GB2179655B - Angiotensin converting enzyme inhibiting compounds - Google Patents

Angiotensin converting enzyme inhibiting compounds

Info

Publication number: GB2179655B
Authority: GB; United Kingdom
Prior art keywords: converting enzyme; angiotensin converting; inhibiting compounds; enzyme inhibiting; compounds
Prior art date: 1985-08-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

GB8619943A

Other versions

GB2179655A (en

GB8619943D0 (en

Inventor

Roger Charles Brown

John Dixon

David Hulme Robinson

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Fisons Ltd

Original Assignee

Fisons Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-08-31

Filing date

1986-08-15

Publication date

1989-08-09

1985-08-31 Priority claimed from GB858521697A external-priority patent/GB8521697D0/en

1985-10-09 Priority claimed from GB858524932A external-priority patent/GB8524932D0/en

1985-12-06 Priority claimed from GB858530143A external-priority patent/GB8530143D0/en

1986-04-22 Priority claimed from GB868609793A external-priority patent/GB8609793D0/en

1986-05-17 Priority claimed from GB868612060A external-priority patent/GB8612060D0/en

1986-08-15 Priority to GB8619943A priority Critical patent/GB2179655B/en

1986-08-15 Application filed by Fisons Ltd filed Critical Fisons Ltd

1986-08-28 Priority to IT8621546A priority patent/IT1235489B/en

1986-09-24 Publication of GB8619943D0 publication Critical patent/GB8619943D0/en

1987-02-09 Priority claimed from SU874202059A external-priority patent/RU1804458C/en

1987-03-11 Publication of GB2179655A publication Critical patent/GB2179655A/en

1989-08-09 Publication of GB2179655B publication Critical patent/GB2179655B/en

1989-08-09 Application granted granted Critical

Status Expired legal-status Critical Current

Links

UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 title 1
102000004270 Peptidyl-Dipeptidase A Human genes 0.000 title 1
108090000882 Peptidyl-Dipeptidase A Proteins 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pyrrole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

GB8619943A 1985-08-31 1986-08-15 Angiotensin converting enzyme inhibiting compounds Expired GB2179655B (en)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
GB8619943A GB2179655B (en)	1985-08-31	1986-08-15	Angiotensin converting enzyme inhibiting compounds
IT8621546A IT1235489B (en)	1985-08-31	1986-08-28	Angiotensin converting enzyme inhibiting cpds.

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
GB858521697A GB8521697D0 (en)	1985-08-31	1985-08-31	Nitrogen & sulphur heterocycles
GB858524932A GB8524932D0 (en)	1985-10-09	1985-10-09	Nitrogen & sulphur heterocycles
GB858530143A GB8530143D0 (en)	1985-12-06	1985-12-06	Nitrogen
GB868609793A GB8609793D0 (en)	1986-04-22	1986-04-22	Nitrogen containing heterocycles
GB868612060A GB8612060D0 (en)	1986-05-17	1986-05-17	Nitrogen containing heterocycles
GB8619943A GB2179655B (en)	1985-08-31	1986-08-15	Angiotensin converting enzyme inhibiting compounds
SU874202059A RU1804458C (en)	1985-08-31	1987-02-09	Method of 1,3,4 -thiadiazole -2- carboxylic acid derivatives or theirs pharmaceutically acceptable salts, esters or amides synthesis

Publications (3)

Publication Number	Publication Date
GB8619943D0 GB8619943D0 (en)	1986-09-24
GB2179655A GB2179655A (en)	1987-03-11
GB2179655B true GB2179655B (en)	1989-08-09

Family

ID=27562736

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GB8619943A Expired GB2179655B (en)	1985-08-31	1986-08-15	Angiotensin converting enzyme inhibiting compounds

Country Status (2)

Country	Link
GB (1)	GB2179655B (en)
IT (1)	IT1235489B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NO178294C (en) *	1989-07-24	1996-02-28	Wiggins Teape Group Ltd	Process for producing an air-permeable sheet of fiberglass-reinforced thermoplastic material

1986
- 1986-08-15 GB GB8619943A patent/GB2179655B/en not_active Expired
- 1986-08-28 IT IT8621546A patent/IT1235489B/en active

Also Published As

Publication number	Publication date
IT1235489B (en)	1992-09-04
IT8621546A0 (en)	1986-08-28
GB2179655A (en)	1987-03-11
GB8619943D0 (en)	1986-09-24

Publication	Publication Date	Title
ZA863660B (en)	1986-12-30	Sealing compound
GB8501999D0 (en)	1985-02-27	Compounds
GB8507942D0 (en)	1985-05-01	Compounds
GB8505285D0 (en)	1985-04-03	Compounds
GB2178740B (en)	1989-08-23	Alkylcarbamoyloxymethylcephem compounds
IE861526L (en)	1986-12-10	1-hydroxyvitamin d compounds
DE3661478D1 (en)	1989-01-26	Novel enzyme inhibiting substance
GB2203433B (en)	1989-09-20	Trizinyl compounds
EP0199465A3 (en)	1987-09-02	Cyanoalkanimidamido compounds
GB2169897B (en)	1988-09-01	5- halopyridine-3-carboxamide compounds
GB8522849D0 (en)	1985-10-23	Direct conversion receiver
GB2170200B (en)	1988-07-20	Acylaminoalkanoyl compounds
ZA873984B (en)	1987-12-01	Substituted aminoalkanoylaminoalkyl phosphonate angiotesin converting enzyme inhibitors
GB2179655B (en)	1989-08-09	Angiotensin converting enzyme inhibiting compounds
JPS6475458A (en)	1989-03-22	Perfluoroalkylnaphthalene compound
GB2183236B (en)	1989-04-12	Carbamoyloxymethylalkylcarbapenem compounds
GB8621702D0 (en)	1986-10-15	Enzyme
GB8503358D0 (en)	1985-03-13	Compounds
GB2173099B (en)	1988-12-21	Covers
GR860973B (en)	1986-08-12	Tightening object
GB2175586B (en)	1988-12-14	Mycotrienin-related compounds
GR861809B (en)	1986-11-30	Waterproofing compound
GB8506642D0 (en)	1985-04-17	Compounds
GB8502690D0 (en)	1985-03-06	Compounds
ZA827665B (en)	1984-06-27	Angiotensin converting enzyme inhibitor compound

Legal Events

Date	Code	Title	Description
1998-04-08	PCNP	Patent ceased through non-payment of renewal fee	Effective date: 19970815