GB2179042B - A process of producing ginsenoside-rd - Google Patents

A process of producing ginsenoside-rd

Info

Publication number: GB2179042B
Authority: GB; United Kingdom
Prior art keywords: producing ginsenoside; ginsenoside; producing
Prior art date: 1985-07-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

GB08617616A

Other versions

GB2179042A (en

GB8617616D0 (en

Inventor

Haruji Oshio

Masaaki Kuwahara

Takeya Komiya

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Takeda Pharmaceutical Co Ltd

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-07-22

Filing date

1986-07-18

Publication date

1988-11-23

1986-07-18 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

1986-08-28 Publication of GB8617616D0 publication Critical patent/GB8617616D0/en

1987-02-25 Publication of GB2179042A publication Critical patent/GB2179042A/en

1988-11-23 Application granted granted Critical

1988-11-23 Publication of GB2179042B publication Critical patent/GB2179042B/en

Status Expired legal-status Critical Current

Links

FBFMBWCLBGQEBU-RXMALORBSA-N (2s,3r,4s,5s,6r)-2-[(2r,3r,4s,5s,6r)-2-[[(3s,5r,6s,8r,9r,10r,12r,13r,14r,17s)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-[(2s)-6-methyl-2-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhept-5-en-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecah Chemical compound O([C@@](C)(CCC=C(C)C)[C@@H]1[C@@H]2[C@@]([C@@]3(C[C@@H]([C@H]4C(C)(C)[C@@H](O)CC[C@]4(C)[C@H]3C[C@H]2O)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)C)(C)CC1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O FBFMBWCLBGQEBU-RXMALORBSA-N 0.000 title 1
FBFMBWCLBGQEBU-GYMUUCMZSA-N 20-gluco-ginsenoside-Rf Natural products O([C@](CC/C=C(\C)/C)(C)[C@@H]1[C@H]2[C@H](O)C[C@H]3[C@](C)([C@]2(C)CC1)C[C@H](O[C@@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)[C@@H](O)[C@H](O)[C@@H](CO)O1)[C@H]1C(C)(C)[C@@H](O)CC[C@]31C)[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 FBFMBWCLBGQEBU-GYMUUCMZSA-N 0.000 title 1
HYPFYJBWSTXDAS-UHFFFAOYSA-N Ginsenoside Rd Natural products CC(=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C4CCC5C(C)(C)C(CCC5(C)C4CC(O)C23C)OC6OC(CO)C(O)C(O)C6OC7OC(CO)C(O)C(O)C7O)C HYPFYJBWSTXDAS-UHFFFAOYSA-N 0.000 title 1
UOJAEODBOCLNBU-UHFFFAOYSA-N vinaginsenoside R4 Natural products C1CC(C2(CC(O)C3C(C)(C)C(OC4C(C(O)C(O)C(CO)O4)OC4C(C(O)C(O)C(CO)O4)O)CCC3(C)C2CC2O)C)(C)C2C1C(C)(CCC=C(C)C)OC1OC(CO)C(O)C(O)C1O UOJAEODBOCLNBU-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J17/005—Glycosides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Steroid Compounds (AREA)

GB08617616A 1985-07-22 1986-07-18 A process of producing ginsenoside-rd Expired GB2179042B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP16226885		1985-07-22
JP5434186		1986-03-11

Publications (3)

Publication Number	Publication Date
GB8617616D0 GB8617616D0 (en)	1986-08-28
GB2179042A GB2179042A (en)	1987-02-25
GB2179042B true GB2179042B (en)	1988-11-23

Family

ID=26395096

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GB08617616A Expired GB2179042B (en)	1985-07-22	1986-07-18	A process of producing ginsenoside-rd

Country Status (3)

Country	Link
KR (1)	KR870001227A (en)
CN (1)	CN86105166A (en)
GB (1)	GB2179042B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1092203C (en) *	1998-07-22	2002-10-09	北京鑫利恒医药科技发展有限公司	Process for extracting ginsenoside Re, and use of medicine thereof
CN1092204C (en) *	1998-07-28	2002-10-09	吉林大学基础医学院科技开发中心	20(S) - Semi-synthetic method of ginsenoside Rg3 and its medicinal application
CN1105781C (en) *	1999-03-17	2003-04-16	金凤燮	Method for preparing rare ginsengoside using enzymatic method to modify ginsenoside glycoside
CN1302811A (en) *	2000-01-03	2001-07-11	广东泰禾生物药业有限公司	Compound (I), extraction process and its application in preparing medicine to cure acute ischemic cerebrovascular disease
CN1479787B (en) *	2000-12-29	2013-07-10	金凤燮	Ginsenoside glycosidase for hydrolyzing ginsenoside glycosyl and its application
DE10158281A1 (en) *	2001-11-19	2003-05-28	Mediwirk Gmbh	Pharmaceutical preparation comprises ginsenoside enclosed in micro-shell, e.g. liposome, providing targeted and controlled delivery, useful e.g. in treatment of liver tumors, diabetes mellitus or hypertension
KR100479803B1 (en) *	2002-04-08	2005-03-30	홍림통산(주)	Composition containing an extract of specially treated ginseng for preventing brain cells and treating brain stroke
CN101333549B (en) *	2008-03-04	2011-08-24	常景玲	Method for directly transforming active dry yeast to be ginsenoside
CN101619340B (en) *	2009-08-13	2012-06-13	安徽农业大学	Method for preparing saponins compounds by fermenting and culturing gen-seng fruits
CN101768619A (en) *	2010-02-10	2010-07-07	华侨大学	Method for preparing rare ginsenoside IH-901 with Rd as substrate
KR100992800B1 (en) *	2010-05-14	2010-11-08	주식회사 지씨에이치앤피	A process for preparing novel processed ginseng or extract thereof showing increased amount of minor ginsenosides
CN103525892A (en) *	2013-09-20	2014-01-22	吉林大学	Method for quickly preparing rare panaxoside Rd
CN105199966B (en) *	2015-08-28	2018-08-17	天津大学	A kind of conversion ginsenoside Rb1 produces aspergillus and the application of Rd
CN112646737B (en) *	2021-01-22	2022-04-19	宁夏农产品质量标准与检测技术研究所(宁夏农产品质量监测中心)	Cryptococcus albidus strain YN14 capable of producing aroma substances at high yield and application thereof
CN115368425B (en) *	2021-08-06	2023-07-18	遵义医科大学	Triterpenes, preparation method and anti-inflammatory application thereof

1986
- 1986-07-18 GB GB08617616A patent/GB2179042B/en not_active Expired
- 1986-07-22 CN CN198686105166A patent/CN86105166A/en active Pending
- 1986-07-22 KR KR1019860005959A patent/KR870001227A/en not_active Ceased

Also Published As

Publication number	Publication date
GB2179042A (en)	1987-02-25
GB8617616D0 (en)	1986-08-28
CN86105166A (en)	1987-03-04
KR870001227A (en)	1987-03-12

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Legal Events

Date	Code	Title	Description
1997-03-12	PCNP	Patent ceased through non-payment of renewal fee	Effective date: 19960718