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GB2181351A - Disinfectant compositions - Google Patents

Disinfectant compositions Download PDF

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Publication number
GB2181351A
GB2181351A GB08600663A GB8600663A GB2181351A GB 2181351 A GB2181351 A GB 2181351A GB 08600663 A GB08600663 A GB 08600663A GB 8600663 A GB8600663 A GB 8600663A GB 2181351 A GB2181351 A GB 2181351A
Authority
GB
United Kingdom
Prior art keywords
composition
thymol
glycol
water
monobutyl ether
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB08600663A
Other versions
GB2181351B (en
GB8600663D0 (en
Inventor
Roger Hengy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STERLING SA
Original Assignee
STERLING SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by STERLING SA filed Critical STERLING SA
Publication of GB8600663D0 publication Critical patent/GB8600663D0/en
Publication of GB2181351A publication Critical patent/GB2181351A/en
Application granted granted Critical
Publication of GB2181351B publication Critical patent/GB2181351B/en
Expired legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00Disinfection, sterilisation or deodorisation of air
    • A61L9/14Disinfection, sterilisation or deodorisation of air using sprayed or atomised substances including air-liquid contact processes
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/08Oxygen or sulfur directly attached to an aromatic ring system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/22Phase substances, e.g. smokes, aerosols or sprayed or atomised substances

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Materials For Medical Uses (AREA)
  • External Artificial Organs (AREA)

Abstract

A composition designed to disinfect surfaces by aerosol dispersion in surrounding air contains, as active components, firstly a methyl-isopropylphenol (e.g. thymol) and secondly a glycol alkyl ether (e.g. ethylene glycol monobutyl ether), dissolved in water.

Description

SPECIFICATION Disinfectant Compositions This invention concerns new compositions designed to be used to disinfect surfaces by air method.
Such compositions are known, as to their principle, and used at present in various aerosol generator appliances such as those described by the Applicant in his French Patents 1.568.295, 75.02188,75.18474, 76.36270 and 77.12479.
Until now compositions of this type basically contain formol as active component, the other components in the compositions only playing a secondary part, their proportion being insufficient for them to exercise any specific action, at least to any appreciable degree.
The recent developments of studies on the dangers offered by formol in various medical areas have incited the Applicant to seek a new composition in which formol no longer figured, but which would nevertheless exercise a satisfactory disinfecting action, if not even better.
The Applicant's research has therefore led him to the surprising observation that this result could be obtained via the combination, in given proportions of several components, themselves known, but which do not possess individually the qualities required for this use.
The first embodiment of the composition according to the invention is selected from the class of methyl-isopropylphenols, such as 5-methyl-2-isopropyl-phenol, or m-thymol, 2-methyl-5-isopropyl-phenol, or carvacrol (or isothymol), or their chlorine derivatives. The preferred member of this group is the m4hymol, and in the rest of this text it will be referred to under the name of "thymol".
The second embodiment of the composition according to the invention is selected from the class of glycol alkyl ethers, such as the monobutyl ether of ethylene glycol or the diethylene glycol ethyl ether. The preferred member of this group is the ethylene glycol monobutyl ether, well known under the trade name of "Butyl Cellosolve" and which will be referred to in the rest of this text under the simplified name of "butyl glycol".
The third embodiment of the compositions according to the invention is water.
If we now consider each of these three components, the following observations can be made: Thymol has been known for a long time amongst products of a natural origin as cleaning agent, for its destructive action on fungus and vegetable parasites. In this respect it has been proposed by chemists as ointment and in an alcoholic solution as contact disinfectant. Owing to the fact that it is not water-soluble, no preparation designed for disinfection by air method only containing thymol as basic ingredient has been proposed until now.
Butyl glycol is also known, but only as solvent without any bactericidal action having been indicated. Its role in the compositions according to the invention is a multiple one: - In the first place it has the effect of solubilizing thymol.
- In the second place experience has shown that it itself shows a certain bactericidal action, but fairly low.
- In the third place experience shows surprisingly that this bactericidal action is notably increased by the presence of thymol.
Finally water is indispensable for the compositions according to the invention, to enable the aerosol formation appliance to diffuse the solution, in the form of sufficiently fine particles to deposit extremely slowly, notably on the upper parts of partitions, and to cross through porous obstacles, such as blankets.
The presence of the right portion of water ensures the provision, in the room to be disinfected, of the rate of relative humidity most favorable to the disinfecting action, of around at least 6070% at 20"C.
The relative proportions of the three components in the compositions according to the invention are defined by the respective part played by the said components: Thymol becomes ineffective below 01 % in weight, and makes the atmosphere difficult to breathe around 5%. In practice its optimum proportion is around 0.75 to 1%.
butyl glycol does not assume its solubilizing role any longer below about 5%, and exercises unacceptable stripping action beyond 30%. In practice its optimum proportion is around 20%.
water normally makes up the restto 100%.
- Finally, according to an alternative version coming within the scope of the invention, a part of the butyl glycol can be replaced by 2-methyl-2,4-pentane-diol (or hexylene glycol), acting both as co-solvent and stabilizing agent.
To take a nonexhaustive example, a composition entering into the scope of the invention will contain, in percentage of weight: Thymol 0.75 Butyl glycol 20 Hexylene Glycol 8 Water (demineralized) 71.25 This composition is obtained by cold dissolving thymol in butyl glycol then, after adding the hexylene glycol, entering the water and stirring. A colorless slightly opalescent liquid is obtained, density d,,.=0.9867--0.9877, refractive index n2OO=1.36601.3670, being preserved without loss of activity for several years.
This composition is used as it is in an aerosol generator as indicated above, with a dose of around 20 ml/m3 of volume of air to be treated, for about 4 hours. An essential advantage of this composition is that the room can be reoccupied after only 30 minutes airing, instead of the well known difficulties which remain after using formol based compositions.
The bactericidal efficiency tests, performed in accordance with French standard T-72-281 on the following microorganisms stocks: Bacterial Stocks - Streptococcus faecalis CNCM 5855 - Staphylococcus aureus-Oxford Stock CNCM 53/54 - Pseudomonas aeruginosa CNCM A 22 - Escherichia coli CNCM 54127.
Fungus Stock - Penicillium verrucosum Var-Cyclopium CNCM 118679.
Yeast Stock - Candida albicans CNCM 1180--79.
have established a bactericidal action equal to or greater than 5 on the bacterial stocks and yeast stocks and equal to or greater than 4 on the fungus stocks (action expressed in decimal Logs).
The relative humidity of the test room which should be at least 60--70"C at the end of the operation, was obtained by diffusing the product itself, owing to its high water content. Experience has shown that the diffusion of 17 g/m3 of the composition according to the invention increases the relative humidity of a room from 45 to 82%.
As an illustration for the phenomenon of potentialization of the bactericidal action of butyl glycol by thymol, it can be indicated that, in identical experimental conditions (10.7 g/m34 hours contact) a 40% aqueous solution of butyl glycol alone and the composition according to the invention respectively produced the following effects, expressed in decimal Logs: : Colibacteria Staphylococci Streptococci Composition according to the invention 5.0 5.0 5.0 Butyl glycol solution alone 1.21 0.33 0.42 These various results clearly show that the compositions according to the invention develop a surface disinfecting action by air method at least as satisfactory as those of the former compositions containing formol, whilst removing their drawbacks, and that this action should be attributed to a potentialization of effects, some of which have moreover not yet been observed owing to their small share in the components of these compositions.

Claims (21)

1. A composition for use in disinfection by aerosol dispersion comprising as active components in aqueous solution a methyl-isopropylphenol and a glycol alkyl ether.
2. A composition as claimed in Claim 1, wherein the methyl-isopropylphenol is m-thymol.
3. A composition as claimed in Claim 1 or Claim 2 wherein the glycol alkyl ether is ethylene glycol monobutyl ether.
4. A composition as claimed in Claim 3 comprising from 0.1 to 5% of m-thymol.
5. A composition as claimed in Claim 4 comprising from 0.5 to 0.75% by weight of m4hymol.
6. A composition as claimed in Claim 4 or Claim 5, comprising from 5 to 30% of ethylene glycol monobutyl ether.
7. A composition as claimed in Claim 6 comprising about 20% of ethylene glycol monobutyl ether.
8. A composition as claimed in Claim 4 or Claim 5 comprising from 5 to 30% in aggregate of hexylene glycol and ethylene glycol monobutyl ether.
9. A composition as claimed in any one of Claims 6 to 8 wherein the balance of the composition is water.
10. A composition as claimed in Claim 1 consisting essentially of:- % by Weight m-thymol 0.75 ethylene glycol monobutyl ether 20 hexylene glycol 8 Water 71.25
11. A composition for use in disinfection by aerosol dispersion substantially as hereinbefore described in the example.
12. A method for disinfecting surfaces comprising difusing a composition as claimed in any preceding claim in aerosol form in air in contact with the surfaces.
13. A method as claimed in Claim 12, wherein the composition is dispersed at a rate of about 200 ml/m3 of air.
14. A method of disinfecting substantially as hereinbefore described in the non-comparative run of the Example.
15. Composition designed to disinfect surfaces by air method, characterized in that it contains as active components, firstly a methyl-isopropylphenol and secondly a glycol alkyl ether, and that the said components are dissolved in water.
16. Composition as claimed in Claim 15, characterized in that the methyl-isopropylphenol is m-thymol and that the glycol alkyl ether is the ethylene glycol monobutyl ether or "butyl glycol".
17. Composition as claimed in Claims 15 and 16, characterized in that the proportion in weight of m-thymol is 0.1 to 5%, and preferably around 0.50.75%, and the proportion in weight of the butyl glycol is 5 to 30%, and preferably around 20%, the rest of the composition consisting of water.
18. Composition as claimed in Claim 17, characterized in that a portion of butyl glycol is replaced by hexylene glycol.
19. Composition as claimed in any one of Claims 15 to 18, characterized in that it contains, in percentage of weight: Thymol 0.75 Butyl glycol 20 Hexylene glycol 8 Water (demineralized) 71.25
20. Application of the composition as claimed in any one of Claims 15 to 19 to the disinfection of surfaces, by diffusion of the said composition in aerosol form in the area to be treated.
21. Application as claimed in Claim 20, characterized in that the composition is diffused in aerosol form at a rate of around 200 ml/m3 of air to be disinfected.
GB8600663A 1985-10-07 1986-01-13 Disinfectant compositions Expired GB2181351B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8514906A FR2588264B1 (en) 1985-10-07 1985-10-07 DISINFECTANT COMPOSITION FOR AIRWAY

Publications (3)

Publication Number Publication Date
GB8600663D0 GB8600663D0 (en) 1986-02-19
GB2181351A true GB2181351A (en) 1987-04-23
GB2181351B GB2181351B (en) 1989-10-11

Family

ID=9323641

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8600663A Expired GB2181351B (en) 1985-10-07 1986-01-13 Disinfectant compositions

Country Status (16)

Country Link
BE (1) BE903664A (en)
CH (1) CH667206A5 (en)
DE (1) DE3541814A1 (en)
DK (1) DK9686A (en)
ES (1) ES2002028A6 (en)
FR (1) FR2588264B1 (en)
GB (1) GB2181351B (en)
GR (1) GR860121B (en)
IT (1) IT1186767B (en)
LU (1) LU86166A1 (en)
MA (1) MA20633A1 (en)
MC (1) MC1745A1 (en)
NO (1) NO860060L (en)
PT (1) PT81864B (en)
SE (1) SE8604230L (en)
TN (1) TNSN86034A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2818151A1 (en) * 2000-12-14 2002-06-21 Prod Berger ANTI-BACTERIAL COMPOSITION FOR DISSEMINATION TO FIGHT AGAINST BACTERIA CONTAINED IN AIR, METHOD FOR THE DISSEMINATION OF SUCH A COMPOSITION
EP1228689A1 (en) * 2001-01-31 2002-08-07 B.B.& M.T.ITALIA S.a.s. Di Bergomi Maurizio New formulations for the sanitisation and hygienisation of houses
EP1487504A4 (en) * 2002-02-19 2010-09-01 Eden Research Plc Improvement of indoor air quality and antiseptic composition for use therein
EP2209381A4 (en) * 2007-09-19 2013-12-25 Xy Llc DIFFERENTIAL EVAPORATING REINFORCED DISINFECTANT SYSTEM
US9474814B2 (en) 2007-09-19 2016-10-25 Xy, Llc Differential evaporation potentiated disinfectant system

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1134918A (en) * 1954-09-01 1957-04-19 Hoechst Ag Disinfection of rooms with volatile substances in aerosol form
US3287214A (en) * 1964-07-20 1966-11-22 Sterling Drug Inc Surface disinfectant and space deodorant aerosol spray compositions
IL28896A (en) * 1967-08-28 1972-01-27 Vineland Labor Inc Disinfectant composition comprising formaldehyde benzalkonium or benzethonium halide and a cresol derrivative
US3787566A (en) * 1969-07-29 1974-01-22 Holliston Labor Inc Disinfecting aerosol compositions
FR2181606B1 (en) * 1972-04-27 1975-10-31 Perrin Robert

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2818151A1 (en) * 2000-12-14 2002-06-21 Prod Berger ANTI-BACTERIAL COMPOSITION FOR DISSEMINATION TO FIGHT AGAINST BACTERIA CONTAINED IN AIR, METHOD FOR THE DISSEMINATION OF SUCH A COMPOSITION
EP1214948A3 (en) * 2000-12-14 2003-01-02 Produits Berger Antibacterial composition for controlling airborne bacteria and corresponding procedure
US6814929B2 (en) 2000-12-14 2004-11-09 Produits Berger Antibacterial composition for diffusing to combat bacteria contained in the air, a method of diffusing such a composition
EP1228689A1 (en) * 2001-01-31 2002-08-07 B.B.& M.T.ITALIA S.a.s. Di Bergomi Maurizio New formulations for the sanitisation and hygienisation of houses
EP1487504A4 (en) * 2002-02-19 2010-09-01 Eden Research Plc Improvement of indoor air quality and antiseptic composition for use therein
EP2209381A4 (en) * 2007-09-19 2013-12-25 Xy Llc DIFFERENTIAL EVAPORATING REINFORCED DISINFECTANT SYSTEM
US9474814B2 (en) 2007-09-19 2016-10-25 Xy, Llc Differential evaporation potentiated disinfectant system

Also Published As

Publication number Publication date
GR860121B (en) 1986-05-19
NO860060L (en) 1987-04-08
TNSN86034A1 (en) 1990-01-01
ES2002028A6 (en) 1988-07-01
IT8522963A0 (en) 1985-11-22
MA20633A1 (en) 1986-10-01
SE8604230D0 (en) 1986-10-06
DK9686A (en) 1987-04-08
FR2588264B1 (en) 1987-11-27
GB2181351B (en) 1989-10-11
IT1186767B (en) 1987-12-16
LU86166A1 (en) 1986-03-24
GB8600663D0 (en) 1986-02-19
PT81864A (en) 1986-02-01
MC1745A1 (en) 1987-02-26
DE3541814A1 (en) 1987-04-09
BE903664A (en) 1986-03-14
DK9686D0 (en) 1986-01-09
SE8604230L (en) 1987-04-08
PT81864B (en) 1988-05-27
FR2588264A1 (en) 1987-04-10
CH667206A5 (en) 1988-09-30

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Legal Events

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PCNP Patent ceased through non-payment of renewal fee

Effective date: 19970113