GB2031441A - Polypyrrolidone-iodine complex - Google Patents
Polypyrrolidone-iodine complex Download PDFInfo
- Publication number
- GB2031441A GB2031441A GB7834404A GB7834404A GB2031441A GB 2031441 A GB2031441 A GB 2031441A GB 7834404 A GB7834404 A GB 7834404A GB 7834404 A GB7834404 A GB 7834404A GB 2031441 A GB2031441 A GB 2031441A
- Authority
- GB
- United Kingdom
- Prior art keywords
- iodine
- polypyrrolidone
- complex
- composition according
- nylon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052740 iodine Inorganic materials 0.000 title claims abstract description 42
- 239000011630 iodine Substances 0.000 title claims abstract description 42
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims abstract description 40
- 229920001007 Nylon 4 Polymers 0.000 claims abstract description 32
- 239000000203 mixture Substances 0.000 claims abstract description 13
- 230000003115 biocidal effect Effects 0.000 claims abstract description 5
- 239000002674 ointment Substances 0.000 claims abstract description 5
- 239000000843 powder Substances 0.000 claims abstract description 5
- 239000000463 material Substances 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 4
- 230000002906 microbiologic effect Effects 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 239000002759 woven fabric Substances 0.000 claims description 2
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 1
- 239000004745 nonwoven fabric Substances 0.000 claims 1
- 239000000835 fiber Substances 0.000 abstract description 6
- 239000004744 fabric Substances 0.000 abstract description 3
- 230000000622 irritating effect Effects 0.000 abstract description 3
- 230000000699 topical effect Effects 0.000 abstract description 3
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 2
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 230000000855 fungicidal effect Effects 0.000 abstract 1
- -1 pulp Substances 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 231100000563 toxic property Toxicity 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
- 239000011347 resin Substances 0.000 description 11
- 229920005989 resin Polymers 0.000 description 11
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 6
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 4
- 239000004753 textile Substances 0.000 description 4
- 238000007654 immersion Methods 0.000 description 3
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000003356 suture material Substances 0.000 description 2
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 229920000153 Povidone-iodine Polymers 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000003139 biocide Substances 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 description 1
- 229940006461 iodide ion Drugs 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 238000002074 melt spinning Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000003883 ointment base Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229940114930 potassium stearate Drugs 0.000 description 1
- ANBFRLKBEIFNQU-UHFFFAOYSA-M potassium;octadecanoate Chemical compound [K+].CCCCCCCCCCCCCCCCCC([O-])=O ANBFRLKBEIFNQU-UHFFFAOYSA-M 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/12—Iodine, e.g. iodophors; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
- A61K31/79—Polymers of vinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/14—Lactams
- C08G69/24—Pyrrolidones or piperidones
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/48—Polymers modified by chemical after-treatment
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M16/00—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/202—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with halogen atoms, e.g. triclosan, povidone-iodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Inorganic Chemistry (AREA)
- Birds (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Textile Engineering (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A novel complex of polypyrrolidone, also known as nylon-4, with iodine is disclosed. The complex has biocidal properties exhibiting expecially the fungicidal and bactericidal properties of free iodine but not its irritating and toxic properties. The complex may be formed with polypyrrolidone having any physical form such as a powder, pulp, film, fibre or moulded article. Bandage material made from fabric woven from nylon-4 fibres and complexed with iodine is a particularly useful form. Dry powders, ointments and other compositions for topical application may also be made.
Description
SPECIFICATION
Polypyrrolidone-iodine complex
This invention relates to a water-insoluble complex of iodine and polypyrrolidone.
The iodine complex formed by mixing polyvinylpyrrolidone (PVP) and iodine, first disclosed in U.S. Patent No. 2,739,922 has established itself as the preferred way of utilizing the desirable biocidal properties of iodine while avoiding the irritating side effects. It has become the product of choice especially in surgery where it is used to coat the skin prior to incision.
PVP is a water soluble polymer and likewise the PVP-iodine complex is water soluble.
There are applications however in which this solubility in water is undesirable. For example, in topical applications the effectiveness of a water soluble antiseptic is of short duration since it is readily washed away not only by water but by perspiration. A water insoluble complex with iodine which exhibits similar "tamed iodine" properties would be much more permanent.
It is a primary object of this invention to provide a water insoluble and therefore more permanent complex of iodine possessing medicinal properties similar to the water soluble
PVP-iodine complex.
It is another object of this invention to provide a water insoluble complex of iodine which slowly releases elemental iodine in small but effective amounts over a long period of time thus prolonging the microbiological activity while minimizing the irritating side effects.
It is a further object of the invention to provide a novel bandage and suture material which in itself is the bactericidal and fungicidal agent.
It is a still further object of this invention to provide water insoluble long lasting antiseptic ointments for topical application.
It has been found that polypyrrolidone, also known as nylon-4, a polymer having the structure
can be made to form a complex with elemental iodine which is very similar to the polyvinylpyrrolidone-iodine complex. Unlike the
PVP-iodine complex, however, the nylon 4iodine complex is not soluble in water.
It is surprising and unexpected that nylon-4 should form a complex with iodine since the polypyrrolidone ring, which is intact in PVP, is opened and non-existent in nylon-4 which has instead a polyamide structure. Nevertheless it has been found that a complex with iodine will form and furthermore it closely resembles the PVP-iodine complex except for the lack of solubility in water.
The polypyrrolidone employed to make the iodine complex may be in any physical form such as the powdered resin, a pulp (fibrils), an extruded rod or filament, a fabric woven from a textile fibre, a film or a moulded article. For purposes of making an ointment the finely powdered resin is used and the molecular weight (i.e. the value of n in the above formula) is unimportant. But for making sutures or bandages from woven fabric it is necessary to melt extrude the resin to form the filaments or fibres and for this purpose a polymer having superior thermal stability is required and the molecular weight of the resin becomes important. A molecular weight sufficient to give an inherent viscosity of at least 2.0 deciliters per gram when measured as a 0.5 gram per diciliter solution in hexafluroisopropanol at 25"C. is needed.Most preferably resins having an inherent viscosity of from 3.0 to 4.0 or higher are used for melt spinning purposes. Methods of making polymers of 2-pyrrolidone having these characteristics are disclosed in U.S. Patent number 3,721,652. The methods of determining the inherent viscosity are also disclosed in this patent.
The complex of nylon-4 with iodine is best formed by immersing the nylon-4 article in a solution of iodine in aqueous potassium iodide. A preferred formula is
Potassium iodide 3.3 grams
Water 100 ml iodine 2.0 grams
Upon immersion in this solution the white polypyrrolidone article turns to a dark chocolate-brown colour almost immediately and then becomes black. Upon drying the colour becomes lighter. Immersion times range from a few seconds to two or three minutes.
Shorter immersion times will produce a golden yellow colour in the dried article while longer times will give a dark brown colour in the dried material. The colour of the dried complex is a measure of the amount of iodine prlesent. Excessive amounts of iodine will tend to degrade the polymer and should be avoided if this is important as it is in a textile fibre.
The iodine complex may be formed by other methods such as exposing the nylon-4 article to iodine vapour or triturating the powered resin with solid iodine crystals. Alternatively the resin may be ball milled after mixing with iodine crystals to form a powdered complex which is well suited for use as a dry powder or for compounding into anointment.
Other ingredients to minimize caking or to impart additional therapeutic properties may be added to the mixture. For compounding an ointment any suitable ointment base may be used such a lanolin, petrolatum, potassium stearate and many others.
The iodine is rather tightly held in the complex. By way of comparison, if cotton (another hydrophilic fibre) is immersed in an iodine solution prepared according to the recipe given above it develops a similar dark brown colour. But the iodine is only held mechanically and washes out completely with water within a minute. The dark brown complex formed with nylon-4 does not readily wash out with water. Small amounts of iodine are released however at a rate which is dependent on the temperature. The rate is very slow at room temperature but at about 100"C. it is quite rapid. Thus if the complex is placed in boiling water the iodine will be removed completely in a matter of minutes. Similarly if placed in an oven at 1 00 C. the iodine will sublime out of the complex very rapidly leaving colourless nylon-4.Samples may be kept for several months at room temperature without appreciable loss of iodine however. At 40"C. no appreciable loss of iodine occurs within 24 hours. Also the complex is quite insensitve to changes in pH. No loss in iodine content (such as to iodide ion) occurs within a range of pH 5 to pH 10.
In order to be effective a slow release of iodine must occur and at body temperature this release takes place at about the proper rate. For many reasons a bandage should be changed every 24 hours but it should remain effective during this period of time. An important feature of the nylon-4 iodine complex is that, unlike its PVP-iodine counterpart, if the bandage or other dressing gets wet even from perspiration the biocidal agent is not washed away.
Another embodiment of the invention is a biocidal suture. In this application the polypyrrolidone resin is melt extruded at temperatures of about 290"C. under high pressure generated by the screw of the extruder. Care must be taken to dry the resin to not more than about 0.03% moisture content before extruding and the resin must be kept under dry nitrogen in the hopper feeding the extruder to prevent further moisture pick-up.
The molten resin is forced through a spinnerette consisting of a single hole to form a monofilament or multiple holes to form a textile fibre. The size of the hole and the amount of draw determine the diameter of the filament or filaments as well as the tensile strength. For certain applications a multifilament structure is preferred. In either case the suture material is then passed through the iodine bath made according to the recipe given earlier. The residence time in the bath may be from a-few seconds to a few minutes depending upon the amount of iodine desired in the complex. The material is then washed briefly in water then air dried.
For bandage applications a suitable fabric is woven from nylon-4 textile fibre and treated in the iodine bath in a similar manner.
The nylon-4 iodine complex may be utilized in many other ways, for example as in inner layer in packaging to serve as a biocidal barrier thus keeping the contents of the package sterile or as a source of a low concentration of iodine vapour to provide a sterile atmosphere.
Claims (11)
1. A composition having microbiological activity comprising a complex of polypyrrolidone and iodine.
2. A composition according to claim 1 wherein the polypyrrolidone is in the form of a bandage or wound dressing material.
3. A composition according to claim 1 wherein the polypyrrolidone is in the form of a suture.
4. A composition according to claim 1 wherein the polypyrrolidone is in the form of a finely divided powder.
5. A composition according to claim 1 wherein the polypyrrolidone is in the form of a film.
6. A composition according to claim 1 wherein the polypyrrolidone is in the form of fibrils.
7. A composition according to claim 1 wherein the polypyrrolidone is in the form of a woven fabric.
8. A composition according to claim 1 wherein the polypyrrolidone is in the form of a non-woven fabric.
9. An ointment comprising a composition according to claim 1 and a suitable pharmaceutically acceptable vehicle.
10. A biocidal powder comprising a composition according to claim 1 and a pharmaceutically acceptable solid carrier.
11. A composition according to claim 1 wherein the polypyrrolidone is in the form of a moulded article.
1 2. A method of preparing a water-insoluble complex of iodine and nylon-4 which comprises contacting the nylon-4 with a solution of an iodide.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7834404A GB2031441B (en) | 1978-08-24 | 1978-08-24 | Polypyrrolidone iodine complex |
| DE19782837093 DE2837093C2 (en) | 1978-08-24 | 1978-08-24 | Microbiologically active substance |
| BE190140A BE870058A (en) | 1978-08-24 | 1978-08-29 | COMPOSITION WITH MICROBIOLOGICAL ACTIVITY |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7834404A GB2031441B (en) | 1978-08-24 | 1978-08-24 | Polypyrrolidone iodine complex |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB2031441A true GB2031441A (en) | 1980-04-23 |
| GB2031441B GB2031441B (en) | 1982-11-17 |
Family
ID=10499244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7834404A Expired GB2031441B (en) | 1978-08-24 | 1978-08-24 | Polypyrrolidone iodine complex |
Country Status (3)
| Country | Link |
|---|---|
| BE (1) | BE870058A (en) |
| DE (1) | DE2837093C2 (en) |
| GB (1) | GB2031441B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5128125A (en) * | 1988-02-16 | 1992-07-07 | Barnes Arthur C | Method for preparing finely divided nylon-4 complex with iodine and antiseptic preparation made therefrom |
| US7217417B2 (en) * | 2002-05-20 | 2007-05-15 | Dermacia, Inc. | Gel-based cosmetic and wound-healing formulation and method |
| WO2016042406A1 (en) * | 2014-09-19 | 2016-03-24 | Galia Textil | Impregnated dry substrates for a dressing material, method and system for manufacturing the same |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6425870A (en) * | 1987-04-30 | 1989-01-27 | Ajinomoto Kk | Support for anastomosis or bonding of living body |
| US5232692A (en) * | 1989-04-28 | 1993-08-03 | Research And Education Institute, Inc. | Povidone-iodine neonatal ophthalmic antimicrobial prophylactic agent |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2739922A (en) * | 1952-03-13 | 1956-03-27 | Herman A Shelanski | Mixtures of polymeric n-vinyl pyrrolidone and halogens |
-
1978
- 1978-08-24 DE DE19782837093 patent/DE2837093C2/en not_active Expired
- 1978-08-24 GB GB7834404A patent/GB2031441B/en not_active Expired
- 1978-08-29 BE BE190140A patent/BE870058A/en not_active IP Right Cessation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5128125A (en) * | 1988-02-16 | 1992-07-07 | Barnes Arthur C | Method for preparing finely divided nylon-4 complex with iodine and antiseptic preparation made therefrom |
| US7217417B2 (en) * | 2002-05-20 | 2007-05-15 | Dermacia, Inc. | Gel-based cosmetic and wound-healing formulation and method |
| WO2016042406A1 (en) * | 2014-09-19 | 2016-03-24 | Galia Textil | Impregnated dry substrates for a dressing material, method and system for manufacturing the same |
Also Published As
| Publication number | Publication date |
|---|---|
| BE870058A (en) | 1978-12-18 |
| DE2837093C2 (en) | 1986-07-31 |
| GB2031441B (en) | 1982-11-17 |
| DE2837093A1 (en) | 1980-03-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19920824 |