GB2228198B - Novel cyclosporin galenic forms - Google Patents

Novel cyclosporin galenic forms

Info

Publication number: GB2228198B
Authority: GB; United Kingdom
Prior art keywords: galenic forms; novel cyclosporin; cyclosporin galenic; novel; forms
Prior art date: 1989-02-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

GB9003616A

Other versions

GB9003616D0 (en

GB2228198A (en

Inventor

Ulrich Posanski

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sandoz AG

Original Assignee

Sandoz AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-20

Filing date

1990-02-16

Publication date

1992-12-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10651981&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB2228198(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-02-16 Application filed by Sandoz AG filed Critical Sandoz AG

1990-04-11 Publication of GB9003616D0 publication Critical patent/GB9003616D0/en

1990-08-22 Publication of GB2228198A publication Critical patent/GB2228198A/en

1992-12-16 Application granted granted Critical

1992-12-16 Publication of GB2228198B publication Critical patent/GB2228198B/en

2010-02-16 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title 1
229930105110 Cyclosporin A Natural products 0.000 title 1
108010036949 Cyclosporine Proteins 0.000 title 1
229960001265 ciclosporin Drugs 0.000 title 1
229930182912 cyclosporin Natural products 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

GB9003616A 1989-02-20 1990-02-16 Novel cyclosporin galenic forms Expired - Lifetime GB2228198B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB898903804A GB8903804D0 (en)	1989-02-20	1989-02-20	Improvements in or relating to organic compounds

Publications (3)

Publication Number	Publication Date
GB9003616D0 GB9003616D0 (en)	1990-04-11
GB2228198A GB2228198A (en)	1990-08-22
GB2228198B true GB2228198B (en)	1992-12-16

Family

ID=10651981

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
GB898903804A Pending GB8903804D0 (en)	1984-07-24	1989-02-20	Improvements in or relating to organic compounds
GB9003616A Expired - Lifetime GB2228198B (en)	1989-02-20	1990-02-16	Novel cyclosporin galenic forms

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
GB898903804A Pending GB8903804D0 (en)	1984-07-24	1989-02-20	Improvements in or relating to organic compounds

Country Status (9)

Country	Link
JP (1)	JPH0611703B2 (en)
BE (1)	BE1005236A3 (en)
CH (1)	CH680650A5 (en)
CY (1)	CY1886A (en)
DE (1)	DE4005190A1 (en)
FR (1)	FR2643262B1 (en)
GB (2)	GB8903804D0 (en)
HK (1)	HK149595A (en)
IT (1)	IT1240765B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7060672B2 (en)	2001-10-19	2006-06-13	Isotechnika, Inc.	Cyclosporin analog formulations
US7799340B2 (en)	1996-01-22	2010-09-21	Watson Laboratories, Inc.	Pharmaceutical compositions for lipophilic drugs
US9498485B2 (en)	2014-08-28	2016-11-22	Lipocine Inc.	Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5639724A (en)	1984-07-24	1997-06-17	Sandoz Ltd.	Cyclosporin galenic forms
GB8904182D0 (en) *	1989-02-23	1989-04-05	Glaxo Canada	Pharmaceutical compositions
HU208491B (en) *	1990-11-27	1993-11-29	Gyogyszerkutato Intezet	Process for producing oral pharmaceutical composition containing cyclosporin
US6262022B1 (en)	1992-06-25	2001-07-17	Novartis Ag	Pharmaceutical compositions containing cyclosporin as the active agent
GB9113872D0 (en) *	1991-06-27	1991-08-14	Sandoz Ag	Improvements in or relating to organic compounds
IL102236A0 (en) *	1991-06-27	1993-01-14	Ltt Inst Co Ltd	Topical preparations containing cyclosporin
AU688920B2 (en) *	1991-06-27	1998-03-19	Novartis Ag	Transesterified corn oil products
ES2098739T3 (en)	1992-05-13	1997-05-01	Sandoz Ltd	OPHTHALMIC COMPOSITIONS CONTAINING A CYCLOSPORIN.
US5759566A (en) *	1992-07-28	1998-06-02	Poli Industria Chimica Spa	Microemulsion pharmaceutical compositions for the delivery of pharmaceutically active agents
ES2168271T3 (en)	1992-09-25	2002-06-16	Novartis Ag	PHARMACEUTICAL COMPOSITIONS CONTAINING CYCLOSPORINS.
DE4310643A1 (en) *	1993-04-01	1994-10-06	Merck Patent Gmbh	Cyclic adhesion inhibitors
DE4412201A1 (en) *	1993-04-20	1994-11-10	Rentschler Arzneimittel	New pharmaceutical preparations for oral administration containing cyclosporin
PT697881E (en) †	1993-04-20	2002-10-31	Novartis Ag	NEW PHARMACEUTICAL COMPOSITIONS CONTAINING CYCLOSPORINE FOR ORAL ADMINISTRATION
NZ247516A (en) *	1993-04-28	1995-02-24	Bernard Charles Sherman	Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant
DE4322826A1 (en) *	1993-07-08	1995-01-12	Galenik Labor Freiburg Gmbh	Pharmaceutical preparation
DE4340781C3 (en) *	1993-11-30	2000-01-27	Novartis Ag	Liquid preparations containing cyclosporin and process for their preparation
US5891846A (en) *	1994-02-17	1999-04-06	Shiseido Company, Ltd.	Cyclosporin-containing emulsion composition
WO1995022343A1 (en) *	1994-02-17	1995-08-24	Shiseido Company, Ltd.	Cyclosporin-containing emulsion composition
GB9405304D0 (en) *	1994-03-16	1994-04-27	Scherer Ltd R P	Delivery systems for hydrophobic drugs
US5474979A (en) *	1994-05-17	1995-12-12	Allergan, Inc.	Nonirritating emulsions for sensitive tissue
RU2119351C1 (en) *	1994-06-01	1998-09-27	Юхан Корпорейшн	Cyclosporin-containing immunosuppressive composition and a method of its preparing
JP3833248B2 (en)	1994-11-03	2006-10-11	ノバルティス・アクチエンゲゼルシャフト	Novel formulation of cyclosporine for oral administration with simple composition and high bioavailability and process for its production
US5603951A (en) *	1994-11-09	1997-02-18	Hanmi Pharm. Ind. Co., Ltd.	Cyclosporin-containing soft capsule compositions
KR0167613B1 (en) *	1994-12-28	1999-01-15	한스 루돌프 하우스, 니콜 케르커	Cyclosporine-containing soft capsule composition
US5766629A (en) *	1995-08-25	1998-06-16	Sangstat Medical Corporation	Oral cyclosporin formulations
US5834017A (en) *	1995-08-25	1998-11-10	Sangstat Medical Corporation	Oral cyclopsporin formulations
US5827822A (en) *	1996-03-25	1998-10-27	Sangstat Medical Corporation	Cyclosporin a formulations as nanoparticles
US5962019A (en) *	1995-08-25	1999-10-05	Sangstat Medical Corporation	Oral cyclosporin formulations
DE19549852B4 (en)	1995-11-29	2009-06-04	Novartis Ag	Cyclosporin containing preparations
CZ288631B6 (en) *	1996-01-18	2001-08-15	Galena, A. S.	Therapeutic preparations containing cyclosporin
AU737053B2 (en)	1997-01-30	2001-08-09	Novartis Ag	Oil-free pharmaceutical compositions containing cyclosporin A
EP0973502A1 (en) *	1997-03-12	2000-01-26	Abbott Laboratories	Lipophilic binary systems for the administration of lipophilic compounds
DK0969856T3 (en) *	1997-03-12	2005-05-02	Abbott Lab	Hydrophilic binary systems for the administration of cyclosporine
US6231887B1 (en) *	1997-07-29	2001-05-15	Pharmacia & Upjohn Company	Pharmaceutical composition for acidic lipophilic compounds in a form of a self-emulsifying formulation
KR100509130B1 (en)	1997-07-29	2005-08-18	파마시아 앤드 업존 캄파니 엘엘씨	Self-Emulsifying Formulation for Lipophilic Compounds
US6346511B1 (en)	1997-09-08	2002-02-12	Panacea Biotec Limited	Pharmaceutical composition comprising cyclosporin
US6008191A (en) *	1997-09-08	1999-12-28	Panacea Biotec Limited	Pharmaceutical compositions containing cyclosporin
US6187747B1 (en)	1997-09-08	2001-02-13	Panacea Biotech Limited	Pharmaceutical composition comprising cyclosporin
US5981607A (en) *	1998-01-20	1999-11-09	Allergan	Emulsion eye drop for alleviation of dry eye related symptoms in dry eye patients and/or contact lens wearers
ID25908A (en) *	1998-03-06	2000-11-09	Novartis Ag	EMULSION PRACTONCENTRATES CONTAINING CYCLOSPORINE OR MACROLIDES
DE19859910C2 (en) *	1998-12-23	2001-03-22	Ratiopharm Gmbh	Oral medicine
US6248363B1 (en) *	1999-11-23	2001-06-19	Lipocine, Inc.	Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
GB9912476D0 (en)	1999-05-28	1999-07-28	Novartis Ag	Organic compounds
GB2362573A (en) *	2000-05-25	2001-11-28	Cipla Ltd	Cyclosporin formulation
WO2001032143A1 (en) *	1999-11-02	2001-05-10	Cipla Ltd.	A pharmaceutical composition for the administration of water-insoluble pharmaceutically active substances and a process for preparation thereof
DE60018715T2 (en) *	2000-05-04	2006-04-27	Panacea Biotec Ltd.	Pharmaceutical composition containing cyclosprin as an active ingredient
DE10030378A1 (en) *	2000-06-21	2002-03-14	Audit Inst For Medical Service	New pharmaceutical composition for topical application of water-insoluble and / or poorly water-soluble active ingredients
US6979672B2 (en)	2002-12-20	2005-12-27	Polichem, S.A.	Cyclosporin-based pharmaceutical compositions
JP4381037B2 (en)	2003-06-04	2009-12-09	花王株式会社	Oil composition
CN101141953A (en)	2005-03-21	2008-03-12	伊瓦克斯制药有限公司	Crystallization inhibitors and their use in gelatin capsules
US8492369B2 (en)	2010-04-12	2013-07-23	Clarus Therapeutics Inc	Oral testosterone ester formulations and methods of treating testosterone deficiency comprising same
EP1871384A4 (en)	2005-04-15	2012-01-25	Clarus Therapeutics Inc	PHARMACEUTICAL SUBSTANCE DELIVERY SYSTEMS FOR HYDROPHOBIC MEDICAMENTS AND COMPOSITIONS COMPRISING THE SAME
FR2914188B1 (en) *	2007-03-28	2012-06-22	Trophos	NEW CHOLEST-4-EN-3-ONE OXIME COMPOSITION
GB2451811A (en)	2007-08-09	2009-02-18	Ems Sa	Delivery composition for solubilising water-insoluble pharmaceutical active ingredients
US11304960B2 (en)	2009-01-08	2022-04-19	Chandrashekar Giliyar	Steroidal compositions
CA2690490C (en) *	2010-01-19	2012-06-26	Accucaps Industries Limited	Pharmaceutical formulations of loratadine for encapsulation and combinations thereof
US20180153904A1 (en)	2010-11-30	2018-06-07	Lipocine Inc.	High-strength testosterone undecanoate compositions
US9034858B2 (en)	2010-11-30	2015-05-19	Lipocine Inc.	High-strength testosterone undecanoate compositions
US9358241B2 (en)	2010-11-30	2016-06-07	Lipocine Inc.	High-strength testosterone undecanoate compositions
US20120148675A1 (en)	2010-12-10	2012-06-14	Basawaraj Chickmath	Testosterone undecanoate compositions
EP3095453B1 (en) *	2014-01-16	2023-03-01	Maruho Co., Ltd.	Topical agent for transdermal administration
US20170246187A1 (en)	2014-08-28	2017-08-31	Lipocine Inc.	(17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
US20160361322A1 (en)	2015-06-15	2016-12-15	Lipocine Inc.	Composition and method for oral delivery of androgen prodrugs
CA3078723A1 (en)	2016-11-28	2018-05-31	Nachiappan Chidambaram	Oral testosterone undecanoate therapy
US12150945B2 (en)	2018-07-20	2024-11-26	Lipocine Inc.	Liver disease
KR20210151185A (en) *	2019-04-11	2021-12-13	알.피.쉐러 테크놀러지즈 엘엘씨	Formulations for Oral Delivery of Impermeable Proteins, Peptides and Small Molecules

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4388307A (en) *	1978-03-07	1983-06-14	Sandoz Ltd.	Galenical compositions
BE895724A (en) *	1982-02-01	1983-07-28	Sandoz Sa	NEW THERAPEUTIC USE OF DIHYDROCYCLOSPORIN D

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH641356A5 (en) *	1979-02-27	1984-02-29	Sandoz Ag	Pharmaceutical compositions containing cyclosporin

1989
- 1989-02-20 GB GB898903804A patent/GB8903804D0/en active Pending
1990
- 1990-02-16 CH CH504/90A patent/CH680650A5/de not_active IP Right Cessation
- 1990-02-16 GB GB9003616A patent/GB2228198B/en not_active Expired - Lifetime
- 1990-02-19 JP JP2038168A patent/JPH0611703B2/en not_active Expired - Lifetime
- 1990-02-19 FR FR9002086A patent/FR2643262B1/en not_active Expired - Lifetime
- 1990-02-19 DE DE4005190A patent/DE4005190A1/en not_active Ceased
- 1990-02-19 BE BE9000181A patent/BE1005236A3/en not_active IP Right Cessation
- 1990-02-20 IT IT47650A patent/IT1240765B/en active IP Right Grant
1995
- 1995-09-21 HK HK149595A patent/HK149595A/en not_active IP Right Cessation
1996
- 1996-04-05 CY CY188696A patent/CY1886A/en unknown

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4388307A (en) *	1978-03-07	1983-06-14	Sandoz Ltd.	Galenical compositions
BE895724A (en) *	1982-02-01	1983-07-28	Sandoz Sa	NEW THERAPEUTIC USE OF DIHYDROCYCLOSPORIN D

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7799340B2 (en)	1996-01-22	2010-09-21	Watson Laboratories, Inc.	Pharmaceutical compositions for lipophilic drugs
US7988995B1 (en)	1996-01-22	2011-08-02	Watson Laboratories, Inc.	Pharmaceutical compositions for lipophilic drugs
US8119157B2 (en)	1996-01-22	2012-02-21	Watson Laboratories, Inc.	Pharmaceutical compositions for lipophilic drugs
US7060672B2 (en)	2001-10-19	2006-06-13	Isotechnika, Inc.	Cyclosporin analog formulations
US7429562B2 (en)	2001-10-19	2008-09-30	Isotechnika Inc.	Cyclosporin analog formulations
US9498485B2 (en)	2014-08-28	2016-11-22	Lipocine Inc.	Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters

Also Published As

Publication number	Publication date
IT9047650A1 (en)	1990-08-21
GB9003616D0 (en)	1990-04-11
CY1886A (en)	1996-04-05
IT9047650A0 (en)	1990-02-20
BE1005236A3 (en)	1993-06-08
GB8903804D0 (en)	1989-04-05
GB2228198A (en)	1990-08-22
DE4005190A1 (en)	1990-08-23
JPH02255623A (en)	1990-10-16
HK149595A (en)	1995-09-29
CH680650A5 (en)	1992-10-15
IT1240765B (en)	1993-12-17
FR2643262B1 (en)	1993-06-11
JPH0611703B2 (en)	1994-02-16
FR2643262A1 (en)	1990-08-24

Publication	Publication Date	Title
GB2228198B (en)	1992-12-16	Novel cyclosporin galenic forms
GB2230440B (en)	1993-05-19	Novel cyclosporin galenic forms
GB2224205B (en)	1992-04-15	Cyclosporin ophthalmic compositions
GB8908250D0 (en)	1989-05-24	Formulations
EP0423928A3 (en)	1992-06-10	Multi-ferrule structure
ZA899459B (en)	1990-09-26	Separator
GB2228843B (en)	1993-01-20	Integration arrangement
GB9027564D0 (en)	1991-02-06	Microlaminated structure
AP9000174A0 (en)	1990-04-30	Antiparasitical formulations
GB2233255B (en)	1993-07-14	Separator
GB8928621D0 (en)	1990-02-21	Condensing economisers
ZA90993B (en)	1991-10-30	Novel cyclosporin galenic forms
GB2227744B (en)	1992-08-05	Pharmaceutically useful nitromethyl-sulphones
GB2231507B (en)	1993-06-09	Separator
HUT60012A (en)	1992-07-28	Height-limiting structure
EP0419411A3 (en)	1991-09-04	Additional alkanophenones
IE893439L (en)	1990-04-26	Cyclosporin ophthalmic compositions
IL90524A0 (en)	1990-01-18	Improved hair-comb
GB8908716D0 (en)	1989-06-07	Improved skipole
GB8907728D0 (en)	1989-05-17	Improved chessboards
GB8906859D0 (en)	1989-05-10	Separator
HUT56427A (en)	1991-08-28	Door-case structure
GB8927241D0 (en)	1990-01-31	Kerbing structure
HUT60011A (en)	1992-07-28	Height-limiting structure
HUT55086A (en)	1991-04-29	Pump-protecting arrangement

Legal Events

Date	Code	Title	Description
1997-06-25	732E	Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
2010-03-10	PE20	Patent expired after termination of 20 years	Expiry date: 20100215