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GB2161805B - Benzylpyrimidine synthesis and intermediates - Google Patents

Benzylpyrimidine synthesis and intermediates

Info

Publication number
GB2161805B
GB2161805B GB08515931A GB8515931A GB2161805B GB 2161805 B GB2161805 B GB 2161805B GB 08515931 A GB08515931 A GB 08515931A GB 8515931 A GB8515931 A GB 8515931A GB 2161805 B GB2161805 B GB 2161805B
Authority
GB
United Kingdom
Prior art keywords
benzylpyrimidine
intermediates
synthesis
benzylpyrimidine synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08515931A
Other versions
GB2161805A (en
GB8515931D0 (en
Inventor
Roy Archibald Swaringan
John Fred Eaddy
Thomas Ranney Henderson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of GB8515931D0 publication Critical patent/GB8515931D0/en
Publication of GB2161805A publication Critical patent/GB2161805A/en
Application granted granted Critical
Publication of GB2161805B publication Critical patent/GB2161805B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
GB08515931A 1981-11-09 1985-06-24 Benzylpyrimidine synthesis and intermediates Expired GB2161805B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31964381A 1981-11-09 1981-11-09

Publications (3)

Publication Number Publication Date
GB8515931D0 GB8515931D0 (en) 1985-07-24
GB2161805A GB2161805A (en) 1986-01-22
GB2161805B true GB2161805B (en) 1986-07-30

Family

ID=23243118

Family Applications (3)

Application Number Title Priority Date Filing Date
GB08231983A Expired GB2109375B (en) 1981-11-09 1982-11-09 Benzylpyrimidine synthesis and intermediates
GB08515931A Expired GB2161805B (en) 1981-11-09 1985-06-24 Benzylpyrimidine synthesis and intermediates
GB08515932A Expired GB2161158B (en) 1981-11-09 1985-06-24 Benzylpyrimidine synthesis & intermediates

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB08231983A Expired GB2109375B (en) 1981-11-09 1982-11-09 Benzylpyrimidine synthesis and intermediates

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB08515932A Expired GB2161158B (en) 1981-11-09 1985-06-24 Benzylpyrimidine synthesis & intermediates

Country Status (5)

Country Link
JP (4) JPS5888368A (en)
CH (4) CH664960A5 (en)
DE (1) DE3241134C2 (en)
FR (1) FR2516081B1 (en)
GB (3) GB2109375B (en)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS194663B2 (en) * 1971-04-16 1979-12-31 Barbara Roth Process for preparing 2,4-diamino-5-benzyl-pyrimidines
GB1401612A (en) * 1971-04-16 1975-07-16 Wellcome Found 2,4-diamino-5-benzylpyrimidines and preparations thereof
CH592066A5 (en) * 1973-02-26 1977-10-14 Hoffmann La Roche
US3923807A (en) * 1973-09-10 1975-12-02 Takeda Chemical Industries Ltd 6-Aminouracil derivatives
CH591456A5 (en) * 1973-09-12 1977-09-15 Hoffmann La Roche
US4008236A (en) * 1975-07-31 1977-02-15 Abbott Laboratories 2,4-Diamino-5-benzylpyrimidines
JPS5353385A (en) * 1976-10-26 1978-05-15 Seiko Epson Corp Clocking device
GR71725B (en) * 1977-11-10 1983-06-22 Hoffmann La Roche
CH639273A5 (en) * 1978-09-12 1983-11-15 Hoffmann La Roche DIURETIC MEANS.

Also Published As

Publication number Publication date
JPH069576A (en) 1994-01-18
CH664961A5 (en) 1988-04-15
FR2516081A1 (en) 1983-05-13
GB2109375B (en) 1986-08-06
GB2161158B (en) 1986-07-30
JPH07606B2 (en) 1995-01-11
JP2657150B2 (en) 1997-09-24
GB8515932D0 (en) 1985-07-24
DE3241134A1 (en) 1983-05-19
CH664959A5 (en) 1988-04-15
CH658246A5 (en) 1986-10-31
GB2161805A (en) 1986-01-22
DE3241134C2 (en) 1996-04-11
GB2161158A (en) 1986-01-08
JPH08188574A (en) 1996-07-23
GB8515931D0 (en) 1985-07-24
JPH0549665B2 (en) 1993-07-26
JPH09227530A (en) 1997-09-02
JPS5888368A (en) 1983-05-26
CH664960A5 (en) 1988-04-15
GB2109375A (en) 1983-06-02
FR2516081B1 (en) 1987-05-29

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Legal Events

Date Code Title Description
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19971109