GB2190378B - Tetrahydronophthalene derivatives and anti-cancerous compositions containing them - Google Patents

Tetrahydronophthalene derivatives and anti-cancerous compositions containing them

Info

Publication number: GB2190378B
Authority: GB; United Kingdom
Prior art keywords: tetrahydronophthalene; cancerous; derivatives; compositions containing; compositions
Prior art date: 1986-05-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

GB8711205A

Other versions

GB8711205D0 (en

GB2190378A (en

Inventor

Michael Klaus

Peter Loeliger

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

F Hoffmann La Roche AG

Original Assignee

F Hoffmann La Roche AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-05-13

Filing date

1987-05-12

Publication date

1990-11-14

1986-05-13 Priority claimed from CH1938/86A external-priority patent/CH668962A5/en

1987-05-12 Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG

1987-06-17 Publication of GB8711205D0 publication Critical patent/GB8711205D0/en

1987-11-18 Publication of GB2190378A publication Critical patent/GB2190378A/en

1990-11-14 Application granted granted Critical

1990-11-14 Publication of GB2190378B publication Critical patent/GB2190378B/en

2007-05-12 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)

GB8711205A 1986-05-13 1987-05-12 Tetrahydronophthalene derivatives and anti-cancerous compositions containing them Expired - Lifetime GB2190378B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH1938/86A CH668962A5 (en)	1986-05-13	1986-05-13	New hydroxy:phenyl:propenyl substd. naphthalene cpds.
CH74287		1987-02-26

Publications (3)

Publication Number	Publication Date
GB8711205D0 GB8711205D0 (en)	1987-06-17
GB2190378A GB2190378A (en)	1987-11-18
GB2190378B true GB2190378B (en)	1990-11-14

Family

ID=25685550

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GB8711205A Expired - Lifetime GB2190378B (en)	1986-05-13	1987-05-12	Tetrahydronophthalene derivatives and anti-cancerous compositions containing them

Country Status (20)

Country	Link
CN (1)	CN87103524A (en)
AU (1)	AU7277987A (en)
BE (1)	BE1001668A5 (en)
DE (1)	DE3715809A1 (en)
DK (1)	DK232087A (en)
ES (1)	ES2005572A6 (en)
FI (1)	FI872027L (en)
FR (1)	FR2598706B1 (en)
GB (1)	GB2190378B (en)
HU (1)	HU198002B (en)
IL (1)	IL82448A0 (en)
IT (1)	IT1203954B (en)
LU (1)	LU86866A1 (en)
MC (1)	MC1817A1 (en)
NL (1)	NL8701101A (en)
NO (1)	NO871961L (en)
NZ (1)	NZ220215A (en)
PT (1)	PT84860B (en)
SE (1)	SE8701933L (en)
ZW (1)	ZW6587A1 (en)

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5677320A (en)	1993-10-18	1997-10-14	Allergan	Phenyl or heteroaryl and tetrahydronaphthyl substituted diene compounds having retinoid like biological activity
US5728846A (en)	1996-12-12	1998-03-17	Allergan	Benzo 1,2-g!-chrom-3-ene and benzo 1,2-g!-thiochrom-3-ene derivatives
US5750693A (en)	1987-03-20	1998-05-12	Allergan	Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity
US5760276A (en)	1997-03-06	1998-06-02	Allergan	Aryl-and heteroarylcyclohexenyl substituted alkenes having retinoid agonist, antagonist or inverse agonist type biological activity
US5808083A (en)	1994-12-29	1998-09-15	Allergan	Acetylenes disubstituted with a 5 alkyl, aryl or heteroaryl substituted dihydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
US5817836A (en)	1995-06-06	1998-10-06	Allergan	2,4-pentadienoic acid derivatives having retinoid-like biological activity
US5847160A (en)	1994-12-29	1998-12-08	Allergan	Acetylenes disubstituted with 2-tetrahydropyranoxy-aryl and aryl of heteroaryl groups having retinoid-like biological activity
US5856490A (en)	1995-11-22	1999-01-05	Allergan	Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity
US5917048A (en)	1995-11-22	1999-06-29	Allergan Sales Inc.	Substituted aryl or heteroarylamides having retinoid-like biological activity
US5917082A (en)	1995-06-06	1999-06-29	Allergan Sales, Inc.	2,4-pentadienoic acid derivatives having retinoid-like biological activity
US5919970A (en)	1997-04-24	1999-07-06	Allergan Sales, Inc.	Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity
US5952345A (en)	1995-09-01	1999-09-14	Allergan Sales, Inc.	Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US5958954A (en)	1995-09-01	1999-09-28	Allergan Sales, Inc.	Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US5998655A (en)	1996-06-21	1999-12-07	Vuligonda; Vidyasagar	Alkylidene substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US6008204A (en)	1995-09-01	1999-12-28	Allergan Sales, Inc.	Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US6037488A (en)	1997-04-19	2000-03-14	Allergan Sales, Inc.	Trisubstituted phenyl derivatives having retinoid agonist, antagonist or inverse agonist type biological activity
US6051731A (en)	1996-06-21	2000-04-18	Allergan Sales, Inc.	O-or S-substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US6117987A (en)	1996-06-21	2000-09-12	Allergan Sales, Inc.	Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist like biological activity
US6218128B1 (en)	1997-09-12	2001-04-17	Allergan Sales, Inc.	Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities
US6555690B2 (en)	1996-06-21	2003-04-29	Allergan, Inc.	Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US6942980B1 (en)	1995-09-01	2005-09-13	Allergan, Inc.	Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5602130A (en) *	1987-03-20	1997-02-11	Allergan	Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity
CA2017956A1 (en) *	1989-07-06	1991-01-06	Werner Bollag	Use of retinoids
US5272156A (en) *	1989-09-19	1993-12-21	Allergan, Inc.	Acetylenes disubstituted with a heteroaromatic group and a 2-substituted 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity
US5183827A (en) *	1989-09-19	1993-02-02	Allergan, Inc.	Acetylenes disubstituted with a heteroaromatic group and a 2-substituted chromanyl, thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity
US5264456A (en) *	1989-12-29	1993-11-23	Allergan, Inc.	Acetylenes disubstituted with a furyl group and a substituted phenyl group having retinoid like activity
US5324840A (en)	1992-06-11	1994-06-28	Allergan, Inc.	Method of treatment with compounds having retinoid-like activity and reduced skin toxicity and lacking teratogenic effects
US5455265A (en)	1993-02-11	1995-10-03	Allergan, Inc.	Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors
US6172115B1 (en)	1993-02-11	2001-01-09	Allergan Sales, Inc.	Method for preventing onset of restenosis after angioplasty employing an RXR-specific retinoid
US5426118A (en) *	1993-12-30	1995-06-20	Allergan, Inc.	[4-(1,2-epoxycyclohexanyl)but-3-en-1-ynyl]aromatic and heteroaromatic acids and derivatives having retinoid-like biological activity
US5498755A (en) *	1994-08-23	1996-03-12	Chandraratna; Roshantha A.	Disubstituted aryl and heteroaryl imines having retinoid-like biological activity
US5618943A (en) *	1994-12-29	1997-04-08	Allergan	Acetylenes disubstituted with a 5 OXO substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
US5556996A (en) *	1994-12-29	1996-09-17	Allergan	Oxiranyls disubstituted with a phenyl group and a substituted chromanyl or tetrahydroquinolinyl group having retinoid like activity
US5599967A (en) *	1994-12-29	1997-02-04	Allergan	Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl of heteroaryl group having retinoid-like biological activity
US5514825A (en) *	1994-12-29	1996-05-07	Allergan, Inc.	Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
US5489584A (en) *	1994-12-29	1996-02-06	Allergan, Inc.	Acetylenes disubstituted with a 5-amino or substituted 5-amino substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
US5618931A (en) *	1994-12-29	1997-04-08	Allergan	Acetylenes disubstituted with a 5 substituted dihydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
US5543534A (en) *	1994-12-29	1996-08-06	Allergan	Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl groups having retinoid-like biological activity
US5534261A (en) *	1995-01-17	1996-07-09	University Of Southern California	Retinoid-based compositions and method for preventing adhesion formation using the same
US6025388A (en)	1995-04-26	2000-02-15	Allergan Sales, Inc.	Method for inhibiting gene expression promoted by AP1 protein with RARβ selective retinoids and method for treatment of diseases and conditions with such retinoids
US5616712A (en) *	1995-05-16	1997-04-01	Allergan	Acetylenes disubstituted with a phenyl or heteroaryl group and a 2-thio-1,2,3,4-tetrahdroquinolinyl, 2-alkylthio-3,4-dihydroquinolinyl or 2-alkoxy-3,4-dihydroquinolinyl group having retinoid-like biological activity
AU7598596A (en) *	1995-11-01	1997-05-22	Allergan, Inc.	Sulfides, sulfoxides and sulfones disubstituted with a tetrahydronaphthalenyl, chromanyl, thiochromanyl or tetrahydroquinolinyl and substituted phenyl or heteroaryl group, having retinoid-like biological activity
US5965606A (en)	1995-12-29	1999-10-12	Allergan Sales, Inc.	Methods of treatment with compounds having RAR.sub.α receptor specific or selective activity
US5688957A (en) *	1995-12-29	1997-11-18	Allergan	(3"-thioxacyclohex-1"-enyl)!-but-3'-ene-1'-ynyl!aryl and (3"-thioxacyclohex-1"-enyl)!-but-3'-ene-1'-ynyl!heteroaryl carboxylic acids and esters having retinoid-like biological activity
US5747542A (en) *	1996-06-21	1998-05-05	Allergan	Oxo-substituted tetrahydronaphthalene derivatives having retinold and/or retinoid antagonist-like biological activity
US5723666A (en) *	1996-06-21	1998-03-03	Allergan	Oxime substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5808124A (en) *	1996-06-21	1998-09-15	Allergan	O- or S-substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5739338A (en) *	1996-11-05	1998-04-14	Allergan	N-aryl substituted tetrahydroquinolines having retinoid agonist, retinoid antagonist or retinoid inverse agonist type biological activity
US6369225B1 (en)	2000-08-29	2002-04-09	Allergan Sales, Inc.	Compounds having activity as inhibitors of cytochrome P450RAI
US6380256B1 (en)	2000-08-29	2002-04-30	Allergan Sales, Inc.	Compounds having activity as inhibitors of cytochrome P450RAI
US6313107B1 (en)	2000-08-29	2001-11-06	Allergan Sales, Inc.	Methods of providing and using compounds having activity as inhibitors of cytochrome P450RAI

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4326055A (en) *	1977-12-22	1982-04-20	Hoffmann-La Roche Inc.	Stilbene derivatives
CA1162200A (en) *	1981-02-13	1984-02-14	Michael Klaus	Process for the manufacture of indanyl (or tetrahydronaphthyl)propenyl phenyl derivatives
DE3202100A1 (en) *	1982-01-23	1983-08-04	Basf Ag, 6700 Ludwigshafen	SUBSTITUTED 4-HYDROXYANILIDES, ITS PRODUCTION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
DE3266442D1 (en) *	1982-01-23	1985-10-24	Basf Ag	Phenylethylene derivatives, their preparation and use as medicines
DE3602473A1 (en) *	1986-01-28	1987-07-30	Basf Ag	VINYLPHENOL DERIVATIVES, THEIR PRODUCTION AND USE

1987
- 1987-04-10 ZW ZW65/87A patent/ZW6587A1/en unknown
- 1987-04-23 IT IT20232/87A patent/IT1203954B/en active
- 1987-05-06 DK DK232087A patent/DK232087A/en not_active Application Discontinuation
- 1987-05-06 NZ NZ220215A patent/NZ220215A/en unknown
- 1987-05-06 LU LU86866A patent/LU86866A1/en unknown
- 1987-05-07 IL IL82448A patent/IL82448A0/en unknown
- 1987-05-07 FI FI872027A patent/FI872027L/en not_active Application Discontinuation
- 1987-05-08 NL NL8701101A patent/NL8701101A/en not_active Application Discontinuation
- 1987-05-11 SE SE8701933A patent/SE8701933L/en not_active Application Discontinuation
- 1987-05-11 BE BE8700505A patent/BE1001668A5/en not_active IP Right Cessation
- 1987-05-11 MC MC871883A patent/MC1817A1/en unknown
- 1987-05-11 HU HU872103A patent/HU198002B/en not_active IP Right Cessation
- 1987-05-11 FR FR878706564A patent/FR2598706B1/en not_active Expired - Lifetime
- 1987-05-12 CN CN198787103524A patent/CN87103524A/en active Pending
- 1987-05-12 AU AU72779/87A patent/AU7277987A/en not_active Abandoned
- 1987-05-12 GB GB8711205A patent/GB2190378B/en not_active Expired - Lifetime
- 1987-05-12 PT PT84860A patent/PT84860B/en not_active IP Right Cessation
- 1987-05-12 DE DE19873715809 patent/DE3715809A1/en not_active Withdrawn
- 1987-05-12 ES ES8701419A patent/ES2005572A6/en not_active Expired
- 1987-05-12 NO NO871961A patent/NO871961L/en unknown

Cited By (52)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6344463B1 (en)	1987-03-20	2002-02-05	Allergan Sales, Inc.	Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity
US5750693A (en)	1987-03-20	1998-05-12	Allergan	Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity
US6090826A (en)	1987-03-20	2000-07-18	Allergan Sales, Inc.	Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity
US5677320A (en)	1993-10-18	1997-10-14	Allergan	Phenyl or heteroaryl and tetrahydronaphthyl substituted diene compounds having retinoid like biological activity
US5998471A (en)	1994-12-29	1999-12-07	Allergan Sales, Inc.	Acetylenes disubstituted with a 5 alkyl, aryl or heteroaryl substituted dihydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
US6355806B1 (en)	1994-12-29	2002-03-12	Allergen Sales, Inc.	Acetylenes disubstituted with a 5 alkyl, aryl or heteroaryl substituted dihydronaphthyl group and with an aryl or heteroaryl group having retinoid-like with an aryl or heteroaryl group having retinoid-like biological activity
US5847160A (en)	1994-12-29	1998-12-08	Allergan	Acetylenes disubstituted with 2-tetrahydropyranoxy-aryl and aryl of heteroaryl groups having retinoid-like biological activity
US5808083A (en)	1994-12-29	1998-09-15	Allergan	Acetylenes disubstituted with a 5 alkyl, aryl or heteroaryl substituted dihydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
US6114533A (en)	1995-06-06	2000-09-05	Allergan Sales, Inc.	2,4-pentadienoic acid derivatives having retinoid-like biological activity
US6313163B1 (en)	1995-06-06	2001-11-06	Allergen Sales, Inc.	2,4-pentadienoic acid derivatives having retinoid-like biological activity
US6034242A (en)	1995-06-06	2000-03-07	Allergan Sales, Inc.	2,4-pentadienoic acid derivatives having retinoid-like biological activity
US5817836A (en)	1995-06-06	1998-10-06	Allergan	2,4-pentadienoic acid derivatives having retinoid-like biological activity
US5917082A (en)	1995-06-06	1999-06-29	Allergan Sales, Inc.	2,4-pentadienoic acid derivatives having retinoid-like biological activity
US6090810A (en)	1995-09-01	2000-07-18	Allergan Sales, Inc.	Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US6469028B1 (en)	1995-09-01	2002-10-22	Allergan, Inc.	Synthesis and use of retinoid compounds having negative hormone and/or anatgonist activities
US5952345A (en)	1995-09-01	1999-09-14	Allergan Sales, Inc.	Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US5958954A (en)	1995-09-01	1999-09-28	Allergan Sales, Inc.	Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US6228848B1 (en)	1995-09-01	2001-05-08	Allergan, Inc.	Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US6008204A (en)	1995-09-01	1999-12-28	Allergan Sales, Inc.	Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US6942980B1 (en)	1995-09-01	2005-09-13	Allergan, Inc.	Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities
US6051713A (en)	1995-11-22	2000-04-18	Allergan Sales, Inc.	Substituted aryl or heteroarylamides having retinoid-like biological activity
US6342602B1 (en)	1995-11-22	2002-01-29	Allergan Sales, Inc.	Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thichroman and 1,2,3,4-tetrahydroquinolinecarboxlic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity
US5856490A (en)	1995-11-22	1999-01-05	Allergan	Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity
US6320047B1 (en)	1995-11-22	2001-11-20	Allergan Sales, Inc.	Substituted aryl or heteroarylamides having retinoid-like biological activity
US6124455A (en)	1995-11-22	2000-09-26	Allergan Sales, Inc.	Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity
US5917048A (en)	1995-11-22	1999-06-29	Allergan Sales Inc.	Substituted aryl or heteroarylamides having retinoid-like biological activity
US6437129B1 (en)	1995-11-22	2002-08-20	Allergan Sales, Llc	Substituted aryl or heteroarylamides having retinoid-like biological activity
US6245786B1 (en)	1995-11-22	2001-06-12	Allergan Sales, Inc.	Substituted aryl or heteroarylamides having retinoid-like biological activity
US6521624B1 (en)	1996-03-11	2003-02-18	Allergan, Inc.	Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US6187933B1 (en)	1996-06-21	2001-02-13	Allergan Sales, Inc.	O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US6653483B1 (en)	1996-06-21	2003-11-25	Alan T. Johnson	Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US6855832B2 (en)	1996-06-21	2005-02-15	Allergan, Inc.	O- or S-substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US6818775B2 (en)	1996-06-21	2004-11-16	Allergan, Inc.	Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US6720425B2 (en)	1996-06-21	2004-04-13	Allergan, Inc.	Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US6117987A (en)	1996-06-21	2000-09-12	Allergan Sales, Inc.	Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist like biological activity
US6555690B2 (en)	1996-06-21	2003-04-29	Allergan, Inc.	Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US6051731A (en)	1996-06-21	2000-04-18	Allergan Sales, Inc.	O-or S-substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US6465663B2 (en)	1996-06-21	2002-10-15	Allergan, Inc.	O- or S-substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5998655A (en)	1996-06-21	1999-12-07	Vuligonda; Vidyasagar	Alkylidene substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US6087505A (en)	1996-12-12	2000-07-11	Allergan Sales, Inc.	Benzo[1,2-G]-chrom-3-ene, and benzo[1,2-G]-thiochrom-3-ene derivatives
US7166726B2 (en)	1996-12-12	2007-01-23	Allergan, Inc.	Aryl substituted 3,4-dihydroanthracene derivatives having retinoid antagonist or retinoid inverse agonist type biological activity
US5728846A (en)	1996-12-12	1998-03-17	Allergan	Benzo 1,2-g!-chrom-3-ene and benzo 1,2-g!-thiochrom-3-ene derivatives
US6538149B1 (en)	1996-12-12	2003-03-25	Allergan	Aryl or heteroaryl substituted 3,4-dihydroanthracene and aryl or heteroaryl substituted benzo [1,2-g]chrom-3-ene, benzo[1,2-g]-thiochrom-3-ene and benzo [1,2-g]-1,2-dihydroquinoline derivatives having retinoid antagonist or retinoid inverse agonist type biological activity
US5760276A (en)	1997-03-06	1998-06-02	Allergan	Aryl-and heteroarylcyclohexenyl substituted alkenes having retinoid agonist, antagonist or inverse agonist type biological activity
US6225494B1 (en)	1997-04-19	2001-05-01	Allergan Sales, Inc.	Trisubstituted phenyl derivatives having retinoid agonist or inverse agonist type biological activity
US6235923B1 (en)	1997-04-19	2001-05-22	Allergan Sales, Inc.	Trisubstituted phenyl derivatives having retinoid agonist, antagonist or inverse agonist type biological activity
US6037488A (en)	1997-04-19	2000-03-14	Allergan Sales, Inc.	Trisubstituted phenyl derivatives having retinoid agonist, antagonist or inverse agonist type biological activity
US6455701B1 (en)	1997-04-24	2002-09-24	Allergan, Inc.	Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity
US6660755B2 (en)	1997-04-24	2003-12-09	Allergan, Inc.	Substituted diaryl or diheteroaryl methans, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity
US6187950B1 (en)	1997-04-24	2001-02-13	Tae K. Song	Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological
US5919970A (en)	1997-04-24	1999-07-06	Allergan Sales, Inc.	Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity
US6218128B1 (en)	1997-09-12	2001-04-17	Allergan Sales, Inc.	Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities

Also Published As

Publication number	Publication date
HUT43806A (en)	1987-12-28
IT1203954B (en)	1989-02-23
BE1001668A5 (en)	1990-02-06
SE8701933D0 (en)	1987-05-11
IT8720232A0 (en)	1987-04-23
MC1817A1 (en)	1988-03-18
NZ220215A (en)	1990-06-26
IL82448A0 (en)	1987-11-30
FI872027A0 (en)	1987-05-07
ZW6587A1 (en)	1987-12-02
ES2005572A6 (en)	1989-03-16
GB8711205D0 (en)	1987-06-17
GB2190378A (en)	1987-11-18
HU198002B (en)	1989-07-28
FR2598706A1 (en)	1987-11-20
DE3715809A1 (en)	1987-11-19
LU86866A1 (en)	1988-06-13
DK232087D0 (en)	1987-05-06
FR2598706B1 (en)	1990-07-06
NL8701101A (en)	1987-12-01
DK232087A (en)	1987-11-14
SE8701933L (en)	1987-11-14
CN87103524A (en)	1987-12-02
PT84860A (en)	1987-06-01
FI872027A7 (en)	1987-11-14
PT84860B (en)	1990-02-08
FI872027L (en)	1987-11-14
NO871961L (en)	1987-11-16
AU7277987A (en)	1987-11-19
NO871961D0 (en)	1987-05-12

Publication	Publication Date	Title
GB2190378B (en)	1990-11-14	Tetrahydronophthalene derivatives and anti-cancerous compositions containing them
PH24830A (en)	1990-10-30	Indolize compounds and compositions containing them
NZ220345A (en)	1990-10-26	Imidazoquinolinylether derivatives and pharmaceutical compositions containing them
IL82221A0 (en)	1987-10-30	Phenyl-piperazines and pharmaceutical compositions containing them
NZ222980A (en)	1989-11-28	3-aryloxy-3-substituted propanamines and pharmaceutical compositions
NZ223096A (en)	1990-09-26	Peptidylaminodiols and pharmaceutical compositions
NZ220880A (en)	1990-10-26	Di-tert-butyl-phenol derivatives and pharmaceutical compositions
IL72028A0 (en)	1984-10-31	Aminomethyl-oxooxazolidinylbenzene derivatives and pharmaceutical compositions containing them
NZ220879A (en)	1990-08-28	Sunscreen compounds and compositions
IL90067A0 (en)	1989-12-15	1alpha-hydroxyvitamin-d compounds and pharmaceutical compositions containing them
NZ221996A (en)	1989-08-29	Imidazo-pyridine derivatives and pharmaceutical compositions
NZ220171A (en)	1990-05-28	Dihydro-benzopyran derivatives and pharmaceutical compositions
IL74865A0 (en)	1985-07-31	9a-aza-9a-homoerythromycin derivatives and pharmaceutical compositions containing them
IL82205A (en)	1991-05-12	Substituted alkane-sulfonamidophenyl derivatives and pharmaceutical compositions containing them
PH21540A (en)	1987-11-16	Cholecalciferol derivatives and pharmaceutical compositions containing the same
IL76188A (en)	1990-11-29	3-aralkylidene-hydroxy-flavanone derivatives and pharmaceutical compositions containing them
GB8617740D0 (en)	1986-08-28	Compositions of matter
GB8616125D0 (en)	1986-08-06	Compositions of matter
NZ234174A (en)	1992-12-23	Dihydroindenoindole derivatives and compositions containing them
GB2167414B (en)	1989-01-11	Flavolignan derivatives and pharmaceutical compositions containing them
DE3473444D1 (en)	1988-09-22	Acylindole derivatives and pharmaceutical compositions containing them
NZ223051A (en)	1990-06-26	Carbamoyloxylabdane derivatives and pharmaceutical compositions
IL73224A (en)	1988-09-30	2-dioxacycloalkylthiopenem derivatives and pharmaceutical compositions containing them
NZ219748A (en)	1989-05-29	Indenopyrimidines and pharmaceutical compositions
AR243320A1 (en)	1993-08-31	Compositions of matter

Legal Events

Date	Code	Title	Description
1990-10-31	732	Registration of transactions, instruments or events in the register (sect. 32/1977)
1992-01-08	PCNP	Patent ceased through non-payment of renewal fee