GB201414902D0 - Methods for identifying modulators of ras using nonlinear techniques - Google Patents
Methods for identifying modulators of ras using nonlinear techniquesInfo
- Publication number
- GB201414902D0 GB201414902D0 GB201414902A GB201414902A GB201414902D0 GB 201414902 D0 GB201414902 D0 GB 201414902D0 GB 201414902 A GB201414902 A GB 201414902A GB 201414902 A GB201414902 A GB 201414902A GB 201414902 D0 GB201414902 D0 GB 201414902D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- ras
- methods
- identifying modulators
- nonlinear techniques
- nonlinear
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4719—G-proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/82—Translation products from oncogenes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261595123P | 2012-02-05 | 2012-02-05 | |
| US201261638026P | 2012-04-25 | 2012-04-25 | |
| PCT/US2012/063286 WO2013115867A1 (en) | 2012-02-05 | 2012-11-02 | Methods for identifying modulators of ras using nonlinear techniques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB201414902D0 true GB201414902D0 (en) | 2014-10-08 |
| GB2520111A GB2520111A (en) | 2015-05-13 |
Family
ID=48905685
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB201414902A Withdrawn GB2520111A (en) | 2012-02-05 | 2012-11-02 | Methods for identifying modulators of Ras using nonlinear techniques |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US9938560B2 (en) |
| GB (1) | GB2520111A (en) |
| WO (1) | WO2013115867A1 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9182406B2 (en) | 2008-08-04 | 2015-11-10 | Biodesy, Inc. | Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability |
| CA2831136A1 (en) | 2011-03-21 | 2012-09-27 | Biodesy, Llc | Classification of kinase inhibitors using nonlinear optical techniques |
| US9395358B2 (en) | 2012-02-05 | 2016-07-19 | Biodesy, Inc. | Methods for detecting allosteric modulators of protein |
| US20130288271A1 (en) | 2012-04-25 | 2013-10-31 | Biodesy, Llc | Methods for detecting allosteric modulators of protein |
| CN107075575B (en) | 2014-06-30 | 2021-12-03 | 蓝光治疗公司 | Systems and methods for high throughput analysis of conformation in biological entities |
| FR3027679B1 (en) * | 2014-10-28 | 2016-12-09 | Univ Claude Bernard Lyon | SUPPORT / PEPTIDE / LIPID BINOUCHE ASSEMBLY, METHODS OF PREPARATION AND DETECTION METHODS THEREOF |
| WO2016106286A1 (en) * | 2014-12-23 | 2016-06-30 | Biodesy, Inc. | Attachment of proteins to interfaces for use in nonlinear optical detection |
| CN107615047A (en) * | 2015-04-02 | 2018-01-19 | 比奥德赛公司 | The method for determining protein structure using surface selectivity nonlinear optical technique |
| EP3455628A4 (en) * | 2016-05-09 | 2019-12-04 | Biodesy, Inc. | METHODS AND DEVICES FOR DETECTION OF PERIPHERAL MEMBRANE PROTEIN INTERACTIONS USING NONLINEAR OPTICAL TECHNIQUES |
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| US5236826A (en) | 1985-12-10 | 1993-08-17 | Murex Corporation | Immunoassay for the detection or quantitation of an analyte |
| US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US5156810A (en) | 1989-06-15 | 1992-10-20 | Biocircuits Corporation | Biosensors employing electrical, optical and mechanical signals |
| US5376556A (en) | 1989-10-27 | 1994-12-27 | Abbott Laboratories | Surface-enhanced Raman spectroscopy immunoassay |
| US5145790A (en) | 1990-05-04 | 1992-09-08 | Abbott Laboratories | Reagents and method for detecting polychlorinated biphenyls |
| JPH0739397A (en) | 1993-08-04 | 1995-02-10 | Kyowa Medex Co Ltd | Method for determining chloride ion |
| GB9508559D0 (en) | 1995-04-27 | 1995-06-14 | Polytech Transfer Ltd | Surface second harmonic and sum-frequency generation immuno and enzyme assays |
| US5633724A (en) | 1995-08-29 | 1997-05-27 | Hewlett-Packard Company | Evanescent scanning of biochemical array |
| US6055051A (en) | 1996-07-31 | 2000-04-25 | The Trustees Of Columbia University In The City Of New York | Method for determining surface properties of microparticles |
| US5696157A (en) | 1996-11-15 | 1997-12-09 | Molecular Probes, Inc. | Sulfonated derivatives of 7-aminocoumarin |
| AU5462498A (en) | 1996-11-29 | 1998-06-22 | Board Of Trustees Of The Leland Stanford Junior University | Arrays of independently-addressable supported fluid bilayer membranes and methods of use thereof |
| US6699719B2 (en) | 1996-11-29 | 2004-03-02 | Proteomic Systems, Inc. | Biosensor arrays and methods |
| WO1998037417A1 (en) | 1997-02-20 | 1998-08-27 | The Regents Of The University Of California | Plasmon resonant particles, methods and apparatus |
| SE9702112D0 (en) | 1997-06-04 | 1997-06-04 | Holdingbolaget Vid Goeteborgs | Method and apparatus for detection of a receptor antagonist |
| US6194222B1 (en) | 1998-01-05 | 2001-02-27 | Biosite Diagnostics, Inc. | Methods for monitoring the status of assays and immunoassays |
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| IL124903A0 (en) | 1998-06-15 | 1999-01-26 | Bauer Alan Josef | An enzyme biosensor |
| US6680377B1 (en) | 1999-05-14 | 2004-01-20 | Brandeis University | Nucleic acid-based detection |
| US6204067B1 (en) | 1999-06-17 | 2001-03-20 | Board Of Trustees Operating Michigan State University | Methods of identifying modulators of the estrogen receptor |
| US7105310B1 (en) | 2000-07-19 | 2006-09-12 | California Institute Of Technology | Detection of biomolecules by sensitizer-linked substrates |
| US6456423B1 (en) | 1999-10-22 | 2002-09-24 | The Board Of Trustees Of The University Of Illinois | Silicon nanoparticle microcrystal nonlinear optical devices |
| US7108970B2 (en) | 2000-01-07 | 2006-09-19 | Transform Pharmaceuticals, Inc. | Rapid identification of conditions, compounds, or compositions that inhibit, prevent, induce, modify, or reverse transitions of physical state |
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| US6953694B2 (en) * | 2000-12-06 | 2005-10-11 | The Trustees Of Columbia University In The City Of New York | Attachment of second harmonic-active moiety to molecules for detection of molecules at interfaces |
| US20030129649A1 (en) | 2001-04-24 | 2003-07-10 | Kobilka Brian K. | Conformational assays to detect binding to G protein-coupled receptors |
| GB0112238D0 (en) | 2001-05-18 | 2001-07-11 | Medical Biosystems Ltd | Sequencing method |
| GB0117326D0 (en) | 2001-07-16 | 2001-09-05 | Univ Aberdeen | Napthoquinone-type inhibitors of protein aggregation |
| US20040146460A1 (en) | 2001-07-17 | 2004-07-29 | Salafsky Joshua S | Design of labels for detection with a surface-seletive nonlinear optical technique |
| WO2003064991A2 (en) | 2001-07-17 | 2003-08-07 | Salafsky Joshua S | Method and apparatus using a nonlinear optical technique for detection of probe-target interactions in a field |
| AU2002364239A1 (en) | 2001-12-24 | 2003-07-15 | Joshua S. Salafsky | Method using a surface-selective nonlinear optical technique for imaging of biological samples |
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| US20110171219A1 (en) | 2008-09-19 | 2011-07-14 | Fahar Merchant | Treating cancer stem cells using targeted cargo proteins |
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| US20120202296A1 (en) | 2011-02-02 | 2012-08-09 | The Trustees Of Columbia University In The City Of New York | System, method, and apparatus for measuring affinity constants |
| CA2831136A1 (en) | 2011-03-21 | 2012-09-27 | Biodesy, Llc | Classification of kinase inhibitors using nonlinear optical techniques |
| WO2013078410A1 (en) | 2011-11-21 | 2013-05-30 | California Institute Of Technology | Functionalization of and use of functionalized second harmonic generating nanoprobes |
| US20130288271A1 (en) | 2012-04-25 | 2013-10-31 | Biodesy, Llc | Methods for detecting allosteric modulators of protein |
| US9395358B2 (en) | 2012-02-05 | 2016-07-19 | Biodesy, Inc. | Methods for detecting allosteric modulators of protein |
| CN106290917B (en) | 2012-04-25 | 2020-06-05 | 比奥德赛公司 | Method for detecting allosteric modulators of proteins |
| GB2538216A (en) | 2013-06-13 | 2016-11-16 | Biodesy Inc | Method of screening candidate biochemical entities targeting a target biochemical entity |
-
2012
- 2012-11-02 US US14/376,613 patent/US9938560B2/en active Active
- 2012-11-02 GB GB201414902A patent/GB2520111A/en not_active Withdrawn
- 2012-11-02 WO PCT/US2012/063286 patent/WO2013115867A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US20150051110A1 (en) | 2015-02-19 |
| GB2520111A (en) | 2015-05-13 |
| US9938560B2 (en) | 2018-04-10 |
| WO2013115867A1 (en) | 2013-08-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |