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GB2355461A - TNFR-like protein with death domain - Google Patents

TNFR-like protein with death domain

Info

Publication number
GB2355461A
GB2355461A GB0028324A GB0028324A GB2355461A GB 2355461 A GB2355461 A GB 2355461A GB 0028324 A GB0028324 A GB 0028324A GB 0028324 A GB0028324 A GB 0028324A GB 2355461 A GB2355461 A GB 2355461A
Authority
GB
United Kingdom
Prior art keywords
deth
protein
tnfr
present
death domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB0028324A
Other versions
GB0028324D0 (en
Inventor
Jian Jason Lu
Bruce Charles Gomez
William Edward Fieles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of GB0028324D0 publication Critical patent/GB0028324D0/en
Publication of GB2355461A publication Critical patent/GB2355461A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides a novel 45 kilodalton protein, <U>D</U>eath Domain <U>E</U>xpressing <U>T</U>umor Necrosis Factor Receptor Family <U>H</U>omologue, referred to as DETH. DETH has a role in apoptosis and appears to be a member of the TNFR1/FAS/NGFR family of receptors. The present invention also provides nucleic acid sequences encoding DETH, fragments thereof or variants thereof and methods of using DETH or fragment thereof to identify compounds that inhibit or induce apoptosis.
GB0028324A 1998-06-12 1999-06-08 TNFR-like protein with death domain Withdrawn GB2355461A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9812607.1A GB9812607D0 (en) 1998-06-12 1998-06-12 Protein
PCT/GB1999/001793 WO1999066039A1 (en) 1998-06-12 1999-06-08 Tnfr-like protein with death domain

Publications (2)

Publication Number Publication Date
GB0028324D0 GB0028324D0 (en) 2001-01-03
GB2355461A true GB2355461A (en) 2001-04-25

Family

ID=10833585

Family Applications (2)

Application Number Title Priority Date Filing Date
GBGB9812607.1A Ceased GB9812607D0 (en) 1998-06-12 1998-06-12 Protein
GB0028324A Withdrawn GB2355461A (en) 1998-06-12 1999-06-08 TNFR-like protein with death domain

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GBGB9812607.1A Ceased GB9812607D0 (en) 1998-06-12 1998-06-12 Protein

Country Status (4)

Country Link
EP (1) EP1084244A1 (en)
AU (1) AU4277899A (en)
GB (2) GB9812607D0 (en)
WO (1) WO1999066039A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6358508B1 (en) 1997-06-11 2002-03-19 Human Genome Sciences, Inc. Antibodies to human tumor necrosis factor receptor TR9
CN1329086A (en) * 2000-06-21 2002-01-02 上海博德基因开发有限公司 A novel polypeptide-human TNFR/NGFR protein 15 contaiing cytochrome C structural domain and polynucleotide for coding this polypeptide

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0869179A1 (en) * 1997-04-02 1998-10-07 Smithkline Beecham Corporation Tumor necrosis related receptor, TR7
WO1998056892A1 (en) * 1997-06-11 1998-12-17 Human Genome Sciences, Inc. Human tumor necrosis factor receptor tr9
WO1999011790A1 (en) * 1997-09-04 1999-03-11 Zymogenetics, Inc. Tumor necrosis factor receptor ztnfr-6
WO1999015663A1 (en) * 1997-09-26 1999-04-01 Millennium Pharmaceuticals, Inc. Novel molecules of the tnf receptor superfamily and uses therefor
WO1999031128A2 (en) * 1997-12-16 1999-06-24 Incyte Pharmaceuticals, Inc. Human tumor necrosis factor-r2-like proteins

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0869179A1 (en) * 1997-04-02 1998-10-07 Smithkline Beecham Corporation Tumor necrosis related receptor, TR7
WO1998056892A1 (en) * 1997-06-11 1998-12-17 Human Genome Sciences, Inc. Human tumor necrosis factor receptor tr9
WO1999011790A1 (en) * 1997-09-04 1999-03-11 Zymogenetics, Inc. Tumor necrosis factor receptor ztnfr-6
WO1999015663A1 (en) * 1997-09-26 1999-04-01 Millennium Pharmaceuticals, Inc. Novel molecules of the tnf receptor superfamily and uses therefor
WO1999031128A2 (en) * 1997-12-16 1999-06-24 Incyte Pharmaceuticals, Inc. Human tumor necrosis factor-r2-like proteins

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Febs Letters Vol. 431 1998. Pan G et.al. pages 351-356 *
Nature Vol. 384 1996. Kitson J et.al. pages 372-375 *
Science Vol. 274 1996. Chinnaiyan A M et.al. pages 990-992 *
Science Vol. 276 1997. Pan G et.al. pages 111-113 *
Science Vol. 277 1997. Pan G et.al. pages 815-818 *

Also Published As

Publication number Publication date
AU4277899A (en) 2000-01-05
WO1999066039A1 (en) 1999-12-23
GB0028324D0 (en) 2001-01-03
GB9812607D0 (en) 1998-08-12
EP1084244A1 (en) 2001-03-21

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)