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GB2244273A - Allelic variants of plasmodium falciparum merozoite surface antigen. - Google Patents

Allelic variants of plasmodium falciparum merozoite surface antigen.

Info

Publication number
GB2244273A
GB2244273A GB9104568A GB9104568A GB2244273A GB 2244273 A GB2244273 A GB 2244273A GB 9104568 A GB9104568 A GB 9104568A GB 9104568 A GB9104568 A GB 9104568A GB 2244273 A GB2244273 A GB 2244273A
Authority
GB
United Kingdom
Prior art keywords
terminal
surface antigen
plasmodium falciparum
merozoite surface
sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB9104568A
Other versions
GB9104568D0 (en
Inventor
Jason Arthur Smythe
Robin Fredric Anders
David James Kemp
Ross Leon Coppel
Allan James Saul
Graham Lloyd Jones
David Owen Irving
Sandra Leigh Dyer
David Wai Wing Chee
Neil Howard Goss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Saramane Pty Ltd
Original Assignee
Saramane Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/AU1989/000388 external-priority patent/WO1990002752A1/en
Application filed by Saramane Pty Ltd filed Critical Saramane Pty Ltd
Publication of GB9104568D0 publication Critical patent/GB9104568D0/en
Publication of GB2244273A publication Critical patent/GB2244273A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C12N9/1088—Glutathione transferase (2.5.1.18)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/20—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
    • C07K16/205—Plasmodium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A merozoite surface antigen of Plasmodium falciparum selected from the class characterised by: (i) having a relative molecular mass, Mr, (determined by SDS-polyacrylamide gel electrophoresis) in the range of approximately 41,000 to 53,000; and (ii) comprising multiple allelic forms of MSA2, having conserved N-terminal and C-terminal sequences; or an antigenic fragment thereof. Particular antigenic fragments include sequence corresponding to repeat sequences and sequences from conserved N-terminal and C-terminal regions. Production of antigens by recombinant DNA techniques as fusion and non-fusion proteins, and use in vaccine compositions is also disclosed.
GB9104568A 1988-09-12 1991-03-05 Allelic variants of plasmodium falciparum merozoite surface antigen. Withdrawn GB2244273A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPJ038288 1988-09-12
AUPJ596289 1989-08-24
PCT/AU1989/000388 WO1990002752A1 (en) 1988-09-12 1989-09-12 Allelic variants of plasmodium falciparum merozoite surface antigen

Publications (2)

Publication Number Publication Date
GB9104568D0 GB9104568D0 (en) 1991-04-17
GB2244273A true GB2244273A (en) 1991-11-27

Family

ID=27156770

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9104568A Withdrawn GB2244273A (en) 1988-09-12 1991-03-05 Allelic variants of plasmodium falciparum merozoite surface antigen.

Country Status (1)

Country Link
GB (1) GB2244273A (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7699887A (en) * 1986-07-17 1988-02-10 Program For Appropriate Technology In Health (Path) Merozoite surface antigen of plasmodium falciparum
US4767622A (en) * 1983-08-19 1988-08-30 University Of Illinois Method and materials for development of immunological responses protective against malarial infection
US4835529A (en) * 1984-10-30 1989-05-30 Kabushiki Kaisha Toshiba Output display apparatus

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4767622A (en) * 1983-08-19 1988-08-30 University Of Illinois Method and materials for development of immunological responses protective against malarial infection
US4835529A (en) * 1984-10-30 1989-05-30 Kabushiki Kaisha Toshiba Output display apparatus
AU7699887A (en) * 1986-07-17 1988-02-10 Program For Appropriate Technology In Health (Path) Merozoite surface antigen of plasmodium falciparum

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Mol. Biochem. Parasitol. 1988, 28(1), 1-10 *
Mol. Biochem. Parasitol. 1989, 32(1), 15-24 *

Also Published As

Publication number Publication date
GB9104568D0 (en) 1991-04-17

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)