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GB2341319A - Drug delivery devices and methods for treatment of viral and microbial infections and wasting syndromes - Google Patents

Drug delivery devices and methods for treatment of viral and microbial infections and wasting syndromes

Info

Publication number
GB2341319A
GB2341319A GB9929189A GB9929189A GB2341319A GB 2341319 A GB2341319 A GB 2341319A GB 9929189 A GB9929189 A GB 9929189A GB 9929189 A GB9929189 A GB 9929189A GB 2341319 A GB2341319 A GB 2341319A
Authority
GB
United Kingdom
Prior art keywords
viral
treatment
methods
drug delivery
delivery devices
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB9929189A
Other versions
GB9929189D0 (en
GB2341319B (en
Inventor
Michelle Olga Patricia Visser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cryopreservation Technologies CC
Original Assignee
Cryopreservation Technologies CC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/874,425 external-priority patent/US5935597A/en
Application filed by Cryopreservation Technologies CC filed Critical Cryopreservation Technologies CC
Publication of GB9929189D0 publication Critical patent/GB9929189D0/en
Publication of GB2341319A publication Critical patent/GB2341319A/en
Application granted granted Critical
Publication of GB2341319B publication Critical patent/GB2341319B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Novel drug delivery devices, methods and therapeutic compositions are described for treating viral and microbial infections and wasting syndromes in an animal, including a human patient. According to the invention, a polar compound such as dimethylformamide or dimethylsulfoxide is administered to a patient in need of treatment, preferably by a transdermal route. The invention further provides a vaccine prepared from antibodies harvested from the body of a patient treated by the method of the invention for a viral infection.
GB9929189A 1997-06-13 1998-06-09 Use of compounds in the preparation of a medicament for the therapeutic treatment of a wasting syndrome Expired - Fee Related GB2341319B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/874,425 US5935597A (en) 1995-12-15 1997-06-13 Drug delivery devices and methods for treatment of viral and microbial infections and wasting syndromes
PCT/US1998/011956 WO1998056325A1 (en) 1997-06-13 1998-06-09 Drug delivery devices and methods for treatment of viral and microbial infections and wasting syndromes

Publications (3)

Publication Number Publication Date
GB9929189D0 GB9929189D0 (en) 2000-02-02
GB2341319A true GB2341319A (en) 2000-03-15
GB2341319B GB2341319B (en) 2002-02-27

Family

ID=25363728

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9929189A Expired - Fee Related GB2341319B (en) 1997-06-13 1998-06-09 Use of compounds in the preparation of a medicament for the therapeutic treatment of a wasting syndrome

Country Status (34)

Country Link
EP (1) EP1011567A4 (en)
JP (1) JP4531141B2 (en)
KR (1) KR20010013709A (en)
CN (1) CN1260703A (en)
AP (1) AP1629A (en)
AR (1) AR012970A1 (en)
AU (1) AU7831598A (en)
BG (1) BG103997A (en)
BR (1) BR9810095A (en)
CA (1) CA2295176A1 (en)
CZ (1) CZ298510B6 (en)
EA (1) EA200000011A1 (en)
EE (1) EE9900562A (en)
ES (1) ES2161187B1 (en)
FI (1) FI19992648L (en)
GB (1) GB2341319B (en)
HU (1) HUP0003034A2 (en)
ID (1) ID23516A (en)
IL (2) IL133396A0 (en)
IS (1) IS5289A (en)
LT (1) LT4714B (en)
LV (1) LV12490B (en)
NO (1) NO996117L (en)
NZ (1) NZ501669A (en)
OA (1) OA11307A (en)
PL (1) PL196256B1 (en)
RO (1) RO121252B1 (en)
SI (1) SI20191A (en)
SK (1) SK172299A3 (en)
TN (1) TNSN98086A1 (en)
TR (1) TR200000540T2 (en)
WO (1) WO1998056325A1 (en)
YU (1) YU66099A (en)
ZA (1) ZA984649B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1638468T3 (en) * 2003-06-30 2008-01-31 Alza Corp Method for coating skin piercing microprojections
OA13331A (en) * 2003-12-05 2007-04-13 Namibia Medical Invest Pty Ltd Patch.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5135480A (en) * 1986-07-10 1992-08-04 Elan Transdermal Limited Transdermal drug delivery device
US5359131A (en) * 1992-02-20 1994-10-25 Merrell Dow Pharmaceuticals Inc. Sulfonic acid derivatives in the treatment of viral diseases
US5534260A (en) * 1989-02-23 1996-07-09 University Of Utah Percutaneous drug delivery system

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4855294A (en) * 1988-09-06 1989-08-08 Theratech, Inc. Method for reducing skin irritation associated with drug/penetration enhancer compositions
US5028435A (en) * 1989-05-22 1991-07-02 Advanced Polymer Systems, Inc. System and method for transdermal drug delivery
US5624912A (en) * 1991-08-21 1997-04-29 Burcoglu; Arsinur Method of treating HIV infection and related secondary infections with defibrotide
SI9620126A (en) * 1995-12-15 1999-10-31 Cryopreservation Technologies Cc (Za/Za) Composition for organ cryopreservation and treatment of viral and bacterial infections

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5135480A (en) * 1986-07-10 1992-08-04 Elan Transdermal Limited Transdermal drug delivery device
US5534260A (en) * 1989-02-23 1996-07-09 University Of Utah Percutaneous drug delivery system
US5359131A (en) * 1992-02-20 1994-10-25 Merrell Dow Pharmaceuticals Inc. Sulfonic acid derivatives in the treatment of viral diseases

Also Published As

Publication number Publication date
LV12490B (en) 2000-12-20
PL338439A1 (en) 2000-11-06
SI20191A (en) 2000-10-31
GB9929189D0 (en) 2000-02-02
ID23516A (en) 2000-04-27
AU7831598A (en) 1998-12-30
BG103997A (en) 2001-07-31
WO1998056325A1 (en) 1998-12-17
LT99148A (en) 2000-07-25
PL196256B1 (en) 2007-12-31
TNSN98086A1 (en) 2005-03-15
FI19992648A7 (en) 2000-02-03
CA2295176A1 (en) 1998-12-17
EP1011567A1 (en) 2000-06-28
LV12490A (en) 2000-06-20
EP1011567A4 (en) 2000-06-28
KR20010013709A (en) 2001-02-26
TR200000540T2 (en) 2000-09-21
YU66099A (en) 2002-10-18
JP2002511862A (en) 2002-04-16
NO996117L (en) 2000-02-11
OA11307A (en) 2003-10-24
RO121252B1 (en) 2007-02-28
CZ298510B6 (en) 2007-10-24
JP4531141B2 (en) 2010-08-25
EE9900562A (en) 2000-06-15
AP9901708A0 (en) 1999-12-31
CN1260703A (en) 2000-07-19
EA200000011A1 (en) 2000-08-28
NZ501669A (en) 2001-09-28
AP1629A (en) 2006-07-11
SK172299A3 (en) 2000-09-12
FI19992648L (en) 2000-02-03
ZA984649B (en) 1999-12-17
IL133396A (en) 2006-10-05
NO996117D0 (en) 1999-12-10
LT4714B (en) 2000-10-25
IS5289A (en) 1999-12-08
AR012970A1 (en) 2000-11-22
HUP0003034A2 (en) 2000-12-28
ES2161187A1 (en) 2001-11-16
BR9810095A (en) 2001-11-13
ES2161187B1 (en) 2003-08-16
GB2341319B (en) 2002-02-27
IL133396A0 (en) 2001-04-30
CZ9904473A3 (en) 2001-03-14

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