GB2286398B - Human metabotropic glutamate receptors,nucleic acids encoding same and uses thereof - Google Patents

Human metabotropic glutamate receptors,nucleic acids encoding same and uses thereof

Info

Publication number: GB2286398B
Authority: GB; United Kingdom
Prior art keywords: metabotropic glutamate; nucleic acids; acids encoding; subtypes; glutamate receptor
Prior art date: 1993-06-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

GB9503691A

Other languages

English (en)

Other versions

GB2286398A (en

GB9503691D0 (en

Inventor

Lorrie P Daggett

Steven B Ellis

Chen Wang Liaw

Aaron Pontsler

Edwin C Johnson

Stephen D Hess

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

SIBIA Neurosciences Inc

Original Assignee

Salk Institute Biotechnology Industrial Associates Inc

SIBIA Neurosciences Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-04

Filing date

1994-06-03

Publication date

1997-10-15

1994-06-03 Application filed by Salk Institute Biotechnology Industrial Associates Inc, SIBIA Neurosciences Inc filed Critical Salk Institute Biotechnology Industrial Associates Inc

1995-04-12 Publication of GB9503691D0 publication Critical patent/GB9503691D0/en

1995-08-16 Publication of GB2286398A publication Critical patent/GB2286398A/en

1997-10-15 Application granted granted Critical

1997-10-15 Publication of GB2286398B publication Critical patent/GB2286398B/en

2014-06-03 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5058—Neurological cells
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70571—Assays involving receptors, cell surface antigens or cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Cell Biology (AREA)
Biochemistry (AREA)
Organic Chemistry (AREA)
Neurology (AREA)
Analytical Chemistry (AREA)
Toxicology (AREA)
Tropical Medicine & Parasitology (AREA)
Biotechnology (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Food Science & Technology (AREA)
Neurosurgery (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Physiology (AREA)
Hospice & Palliative Care (AREA)

GB9503691A 1993-06-04 1994-06-03 Human metabotropic glutamate receptors,nucleic acids encoding same and uses thereof Expired - Fee Related GB2286398B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/072,574 US5521297A (en)	1993-06-04	1993-06-04	Nucleic acids encoding human metabotropic glutamate receptors
PCT/US1994/006273 WO1994029449A1 (fr)	1993-06-04	1994-06-03	Recepteurs humains du glutamate metabotropique, acides nucleiques codant ceux-ci et leurs utilisations

Publications (3)

Publication Number	Publication Date
GB9503691D0 GB9503691D0 (en)	1995-04-12
GB2286398A GB2286398A (en)	1995-08-16
GB2286398B true GB2286398B (en)	1997-10-15

Family

ID=22108488

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GB9503691A Expired - Fee Related GB2286398B (en)	1993-06-04	1994-06-03	Human metabotropic glutamate receptors,nucleic acids encoding same and uses thereof

Country Status (9)

Country	Link
US (2)	US5521297A (fr)
EP (1)	EP0701611B1 (fr)
JP (4)	JPH08511168A (fr)
AT (1)	ATE458048T1 (fr)
AU (1)	AU685471B2 (fr)
CA (1)	CA2161811A1 (fr)
DE (1)	DE69435268D1 (fr)
GB (1)	GB2286398B (fr)
WO (1)	WO1994029449A1 (fr)

Families Citing this family (44)

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IL105587A0 (en)	1992-05-08	1993-09-22	Lilly Co Eli	Human metabotropic glutamate receptor and related dna compounds
US6441155B1 (en) *	1992-06-10	2002-08-27	Nps Allelix Corp.	Ampa-binding human GluR2 receptors
US5912122A (en) *	1993-06-04	1999-06-15	Sibia Neurosciences, Inc.	Nucleic acids encoding and method for detecting nucleic acid encoding human metabotropic glutamate receptor subtype mGluR6
US6001581A (en) *	1993-06-04	1999-12-14	Sibia Neurosciences, Inc.	Cation-based bioassay using human metabotropic glutamate receptors
ATE522610T1 (de)	1993-09-20	2011-09-15	Novartis Pharma Gmbh	Menschliche, metabotrope glutamatrezeptor- subtypen (hmr6) und verwandte dns-verbindungen
DE4403666A1 (de) *	1994-02-07	1995-08-10	Basf Ag	Untereinheiten von Glutamatrezeptoren, Verfahren zu ihrer Herstellung und ihre Verwendung
WO1995022609A2 (fr) *	1994-02-21	1995-08-24	The Wellcome Foundation Limited	Proteines des recepteurs humains du glutamate
US6211353B1 (en) *	1994-07-29	2001-04-03	Eli Lilly And Company	Isolated nucleic acid encoding a human mGluR5
GB9416554D0 (en) *	1994-08-19	1994-10-12	Ciba Geigy Ag	Glutamate receptor
US6017697A (en) *	1994-11-14	2000-01-25	Eli Lilly And Company	Excitatory amino acid receptor protein and related nucleic acid compounds
AU2777800A (en) *	1995-03-20	2000-07-06	Sibia Neurosciences, Inc.	Human metabotropic glutamate receptor subtype mGluR6
CA2200606A1 (fr) *	1995-07-26	1997-02-13	Nps Pharmaceuticals, Inc.	Recepteurs chimeriques, procedes d'identification de composes actifs au niveau des recepteurs de glutamates metabotropes, et utilisation de tels composes pour le traitement des troubles et affections neurologiques
US5723315A (en) *	1996-08-23	1998-03-03	Genetics Institute, Inc.	Secreted proteins and polynucleotides encoding them
US6387655B1 (en) *	1995-12-20	2002-05-14	Eli Lilly And Company	Excitatory amino acid receptor protein and related nucleic acid compounds
US6881571B1 (en)	1998-03-11	2005-04-19	Exonhit Therapeutics S.A.	Qualitative differential screening
FR2775984B1 (fr) *	1998-03-11	2006-09-15	Bioscreen Therapeutics Sa	Criblage differentiel qualitatif
US6362009B1 (en)	1997-11-21	2002-03-26	Merck & Co., Inc.	Solid phase synthesis of heterocycles
AU2486999A (en) *	1998-01-30	1999-08-16	University Technology Corporation	Polynucleotide and polypeptide sequences associated with cns depressant sensitivity and methods of use thereof
US7262280B1 (en)	1998-04-03	2007-08-28	Nps Pharmaceuticals, Inc.	G-protein fusion receptors and constructs encoding same
CA2342833A1 (fr) *	1998-09-17	2000-03-23	Incyte Pharmaceuticals, Inc.	Proteines gpcr humaines
FR2798392B1 (fr) *	1999-09-13	2005-07-15	Exonhit Therapeutics Sa	Marqueurs genetiques de la toxicite, preparation et utilisations
FR2798673B1 (fr) *	1999-09-16	2004-05-28	Exonhit Therapeutics Sa	Methodes et compositions pour la detection d'evenements pathologiques
US6534287B1 (en) *	1999-10-25	2003-03-18	Nps Pharmaceuticals, Inc.	Human metabotropic glutamate receptor
WO2001092335A1 (fr) *	2000-05-31	2001-12-06	Biomolecular Engineering Research Institute	Cristaux de complexes proteiques, coordonnees structurales, et utilisation de ces coordonnees structurales
CN1714151A (zh) *	2000-12-22	2005-12-28	惠氏公司	新的谷氨酸受体调节蛋白和核酸分子及其用途
AU2003211958A1 (en)	2002-02-14	2003-09-04	Ajinomoto Co., Inc.	Novel glutamate receptor and utilization thereof
WO2004024936A2 (fr) *	2002-09-11	2004-03-25	Merck & Co., Inc.	Sequences d'acides nucleiques codant des mutations ponctuelles de mglur2 et mglur3
US20050186658A1 (en) *	2003-10-17	2005-08-25	Nps Pharmaceuticals, Inc.	Chimeric metabotropic glutamate receptors and uses thereof
WO2005075987A2 (fr) *	2004-01-28	2005-08-18	Bayer Healthcare Ag	Diagnostic et traitement de maladies liees au recepteur humain mglur1
WO2005086934A2 (fr) *	2004-03-10	2005-09-22	Board Of Regents, The University Of Texas System	Banques d'expression d'adnc enrichies et procedes de construction et d'utilisation correspondants
WO2006003100A1 (fr)	2004-06-25	2006-01-12	Janssen Pharmaceutica N.V.	Essai de criblage fonctionnel
GB0503646D0 (en) *	2005-02-22	2005-03-30	Novartis Ag	Organic compounds
GB0508318D0 (en) *	2005-04-25	2005-06-01	Novartis Ag	Organic compounds
GB0508319D0 (en) *	2005-04-25	2005-06-01	Novartis Ag	Organic compounds
GB0508314D0 (en) *	2005-04-25	2005-06-01	Novartis Ag	Organic compounds
AU2007296964B2 (en)	2006-09-11	2012-05-31	Novartis Ag	Nicotinic acid derivatives as modulators of metabotropic glutanate receptors
PT2126093E (pt) *	2007-03-02	2012-12-03	Boehringer Ingelheim Pharma	Melhoramento da produção de proteínas
US20090018099A1 (en) *	2007-03-02	2009-01-15	Hitto Kaufmann	Protein production
RU2496494C2 (ru)	2008-06-30	2013-10-27	Новартис Аг	КОМБИНАЦИИ, СОДЕРЖАЩИЕ МОДУЛЯТОРЫ mGluR, ДЛЯ ЛЕЧЕНИЯ БОЛЕЗНИ ПАРКИНСОНА
EP2427557B1 (fr)	2009-05-05	2015-03-18	Boehringer Ingelheim International GmbH	Lignes de cellules cho/cert
US20130274294A1 (en)	2010-12-20	2013-10-17	David Carcache	4-(Hetero)Aryl-Ethynyl-Octahydro-Indole-1-Esters
WO2012101058A1 (fr)	2011-01-24	2012-08-02	Novartis Ag	Dérivés de 4-tolyl-éthynyl-octahydro-indole-1-ester
JP7026613B2 (ja)	2015-08-07	2022-02-28	イマジナブ・インコーポレーテッド	標的分子に対する抗原結合コンストラクト
WO2018147960A1 (fr)	2017-02-08	2018-08-16	Imaginab, Inc.	Séquences d'extension pour dianticorps

Citations (2)

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Publication number	Priority date	Publication date	Assignee	Title
WO1992010583A1 (fr) *	1990-12-12	1992-06-25	Zymogenetics, Inc.	Recepteurs de glutamate couples a une proteine g
EP0569240A1 (fr) *	1992-05-08	1993-11-10	Eli Lilly And Company	Récepteur métabotropique de glutamate humain et composés d'ADN apparentés

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1993
- 1993-06-04 US US08/072,574 patent/US5521297A/en not_active Expired - Lifetime
1994
- 1994-06-03 EP EP94920075A patent/EP0701611B1/fr not_active Expired - Lifetime
- 1994-06-03 JP JP7501975A patent/JPH08511168A/ja not_active Withdrawn
- 1994-06-03 GB GB9503691A patent/GB2286398B/en not_active Expired - Fee Related
- 1994-06-03 DE DE69435268T patent/DE69435268D1/de not_active Expired - Fee Related
- 1994-06-03 AT AT94920075T patent/ATE458048T1/de not_active IP Right Cessation
- 1994-06-03 AU AU70989/94A patent/AU685471B2/en not_active Ceased
- 1994-06-03 CA CA002161811A patent/CA2161811A1/fr not_active Abandoned
- 1994-06-03 WO PCT/US1994/006273 patent/WO1994029449A1/fr not_active Ceased
1998
- 1998-09-15 US US09/153,757 patent/US6413764B1/en not_active Expired - Fee Related
2003
- 2003-10-22 JP JP2003362046A patent/JP2004147653A/ja not_active Withdrawn
2004
- 2004-11-25 JP JP2004340504A patent/JP2005160480A/ja active Pending
2006
- 2006-03-27 JP JP2006085289A patent/JP2006254915A/ja active Pending

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WO1992010583A1 (fr) *	1990-12-12	1992-06-25	Zymogenetics, Inc.	Recepteurs de glutamate couples a une proteine g
EP0569240A1 (fr) *	1992-05-08	1993-11-10	Eli Lilly And Company	Récepteur métabotropique de glutamate humain et composés d'ADN apparentés

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Nature 1991,349,760-765 *
Neuron 1992,8,169-179 *
Science 1991,252,1318-1321 *

Also Published As

Publication number	Publication date
US5521297A (en)	1996-05-28
EP0701611B1 (fr)	2010-02-17
JP2005160480A (ja)	2005-06-23
AU685471B2 (en)	1998-01-22
US6413764B1 (en)	2002-07-02
WO1994029449A1 (fr)	1994-12-22
GB2286398A (en)	1995-08-16
GB9503691D0 (en)	1995-04-12
EP0701611A1 (fr)	1996-03-20
ATE458048T1 (de)	2010-03-15
CA2161811A1 (fr)	1994-12-22
DE69435268D1 (de)	2010-04-01
AU7098994A (en)	1995-01-03
JP2004147653A (ja)	2004-05-27
JP2006254915A (ja)	2006-09-28
JPH08511168A (ja)	1996-11-26

Publication	Publication Date	Title
GB2286398B (en)	1997-10-15	Human metabotropic glutamate receptors,nucleic acids encoding same and uses thereof
DE60335216D1 (de)	2011-01-13	Adiponektin-rezeptor und dafür kodierendes gen
CY1108998T1 (el)	2014-07-02	Πρωτεϊνες που δεσμευονται με οστεοπροτεγερινη και υποδοχεις
EP1229047A3 (fr)	2002-10-02	Protéines de fusion du récepteur de IL-1 utilisées comme antagonistes et méthodes d'utilisation et de fabrication
IL100343A0 (en)	1992-09-06	G protein coupled glutamate receptors
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PE20010516A1 (es)	2001-04-29	Peptidos ciclicos con afinidad mejorada por los receptores de somatostatina
NO20000215D0 (no)	2000-01-17	Adipocyttspesifikke proteinhomologer
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DK0874625T3 (da)	2005-06-20	Indanderivater til antipsykotiske præparater
DE69535831D1 (de)	2008-10-16	Hemopoietin-rezeptor
ATE273389T1 (de)	2004-08-15	Rezeptor des y-y5 neuropeptids
DE69832156D1 (de)	2005-12-08	Zusammensetzungen und verfahren des synaptischen aktivierungsproteins
DK0529995T3 (da)	2000-07-03	Human KA-receptor, receptor af EAA2-familien (Excitatorisk aminosyre) med høj affinitet for kainat

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