GB2144409B - Preparation of 5'-deoxy-5'-methylthioadenosine - Google Patents

Preparation of 5'-deoxy-5'-methylthioadenosine

Info

Publication number: GB2144409B
Authority: GB; United Kingdom
Prior art keywords: methylthioadenosine; deoxy; preparation
Prior art date: 1980-04-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

GB08321947A

Other versions

GB8321947D0 (en

GB2144409A (en

Inventor

Giorgio Stramentinoli

Federico Gennari

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bioresearch SRL

Original Assignee

Bioresearch SRL

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-04-22

Filing date

1983-08-15

Publication date

1985-09-11

1983-08-15 Application filed by Bioresearch SRL filed Critical Bioresearch SRL

1983-09-14 Publication of GB8321947D0 publication Critical patent/GB8321947D0/en

1985-03-06 Publication of GB2144409A publication Critical patent/GB2144409A/en

1985-09-11 Application granted granted Critical

1985-09-11 Publication of GB2144409B publication Critical patent/GB2144409B/en

Status Expired legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pain & Pain Management (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

GB08321947A 1980-04-22 1983-08-15 Preparation of 5'-deoxy-5'-methylthioadenosine Expired GB2144409B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT21550/80A IT1193529B (en)	1980-04-22	1980-04-22	ADENOSINIC DERIVATIVES FOR ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES AND THERAPEUTIC COMPOSITIONS THAT CONTAIN THEM AS AN ACTIVE PRINCIPLE

Publications (3)

Publication Number	Publication Date
GB8321947D0 GB8321947D0 (en)	1983-09-14
GB2144409A GB2144409A (en)	1985-03-06
GB2144409B true GB2144409B (en)	1985-09-11

Family

ID=11183457

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
GB8112428A Expired GB2074446B (en)	1980-04-22	1981-04-22	Adenosine derivatives of antiinflammatory and analgesic activity and therapeutic compositions containing them
GB08321947A Expired GB2144409B (en)	1980-04-22	1983-08-15	Preparation of 5'-deoxy-5'-methylthioadenosine
GB08413454A Expired GB2144038B (en)	1980-04-22	1984-05-25	Adenosine derivatives of anti-inflammatory and analgesic activity and therapeutic compositions containing them

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
GB8112428A Expired GB2074446B (en)	1980-04-22	1981-04-22	Adenosine derivatives of antiinflammatory and analgesic activity and therapeutic compositions containing them

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
GB08413454A Expired GB2144038B (en)	1980-04-22	1984-05-25	Adenosine derivatives of anti-inflammatory and analgesic activity and therapeutic compositions containing them

Country Status (17)

Country	Link
JP (2)	JPS56166117A (en)
AR (1)	AR231144A1 (en)
BE (1)	BE888472A (en)
CA (1)	CA1198105A (en)
CH (2)	CH650514A5 (en)
DE (1)	DE3116067A1 (en)
DK (1)	DK159453C (en)
ES (2)	ES8206551A1 (en)
FI (1)	FI70227C (en)
FR (1)	FR2491761A1 (en)
GB (3)	GB2074446B (en)
IT (1)	IT1193529B (en)
LU (1)	LU83307A1 (en)
MX (1)	MX9203630A (en)
NL (1)	NL192111C (en)
NO (1)	NO150515C (en)
SE (3)	SE460198B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1177373B (en) *	1984-12-06	1987-08-26	Bioresearch Spa	SALTS OF 5'-METHYLLIUM-5'-DEOXYDENOSINE WITH LONG ALCHYLIC CHAIN SULPHONIC ACIDS
IT1227049B (en) *	1988-07-29	1991-03-14	Bioresearch Spa	USE OF ADENOSINIC DERIVATIVES FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS HAVING IMMUNOSTIMULATING ACTIVITIES.
JPH0497287A (en) *	1990-08-10	1992-03-30	Nec Ic Microcomput Syst Ltd	Picture display integrated circuit
ES2259552B1 (en) *	2005-03-17	2007-06-16	Proyecto De Biomedicina Cima, S.L.	EMPLOYMENT OF 5'-METHYLTIOENENINE (MTA) IN THE PREVENTION AND / OR TREATMENT OF AUTOIMMUNE DISEASES AND / OR REPLACEMENT OF TRANSPLANTS.
AU2005329287B2 (en)	2005-03-17	2011-01-27	Proyecto De Biomedicina Cima S.L.	Use of 5'-methylthioadenosine (MTA) in the prevention and/or treatment of autoimmune diseases and/or transplant rejection
DE102010027595A1 (en) *	2010-07-23	2012-01-26	Helmut Vorbrüggen	Clinical application of adenosine derivative, preferably (dihydroxyphenyl)ethyl-amino-purin-9-yl-(hydroxymethyl)oxolane-diol, for reducing body temperature during impending ischemia of brain vessels, which occur during heart attacks
DE102011005232A1 (en) *	2011-03-08	2012-09-13	AristoCon GmbH & Co. KG	Adenosine and its derivatives for use in pain therapy
JP6226962B2 (en) *	2013-04-05	2017-11-08	ライオン株式会社	Non-REM sleep enhancer, deep sleep enhancer, natural sleep inducer, and early sleep delta power enhancer
KR20150139508A (en) *	2013-04-05	2015-12-11	라이온 가부시키가이샤	Yeast culture, and composition for internal application
WO2014163150A1 (en) *	2013-04-05	2014-10-09	ライオン株式会社	Composition for internal use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1259341B (en) *	1962-12-22	1968-01-25	Boehringer & Soehne Gmbh	Process for the preparation of new 5'-sulfoxides of nucleosides
DE1545645A1 (en) *	1965-12-06	1969-08-21	Boehringer Mannheim Gmbh	Process for the preparation of disubstituted adenosine derivatives
GB1436509A (en) *	1973-11-27	1976-05-19	Ajinomoto Kk	Method for producing s-adenosylmethionine or methylthioadenosine from yeast
FR2313937A1 (en) *	1975-06-09	1977-01-07	Anvar	DRUG BASED ON 5 'THIOETHERS OF ADENOSINE
FR2424027A1 (en) *	1978-04-28	1979-11-23	Merieux Inst	NEW MEDICINAL PRODUCT, IN PARTICULAR SEDATIVE AND SLEEP INDUCER AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT

1980
- 1980-04-22 IT IT21550/80A patent/IT1193529B/en active
1981
- 1981-04-17 BE BE0/204529A patent/BE888472A/en not_active IP Right Cessation
- 1981-04-21 LU LU83307A patent/LU83307A1/en unknown
- 1981-04-21 SE SE8102489A patent/SE460198B/en not_active IP Right Cessation
- 1981-04-21 DK DK176481A patent/DK159453C/en not_active IP Right Cessation
- 1981-04-21 AR AR285020A patent/AR231144A1/en active
- 1981-04-21 JP JP5930181A patent/JPS56166117A/en active Granted
- 1981-04-21 CA CA000375784A patent/CA1198105A/en not_active Expired
- 1981-04-21 NO NO811346A patent/NO150515C/en unknown
- 1981-04-21 ES ES501539A patent/ES8206551A1/en not_active Expired
- 1981-04-22 CH CH4716/84A patent/CH650514A5/en not_active IP Right Cessation
- 1981-04-22 CH CH263281A patent/CH645544A5/en not_active IP Right Cessation
- 1981-04-22 NL NL8101984A patent/NL192111C/en not_active IP Right Cessation
- 1981-04-22 DE DE19813116067 patent/DE3116067A1/en active Granted
- 1981-04-22 FI FI811249A patent/FI70227C/en not_active IP Right Cessation
- 1981-04-22 GB GB8112428A patent/GB2074446B/en not_active Expired
- 1981-04-22 FR FR8107992A patent/FR2491761A1/en active Granted
1982
- 1982-04-01 ES ES511039A patent/ES511039A0/en active Granted
1983
- 1983-08-15 GB GB08321947A patent/GB2144409B/en not_active Expired
1984
- 1984-05-25 GB GB08413454A patent/GB2144038B/en not_active Expired
1987
- 1987-03-04 SE SE8700914A patent/SE464635B/en not_active IP Right Cessation
- 1987-03-04 SE SE8700913A patent/SE466238B/en not_active IP Right Cessation
1989
- 1989-02-02 JP JP1022771A patent/JPH01301692A/en active Granted
1992
- 1992-06-26 MX MX9203630A patent/MX9203630A/en unknown

Also Published As

Publication number	Publication date
GB2074446B (en)	1985-04-11
NL192111B (en)	1996-10-01
LU83307A1 (en)	1981-07-24
IT8021550A0 (en)	1980-04-22
SE8700913D0 (en)	1987-03-04
NO150515C (en)	1984-10-31
ES8306378A1 (en)	1983-06-01
DK159453B (en)	1990-10-15
GB2144038B (en)	1985-08-29
SE8700913L (en)	1987-03-04
GB8321947D0 (en)	1983-09-14
BE888472A (en)	1981-08-17
SE8102489L (en)	1981-10-23
JPH01301692A (en)	1989-12-05
SE466238B (en)	1992-01-20
FR2491761A1 (en)	1982-04-16
CH645544A5 (en)	1984-10-15
NL8101984A (en)	1981-11-16
ES501539A0 (en)	1982-08-16
NO150515B (en)	1984-07-23
NO811346L (en)	1981-10-23
FI811249L (en)	1981-10-23
GB2074446A (en)	1981-11-04
DE3116067C2 (en)	1992-12-17
DK159453C (en)	1991-03-18
SE8700914L (en)	1987-03-04
GB8413454D0 (en)	1984-07-04
SE460198B (en)	1989-09-18
FI70227C (en)	1986-09-15
GB2144409A (en)	1985-03-06
GB2144038A (en)	1985-02-27
IT1193529B (en)	1988-07-08
DK176481A (en)	1981-10-23
SE464635B (en)	1991-05-27
ES8206551A1 (en)	1982-08-16
DE3116067A1 (en)	1982-03-11
MX9203630A (en)	1992-09-01
CA1198105A (en)	1985-12-17
JPS56166117A (en)	1981-12-21
NL192111C (en)	1997-02-04
FR2491761B1 (en)	1984-01-06
JPH0246599B2 (en)	1990-10-16
JPH0249288B2 (en)	1990-10-29
ES511039A0 (en)	1983-06-01
CH650514A5 (en)	1985-07-31
AR231144A1 (en)	1984-09-28
FI70227B (en)	1986-02-28
SE8700914D0 (en)	1987-03-04

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Legal Events

Date	Code	Title	Description
1993-04-21	732E	Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
1997-12-10	PCNP	Patent ceased through non-payment of renewal fee	Effective date: 19970422