GB2024010A - Compositions containing fatty acids for the treatment of seborrhoeic conditions - Google Patents
Compositions containing fatty acids for the treatment of seborrhoeic conditions Download PDFInfo
- Publication number
- GB2024010A GB2024010A GB7921890A GB7921890A GB2024010A GB 2024010 A GB2024010 A GB 2024010A GB 7921890 A GB7921890 A GB 7921890A GB 7921890 A GB7921890 A GB 7921890A GB 2024010 A GB2024010 A GB 2024010A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- treatment
- seborrhoeic
- conditions
- alcoholic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 20
- 235000014113 dietary fatty acids Nutrition 0.000 title claims abstract description 12
- 229930195729 fatty acid Natural products 0.000 title claims abstract description 12
- 239000000194 fatty acid Substances 0.000 title claims abstract description 12
- 150000004665 fatty acids Chemical class 0.000 title claims abstract description 12
- 230000001476 alcoholic effect Effects 0.000 claims abstract description 12
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 14
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims description 10
- GYSCBCSGKXNZRH-UHFFFAOYSA-N 1-benzothiophene-2-carboxamide Chemical compound C1=CC=C2SC(C(=O)N)=CC2=C1 GYSCBCSGKXNZRH-UHFFFAOYSA-N 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- HABLENUWIZGESP-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O.CCCCCCCCCC(O)=O HABLENUWIZGESP-UHFFFAOYSA-N 0.000 claims description 4
- 235000019441 ethanol Nutrition 0.000 claims description 4
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 150000007513 acids Chemical class 0.000 claims description 2
- 239000005456 alcohol based solvent Substances 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 125000005909 ethyl alcohol group Chemical group 0.000 claims description 2
- 150000004667 medium chain fatty acids Chemical class 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229940068918 polyethylene glycol 400 Drugs 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 230000002110 toxicologic effect Effects 0.000 claims description 2
- 231100000027 toxicology Toxicity 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Detergent Compositions (AREA)
Abstract
A pharmaceutical composition is disclosed for the treatment of seborrhoeic conditions in man comprising a solution of a C8-C12 fatty acid, or mixture of such fatty acids in an alcoholic or aqueous alcoholic medium.
Description
SPECIFICATION
Agents for the treatment of seborrhoeic conditions
The invention relates to agents for the treatment of seborrhoeic conditions.
The treatment of seborrhoeic conditions in dermatology is still unsatisfactory in many respects. For the most widely varying reasons, all previously used agents and substances suffer from therapeutic disadvantages or disadvantages arising out of toxicological considerations. In comparison, the agents described hereinafter substantially avoid these disadvantages.
The invention lies in the use of mediumchain fatty acids containing 8-1 2 carbon atoms preferably decanoic acid (C10) and/or dodecanoic acid (C,2), in particular in alcoholic or aqueous-alcoholic solutions. The concentrations of the fatty acids and the mixture thereof in the solvents may be widely varied but will usually be in the range 1-40%. Likewise, the alcohol solvents may be widely varied as such, but may also be widely varied in their proportion of mixing with water or with each other.
The following examples illustrate the invention:
Example 1
Decanoic acid (capric acid ) is dissolved in a 5% concentration in 96% ethyl alcohol, and used for the treatment of seborrhoeic conditions.
Example 2
Dodecanoic acid (lauric acid) is dissolved in a 5% concentration in isopropyl alcohol, and used for the treatment of seborrhoeic conditions.
Example 3
Decanoic acid (capric acid) is dissolved in a 5% concentration in propylene glycol and used for the treatment of seborrhoeic conditions.
Example 4
Decanoic acid (capric acid) is dissolved in a 10% concentration in a solution of polyethylene glycol 400, and used for the treatment of seborrhoeic conditions.
1. A composition for use in the treatment of seborrhoeic conditions comprising a C8-C12 fatty acid or mixture of such acids in alcoholic or aqueous alcoholic solution.
2. A composition according to claim 1, wherein the fatty acid is decanoic acid and/or dodecanoic acid.
3. A composition according to claim 1 or 2, wherein the concentration of fatty acid in said solution is from 1-40%.
4. A composition according to claim 1, 2 or 3, wherein the alcoholic solvent is ethyl alcohol, isopropyl alcohol, propylene glycol or polyethylene glycol.
5. A composition according to any one of claims 1-4, wherein the solvent medium is an aqueous alcoholic medium.
6. A C8-C,2 fatty acid or mixtures thereof for use in the treatment of seborrhoeic conditions in man.
7. A fatty acid according to claim 6, which is decanoic acid or dodecanoic acid, or a mixture of the two.
**WARNING** end of DESC field may overlap start of CLMS **.
Claims (7)
1. A composition for use in the treatment of seborrhoeic conditions comprising a C8-C12 fatty acid or mixture of such acids in alcoholic or aqueous alcoholic solution.
2. A composition according to claim 1, wherein the fatty acid is decanoic acid and/or dodecanoic acid.
3. A composition according to claim 1 or 2, wherein the concentration of fatty acid in said solution is from 1-40%.
4. A composition according to claim 1, 2 or 3, wherein the alcoholic solvent is ethyl alcohol, isopropyl alcohol, propylene glycol or polyethylene glycol.
5. A composition according to any one of claims 1-4, wherein the solvent medium is an aqueous alcoholic medium.
6. A C8-C,2 fatty acid or mixtures thereof for use in the treatment of seborrhoeic conditions in man.
7. A fatty acid according to claim 6, which is decanoic acid or dodecanoic acid, or a mixture of the two.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2828352A DE2828352C3 (en) | 1978-06-28 | 1978-06-28 | Agents for treating seborrheic conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB2024010A true GB2024010A (en) | 1980-01-09 |
| GB2024010B GB2024010B (en) | 1982-11-10 |
Family
ID=6043011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7921890A Expired GB2024010B (en) | 1978-06-28 | 1979-06-22 | Compositions for containing fatty acids for the treatment of seborrhoeic conditions |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS559069A (en) |
| AT (1) | AT365450B (en) |
| BE (1) | BE877351A (en) |
| CA (1) | CA1142854A (en) |
| CH (1) | CH641042A5 (en) |
| CS (1) | CS275816B6 (en) |
| DE (1) | DE2828352C3 (en) |
| DK (1) | DK153738C (en) |
| FR (1) | FR2437210A1 (en) |
| GB (1) | GB2024010B (en) |
| IT (1) | IT1124116B (en) |
| LU (1) | LU81429A1 (en) |
| NL (1) | NL7904776A (en) |
| SE (1) | SE7905659L (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0068552A3 (en) * | 1981-06-23 | 1984-03-28 | THE PROCTER & GAMBLE COMPANY | Topical antimicrobial composition |
| DE3410850A1 (en) * | 1983-03-25 | 1984-10-04 | Otsuka Pharmaceutical Co. Ltd., Tokio/Tokyo | MEDICINAL PRODUCTS FOR REINFORCING AND USING BLOOD VESSELS |
| EP0116439A3 (en) * | 1983-02-02 | 1986-01-29 | Suntory Limited | Fatty acid containing hair tonic composition |
| US4839165A (en) * | 1986-02-06 | 1989-06-13 | Beiersdorf Aktiengesellschaft | Cosmetic agents for hair |
| WO1994005253A3 (en) * | 1992-09-05 | 1994-04-14 | Beiersdorf Ag | Deodorizing cosmetics containing fatty acids |
| EP0702950A1 (en) * | 1994-09-26 | 1996-03-27 | Beiersdorf Aktiengesellschaft | Use of fatty acids against skin superinfections |
| WO1998006378A1 (en) * | 1996-08-13 | 1998-02-19 | Pierre Fabre Dermo-Cosmetique | Anti-seborrheic guanidine salts |
| WO2007068358A1 (en) * | 2005-12-16 | 2007-06-21 | Unilever Plc | Skin benefit composition and a method for using the same |
| EP4410270A4 (en) * | 2021-10-01 | 2025-10-15 | Chemyunion Ltda | Antiseptic composition, formulation and use of the composition |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2912438A1 (en) * | 1979-03-29 | 1980-10-16 | Eckert Theodor | Topical treatment of skin diseases - with alcoholic soln. of fatty acid |
| JP5850453B2 (en) * | 2012-01-04 | 2016-02-03 | 洋一 赤間 | External skin analgesics, skin puncture pain relievers and subcutaneous vein vasodilators |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR46241E (en) * | 1935-04-03 | 1936-04-02 | Ig Farbenindustrie Ag | Cosmetic product |
| GB801726A (en) * | 1956-01-25 | 1958-09-17 | Havva Rabinovitch | Improvements in or relating to pharmaceutical preparations |
| GB1137125A (en) * | 1965-12-08 | 1968-12-18 | Unilever Ltd | Improved soap products |
-
1978
- 1978-06-28 DE DE2828352A patent/DE2828352C3/en not_active Expired
-
1979
- 1979-06-12 AT AT0419279A patent/AT365450B/en not_active IP Right Cessation
- 1979-06-19 NL NL7904776A patent/NL7904776A/en not_active Application Discontinuation
- 1979-06-22 GB GB7921890A patent/GB2024010B/en not_active Expired
- 1979-06-26 CA CA000330577A patent/CA1142854A/en not_active Expired
- 1979-06-26 CS CS794393A patent/CS275816B6/en unknown
- 1979-06-27 IT IT12655/79A patent/IT1124116B/en active
- 1979-06-27 FR FR7917398A patent/FR2437210A1/en active Granted
- 1979-06-27 SE SE7905659A patent/SE7905659L/en unknown
- 1979-06-27 DK DK271279A patent/DK153738C/en not_active IP Right Cessation
- 1979-06-27 LU LU81429A patent/LU81429A1/en unknown
- 1979-06-27 CH CH602279A patent/CH641042A5/en not_active IP Right Cessation
- 1979-06-28 JP JP8084179A patent/JPS559069A/en active Pending
- 1979-06-28 BE BE0/196029A patent/BE877351A/en not_active IP Right Cessation
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0068552A3 (en) * | 1981-06-23 | 1984-03-28 | THE PROCTER & GAMBLE COMPANY | Topical antimicrobial composition |
| EP0116439A3 (en) * | 1983-02-02 | 1986-01-29 | Suntory Limited | Fatty acid containing hair tonic composition |
| DE3410850A1 (en) * | 1983-03-25 | 1984-10-04 | Otsuka Pharmaceutical Co. Ltd., Tokio/Tokyo | MEDICINAL PRODUCTS FOR REINFORCING AND USING BLOOD VESSELS |
| GB2140688A (en) * | 1983-03-25 | 1984-12-05 | Otsuka Pharma Co Ltd | Fatty acid containing compositions |
| US4839165A (en) * | 1986-02-06 | 1989-06-13 | Beiersdorf Aktiengesellschaft | Cosmetic agents for hair |
| WO1994005253A3 (en) * | 1992-09-05 | 1994-04-14 | Beiersdorf Ag | Deodorizing cosmetics containing fatty acids |
| EP0702950A1 (en) * | 1994-09-26 | 1996-03-27 | Beiersdorf Aktiengesellschaft | Use of fatty acids against skin superinfections |
| WO1998006378A1 (en) * | 1996-08-13 | 1998-02-19 | Pierre Fabre Dermo-Cosmetique | Anti-seborrheic guanidine salts |
| FR2752421A1 (en) * | 1996-08-13 | 1998-02-20 | Fabre Pierre Dermo Cosmetique | ANTI-SEBORRHEIC GUANIDINE SALTS |
| WO2007068358A1 (en) * | 2005-12-16 | 2007-06-21 | Unilever Plc | Skin benefit composition and a method for using the same |
| EP4410270A4 (en) * | 2021-10-01 | 2025-10-15 | Chemyunion Ltda | Antiseptic composition, formulation and use of the composition |
Also Published As
| Publication number | Publication date |
|---|---|
| CS439379A3 (en) | 1992-03-18 |
| ATA419279A (en) | 1981-06-15 |
| CH641042A5 (en) | 1984-02-15 |
| CS275816B6 (en) | 1992-03-18 |
| FR2437210B1 (en) | 1983-02-18 |
| DE2828352B2 (en) | 1980-09-25 |
| DK153738C (en) | 1989-01-09 |
| CA1142854A (en) | 1983-03-15 |
| FR2437210A1 (en) | 1980-04-25 |
| IT1124116B (en) | 1986-05-07 |
| GB2024010B (en) | 1982-11-10 |
| DK271279A (en) | 1979-12-29 |
| DE2828352C3 (en) | 1981-08-20 |
| IT7912655A0 (en) | 1979-06-27 |
| AT365450B (en) | 1982-01-11 |
| SE7905659L (en) | 1979-12-29 |
| DE2828352A1 (en) | 1980-01-17 |
| DK153738B (en) | 1988-08-29 |
| LU81429A1 (en) | 1979-10-30 |
| JPS559069A (en) | 1980-01-22 |
| BE877351A (en) | 1979-10-15 |
| NL7904776A (en) | 1980-01-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19930622 |