GB2158353A - Veterinary preparations - Google Patents
Veterinary preparations Download PDFInfo
- Publication number
- GB2158353A GB2158353A GB08510673A GB8510673A GB2158353A GB 2158353 A GB2158353 A GB 2158353A GB 08510673 A GB08510673 A GB 08510673A GB 8510673 A GB8510673 A GB 8510673A GB 2158353 A GB2158353 A GB 2158353A
- Authority
- GB
- United Kingdom
- Prior art keywords
- composition
- acid
- antiprotozoal
- antibacterial
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000002360 preparation method Methods 0.000 title description 8
- 239000000203 mixture Substances 0.000 claims abstract description 17
- KYGZCKSPAKDVKC-UHFFFAOYSA-N Oxolinic acid Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC2=C1OCO2 KYGZCKSPAKDVKC-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229960000321 oxolinic acid Drugs 0.000 claims abstract description 13
- 229960000210 nalidixic acid Drugs 0.000 claims abstract description 12
- MHWLWQUZZRMNGJ-UHFFFAOYSA-N nalidixic acid Chemical compound C1=C(C)N=C2N(CC)C=C(C(O)=O)C(=O)C2=C1 MHWLWQUZZRMNGJ-UHFFFAOYSA-N 0.000 claims abstract description 12
- 230000000241 respiratory effect Effects 0.000 claims abstract description 10
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 10
- 241001465754 Metazoa Species 0.000 claims abstract description 9
- 239000003904 antiprotozoal agent Substances 0.000 claims abstract description 9
- YXQXDXAHCSEVSD-GCYNEOGWSA-N dynamutilin Chemical compound OC(=O)\C=C\C(O)=O.CCN(CC)CCSCC(=O)O[C@@H]1C[C@@](C)(C=C)[C@@H](O)[C@H](C)[C@@]23CC[C@@H](C)[C@]1(C)[C@@H]2C(=O)CC3 YXQXDXAHCSEVSD-GCYNEOGWSA-N 0.000 claims abstract description 9
- 208000015181 infectious disease Diseases 0.000 claims abstract description 9
- 150000007524 organic acids Chemical class 0.000 claims abstract description 9
- 230000002195 synergetic effect Effects 0.000 claims abstract description 9
- 230000002496 gastric effect Effects 0.000 claims abstract description 5
- 235000005985 organic acids Nutrition 0.000 claims abstract description 5
- 239000004480 active ingredient Substances 0.000 claims description 7
- 239000000969 carrier Substances 0.000 claims description 5
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 5
- 239000002775 capsule Substances 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 239000008101 lactose Substances 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 231100000252 nontoxic Toxicity 0.000 claims description 3
- 230000003000 nontoxic effect Effects 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 2
- 210000000481 breast Anatomy 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 2
- 239000008158 vegetable oil Substances 0.000 claims description 2
- 230000037396 body weight Effects 0.000 claims 1
- UURAUHCOJAIIRQ-QGLSALSOSA-N tiamulin Chemical compound CCN(CC)CCSCC(=O)O[C@@H]1C[C@@](C)(C=C)[C@@H](O)[C@H](C)[C@@]23CC[C@@H](C)[C@]1(C)[C@@H]2C(=O)CC3 UURAUHCOJAIIRQ-QGLSALSOSA-N 0.000 description 8
- 229960004885 tiamulin Drugs 0.000 description 8
- 241000588724 Escherichia coli Species 0.000 description 6
- 241000282898 Sus scrofa Species 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 241000204031 Mycoplasma Species 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 241000588748 Klebsiella Species 0.000 description 4
- 230000001079 digestive effect Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 210000000056 organ Anatomy 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 3
- 208000004232 Enteritis Diseases 0.000 description 3
- 241000186779 Listeria monocytogenes Species 0.000 description 3
- 241000191940 Staphylococcus Species 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 241000194017 Streptococcus Species 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 208000001848 dysentery Diseases 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 206010035664 Pneumonia Diseases 0.000 description 2
- 206010046793 Uterine inflammation Diseases 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 244000309466 calf Species 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000012009 microbiological test Methods 0.000 description 2
- 239000002547 new drug Substances 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 244000144977 poultry Species 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- -1 2-diethylamino-ethyl Chemical group 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 241000588747 Klebsiella pneumoniae Species 0.000 description 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 1
- 241000588769 Proteus <enterobacteria> Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
- 241000589886 Treponema Species 0.000 description 1
- 208000038016 acute inflammation Diseases 0.000 description 1
- 230000006022 acute inflammation Effects 0.000 description 1
- 230000000842 anti-protozoal effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 229940064004 antiseptic throat preparations Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000000721 bacterilogical effect Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000000890 drug combination Substances 0.000 description 1
- 239000003640 drug residue Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- WXXVQWSDMOAHHV-UHFFFAOYSA-N quinoline-7-carboxylic acid Chemical compound C1=CC=NC2=CC(C(=O)O)=CC=C21 WXXVQWSDMOAHHV-UHFFFAOYSA-N 0.000 description 1
- 229960002771 retapamulin Drugs 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
- 229960001082 trimethoprim Drugs 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/265—Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic, or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU841681A HU192982B (en) | 1984-04-28 | 1984-04-28 | Process for producing synergetic pharmaceutical compositions containing thiamulin and antibacterial and antiprotozoal organic acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB8510673D0 GB8510673D0 (en) | 1985-06-05 |
| GB2158353A true GB2158353A (en) | 1985-11-13 |
Family
ID=10955659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB08510673A Withdrawn GB2158353A (en) | 1984-04-28 | 1985-04-26 | Veterinary preparations |
Country Status (11)
| Country | Link |
|---|---|
| AT (1) | AT388669B (sv) |
| BE (1) | BE902250A (sv) |
| CH (1) | CH666407A5 (sv) |
| DE (1) | DE3515185A1 (sv) |
| ES (1) | ES8607333A1 (sv) |
| GB (1) | GB2158353A (sv) |
| HU (1) | HU192982B (sv) |
| IT (1) | IT1200461B (sv) |
| LU (1) | LU85870A1 (sv) |
| NL (1) | NL8501061A (sv) |
| SE (1) | SE8502038L (sv) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4041563A1 (de) * | 1990-12-22 | 1992-06-25 | Sanol Arznei Schwarz Gmbh | Verfahren zur herstellung wirkstoffhaltiger mikropartikel aus hydrolytisch abbaubaren polymeren |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2027590A (en) * | 1978-08-14 | 1980-02-27 | Squibb & Sons Inc | Parenteral compositions containing tiamulin |
| GB2035800A (en) * | 1978-10-20 | 1980-06-25 | Ausonia Farma Srl | Pharmaceutical compositions containing anantibiotic and a beta ketoacid |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1208279A (en) * | 1967-05-12 | 1970-10-14 | Ici Ltd | Veterinary compositions containing 4-hydroxy-1,8-naphthyridine derivatives |
| GB2072012B (en) * | 1980-03-14 | 1984-07-25 | Squibb & Sons Inc | Veterinary compositions containing pleuromutilin derivatives |
-
1984
- 1984-04-28 HU HU841681A patent/HU192982B/hu not_active IP Right Cessation
-
1985
- 1985-04-11 NL NL8501061A patent/NL8501061A/nl not_active Application Discontinuation
- 1985-04-22 BE BE1/011243A patent/BE902250A/fr not_active IP Right Cessation
- 1985-04-24 CH CH1749/85A patent/CH666407A5/de not_active IP Right Cessation
- 1985-04-24 AT AT0122985A patent/AT388669B/de not_active IP Right Cessation
- 1985-04-26 IT IT20515/85A patent/IT1200461B/it active
- 1985-04-26 LU LU85870A patent/LU85870A1/fr unknown
- 1985-04-26 SE SE8502038A patent/SE8502038L/sv not_active Application Discontinuation
- 1985-04-26 ES ES542610A patent/ES8607333A1/es not_active Expired
- 1985-04-26 DE DE19853515185 patent/DE3515185A1/de not_active Withdrawn
- 1985-04-26 GB GB08510673A patent/GB2158353A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2027590A (en) * | 1978-08-14 | 1980-02-27 | Squibb & Sons Inc | Parenteral compositions containing tiamulin |
| GB2035800A (en) * | 1978-10-20 | 1980-06-25 | Ausonia Farma Srl | Pharmaceutical compositions containing anantibiotic and a beta ketoacid |
Also Published As
| Publication number | Publication date |
|---|---|
| HUT37347A (en) | 1985-12-28 |
| ES8607333A1 (es) | 1986-05-16 |
| GB8510673D0 (en) | 1985-06-05 |
| NL8501061A (nl) | 1985-11-18 |
| IT8520515A0 (it) | 1985-04-26 |
| HU192982B (en) | 1987-08-28 |
| ATA122985A (de) | 1989-01-15 |
| DE3515185A1 (de) | 1985-11-07 |
| AT388669B (de) | 1989-08-10 |
| IT1200461B (it) | 1989-01-18 |
| LU85870A1 (fr) | 1986-11-05 |
| SE8502038L (sv) | 1985-10-29 |
| CH666407A5 (de) | 1988-07-29 |
| ES542610A0 (es) | 1986-05-16 |
| SE8502038D0 (sv) | 1985-04-26 |
| BE902250A (fr) | 1985-10-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |