GB2268879A - Disinfectant compositions - Google Patents
Disinfectant compositions Download PDFInfo
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- GB2268879A GB2268879A GB9215772A GB9215772A GB2268879A GB 2268879 A GB2268879 A GB 2268879A GB 9215772 A GB9215772 A GB 9215772A GB 9215772 A GB9215772 A GB 9215772A GB 2268879 A GB2268879 A GB 2268879A
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- composition
- ammonium
- qac
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- 239000000203 mixture Substances 0.000 title claims description 52
- 239000000645 desinfectant Substances 0.000 title description 5
- 239000002243 precursor Substances 0.000 claims abstract description 21
- 230000003115 biocidal effect Effects 0.000 claims abstract description 13
- 230000001954 sterilising effect Effects 0.000 claims abstract description 11
- 238000004140 cleaning Methods 0.000 claims abstract description 10
- 150000003856 quaternary ammonium compounds Chemical class 0.000 claims abstract description 8
- 150000004967 organic peroxy acids Chemical class 0.000 claims abstract description 4
- 238000002360 preparation method Methods 0.000 claims abstract description 4
- 238000011012 sanitization Methods 0.000 claims abstract description 4
- 239000008247 solid mixture Substances 0.000 claims abstract description 4
- 239000000243 solution Substances 0.000 claims description 33
- FRPJTGXMTIIFIT-UHFFFAOYSA-N tetraacetylethylenediamine Chemical group CC(=O)C(N)(C(C)=O)C(N)(C(C)=O)C(C)=O FRPJTGXMTIIFIT-UHFFFAOYSA-N 0.000 claims description 16
- 239000002253 acid Substances 0.000 claims description 14
- -1 poly(oxyalkyl) Polymers 0.000 claims description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 7
- 125000000217 alkyl group Chemical group 0.000 claims description 6
- 150000001450 anions Chemical class 0.000 claims description 6
- 229910052736 halogen Inorganic materials 0.000 claims description 6
- 150000002367 halogens Chemical class 0.000 claims description 6
- 150000001768 cations Chemical class 0.000 claims description 5
- QSKQNALVHFTOQX-UHFFFAOYSA-M sodium nonanoyloxybenzenesulfonate Chemical compound [Na+].CCCCCCCCC(=O)OC1=CC=CC=C1S([O-])(=O)=O QSKQNALVHFTOQX-UHFFFAOYSA-M 0.000 claims description 5
- UAOKXEHOENRFMP-ZJIFWQFVSA-N [(2r,3r,4s,5r)-2,3,4,5-tetraacetyloxy-6-oxohexyl] acetate Chemical compound CC(=O)OC[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)C=O UAOKXEHOENRFMP-ZJIFWQFVSA-N 0.000 claims description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 230000000249 desinfective effect Effects 0.000 claims description 4
- 125000001453 quaternary ammonium group Chemical group 0.000 claims description 4
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 3
- 125000005211 alkyl trimethyl ammonium group Chemical group 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 3
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 claims description 2
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical group N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 claims description 2
- 239000004254 Ammonium phosphate Substances 0.000 claims description 2
- 235000019257 ammonium acetate Nutrition 0.000 claims description 2
- 235000011114 ammonium hydroxide Nutrition 0.000 claims description 2
- ZRIUUUJAJJNDSS-UHFFFAOYSA-N ammonium phosphates Chemical group [NH4+].[NH4+].[NH4+].[O-]P([O-])([O-])=O ZRIUUUJAJJNDSS-UHFFFAOYSA-N 0.000 claims description 2
- 235000019289 ammonium phosphates Nutrition 0.000 claims description 2
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims description 2
- 125000005131 dialkylammonium group Chemical group 0.000 claims description 2
- VTIIJXUACCWYHX-UHFFFAOYSA-L disodium;carboxylatooxy carbonate Chemical compound [Na+].[Na+].[O-]C(=O)OOC([O-])=O VTIIJXUACCWYHX-UHFFFAOYSA-L 0.000 claims description 2
- 125000005342 perphosphate group Chemical group 0.000 claims description 2
- 229960001922 sodium perborate Drugs 0.000 claims description 2
- 229940045872 sodium percarbonate Drugs 0.000 claims description 2
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 239000001361 adipic acid Substances 0.000 claims 1
- 235000011037 adipic acid Nutrition 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- 235000015165 citric acid Nutrition 0.000 claims 1
- 239000001384 succinic acid Substances 0.000 claims 1
- 235000011044 succinic acid Nutrition 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 21
- 239000002904 solvent Substances 0.000 description 17
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 14
- OCBHHZMJRVXXQK-UHFFFAOYSA-M benzyl-dimethyl-tetradecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 OCBHHZMJRVXXQK-UHFFFAOYSA-M 0.000 description 9
- 150000004965 peroxy acids Chemical class 0.000 description 9
- 230000002378 acidificating effect Effects 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 230000003641 microbiacidal effect Effects 0.000 description 4
- 229940124561 microbicide Drugs 0.000 description 4
- 244000286779 Hansenula anomala Species 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 241000521553 Pichia fermentans Species 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 235000013365 dairy product Nutrition 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- HFVMEOPYDLEHBR-UHFFFAOYSA-N (2-fluorophenyl)-phenylmethanol Chemical compound C=1C=CC=C(F)C=1C(O)C1=CC=CC=C1 HFVMEOPYDLEHBR-UHFFFAOYSA-N 0.000 description 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 1
- QLAJNZSPVITUCQ-UHFFFAOYSA-N 1,3,2-dioxathietane 2,2-dioxide Chemical compound O=S1(=O)OCO1 QLAJNZSPVITUCQ-UHFFFAOYSA-N 0.000 description 1
- PXRKCOCTEMYUEG-UHFFFAOYSA-N 5-aminoisoindole-1,3-dione Chemical compound NC1=CC=C2C(=O)NC(=O)C2=C1 PXRKCOCTEMYUEG-UHFFFAOYSA-N 0.000 description 1
- 235000014683 Hansenula anomala Nutrition 0.000 description 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- 239000004115 Sodium Silicate Substances 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000007983 food acid Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000002855 microbicide agent Substances 0.000 description 1
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 125000005429 oxyalkyl group Chemical group 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 1
- 229910052911 sodium silicate Inorganic materials 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/14—Boron; Compounds thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Inorganic Chemistry (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
A solid composition, suitable for use in in the preparation of a rapidly effective cleaning, sanitizing or sterilising solution, comprises an organic peracid precursor, a per-salt and a biocidal quaternary ammonium compound.
Description
Compositions
This invention is concerned with compositions which are useful in the preparation of cleaning, disinfecting, sanitising and sterilising compositions. More particularly, the present invention is concerned with solid compositions which when dissolved in an appropriate solvent form compositions comprising organic peroxygenated acids and biocidal quaternary ammonium compounds (QAC's) useful in or as cleaning, sanitising and sterilising compositions.
It is known that peracetic acid (PAA) and certain QAC's have biocidal activity and this fact has been exploited in the past by incorporating the compounds individualiy into, for example, cleaning, sanitizing and sterilising compositions used in hospitals and dairies.
PAA based compositions are most effective at acidic pH's, whereas the
QAC based compositions are most effective at alkaline pH's.
WO 88/00795 discloses an antiseptic composition comprising PAA, alkyldimethylbenzyl ammonium chloride and an essential oil.
In US-A-4847089 and US-A-4850729 there are disclosed dry, wateractivated compositions comprising per-salts and phase-transfer agents which are useful for preparing disinfectants and cleansing and decontaminating agents.
These compositions, however, tend to be relatively slow acting, requiring more than 5 minutes from addition of the solid composition to water for the resulting disinfectant or cleansing and decontaminating agent to be effective against microbes.
It is an object of the present invention to provide a dry composition which may be used for preparing relatively fast acting cleaning, disinfecting, sanitising and sterilising compositions
In accordance with the present invention there is provided a dry composition suitable for use in the preparation of aqueous cleaning, sanitizing or sterilising composition, characterised in that the composition comprises an organic peroxyacid precursor, a persalt, and a biocidal quaternary ammonium compound. Any biocidal QAC is suitable for use in the compositions of the present though, for storage stable solutions, preferably, the QAC has a nonhalogen or non-halogenated anion. More preferably, the QAC is a nonhalogenated QAC, where both the anion and cation of the QAC comprise groups other than halogen or halogenated groups.Surprisingly, the compositions of the present invention are relatively fast acting, in that when made into a solution, e.g. an aqueous solution, the solution requires substantially less than 5 minutes, e.g. less than 1 minute, to be effective against microbes at ambient temperature (200C). Furthermore, within the first 5 minutes from when a composition of the present invention is added to an appropriate solvent, the resulting composition demonstrates synergistic improvements in effectiveness against microbials over the per-salt and QAC alone or together and over the per-salt and precursor together.
The weight ratio of precursor: per-salt in the composition is preferably from about 4:1 to about 1:20, more preferably from about 1:1 to about 1:10, and most preferably from about 1:2 to about 1:5.
The weight ratio of precursor and per-salt:QAC in the composition is preferably from about 1:1 to about 1:30, more preferably from about 1: to 1:20, and most preferably from about 1:2 to about 1:10.
The per-salts and precursors may be completely soluble or only sparingly soluble in the appropriate solvent, but each must dissolve to such an extent to enable formation of peroxyacid in a sufficient quantity, as will be readily appreciated by the skilled person.
The peroxyacid precursors used in the present invention are compounds which, in the appropriate solvent and in the presence of the per-salt, generate organic peroxyacids The peroxyacids which may be generated from the precursors useful in the composition of the present invention are preferably organic peroxycarboxylic acids, more preferably C2-C 10 aliphatic peroxyacids, e.g. peracetic acid (PAA) and pernonanoic acid (PNA). The peracid may be unsubstituted or substituted. The preferred precursors are tetra acetyl ethylene diamine (TAED), sodium nonanoyl oxy benzene sulphonate (SNOBS) and penta acetyl glucose (PAG). The most preferred precursor is TAED and, consequently, the most preferred peroxyacid is PAA.
The per-salts used in the present invention are salts having hydrogen peroxide of crystallisation or salts which when dissolved in an appropriate solvent release peroxygen or peroxide ions. Such salts are well known to the skilled person. Examples of suitable per-salts are selected from the group consisting of percarbonates, perborates, persilicates and perphosphates. The persalt is preferably sodium percarbonate (2Na2C03.3H202) or sodium perborate.
The QAC's useful in the present invention must be biocidal and preferably contain non-halogen or non-halogenated counter ions. Examples of suitable QAC's include alkyl dimethylbenzyl ammonium chloride, e.g.
tetradecyl(C14)dimethylbenzylammonium chloride, alkyl trimethylammonium chloride, e.g. C1 galkyltrimethylammonium chloride, dialkyldimethylammonium chloride, e.g. Cgalkyl- C1 1alkyl- dimethyl ammonium chloride, and cetrylpyridiniumchloride, and other biocidal QAC's with halogen or halogenated cations and/or halogenated anions though, for preparing storage stable solutions, the most preferred QAC's are the biocidal QAC's having non-halogen or nonhalogenated cations and non-halogenated anions and include alkyl poly(oxyalkyl)ammonium propionates such as N,N-didecyl-N-methylpoly(oxyethyl)ammonium propionates, alkyl or alkylaryl ammonium methosulphates such as alkyltrimethyl ammonium methosulphates or alkyldimethylbenzylammonium methosulphate, dialkylammonium methosulphates, alkyldimethylbenzylammonium saccharinates, quaternary ammonium ethosulphates, quaternary ammonium hydroxides, polypropoxyquaternary ammonium acetates and polypropoxyquaternary ammonium phosphates.
Preferably, the alkyl groups are C1-C30, more preferably C10-C20 and most preferably C12-C16, alkyl groups. The oxyalkyl groups are preferably oxy(C1
C6)alkyl groups.
The compositions of the present invention are preferably presented in the form of a powdered solid, though the components of the composition may be conveniently compounded into, for example, a tablet which is readily dispersible in an appropriate volume of the appropriate solvent.
The compositions of the present invention may comprise other components, such as surfactants, sequestering agents and dispersants, which are well known in the art for assisting the composition to dissolve in the solvent.
The preferred solvents include water and appropriate organic polar solvents such as methanol or ethanol. Water is the most preferred solvent.
When the compositions of the present invention are dissolved in the solvents, the resultant solutions usually take an alkaline pH of about 9 to 11.
Whilst the resultant solutions are extremely effective against microbes at these pH's, it is preferred that the solutions are made acidic, e.g. having a pH of from 1 to 7, preferably pH4, for enhanced storage stability. The solution may be made acidic by adding any acid, preferably a food acid such as citric, tartaric, adipic, succinic or glutaric acid, to the solution after the peracid has formed. The acid may be added to the solution preferably at a time to coincide with the maximum generation of peracid from the precursor and per-salt. As will be appreciated by the skilled person, the exact time for addition of the acid will depend upon the particular precursor/per-salt system, concentration of the precursor/per-salt system in the solvent, temperature and the pH of the solvent used, though typically, at ambient temperatures (2O0C), the acid is added from about 5 up to about 15 minutes or more after the composition has been added to the solvent.
In an embodiment of the present invention, there is provided a tablet comprising a single solid acidic core, or a plurality of solid acidic cores, embedded in a solid per-salt. The core or cores are preferably coated with a slow dissolving layer, such as silicate, which enables a delayed release of the acid when the tablet is added to an appropriate solvent. The per-salt is preferably mixed with an organic acid precursor and, optionally, a biocidal QAC, preferably a biocidal QA:C which has a non-halogen or non-halogenated cation. In practice, the tablet is added to a solvent, e.g. water, and the per-salt, and any precursor and QAC, is allowed to dissolve or disperse into the solvent. At this point in time, the solution has a pH of about 9 and is unstable for long periods of time.A few minutes later, e.g. after about 5 to 15 minutes when at ambient temperatures, to coincide with the maximum generation of peroxide or, when the precursor is present, to coincide with the maximum generation of peroxyacid, the acid is released from the core(s) into the solvent and the pH of the solution drops to about 4, thereby rendering the solution more time stable.
The compositions of the present invention may find use in a number of applications where cleaning, sanitising or sterilising solutions are required.
One particular use of the compositions is in the formation of a sterilizing solution which may be used by doctors or dentists to sterilise their instruments.
The solutions of the present invention offer the advantage that sterilisation of surgical instruments and the like may be effected in a one step process, rather than a two step process as currently practiced with prior art sterilisation systems. The solutions based on the compositions may also be used in dairies, food processing plants, animal houses, dairy farms and breweries, where the rapid, broad spectrum activity of the compositions together with their ability to wet and penetrate give significant advantages over traditional sanitisers and disinfectants. The solutions may also be used in paper mills, where a disinfectant is required to prevent microbial growth in the papermaking processes.
The present invention will now be further described by reference to the following specific examples and Figure 1 and Figure 2.
Figure 1 and Figure 2 are graphs which demonstrate the fast acting effect as a microbicide of compositions of the present invention dissolved in water.
In a first series of experiments, five aqueous solutions were prepared by dissolving in water: 1. 0.29 of powdered PCS in 100ml of demineralised (DM) water, 2. 0.1 g of powdered ARQUAD DM 14B-90 in 100ml of DM water, 3. 0.29 of powdered PCS and 0.lg of powdered ARQUAD DM 14B-90 in
100ml of DM water, 4. 0.29 of powdered PCS and 0.15g of powdered TAED in 100ml of DM
water, and 5. 0.29 of powdered PCS. 0.15g of powdered TAED and 0.19 of
powdered ARQUAD DM 14B-90 in 100ml of DM water.
The solutions were allowed to stand for 5 minutes at ambient temperature to allow perhydrolysis of the precursor to generate peroxyacid.
1.0ml of each of the solutions were then added to 1.0ml of a suspension of 107 cfu/ml Candida lambica contained in 8.0ml of DM water and the clock started.
The performance of the solutions as microbicides against Candida lambica was evaluated by comparing the LRF values and time from adding the 1.0ml aliquot of solution to the yeast suspension. The results are shown in
Figure 1 (ARQUAD DM 14B-90 is a tetradecylbenzyldimethylammonium chloride available from Akzo)
In a second series of experiments, six aqueous solutions were prepared by dissolving in water: 1. 0.29 of powdered PCS in 100ml of demineralised (DM) water, 2. 0.lg of powdered ARQUAD DM 14B-90 in 100ml of DM water, 3. 0.29 of powdered PCS and 0.15g of powdered TAED in 100ml of DM
water, 4. 0.29 of powdered PCS. 0.159 of powdered TAED and 0.19 of
powdered ARQUAD DM 1 4B-90 in 100ml of DM water, 5. 0.39 of powdered STEPANQUAT F in 100ml of DM water, and 6. 0.29 of powdered PCS, 0.15g of powdered TAED and 0.19 of
powdered ARQUAD DM 14B-90 in 100ml of DM water.
The procedure of the first series of experiments was repeated for the above solutions. The performance of the solutions as microbicides against
Candida pelliculosa was evaluated as above by comparing the LRF values and time from adding the 1.0ml aliquot to the yeast suspension. The results are shown in Figure 2 (STEPANQUAT F is a non-biocidal QAC available from Stepan).
The surprising synergistic biocidal advantage of the compositions of the present invention in solution over the other solutions is readily seen from Figure 1 and
Figure 2.
In a third series of experiments, the performance of 5 compositions as microbicides against Candida lambica was evaluated by determining the LRF over a period of a few minutes. The QAC used was ARQUAD DM 14B-90. The results are given in Table 1 below:
TABLE 1
Concn per litre Log Reduction
1 min 3mins 5mins 10minus 0.29 PCS 1.9 2.8
1.8 2.8 0.2gPCS + 0.15g TAED 2.2 3.4 4.2
2.3 3.1 0.2gPCS + 0.29 SNOBS 4.5 5.5 > 5.5 > 5.5
2.9 3.6 4.2 4.8 0.2gPCS + O.15gTAED + 0.19 QAC 4.6 5.2 > 5.5 > 5.5 0.2gPCS + 0.l5gTAED + 0.059 QAC 5.4 5.4 > 5.5 > 5.5 0.2gPCS + 0.2gSNOBS
+ O.1g QAC 5.2 5.2 > 5.5 > 5.5 0.2gPCS + 0.2gSNOBS
+ 0.059 QAC 5.4 > 5.5 > 5.5 > 5.5
In a forth series of experiments, the stability performance of two compositions of the present invention held over a period of 12 weeks are compared with one another. The results are shown in Table 2 below. The preference for using PBS instead of PCS can be readily seen. The QAC used was ARQUAD DM 14B-90.
TABLE 2
30% PBS-1 30% PCS 20%TAED 20% TAED 20% QAC 20%QAC 50% Na2S04 50% Na2S04
Week %AvOx % Loss %AvOx % Loss 0 1.94 1.79 1 1.93 0.5 1.52 14.8 6 1.75 8.5 1.25 30.2 8 1.77 8.8 1.26 29.4 12 1.77 8.8 1.08 39.7
A tablet comprising a composition of the present invention may be prepared as follows:
Particles of citric acid are fed to an aeromatic and sprayed with a solution of sodium silicate to encapsulate the acid in a coating which is slowly soluble in water. The coating is effected at room temperature followed by drying at elevated temperature. Next, granules of PCS and TAED, together with a solution of PVA binding agent, are added to the coated acid particles and the mixture formed to a tablet and allowed to dry at elevated temperature. Each tablet comprised an acid core embedded in a solid PCS/TAED casing. The tablet was readily soluble in water over a period of 10 minutes, first the PCS/TAED being dissolved then, more slowly, the acid core was dissolved. The resulting solution had a pH of about 4 and was stable for at least 24 hours.
Claims (11)
1. A solid composition suitable for use in preparing a cleaning, sanitizing or sterilising composition, characterised in that the composition comprises an organic peracid precursor, a per-salt and a biocidal quaternary ammonium compound (QAC).
2. A composition as claimed in claim 1, wherein the weight ratio of precursor: per-salt is from about 4:1 to about 1:20, preferably from about 1:1 to about 1:10, and more preferably from about 1:2 to about 1:5.
3. A composition as claimed in claim 1 or claim 2, wherein the weight ratio of precursor and persalt:QAC is from about 1:1 to about 1:30, preferably from about 1:1 to about 1:20, and most preferably from about 1:2 to about 1:10.
4. A composition as claimed in claim 1, claim 2 or claim 3, wherein the
QAC has a non-halogen or non-halogenated anion, and preferably has a nonhalogen or non-halogenated anion and a non-halogenated cation.
5. A composition as claimed in any one of the preceding claims, wherein the QAC is one or more compounds selected from the group consisting of alkyl poly(oxyalkyl)ammonium propionates such as N,N-didecyl-N-methylpoly(oxyethyl)ammonium propionates, alkyl or alkylaryl ammonium methosulphates such as alkyltrimethyl ammonium methosulphates or alkyldimethylbenzylammonium methosulphates, dialkylammonium methosulphates, alkyldimethylbenzylammonium saccharinates, quaternary ammonium ethosulphates, quaternary ammonium hydroxides, polypropoxyquaternary ammonium acetates and polypropoxyquaternary ammonium phosphates.
6. A composition as claimed in any one of the preceding claims, wherein the per-salt is selected from the group consisting of percarbonates, perborates, persilicates and perphosphates, and is preferably sodium percarbonate (2Na2C03.3H202) or sodium perborate.
7. A composition as claimed in any one of the preceding claims, wherein the precursor is tetra acetyl ethylene diamine (TAED), sodium nonanoyl oxy benzene sulphonate (SNOBS) or penta acetyl glucose (PAG).
8. Use of a composition as claimed in any one of claims 1 to 7 in the preparation of a cleaning, disinfecting, sanitising or sterilising composition.
9. A solution, preferably an aqueous solution, comprising the reaction product of a composition as claimed in any one of claims 1 to 7.
10. A solution as claimed in claim 9, wherein the solution also includes an acid, preferably selected from citric acid, tartaric acid, adipic acid, succinic acid and glutaric acid.
11. Use of a solution as claimed in claim 9 or claim 10 in or as a cleaning, disinfecting, sanitising or sterilising composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9215772A GB2268879A (en) | 1992-07-24 | 1992-07-24 | Disinfectant compositions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9215772A GB2268879A (en) | 1992-07-24 | 1992-07-24 | Disinfectant compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB9215772D0 GB9215772D0 (en) | 1992-09-09 |
| GB2268879A true GB2268879A (en) | 1994-01-26 |
Family
ID=10719249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB9215772A Withdrawn GB2268879A (en) | 1992-07-24 | 1992-07-24 | Disinfectant compositions |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2268879A (en) |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996018297A1 (en) * | 1994-12-14 | 1996-06-20 | Chemoxal S.A. | Producing peracetic ion-based biocidal disinfecting compositions |
| ES2092956A1 (en) * | 1994-11-16 | 1996-12-01 | Medilent S L | Aqueous solution for contact lenses |
| WO1998013451A1 (en) * | 1996-09-24 | 1998-04-02 | The Procter & Gamble Company | Detergent compositions |
| WO1998025468A1 (en) * | 1996-12-11 | 1998-06-18 | Henkel-Ecolab Gmbh & Co. Ohg | Process for disinfecting instruments |
| EP0929622A4 (en) * | 1996-09-24 | 2000-01-05 | Procter & Gamble | Detergent compositions |
| EP0929623A4 (en) * | 1996-09-24 | 2000-01-05 | Procter & Gamble | Detergent compositions |
| WO2000057730A1 (en) * | 1999-03-26 | 2000-10-05 | Ecolab Inc. | Antimicrobial and antiviral compositions and treatments for food surfaces |
| GB2367741A (en) * | 1998-02-25 | 2002-04-17 | Bissell Homecare Inc | Extraction cleaning methods |
| US6436445B1 (en) | 1999-03-26 | 2002-08-20 | Ecolab Inc. | Antimicrobial and antiviral compositions containing an oxidizing species |
| EP1269844A1 (en) * | 2001-06-20 | 2003-01-02 | CASTELLINI S.p.A. | A disinfectant composition and method for disinfecting and/or sterilising a dental unit |
| US6855328B2 (en) | 2002-03-28 | 2005-02-15 | Ecolab Inc. | Antimicrobial and antiviral compositions containing an oxidizing species |
| EP1557088A1 (en) * | 2004-01-20 | 2005-07-27 | A-Dec, Inc. | Sustained water treatment in dental equipment |
| US7615109B2 (en) | 2005-06-10 | 2009-11-10 | Electrolux Home Care Products, Inc. | Sodium bicarbonate vacuum bag inserts |
| US7862623B1 (en) | 1997-07-09 | 2011-01-04 | Bissell Homecare, Inc. | Extraction cleaning with oxidizing agent |
| CN105899072A (en) * | 2013-11-11 | 2016-08-24 | 怀特利集团控股有限公司 | Disinfectant composition |
| US9497964B2 (en) | 2010-10-22 | 2016-11-22 | Agri-Neo Inc. | Synergistic activity of peracetic acid and at least one SAR inducer for the control of pathogens in and onto growing plants |
| US10136642B2 (en) | 2015-02-19 | 2018-11-27 | Agri-Neo, Inc. | Composition of peracetic acid and at least one organic fungicide for the control and/or the treatment of diseases associated with the presence of pathogens, and method, use and kit involving said composition |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110934141B (en) * | 2018-09-21 | 2023-04-07 | 利康医药科技江苏有限公司 | Solid-state peracetic acid long-acting sterilization powder and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988000795A1 (en) * | 1986-07-25 | 1988-02-11 | Garcin Francoise | Antiseptic composition incorporating essential oils |
-
1992
- 1992-07-24 GB GB9215772A patent/GB2268879A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988000795A1 (en) * | 1986-07-25 | 1988-02-11 | Garcin Francoise | Antiseptic composition incorporating essential oils |
Cited By (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2092956A1 (en) * | 1994-11-16 | 1996-12-01 | Medilent S L | Aqueous solution for contact lenses |
| WO1996018297A1 (en) * | 1994-12-14 | 1996-06-20 | Chemoxal S.A. | Producing peracetic ion-based biocidal disinfecting compositions |
| FR2728171A1 (en) * | 1994-12-14 | 1996-06-21 | Chemoxal Sa | PRODUCTION OF BIOCIDAL DISINFECTANT FORMULATIONS BASED ON PERACETIC IONS |
| EP0720814A1 (en) | 1994-12-14 | 1996-07-10 | Chemoxal Sa | Production of disinfecting biocidal formulations based on peracetic ions |
| EP0929622A4 (en) * | 1996-09-24 | 2000-01-05 | Procter & Gamble | Detergent compositions |
| EP0929623A4 (en) * | 1996-09-24 | 2000-01-05 | Procter & Gamble | Detergent compositions |
| WO1998013451A1 (en) * | 1996-09-24 | 1998-04-02 | The Procter & Gamble Company | Detergent compositions |
| WO1998025468A1 (en) * | 1996-12-11 | 1998-06-18 | Henkel-Ecolab Gmbh & Co. Ohg | Process for disinfecting instruments |
| US6540960B2 (en) | 1996-12-11 | 2003-04-01 | Henkel-Ecolab Gmbh & Co. Ohg (Henkel-Ecolab) | Process for disinfecting instruments |
| US7862623B1 (en) | 1997-07-09 | 2011-01-04 | Bissell Homecare, Inc. | Extraction cleaning with oxidizing agent |
| GB2367741A (en) * | 1998-02-25 | 2002-04-17 | Bissell Homecare Inc | Extraction cleaning methods |
| GB2367741B (en) * | 1998-02-25 | 2002-09-04 | Bissell Homecare Inc | Extraction cleaning methods |
| WO2000057730A1 (en) * | 1999-03-26 | 2000-10-05 | Ecolab Inc. | Antimicrobial and antiviral compositions and treatments for food surfaces |
| US6436445B1 (en) | 1999-03-26 | 2002-08-20 | Ecolab Inc. | Antimicrobial and antiviral compositions containing an oxidizing species |
| US6534075B1 (en) | 1999-03-26 | 2003-03-18 | Ecolab Inc. | Antimicrobial and antiviral compositions and treatments for food surfaces |
| EP1269844A1 (en) * | 2001-06-20 | 2003-01-02 | CASTELLINI S.p.A. | A disinfectant composition and method for disinfecting and/or sterilising a dental unit |
| US6855328B2 (en) | 2002-03-28 | 2005-02-15 | Ecolab Inc. | Antimicrobial and antiviral compositions containing an oxidizing species |
| EP1557088A1 (en) * | 2004-01-20 | 2005-07-27 | A-Dec, Inc. | Sustained water treatment in dental equipment |
| JP2005247829A (en) * | 2004-01-20 | 2005-09-15 | A-Dec Inc | Sustained water treatment in dental equipment |
| US7033511B2 (en) | 2004-01-20 | 2006-04-25 | A-Dec, Inc. | Sustained water treatment in dental equipment |
| AU2005200238B2 (en) * | 2004-01-20 | 2007-07-12 | A-Dec, Inc. | Sustained water treatment in dental equipment |
| AU2005200238C1 (en) * | 2004-01-20 | 2011-04-21 | A-Dec, Inc. | Sustained water treatment in dental equipment |
| US7615109B2 (en) | 2005-06-10 | 2009-11-10 | Electrolux Home Care Products, Inc. | Sodium bicarbonate vacuum bag inserts |
| US7837772B2 (en) | 2005-06-10 | 2010-11-23 | Electrolux Home Care Products, Inc. | Vacuum cleaner filter assembly |
| US9497964B2 (en) | 2010-10-22 | 2016-11-22 | Agri-Neo Inc. | Synergistic activity of peracetic acid and at least one SAR inducer for the control of pathogens in and onto growing plants |
| CN105899072A (en) * | 2013-11-11 | 2016-08-24 | 怀特利集团控股有限公司 | Disinfectant composition |
| US10136642B2 (en) | 2015-02-19 | 2018-11-27 | Agri-Neo, Inc. | Composition of peracetic acid and at least one organic fungicide for the control and/or the treatment of diseases associated with the presence of pathogens, and method, use and kit involving said composition |
Also Published As
| Publication number | Publication date |
|---|---|
| GB9215772D0 (en) | 1992-09-09 |
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| Date | Code | Title | Description |
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| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |