GB2277862A - A nutritional composition for oral administration to an animal - Google Patents
A nutritional composition for oral administration to an animal Download PDFInfo
- Publication number
- GB2277862A GB2277862A GB9309723A GB9309723A GB2277862A GB 2277862 A GB2277862 A GB 2277862A GB 9309723 A GB9309723 A GB 9309723A GB 9309723 A GB9309723 A GB 9309723A GB 2277862 A GB2277862 A GB 2277862A
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- Prior art keywords
- triglyceride
- nutrient
- composition according
- composition
- additive
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 129
- 241001465754 Metazoa Species 0.000 title claims abstract description 51
- 235000016709 nutrition Nutrition 0.000 title claims description 16
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims abstract description 68
- 235000015097 nutrients Nutrition 0.000 claims abstract description 52
- 239000000654 additive Substances 0.000 claims abstract description 30
- 230000000996 additive effect Effects 0.000 claims abstract description 30
- 230000004083 survival effect Effects 0.000 claims abstract description 11
- 238000010521 absorption reaction Methods 0.000 claims abstract description 9
- 239000008280 blood Substances 0.000 claims abstract description 9
- 210000004369 blood Anatomy 0.000 claims abstract description 9
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 6
- 239000000787 lecithin Substances 0.000 claims abstract description 6
- 229940067606 lecithin Drugs 0.000 claims abstract description 6
- 235000010445 lecithin Nutrition 0.000 claims abstract description 6
- 230000002503 metabolic effect Effects 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 25
- 235000021277 colostrum Nutrition 0.000 claims description 19
- 210000003022 colostrum Anatomy 0.000 claims description 19
- 229930003231 vitamin Natural products 0.000 claims description 13
- 235000013343 vitamin Nutrition 0.000 claims description 13
- 239000011782 vitamin Substances 0.000 claims description 13
- 229940088594 vitamin Drugs 0.000 claims description 13
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 11
- 235000010755 mineral Nutrition 0.000 claims description 11
- 239000011707 mineral Substances 0.000 claims description 11
- 239000003963 antioxidant agent Substances 0.000 claims description 9
- 235000006708 antioxidants Nutrition 0.000 claims description 9
- 239000003995 emulsifying agent Substances 0.000 claims description 9
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims description 7
- 150000004665 fatty acids Chemical group 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 7
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 7
- 230000003078 antioxidant effect Effects 0.000 claims description 6
- 235000021588 free fatty acids Nutrition 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 230000001737 promoting effect Effects 0.000 claims description 4
- 239000004094 surface-active agent Substances 0.000 claims description 4
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims description 3
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- 239000000839 emulsion Substances 0.000 claims description 3
- 229960002446 octanoic acid Drugs 0.000 claims description 3
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 3
- 239000008158 vegetable oil Substances 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims 6
- 150000003722 vitamin derivatives Chemical class 0.000 claims 4
- 238000001816 cooling Methods 0.000 claims 2
- 238000001914 filtration Methods 0.000 claims 2
- 239000008240 homogeneous mixture Substances 0.000 claims 2
- 150000003626 triacylglycerols Chemical class 0.000 abstract description 7
- 229940057917 medium chain triglycerides Drugs 0.000 abstract description 3
- 239000003925 fat Substances 0.000 description 7
- 235000019197 fats Nutrition 0.000 description 7
- 238000003860 storage Methods 0.000 description 6
- 208000018773 low birth weight Diseases 0.000 description 5
- 231100000533 low birth weight Toxicity 0.000 description 5
- 239000003921 oil Substances 0.000 description 5
- 235000019198 oils Nutrition 0.000 description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 2
- 235000019155 vitamin A Nutrition 0.000 description 2
- 239000011719 vitamin A Substances 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 235000019687 Lamb Nutrition 0.000 description 1
- 208000005107 Premature Birth Diseases 0.000 description 1
- 206010036590 Premature baby Diseases 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 229930003779 Vitamin B12 Natural products 0.000 description 1
- 229930003471 Vitamin B2 Natural products 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical class CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 239000000574 octyl gallate Substances 0.000 description 1
- NRPKURNSADTHLJ-UHFFFAOYSA-N octyl gallate Chemical compound CCCCCCCCOC(=O)C1=CC(O)=C(O)C(O)=C1 NRPKURNSADTHLJ-UHFFFAOYSA-N 0.000 description 1
- 235000010387 octyl gallate Nutrition 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings or cooking oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Health & Medical Sciences (AREA)
- Mycology (AREA)
- Birds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The composition comprises a triglyceride nutrient and an additive eg Lecithin to promote absorption of the nutrient, or a metabolic derivative thereof, into the blood stream of the animal. The triglyceride nutrient includes at least one medium-chain triglyceride. When the composition comprises more than one triglyceride, there is provided a higher proportion of medium-chain triglycerides than short- and long-chain triglycerides. The composition is particularly useful for increasing the probability of survival of young animals, e.g. infant and neonatal animals.
Description
NUTRITIONAL COMPOSITION FOR ORAL ADMINISTRATION
TO AN ANIMAL
The present invention relates to a nutritional composition for oral administration to an animal, and to a method of preparing the composition.
The invention is particularly applicable to the fields of agriculture and veterinary science, where practitioners are likely to be concerned with the care of young animals, e.g. infant and neonatal animals. For example, animals which are born with a low birth weight (eg, due to premature birth) tend to have a lower probability of surviving the early stages of life than those animals born with a birth weight within normal limits. It is desirable to maximise the chances of survival of low birth weight animals for many reasons. To a farmer, for example, the death of neonatal livestock represents an economic loss.
It is common practice in the fields of agriculture and veterinary science to feed low birth weight animals with compositions intended to have a high nutritional and calorific content. This form of neonatal intensive care aims rapidly to increase the energy available to the low birth weight animal being treated, thereby increasing its probability of survival. Examples of such nutritional compositions include those marketed under the trade marks "Col-late Lamb Care Liquid", "Col-late
Litter Care Liquid", "Col-late Rapid" and "Twin Lamb Drench". These compositions typically include fats as an energy source, together with minerals and/or vitamins. Fats represent high-energy nutrients.
We have discovered that there are problems with the nutritional compositions known in the art, however, because they contain high proportions of long-chain triglycerides as the fat source. (Long-chain triglycerides are those having respectively 2 or 3 long-chain (ie > 10 carbon) fatty acid moieties per molecule of triglyceride.) These triglycerides are absorbed from the alimentary canal and into the blood stream of the animal being treated at a relatively slow rate, which, consequently, slows down the availability of energy to the animal. Rapid availability of energy at high levels is extremely important in order to pull the animal away from the danger of death during the intensive care period.
The use of long-chain triglycerides in prior art compositions restricts the efficiency of these compositions in increasing the survival rate of treated animals.
The manufacturers of prior art compositions have previously considered it necessary to provide the compositions in gel or paste form owing to the insolubility of minerals and some vitamins in compositions with a high proportion of fat. There is a tendency, however, for the fat component to separate out of the prior art compositions because they are in paste or gel form. This makes it difficult to determine the quantities of fat and minerals/vitamins that have been administered to the animal in the dose of the composition used. Thus, it is difficult to ascertain whether the treated animal has received sufficient amounts of the nutrients.With prior art compositions, therefore, it is necessary to employ an additional mixing step before administration of the dose in order to re-establish an homogenous distribution of components throughout the composition, thereby enabling the dosage of fats and minerals/vitamins to be determined.
The tendency of prior art compositions to separate also makes their storage for long periods impractical and undesirable, so that they typically have short shelf-lives. The storage conditions of prior art compositions must further be carefully controlled, since these compositions oxidise and go rancid if exposed to the air for prolonged periods of time, owing to the presence of free fatty acids.
It is an object of the present invention to provide a nutritional composition for oral adminstration to an animal which can rapidly provide the animal with energy at high levels, and to provide a method of preparing such a composition.
A secondary object is to provide a nutritional composition in a form which can be stored for prolonged periods of time and without the need for special storage conditions.
According to the present invention there is provided a nutritional composition for oral administration to an animal, comprising a triglyceride nutrient including at least 205G w/w of at least one medium chain triglyceride, and an additive to promote absorption of the nutrient or a metabolic derivative thereof into the blood stream of the animal.
There is further provided use of a medium-chain triglyceride in the manufacture of a nutritional composition for oral administration to a young animal to increase the probability of survival of the animal.
There is yet further provided use of a medium-chain triglyceride and an additive in the manufacture of a nutrient composition for oral administration to a young animal to increase the probability of survival of the animal, wherein the additive is for promoting absorption of the medium-chain triglyceride or a derivative thereof into the blood stream of the animal.
It has been found that medium-chain triglyceride (MCT's) are absorbed in the blood stream of the treated animal much more rapidly than other triglycerides, particularly long-chain triglycerides. Thus, the composition of the present invention represents an improvement over prior art compositions because it is much more effective than prior art compositions in quickly providing energy at high levels to the treated animal.
Indeed, it has been found that MCT's are absorbed particularly rapidly in young animals. Nevertheless, the composition of the present invention, like those known in the prior art, is not confined to use with young animals, and can be used to treat animals at later stages of life who may rapidly require high levels of energy due to sickness, for example.
The composition of the present invention comprises a high level of at least one MCT, such that the composition comprises at least 20% w/w of MCT. Preferably, the composition comprises from 40% w/w to 80% w/w of MCT, and even more preferably from 60% w/w to 80% w/w of
MCT.
The triglyceride nutrient may contain more than one triglyceride, and where this is the case the nutrient should contain a higher proportion of medium-chain triglyceride than short- and long chain triglyceride.
Obviously, it is desirable to maximise the proportion of medium-chain triglyceride in the composition in order to maximise the efficiency with which energy is made available to the treated animal. In any case, the composition preferably should contain 70-90% triglyceride by weight.
Medium-chain triglycerides are those wherein 2 or 3 of the fatty acid moieties have from 8 to 10 carbon atoms. In a preferred embodiment, each fatty acid moiety of every medium-chain triglyceride in the composition is derived either from caprylic acid (C8:0), or capric acid (C10:0). Vegetable oils, e.g. fractionated coconut oil, have been found to be a good source of medium-chain triglycerides. A triglyceride of fractionated C8-C10 coconut oil fatty acids is particularly suitable for use in the composition of the present invention.
Absorption of the MCT in the composition of the present invention is made even more rapid by the presence of an additive which is capable of promoting the absorption of the triglyceride nutrient, which includes the
MCT. The additive is also capable of promoting the absorption of derivatives of the triglyceride nutrient which arise as the nutrient is metabolised in the alimentary canal of the animal.
Preferably, the additive is an emulsifier and/or a surfactant so that digestion of the triglyceride nutrient in the stomach is promoted, as is transport across the mucosal membrane of the alimentary canal. Lecithin, which is an emulsifier and a surfactant, is one example of an additive which may be used.
In a preferred embodiment, at least one additional nutrient is present in the composition. For example, it may be desirable to incorporate minerals and/or vitamins (or derivatives thereof) in the composition which may be necessary to improve the health of the animal, and thus its probability of survival. Fat-soluble vitamins, eg. vitamins A,
D and E, can be dissolved in the triglyceride nutrient. Thus, where the absorption-promoting additive is also fat-soluble, the composition is provided in an homogeneous oil form, so that the problems of component separation and associated storage problems which are met with prior art compositions are avoided. The composition of the present invention, therefore, has a longer average shelf-life than prior art compositions.
MCT - containing compositions according to the present invention which are in oil form tend to be liquid at temperatures from OOC and above, so that they are easier to handle than the paste/gel compositions known in the
art. Furthermore, the homogeneity and liquid nature of MCT - containing
oil compositions make accurate dosage of the composition components
relatively simple to achieve.
In cases where minerals and/or water-soluble vitamins (eg. vitamin
C) are incorporated into the composition, it is necessary to provide the
composition as an emulsion. Clearly, where the absorption-promoting
additive is an emulsifier, an additional emulsifier need not be added.
Colostrum and/or colostrum substitutes can be incorporated when the composition is used to treat neonatal animals. Colostrum is high in minerals and contains up to 20 % protein, predominantly immunoglobulins (Ig's) which represent the antibodies found in maternal blood. These Ig's play a very important role in enhancing the immunity of the neonatal recipient. A low-birth weight neonatal animal may have a reduced immunity to infection so that the oral administration of a composition containing MCT's and colostrum/colostrum substitutes represents a very effective way of increasing the probability of survival of the neonatal animal. The composition is usually provided as a gel or paste when colostrum/colostrum substitute is present as an additional nutrient with the triglyceride nutrient acting as a carrier for the colostrum/colostrum substitute.
It is preferable to prepare the composition so that it contains substantially no free fatty acids. Free fatty acids are very susceptible to oxidation. Hence, their elimination from the composition helps to prevent the composition from going rancid during storage, thereby further prolonging the shelf-life of the composition. Handling of the composition is also facilitated because the composition can be exposed to air for periods of time, eg. during making up of doses, without the composition "going off". In a preferred embodiment, an arti-oxidant can be added to further prevent oxidation of the composition. Examples of anti-oxidants that may be used include butylated hydroxanisole (BHA) and octyl gallate.
The formula of a nutritional composition that has been found to be particularly effective for treating young animals is given below:
COMPONENT OUANTITY
MCT - 76.58% Emulsifier - 19.42%
Antioxidants - 0.02% Oil soluble vitamins - 0.78% Water soluble vitamins - 3.20%
A composition according to the above formula, can be prepared as follows:: (a) Heat the MCT at a temperature from 35"C to 85"C, preferably 60 C; (b) Add the emulsifier to the MCT and mix at a temperature of from 35"C to 85"C, preferably 60"C, for approximately 2 hours or until substantially all of the emulsifier has dissolved; (c) Add the anti-oxidants and mix until substantially all the anti-oxidant has dissolved.The anti-oxidant may, alternatively, be added at step (a) or (b); (d) Allow the resulting mixture to settle and cool to room temperature; (e) Filter the mixture, preferably through a 10ym filter; (f) Add to the filtrate the remaining components listed in the table above and mix until a clear yellow oil is seen; (g) Mix for approximately 2 hours more; and (h) Filter, preferably through a 10,L4m filter.
The resulting composition is an orange coloured oily clear liquid, having a representative specification per lml as follows.
COMPONENT ACTIVITY/WEIGHT/ml
Vitamin A 333 IU
Vitamin E 4.2 IU
Biotin 12.5 ,ug Vitamin B2 825 tcg Vitamin B, 445 CLg Vitamin B6 205 ,ug Vitamin B12 2.5 g
Nicotinamide 8.25 mg
Pantothenic acid 3.5 mg
The product has excellent storage and handling properties and rapidly provides energy at high levels to animals to which it has been administered.
Claims (28)
1. A nutritional composition for oral administration to an animal,
comprising a triglyceride nutrient including at least 20% w/w of at
least one medium- chain triglyceride, and an additive to promote
absorption of the nutrient or a metabolic derivative thereof into the
blood stream of the animal.
2. A composition according to Claim 1, comprising at least 40 O/o w/w of said medium-chain triglyceride.
3. A composition according to Claim 1 or 2, comprising at least 60%
w/w of said medium-chain triglyceride.
4. A composition according to any preceding Claim, wherein the
triglyceride nutrient includes at least a second triglyceride, the
second triglyceride being a short- or long-chain triglyceride and the
triglyceride nutrient having a higher proportion of medium-chain
triglyceride than short- and long-chain triglyceride.
5. A composition according to any preceding claim, wherein two or
three of the fatty acid moieties of said medium-chain triglyceride
have 8 to 10 carbon atoms.
6. A composition according to Claim 5, wherein each fatty acid
moiety is derived from caprylic acid or capric acid.
7. A composition according to any preceding claim, wherein said
medium-chain triglyceride is derived from vegetable oil.
8. A composition according to any preceding claim, comprising at
least one additional nutrient.
9. A composition according to Claim 8. wherein said additional
nutrient is selected from the group comprising vitamins, vitamin
derivatives, minerals, colostrum and colostrum substitutes.
10. A composition according to any preceding claim, wherein said
composition includes substantially no free fatty acids.
11. A composition according to any preceding claim, wherein said
composition is a liquid at temperatures from 0 C and above.
12. A composition according to any one of Claims 1 to 10, wherein
said composition is a paste or a gel.
13. A composition according to any preceding claim, wherein said
composition is an emulsion.
14. A composition according to any preceding claim, wherein said
additive is an emulsifier.
15. A composition according to any preceding claim, wherein said
additive is a surfactant.
16. A composition according to Claim 14 or 15, wherein said additive
is lecithin.
17. A composition according to any preceding claim, comprising an
anti-oxidant.
18. A composition according to any preceding claim wherein the
triglyceride nutrient comprises 70-90% by weight of the
composition.
19. A method of preparing a nutritional composition according to claim
1, comprising the steps of (a) adding the additive to the
triglyceride nutrient and (b) mixing the triglyceride nutrient with
the additive while heating to produce a substantially homogenous
mixture.
20. A method according to claim 19 wherein the triglyceride nutrient
is heated immediately before step (a).
21. A method according to claim 19 or 20, wherein said heating is at
a temperature from 35"C to 850C.
22. A method according to claim 21, wherein said heating as at a
temperature of 60"C.
23. A method according to any one of claims 19 to 22, wherein step
(b) is carried out for substantially 2 hours.
24. A method according to any one of claims 19 to 23, comprising the
step of mixing the triglyceride nutrient with an additional nutrient.
25. A method according to claim 24, comprising the steps of (c)
cooling said mixture of the triglyceride nutrient and additive after
step (b) and (d) thereafter mixing the triglyceride nutrient and
additive mixture with an additional nutrient.
26. A method according to claim 25, comprising the step of filtering
the mixture between steps (b) and (c).
27. A method according to claim 24, 25 or 26, wherein said additional
nutrient is selected from amongst the group comprising vitamins,
vitamin derivatives, minerals, colostrum and colostrum substitutes.
28. A method according to claim 24, comprising the step of adding an
anti-oxidant before step (c).
28. A method according to any one of clailns 19 to 27, wherein said
additive is lecithin.
29. A method according to claim 25, comprising the step of adding an
anti-oxidant before step (c).
30. A method according to claims 19 to 29, comprising forming the
composition into a gel or paste.
31. Use of a medium-chain triglyceride in the manufacture of a
nutritional composition for oral administration to a young animal
to increase the probability of survival of the animal.
32. Use of a medium-chain triglyceride and an additive in the
manufacture of a nutrient composition for oral administration to a
young animal to increase the probability of survival of the animal,
wherein the additive is for promoting absorption of the medium
chain triglyceride or a derivative thereof into the blood stream of
the animal.
33. Use according to claim 31 or 32 wherein the composition is
according to any one of Claims 1 to 18 for increasing the
probability of survival of an a young animal.
Amendments to the claims have been filed as follows
CLAIMS 1. A nutritional composition for oral administration to an animal,
comprising a triglyceride nutrient including at least 20 to w/w of at
least one medium- chain triglyceride, an additive to promote
absorption of the nutrient or a metabolic derivative thereof into the
blood stream of the animal, and colostrum and/or a colostrum
substitute.
2. A composition according to Claim 1, comprising at least 40% w/w
of said medium-chain triglyceride.
3. A composition according to Claim 1 or 2, comprising at least 60%
w/w of said medium-chain triglyceride.
4. A composition according to any preceding Claim, wherein the
triglyceride nutrient includes at least a second triglyceride, the
second triglyceride being a short- or long-chain triglyceride and the
triglyceride nutrient having a higher proportion of medium-chain
triglyceride than short- and long-chain triglyceride.
5. A composition according to any preceding claim, wherein two or
three of the fatty acid moieties of said medium-chain triglyceride
have 8 to 10 carbon atoms.
6. A composition according to Claim 5, wherein each fatty acid
moiety is derived from caprylic acid or capric acid.
7. A composition according to any preceding claim, wherein said
medium-chain triglyceride is derived from vegetable oil.
8. A composition according to any preceding claim, comprising at
least one additional nutrient.
9. A composition according to Claim 8, wherein said additional
nutrient is selected from the group comprising vitamins, vitamin
derivatives and minerals.
10. A composition according to any preceding claim, wherein said
composition includes substantially no free fatty acids.
11. A composition according to any preceding claim, wherein said
composition is a liquid at temperatures from 0 C and above.
12. A composition according to any preceding claim, wherein said
composition is an emulsion.
13. A composition according to any preceding claim, wherein said
additive is an emulsifier.
14. A composition according to any preceding claim, wherein said
additive is a surfactant.
15. A composition according to Claim 13 or 14, wherein said additive
is lecithin.
16. A composition according to any preceding claim, comprising an
anti-oxidant.
17. A composition according to any preceding claim wherein the
triglyceride nutrient comprises 70-90 % by weight of the
composition.
18. A method of preparing a nutritional composition according to claim
1, comprising the steps of (a) adding the additive to the triglyceride
nutrient and (b) mixing the triglyceride nutrient with the additive
while heating to produce a substantially homogenous mixture.
wherein the triglyceride nutrient is mixed with colostrum and/or a
colostrum substitute.
19. A method according to claim 18 wherein the triglyceride nutrient
is heated immediately before step (a).
20. A method according to claim 18 or 19, wherein said heating is at
a temperature from 35"C to 850C.
21. A method according to claim 20, wherein said heating is at a
temperature of 60"C.
22. A method according to any one of claims 18 to 21, wherein step
(b) is carried out for substantially 2 hours.
23. A method according to any one of claims 18 to 22, comprising the
step of mixing the triglyceride nutrient with an additional nutrient.
24. A method according to any one of claims 18 to 23, comprising the
steps of (c) cooling said mixture of the triglyceride nutrient and
additive after step (b) and (d) thereafter mixing the triglyceride
nutrient and additive mixture with colostrum and/or a colostrum
substitute, with or without an additional nutrient.
25. A method according to claim 24, comprising the step of filtering
the mixture between steps (b) and (c).
26. A method according to claim 23, 24 or 25, wherein said additional
nutrient is selected from amongst the group comprising vitamins,
vitamin derivatives and minerals.
27. A method according to any one of claims 18 to 26, wherein said
additive is lecithin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9309723A GB2277862A (en) | 1993-05-12 | 1993-05-12 | A nutritional composition for oral administration to an animal |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9309723A GB2277862A (en) | 1993-05-12 | 1993-05-12 | A nutritional composition for oral administration to an animal |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB9309723D0 GB9309723D0 (en) | 1993-06-23 |
| GB2277862A true GB2277862A (en) | 1994-11-16 |
Family
ID=10735299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB9309723A Withdrawn GB2277862A (en) | 1993-05-12 | 1993-05-12 | A nutritional composition for oral administration to an animal |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2277862A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001005245A1 (en) * | 1999-07-20 | 2001-01-25 | Danmarks Jordbrugsforskning | A method of feeding piglets in a weaning period, a weaning feed for piglets and the use of a special fat for the manufacture of a weaning feed |
| US8603568B2 (en) | 2010-01-15 | 2013-12-10 | Kemin Industries, Inc. | Hydrolyzed lecithin product to improve digestibility |
| EP1952700B1 (en) | 2002-04-05 | 2017-05-17 | Nestec S.A. | Method of improving absorption of vitamin E by a pet animal |
| CN109907180A (en) * | 2019-04-04 | 2019-06-21 | 山东信得科技股份有限公司 | A kind of polynary liposome oral fluid to quickly supplement energy and preparation method thereof, application method and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4216236A (en) * | 1977-04-27 | 1980-08-05 | Societe D'assistance Technique Pour Produits Nestle S.A. | Infant milk formula and process for its manufacture |
| EP0216419A2 (en) * | 1985-09-26 | 1987-04-01 | The Procter & Gamble Company | Nutritional fat suitable for enteral and parenteral products |
| GB2226569A (en) * | 1988-12-29 | 1990-07-04 | American Home Prod | Vegetable oil fat composition |
| GB2227919A (en) * | 1987-05-01 | 1990-08-15 | Otsuka Pharma Co Ltd | Nutritive emulsion |
| EP0488800A2 (en) * | 1990-11-30 | 1992-06-03 | American Home Products Corporation | Corandomized fat compositions for infant formulas |
-
1993
- 1993-05-12 GB GB9309723A patent/GB2277862A/en not_active Withdrawn
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4216236A (en) * | 1977-04-27 | 1980-08-05 | Societe D'assistance Technique Pour Produits Nestle S.A. | Infant milk formula and process for its manufacture |
| EP0216419A2 (en) * | 1985-09-26 | 1987-04-01 | The Procter & Gamble Company | Nutritional fat suitable for enteral and parenteral products |
| GB2227919A (en) * | 1987-05-01 | 1990-08-15 | Otsuka Pharma Co Ltd | Nutritive emulsion |
| GB2226569A (en) * | 1988-12-29 | 1990-07-04 | American Home Prod | Vegetable oil fat composition |
| EP0488800A2 (en) * | 1990-11-30 | 1992-06-03 | American Home Products Corporation | Corandomized fat compositions for infant formulas |
| GB2250749A (en) * | 1990-11-30 | 1992-06-17 | American Home Prod | Randomised fat compositions for infant food formulae |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001005245A1 (en) * | 1999-07-20 | 2001-01-25 | Danmarks Jordbrugsforskning | A method of feeding piglets in a weaning period, a weaning feed for piglets and the use of a special fat for the manufacture of a weaning feed |
| EP1952700B1 (en) | 2002-04-05 | 2017-05-17 | Nestec S.A. | Method of improving absorption of vitamin E by a pet animal |
| US8603568B2 (en) | 2010-01-15 | 2013-12-10 | Kemin Industries, Inc. | Hydrolyzed lecithin product to improve digestibility |
| US9173419B2 (en) | 2010-01-15 | 2015-11-03 | Kemin Industries, Inc. | Method of improving animal feeds using hydrolyzed lecithins |
| CN109907180A (en) * | 2019-04-04 | 2019-06-21 | 山东信得科技股份有限公司 | A kind of polynary liposome oral fluid to quickly supplement energy and preparation method thereof, application method and application |
Also Published As
| Publication number | Publication date |
|---|---|
| GB9309723D0 (en) | 1993-06-23 |
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| Date | Code | Title | Description |
|---|---|---|---|
| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |