GB2182339A - Buffered thickening agents for protective cleansing lotions - Google Patents
Buffered thickening agents for protective cleansing lotions Download PDFInfo
- Publication number
- GB2182339A GB2182339A GB08521484A GB8521484A GB2182339A GB 2182339 A GB2182339 A GB 2182339A GB 08521484 A GB08521484 A GB 08521484A GB 8521484 A GB8521484 A GB 8521484A GB 2182339 A GB2182339 A GB 2182339A
- Authority
- GB
- United Kingdom
- Prior art keywords
- agent
- gum
- lotion
- buffered
- buffer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000006210 lotion Substances 0.000 title claims abstract description 28
- 239000002562 thickening agent Substances 0.000 title claims abstract description 16
- 230000001681 protective effect Effects 0.000 title claims abstract description 13
- 239000000872 buffer Substances 0.000 claims abstract description 12
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000004264 Petrolatum Substances 0.000 claims abstract description 5
- 229940066842 petrolatum Drugs 0.000 claims abstract description 5
- 235000019271 petrolatum Nutrition 0.000 claims abstract description 5
- 239000000230 xanthan gum Substances 0.000 claims abstract description 5
- 235000010493 xanthan gum Nutrition 0.000 claims abstract description 5
- 229920001285 xanthan gum Polymers 0.000 claims abstract description 5
- 229940082509 xanthan gum Drugs 0.000 claims abstract description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract description 3
- 239000003995 emulsifying agent Substances 0.000 claims description 6
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 4
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 4
- 230000008719 thickening Effects 0.000 claims description 3
- 229940072056 alginate Drugs 0.000 claims description 2
- 235000010443 alginic acid Nutrition 0.000 claims description 2
- 229920000615 alginic acid Polymers 0.000 claims description 2
- 229910052783 alkali metal Inorganic materials 0.000 claims description 2
- 210000001124 body fluid Anatomy 0.000 claims description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 150000001340 alkali metals Chemical group 0.000 claims 1
- 239000000376 reactant Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 abstract description 4
- 239000002537 cosmetic Substances 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 2
- 239000000203 mixture Substances 0.000 description 12
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 6
- 238000009472 formulation Methods 0.000 description 6
- 239000003921 oil Substances 0.000 description 6
- 239000003755 preservative agent Substances 0.000 description 5
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 4
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 4
- 239000004166 Lanolin Substances 0.000 description 4
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 4
- 230000003139 buffering effect Effects 0.000 description 4
- 229940039717 lanolin Drugs 0.000 description 4
- 235000019388 lanolin Nutrition 0.000 description 4
- 239000012071 phase Substances 0.000 description 4
- 230000002335 preservative effect Effects 0.000 description 4
- 235000010413 sodium alginate Nutrition 0.000 description 4
- 239000000661 sodium alginate Substances 0.000 description 4
- 229940005550 sodium alginate Drugs 0.000 description 4
- 206010012444 Dermatitis diaper Diseases 0.000 description 3
- 229910021529 ammonia Inorganic materials 0.000 description 3
- 231100000021 irritant Toxicity 0.000 description 3
- 239000002085 irritant Substances 0.000 description 3
- 229920002545 silicone oil Polymers 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 229940075507 glyceryl monostearate Drugs 0.000 description 2
- 238000009775 high-speed stirring Methods 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- 230000000774 hypoallergenic effect Effects 0.000 description 2
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- 239000001587 sorbitan monostearate Substances 0.000 description 2
- 235000011076 sorbitan monostearate Nutrition 0.000 description 2
- 229940035048 sorbitan monostearate Drugs 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 229940099259 vaseline Drugs 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- WSWCOQWTEOXDQX-MQQKCMAXSA-M (E,E)-sorbate Chemical compound C\C=C\C=C\C([O-])=O WSWCOQWTEOXDQX-MQQKCMAXSA-M 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 229920004511 Dow Corning® 200 Fluid Polymers 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- -1 alkali metal alginate Chemical class 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 235000010410 calcium alginate Nutrition 0.000 description 1
- 239000000648 calcium alginate Substances 0.000 description 1
- 229960002681 calcium alginate Drugs 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical class [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- UQEAIHBTYFGYIE-UHFFFAOYSA-N hexamethyldisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)C UQEAIHBTYFGYIE-UHFFFAOYSA-N 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 235000021129 infant diet Nutrition 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 231100000489 sensitizer Toxicity 0.000 description 1
- 229940075554 sorbate Drugs 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000008340 white lotion Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
A buffered thickening agent, for use in cleansing lotions or in topically applied medicaments or cosmetics, comprises a naturally occurring gum, such as a Xanthan gum, and an orthophosphate buffer. The buffer thus acts to increase the viscosity of the gum in use so that higher ionic concentrations can be tolerated without destabilisation of the emulsion when the buffered thickening agent is formed into a lotion. Preferably the buffered agent constitutes 0.5% to 2% by weight of an oil-in-water protective cleansing lotion which may also comprise 10% to 20% by weight of petrolatum.
Description
SPECIFICATION
Protective cleansing lotions and buffered thickening agents for use therewith
The present invention relates to protective cleansing lotions, and particularly to buffered thickening agents for use therewith. Such lotions are of particularvalue in infant care, butofcourse have a wider range of use in medicinal and cosmetic applications.
The use of greasy skin protectives has long been used in infant care to protect an infant's skin, interalia, adjacent the'nappy' area. Vaseline (Registered Trade Mark) is a pharmaceutically acceptable form of Petro latum and is often used forthis purpose, although it suffers the disadvantage that because it is greasy it is unpleasant to use, although moderately effective. Other drying agents such as talcum powder etc. are also used to make an infant's skin as dry as possible in orderto protect against nappy rash etc. butthis is not particularly effective. Both these traditional measures are of limited use since the Vaseline tends to protect, although not really to dense, while powders tend to cleanse but have a limited protective role.
Other attempts at providing combined protective cleansing creams for use in infant care have been tried; one such being available as Milton Milguard. This product acts at the environment of use in partto protectthe skin by means of a protective agent, and in part by the inclusion in the composition of a bufferto maintain the composition at a non-irritant pH of between 6 and 7 and which tends to neutralise the alkaline products present in urine.
Effective buffering of such compositions is dependent upon the amount of ionic concentration which can be present in the composition without destabilising the emulsion. Accordingly, the prior art protective lotions are of limited protective value since although they can physically protect the skin by means of a film there- upon, the power of the buffering system which can be included therein is of a low order.
According to the present invention therefore there is provided a buffered thickening agent for use in a topically applied medicament or cosmetic, said thickening agent comprising a naturally occurring gum and an orthophosphate buffer, wherein the buffer also acts to increase the viscosity of the gum. It will be appreciated that where the buffer also acts to increase the viscosity ofthe gum higher ionic concentrations can be tolerated without destabilisation of the emulsions and hence a greater protective effect is experienced at the environment of use.
The gum is preferably a Xanthan gum which may be used alone or in conjunction with a secondary thicken ing agent which reacts with a bodilyfluid atthesite ofintended use to renderthe same insoluble. Such a secondary thickening agent may be an alkali metal alginate such as sodium alginate. The buffermaybe selected from sodium dihydrogen orthophosphate or di-sodium hydrogen orthophosphate or a mixture thereof. Such a buffer system will maintain the lotion into which it informed at a pH of about6.5.
In another aspect of the invention there is provided an oil-in-water protective cleansing lotion comprising from 10% tp 20% by weight of petrolatum, and from 0.5% to 2% by weight of buffered thickening agent asjust described. Because of the beneficial effect of the thickening, and particularlyXanthan gum, only small amounts of emulsifiers need be used. An acceptable quantity is in the range 0.3%to 1% and preferablyabout 0.6% in total. Such emulsifiers may be selected from monostearates known forthis purpose and particularly glyceryl monostearate and/or sorbitan monostearate.
The oil portion of the oil-in-water phase may in addition to the naturally occurring gum include a hypoallergenic lanolin and/or a high viscosity silicone fluid.
When sodium alginate is used as a secondary thickener, it will be converted to calcium alginatefollowing contact with urine in the nappy area since an infant's diet contains a high proportion of calcium ions. This calcium alginate is of course insoluble in water and hence essentially non-irritant.
The invention will now be described, byway of illustration only, in the following example and accompanying drawing. The accompanying drawing shows a graph indicating the neutralisation of ammonia by a composition in accord with the present invention as compared with that of the prior art.
Example 1.
Acleansing lotion formulation was made upto consistofthefollowing :
Percentage (wiz) Petroleum (Snowhite EC) 14.0
Croda Refined Lanolin Ester 1.0
Dowcoming Silicone oil DC 200m (1000 cps) 1.0
Croda Self-Emulsifyiung glyceryl monstearate (SEGMS) 0.6
Croda Crill 3 (Sorbitan monostearate;
Emulsifier) 0.3 KeltrolF(Kelco) or )Xanthan Gum Primary
May and Baker )thickening agent 0.6
Example 1. (continued) Acleansing lotion formulation was made up to consist ofthefollowing:- Percentage (wiz) Mannucol DM (Kelco; Sodium Alginate) 0.13 (SecondaryThickening Agent)
Sodium dihydrogen orthophosphate (Buffer) 0.2
Di-sodium hydrogen orthophosphate (Buffer) 0.1
Germall 115 (Imidazolidinyl urea;Preservative) 0.55
Postassium Sorbate 0.2
EDTA as di-sodium Salt 0.05
Demineralised water to 100
The formulation was made up as follows:
The water was heated to 60"C and the Mannucol was dispersed and dissolved therein with high speed stirring, followed by dispersion and dissolution ofthe Keltrol F, again at high speed.
Heating was then continued to 75"C. Whilst this aqueous phase was being prepared, the oil phase was mixed in a separate vessel. The petroleum was first heated and melted before the refined lanolin and silicone oil were added with low speed stirring.The Emulsifies (SEGMS and Crill 33) were then dissolved thereinto 60"C. The oil phase was then heated further to 75"C. The oil and water phases were then admixed with high speed stirring in conjunction with high shear mixing such as by a Silvercome mixer.
Air incorporation should be avoided since the lotion has a significant viscosity which increased the op- portunity ofairentrappment.
The preservatives and phosphate salts were then dissolved in water and mixed into the emulsion at400C.
This has a considerable thickening effect.
The lotion was then bottled. The lotion is pseudoplastic and hence will then when pumped.
Properties
Thick white lotion, pH 6.5 viscosity ca 50,000 cps at 0.5 rpm (Brookfield RVT Spindle 5) ca 640 cps at 100 rpm.
Example 2.
Cleansing Lotion and formulation. A cleansing lotion formulation was made up in a similarfashion to
Example 1 and comprised the following ingredients:
Ingredient Percentage (wiz) 1. Petrolatum
(Witco Snowhite EC) 14.0 2. Supersterol ester
(Croda CH 4986) (hypoallergenic lanolin) 1.0 3. Silicone Oil
(Dow Corning 200; 1000cs) 1.0 4. Self-emulsifying glyceryl monostearate
(SeppicSimulsol 165-CheshamChemical) 0.4 5. Sorbitan monstearate (Emulsifier) 0.2
(Croda Crill 3) 6. Xanthan gum (primarythickening agent)
(Kelco Keltrol) 0.6 7. Sodium alginate (secondarythickening
agent) (Kelco Manucol DM) 0.13 8. Sodium dihydrogen orthophosphate (Buffer) 0.20 9. Di-sodium hydrogen orthophosphate (Buffer) 0.12 10. Germail II (Preservative)
(Sutton Labs Inc: Blagden Campbell in UK) 0.30 11. Methyl parahydroxybenzoate (Preservative) 0.1 12. Propyl parahydroxybenzoate (Preservative) 0.1
(Nipa Labs) 13. Water to 100
Final pH = 6.5
Example 3.
The cleansing lotion of Example 2 wastested for neutralisation of ammonia againstthe nearestavailable cleansing lotion currently available, namely Milton Milguard. Results are shown in the accompanying draw ing wherein it will be seen that products in accordance with the present invention has a buffering capacity approximately seven times greaterto a pH of 8than thatofthe prior art.
Itwill also be seen from the formulation of Examples 1 and 2that no humectants are required. Theseare undesirable in that they can tend to dry out the skin in conditions of low humidity. Further, humectants are potential sensitisers and also act to assist skin wash off of the lotion which is precisely the effect which the present invention seeks to avoid.
In accordance with the present invention, therefore, there is provided a lotion which is buffered to a slightly acidic pH which matches the natural pH of the skin thereby to minimise irritation thereof. This natural buffering system also neutralises ammonia which is well known to initiate nappy rash. The lotion made in accord with the present invention does not require solubilising oils which tend to remove the skin's natural protect- ive oils and increase the skin's susceptibility to irritation and infection. Further, because the lotion is thickened with naturally derived gums the need for high concentrations of emulsifiers is reduced whilesatisfactory thickness, i.e. viscosity, is attained. These naturally occurring gums also help to form a barrier to waterborne irritants on the skin and hence further reduce the incidence of nappy rash.
Accordingly, the present invention relates to buffered thickening agents for use generally with lotions for application to the skin, and to specific lotions including such agents.
Claims (9)
1. Abuffered thickening agentforuse in a topically applied medicamentorcosmetic, said thickening agent comprising a naturally occurring gum and an orthophosphate buffer, wherein the buffer also acts to increase the viscosity of the gum.
2. An agent according to claim 1 wherein the gum isa Xanthan gum.
3. An agent according to either of claims 1 or 2 additionally comprising a secondarythickening agent which is adapted to insolubilise reactants in a bodily fluid at an environment of use.
4. An agent according to claim 3 wherein the second thickening agent is an alkali metal alginate.
5. An agent according to any preceding claim wherein the buffer is selected form sodium dihydrogen orthophosphate or di-sodium hydrogen orthophosphate.
6. A bufferthickening agent substantially as hereinbefore described with referenceto Example 1.
7. An oil-in-water protective cleansing lotion comprising from 10% to 20% by weight of petrolatum, and from 0.5% to 2% by weight of a buffered thickening agent as claimed in any one of claims 1 to6.
8. A lotion according to claim 7 comprising a maximum of 1% by weight of emulsifier.
9. A lotion according to claim 7 and substantially as herninbeforn set forth with reference to the foregoing Example.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8521484A GB2182339B (en) | 1985-08-29 | 1985-08-29 | Protective cleansing lotions and buffered thickening agents for use therewith |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8521484A GB2182339B (en) | 1985-08-29 | 1985-08-29 | Protective cleansing lotions and buffered thickening agents for use therewith |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| GB8521484D0 GB8521484D0 (en) | 1985-10-02 |
| GB2182339A true GB2182339A (en) | 1987-05-13 |
| GB2182339B GB2182339B (en) | 1989-08-09 |
Family
ID=10584422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8521484A Expired GB2182339B (en) | 1985-08-29 | 1985-08-29 | Protective cleansing lotions and buffered thickening agents for use therewith |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2182339B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6083890A (en) * | 1996-06-06 | 2000-07-04 | Monsanto Company | Acidic cleaning compositions containing low acetate xanthan gum |
| WO2002098372A1 (en) | 2001-06-01 | 2002-12-12 | Masaya Tanaka | Acidic composition for external use and agent for accelerating infiltration of cosmetic preparation, hair-growing agent, and preparation for external use each containing the composition into skin or the like |
| ITTO20090259A1 (en) * | 2009-04-03 | 2010-10-04 | Rottapharm Spa | COMPOSITION FOR INTIMATE HYGIENE |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB355130A (en) * | 1929-11-12 | 1931-08-20 | Fruit Growers Exchange Ca | Product for and method of jelly preparation |
| GB741990A (en) * | 1952-03-31 | 1955-12-14 | Alginate Ind Ltd | Improvements in or relating to the manufacture of alginic products |
| GB998635A (en) * | 1962-12-13 | 1965-07-21 | Kelco Co | Algin gel compositions and method |
| GB1390811A (en) * | 1971-04-26 | 1975-04-16 | Eastman Kodak Co | Lithographic plate desesitizer |
| GB1508902A (en) * | 1975-05-07 | 1978-04-26 | Sucrest Corp | Composition for use in forming tablets |
| GB1546647A (en) * | 1975-10-31 | 1979-05-31 | Hayashibara Biochem Lab | Protective coating material for lithographic printing plate |
| GB1557254A (en) * | 1977-06-18 | 1979-12-05 | Beiersdorf Ag | Electric ally conductive visco-elastic gel |
| GB2151245A (en) * | 1983-11-02 | 1985-07-17 | G C Dental Ind Corp | Low dusting powdery alginate impression material for dental use |
-
1985
- 1985-08-29 GB GB8521484A patent/GB2182339B/en not_active Expired
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB355130A (en) * | 1929-11-12 | 1931-08-20 | Fruit Growers Exchange Ca | Product for and method of jelly preparation |
| GB741990A (en) * | 1952-03-31 | 1955-12-14 | Alginate Ind Ltd | Improvements in or relating to the manufacture of alginic products |
| GB998635A (en) * | 1962-12-13 | 1965-07-21 | Kelco Co | Algin gel compositions and method |
| GB1390811A (en) * | 1971-04-26 | 1975-04-16 | Eastman Kodak Co | Lithographic plate desesitizer |
| GB1508902A (en) * | 1975-05-07 | 1978-04-26 | Sucrest Corp | Composition for use in forming tablets |
| GB1546647A (en) * | 1975-10-31 | 1979-05-31 | Hayashibara Biochem Lab | Protective coating material for lithographic printing plate |
| GB1557254A (en) * | 1977-06-18 | 1979-12-05 | Beiersdorf Ag | Electric ally conductive visco-elastic gel |
| GB2151245A (en) * | 1983-11-02 | 1985-07-17 | G C Dental Ind Corp | Low dusting powdery alginate impression material for dental use |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6083890A (en) * | 1996-06-06 | 2000-07-04 | Monsanto Company | Acidic cleaning compositions containing low acetate xanthan gum |
| WO2002098372A1 (en) | 2001-06-01 | 2002-12-12 | Masaya Tanaka | Acidic composition for external use and agent for accelerating infiltration of cosmetic preparation, hair-growing agent, and preparation for external use each containing the composition into skin or the like |
| EP1402874A4 (en) * | 2001-06-01 | 2005-10-19 | Masaya Tanaka | Acidic composition for external use and agent for accelerating infiltration of cosmetic preparation, hair-growing agent, and preparation for external use each containing the composition into skin or the like |
| KR100945971B1 (en) * | 2001-06-01 | 2010-03-09 | 네오케미아 가부시키가이샤 | Acidic external composition and penetration accelerator for cosmetics, hair growth agents, skin for external use, etc. containing the same |
| US8153143B2 (en) | 2001-06-01 | 2012-04-10 | Neochemir Inc. | Acidic compositon for external use and agent for accelerating infiltration of cosmetic preparation, hair-growing agent, and preparation for external use each containing the composition into skin or the like |
| US8778388B2 (en) | 2001-06-01 | 2014-07-15 | Neochemir Inc. | Acidic carrageenan composition for external use |
| ITTO20090259A1 (en) * | 2009-04-03 | 2010-10-04 | Rottapharm Spa | COMPOSITION FOR INTIMATE HYGIENE |
| EP2236127A1 (en) * | 2009-04-03 | 2010-10-06 | Rottapharm S.p.A. | A composition for intimate hygiene |
Also Published As
| Publication number | Publication date |
|---|---|
| GB8521484D0 (en) | 1985-10-02 |
| GB2182339B (en) | 1989-08-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA1322532C (en) | Trehalose containing cosmetic composition and method of using it | |
| EP0150914B1 (en) | Skin treatment composition | |
| US6103245A (en) | Topical barrier composition containing silicone and bentonite | |
| US5728391A (en) | Hyaluronic acid and its salt for treating skin diseases | |
| US6582709B1 (en) | Cream composition comprising Dead Sea Mud | |
| US4956173A (en) | Composition and use of ademetionine against ageing of the skin | |
| JPH09511763A (en) | Stable water-in-oil emulsion system | |
| GB2130486A (en) | Anti-acne compositions based on benzoyl peroxide | |
| NZ228563A (en) | Skin care composition comprising an oil phase containing a non-ionic surfactant and an aqueous phase containing a thickening agent; preparation thereof | |
| US5137718A (en) | Infection fighting composition for topical application | |
| PT89624B (en) | PREPARATION PROCESS OF A COMPOSITION UNDER THE FORM OF OIL EMULSION IN WATER | |
| BR112017012806B1 (en) | soluble zinc polyphosphate complex and zinc polyphosphate production method | |
| JP3776139B2 (en) | Topical skin preparation | |
| JPH0380123B2 (en) | ||
| JP4070065B2 (en) | Skin preparation for preventing and improving skin roughness | |
| BR112017012805B1 (en) | soluble zinc polyphosphate complex and zinc polyphosphate production method | |
| US5959019A (en) | Topical tale containing compositions | |
| JP2549119B2 (en) | Topical | |
| US5482714A (en) | Water impermeable skin protectant based upon reverse water emulsion | |
| BR112017012807B1 (en) | COMPOSITION FOR ORAL HYGIENE AND USE OF A SOLUBLE ZINC POLYPHOSPHATE COMPLEX IN THE PREPARATION OF THE SAME | |
| EP4173612B1 (en) | Compositions suitable for use in skin care | |
| GB2182339A (en) | Buffered thickening agents for protective cleansing lotions | |
| JP3360175B2 (en) | Cosmetic or pharmaceutical composition in the form of a hard gel, especially for containing inclusions therein | |
| BR112017013008B1 (en) | personal hygiene compositions with active zinc phosphate and method for depositing zinc on an individual's skin and / or hair | |
| BR112017012809B1 (en) | COMPOSITION FOR ORAL HYGIENE AND USE OF A SOLUBLE ZINC POLYPHOSPHATE COMPLEX IN THE PREPARATION OF THE SAME |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |