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GB2340490A - Diphenylacetic acid derivatives and their use as antiviral agents - Google Patents

Diphenylacetic acid derivatives and their use as antiviral agents

Info

Publication number
GB2340490A
GB2340490A GB9926138A GB9926138A GB2340490A GB 2340490 A GB2340490 A GB 2340490A GB 9926138 A GB9926138 A GB 9926138A GB 9926138 A GB9926138 A GB 9926138A GB 2340490 A GB2340490 A GB 2340490A
Authority
GB
United Kingdom
Prior art keywords
group
acid derivatives
antiviral agents
diphenylacetic acid
diphenylvalerate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB9926138A
Other versions
GB9926138D0 (en
Inventor
David John Garnett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lovesgrove Research Ltd
Original Assignee
Lovesgrove Research Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9709073.2A external-priority patent/GB9709073D0/en
Priority claimed from GBGB9804337.5A external-priority patent/GB9804337D0/en
Application filed by Lovesgrove Research Ltd filed Critical Lovesgrove Research Ltd
Publication of GB9926138D0 publication Critical patent/GB9926138D0/en
Publication of GB2340490A publication Critical patent/GB2340490A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C219/10—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to an acyclic carbon atom of a carbon skeleton containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A new broad-spectrum anti-viral compound for the treatment of viral infections, such as human immune deficiency virus. The compound has general formula (I). Ar<SP>1</SP> and Ar<SP>2</SP> are each either a phenyl group or substituted aromatic group; R<SP>1</SP> is a primary, secondary or tertiary alkyl or alkenyl group, a phenyl or hydrogen; R<SP>2</SP> is an alkyl group, a primary, secondary or tertiary alkyl amino group or hydrogen; and X is C, O, N or S. Preferred compounds include diethylamino-ethyl-2,2-diphenylvalerate and aminoethyl-2,2-diphenylvalerate.
GB9926138A 1997-05-07 1998-05-06 Diphenylacetic acid derivatives and their use as antiviral agents Withdrawn GB2340490A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9709073.2A GB9709073D0 (en) 1997-05-07 1997-05-07 Broad-spectrum anti-viral
GBGB9720837.5A GB9720837D0 (en) 1997-05-07 1997-10-02 Anti-viral compounds
GBGB9804337.5A GB9804337D0 (en) 1998-03-03 1998-03-03 Anti-viral compounds
PCT/GB1998/001313 WO1998050022A1 (en) 1997-05-07 1998-05-06 Diphenylacetic acid derivatives and their use as antiviral agents

Publications (2)

Publication Number Publication Date
GB9926138D0 GB9926138D0 (en) 2000-01-12
GB2340490A true GB2340490A (en) 2000-02-23

Family

ID=27268832

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9926138A Withdrawn GB2340490A (en) 1997-05-07 1998-05-06 Diphenylacetic acid derivatives and their use as antiviral agents

Country Status (3)

Country Link
AU (1) AU7343398A (en)
GB (1) GB2340490A (en)
WO (1) WO1998050022A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2347858A (en) * 1999-03-18 2000-09-20 Lovesgrove Res Ltd Anti-viral compounds
CN106659697B (en) 2014-05-30 2022-03-29 斯菲叶尔制药私有公司 Compounds as antituberculosis agents

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2714376A1 (en) * 1993-12-29 1995-06-30 Khimbio Di:methyl amino ethyl phenyl propionate(s)

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2714376A1 (en) * 1993-12-29 1995-06-30 Khimbio Di:methyl amino ethyl phenyl propionate(s)

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
A KREUTZBERGER ET AL: ARCHIV DER PHARMAZIE vol. 307, no.10 1974 pgs 766-774 XP002075775 *
BIOCHEM PHARMACOL vol29 no19, 1980 pgs 2577-2582 *
CHEMICAL ABSTRACTS vol68 no15, 1968 abstract 66647b S AARON SON ET AL pg 6420 XP002075779 *
CHEMICAL ABSTRACTS vol73 no5, 1970 US abstract 23655p H SESAME ET AL pg 213 XP002075781 *
CHEMICAL ABSTRACTS vol84 no5, Feb 1976, abstract no. 0682a G TSUCHIHASHI pg 425, XP002075778 *
CHEMICAL ABSTRACTS vol94 no9, 1981 US abstract 57860a P J BARBER ET AL pg 12 XP002075782 *
CHEMICLA ABSTRACTS vol112 no15, 1990 US abstract 131959y E MALVOISIN ET AL pg 24 XP002075780 *
MC LU ET AL "Molecular modification.." JOURNAL OF MEDICINAL CHEMISTRY vol30. no2, pgs 273-278 1987 *
T UEDA ET AL - CHEMICAL & PHARMACEUTICAL BULLETIN vol16 no121968 pgs 2355-2361 XP002075777 *

Also Published As

Publication number Publication date
AU7343398A (en) 1998-11-27
GB9926138D0 (en) 2000-01-12
WO1998050022A1 (en) 1998-11-12

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)