C9_1 I 6EO Ineffective Fatty Alcohol Ethoxylate CIO-13 3EO Ineffective Fatty Alcohol Ethoxylate C 12-14 / 7EO (Natural) Ineffective Alkyl Polyglucoside C8-10 Effective Alkyl Polyglucoside C8-14 Effective The compositions that used an alkyl polyglucoside non-ionic surfactant were much more effective than those using a fatty alcohol ethoxylate.

Comparative Example 4 Following the relative poor overall performance of OPP and its sodium salt as a bactericide, the OPP was supplemented with Dichlosan and sodium cumene sulphonate (SCS 40) as a compatibiliser. The exact nature of the compositions and their efficacy against certain microbes is shown in table 4.

12 Table 4

Sample Preventol ON Tinosan HP SCS 40 S E.c E.h P.a Concentration Concentration Concentration 986 2.5 1.1 >5 <0.9 >S >5 986 - 0.7 5 -31-8 5: >5 >5 1105 0.35 2.5 4.2 >5 <1.0 1105 0.35 0.3 4.0 >5 >5 Where S = Staphylococcus. Aureus E.e = Escherichia Coli E.h = Enterococcus Hirae P.a = Pseudomonas Aeruginosa (The same shorthand is used in all the following examples).

It can be seen that the addition of Dichlosan improved the bactericidal action of the sodium OPP compound. Together the two compounds show a high efficacy against Staphylococcus. Aureus.

Comparative Example 5 Cleaning compositions including OPP and Dichlosan were tested for their long term bactericidal effect against certain microbes. In each case 50g of the APC composition was dissolved in 1 litre of water. Eight discs of PVC were soaked in the composition for 2 minutes. The PVC discs were then dried at 220C and applied to the top surface of an agar culture containing the microbes at 1:600 (Staphylococcus. Aureus) or 1:1000 dilution (Escherichia Coli) and incubated for 18-24 hours at 37'C. The efficacy of the compositions is shown in table 5.

Table 5

Sample Preventol ON Tinosan HP SCS 40 S E.c Concentration Concentration Concentration Inhibition Inhibition Zone Zone (MM) (mm) 0/0 0/0 986 0.3 5 4/5 4/4 6 0.7 5 10/10 7/7 1105 0. J - - 00 0/0 1105 0.35 0.3 1/1 2/2 Comparative Example 6 APC including OPP compounds and Tinosan were tested with the replacement of the alcohol ethoxylate by alkyl polyglucoside. Ethanol was also added to the compositions to observe its effect.

In tables 6a and 6c the effect of the compositions upon certain cultures in 0.03% bovine albumin after 5 minutes contact time is shown.

In table 6b the effect of the compositions using a technique similar to comparative example 5 with the exception that the product concentration was 1.2% is shown.

14 Table 6a

Sample Preventol ON Tinosan HP Ethanol S E.c E.h Ra Concentration Concentration Concentration N 1023 0.35 0.3 >5 >5 --5 >5 1024 0.5 0.35 >5 >5 >5 >5 1026 0.35 0.35 2 >5 >5 >5 >5 Each of the compositions was found to be very effective.

Table 6b

Preventol ON Tinosan HP Ethanol St Sa E.c Concentration Concentration Concentration 1023 0.35 0.3 3/3 0/0 7/7 1024 0.5 0.3 - 4/4 0/0 6/6 1026 0.35 0.3 2 515 0/0 6/6 L- L--j Against the Staphylococcus Aureus a higher concentration of Preventol or addition of ethanol causes the inhibition zone to increase. The opposite effect is observed against Escherichia Coli.

Table 6c

Sample Preventol ON Tinosan HP Sodium Cumene S Ex E.h P.a Concentration Concentration Sulphate (%) (%) Concentration 1182 0.35 0.35 5 <5 >5 <5 >5 1 1183 0.35 0.125 5 <5 >5 <5 - 1 >5 Comparative Example 7 APC including OPP compounds and Tinosan were tested further with other additives at 20'C in 0.3% bovine albumin against the test microbes to see if the compositions complied with EN 1276. Table 7 shows the compositions that were unable to meet this requirement.

Table 7

Sample Component 1962 1965 1964 1961 1963 Water 74.54 77.5 76.2 76.7 74.5 Sodium Hydroxide (30%) 3.659 3.00 3.36 3.00 2.64 Fatty Coco 0.45 0.45 0.45 0.45 0.45 Sodium EDTA 0.17 0.17 0.17 0.17 0.17 Purac 2.0 1.0 - 1.0 2.0 Citric Acid (92%) 0.869 0.869 1.685 0.869 0.055 Sodium Parafin Sulphonate 5.0 5.0 5.0 5.0 5.0 DPM 2.0 2.0 2.0 2.0 2.0 Alkyl polyglucoside 4.0 4.0 4.0 4.0 4.0 Perfume 0.53 0.53 0.53) 0.53 0.53 Sodium OPP 0.35 0.35 0.35 0.35 0.35 Bromopol 0.015 0.015 0.015 0.015 0.015 Dye 0.0021 0.0021 0.0021 0.0021 Dichlosan 0.125 0.125 0.125 0.125 0.125 Sodium Xylene sulphonate 5.0 5.0 5.0 5.0 5.0 Eumilgin 0.75 - 0.75 0.75 0.75 Other - 0.35 2.5 Lonza Trilon 16 Example 1

APC including OPP compounds and Tinosan were tested further with other additives at 20T in 0.3% bovine albumin against the test microbes to see if the compositions complied with EN 1276. Table 8 shows the compositions that were able to meet this requirement.

Table 8 ample Component 2120 2115 2117 Water 76.6 75.7 76.8 So ium Hyd oxide (30%) 3. 3 6 3.36 3.36 Fatty Coco 0.45 0.45 0.45 Sodium EDTA 0.17 0 17 0 17 Purac - Citric Acid (92%) 1.685 1.685 1.685 Sodium Parafin Sulphonate 5.0 5.0 5.0 DPM 2.0 2.0 2.0 Alkyl polyglucoside 4.0 4.0 4.0 Perfume 0.53 0.53 0.53 Sodium OPP 0.35 0.35 0.35 Bromopol 0.015 0.015 0.015 Dye 0.0021 0.0021 0.0021 Dichlosan 0.125 0.125 0.125 Sodium Xylene sulphonate 5.0 5.0 5.0 Eumilgin 0.75 - 0.75 Other 0.64 0.05 1 0.51 Rewocid Rhodia Dowicil 17 Example 2

From the results in Example 1 a preferred composition of the APC was arrived at. lt is shown in Table 9 Table 9

Component Trade Name Product Weight % Active Matter Concentration (%) Water To 100 To 100 To 100 Surfactant-Anionic (Sodium Hostapur SAS 60 5 3 parafinesulphonate) (Clariant) Surfactant-Non-ionic (Alkyl Glucopon 50 4 2 polyglucosideCg-14) 650EC (Cognis) Soap (Sodium Cocosoap) 100 0.5 0.5 Solvent (dipropropylene glycol Dowanol DPM 100 2 2 methyl ether) (DOW) Sequesterant (MGDA) Trilon M 40 0.2 0.08 (BASF) Sequesterant (Sodium Citrate) 100 2.0 2 Hydrotrope (Sodium Xylene Eltesol SXS 40 40 5 2 Sulphonate) (Albright & Wilson) Perfume 0.2-0.5 Dye 0.002-0.005 Preservative Bronopol Myacide BT 99 0.15 0.015 Bactericide (OPP) Preventol ON 100 0.35 0.35 extra (Bayer) Bactericide (Undecylnic acid Rewocid 48 0.1 0.21 derivative) UTM 185 (Witco) Long-lasting bactericide Tinosan HP 30 0.125 0.0375 (Dichlosan) 100 I::::_- Total active matter 11.5 18

Claims

Claims

1) A liquid bactericidal cleaning composition comprising an alkyl (C8-22) polyglycoside surfactant, a surface active quaternary ammonium salt, a non halogenated phenyl-phenol compound and Dichlosan in a liquid vehicle.

2) A composition according to claim 1, wherein the Dichlosan is present in the composition according to the invention at between 0. 0 1 wt% to 0. 1 wt%.

A composition according to claim 2, wherein the Dichlosan is present in the composition at between 0.02 and 0.06wt%.

4) A composition according to claim 3, wherein the Dichlosan is present in the composition at 0.0375wt%.

5) A composition according to any one of claims 1 to 4, wherein the composition includes a compatibiliser.

6) A composition according to claim 5, wherein the compatibiliser constitutes 5Wt% of the composition.

7) A composition according to claim 6, wherein the compatibiliser is sodium cumene sulphonate.

8) A composition according to any one of claims I to 7, wherein the non halogenated phenyl-phenol compound has the following formula:- Oz Ph where Z = H or an alkali metal 19 9) A composition according to claim 8, wherein the non halogenated phenyl- phenol compound has the following formula:- ox where X = H or an alkali metal (preferably sodium).

10) A composition according to claim 8 or 9, wherein the non-halogenated phenylphenol compound constitutes from 0. 00 1 to 0. 5 Owt% of the compo sition.

11) A composition according to claim 10, wherein the non-halogenated phenylphenol compound constitutes from 0. 1 to 0.3 5wtO/o of the composition.

12) A composition according to claim 11, wherein the non-halogenated phenylphenol compound constitutes 0.35wt% of the composition.

13) A composition according to any one of the preceding claims, wherein the quaternary ammonium salt has the following formula:

0 R 3_ + - Y R where: W= C8-C20 alkyl, more preferably C8-C15 alkyl and most preferably C9-CI3 alkyl. R = H or C I -C4 alkyl. R3-5 = C I -C4 alkyl (the same or different).

y = Counterbalancing anion, e.g. halogen (F, Cl, Br, I), Sulphate or ClC4 Alkylsulphate.

14) A composition according to claim 1 -3 3, wherein the quaternary ammonium salt has the following formula:

0 Me + R"-kNH"'.IJ-Me CH3OS03 1 Me 15) A composition according to any one of the preceding claims, wherein the quaternary ammonium salt constitutes from 0. 0 1 to 0.4wt% of the composition.

16) A composition according to claim 15, wherein the quaternary ammonium salt constitutes from 0.05 to 0.3wt% of the composition.

17) A composition according to claim 16, wherein the quaternary ammonium salt constitutes 0. 1 Owt% of the composition.

18) A composition according to any one of the preceding claims, wherein the glycoside is a glucoside.

19) A composition according to claim 18, wherein the glucoside constitutes from 0.1 to 5wt% of the weight of the composition.

20) A composition according to claim 19, wherein the glucoside constitutes from 0.1 to % of the weight of the composition.

21) A composition according to claim 20, wherein the glucoside constitutes 2Wt% of the weight of the composition.

21 22) A composition according to any one of the preceding claims, wherein the composition includes a further surfactant chosen from the group comprising nonionic, cationic, anionic and zwitterionic surfactants.

23) A composition according to claim 22, wherein the surfactant is an anionic surfactant.

24) A composition according to claim 23, wherein the surfactant active agent constitutes from 1 % to 5% by weight of the composition.

25) A composition according to claim 24, wherein the surfactant active agent constitutes 3% by weight of the composition.

26) A composition according to any one of the preceding claims, wherein the pH of the composition is in the range of 8-11, more preferably from 9 to 10.

27) A composition according to any one of the preceding claims, wherein the cleaning composition according to the invention includes a co-agent selected from the group comprising sequestering agents, hydrotropes, sources of alkalinity, perfumes, dyes, preservatives, solvents and fillers.