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GB201301368D0 - Syringe - Google Patents

Syringe

Info

Publication number
GB201301368D0
GB201301368D0 GBGB1301368.5A GB201301368A GB201301368D0 GB 201301368 D0 GB201301368 D0 GB 201301368D0 GB 201301368 A GB201301368 A GB 201301368A GB 201301368 D0 GB201301368 D0 GB 201301368D0
Authority
GB
United Kingdom
Prior art keywords
syringe
plunger
stopper
outlet
contact surface
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GBGB1301368.5A
Other versions
GB2500092A (en
GB2500092B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47790686&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB201301368(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from AU2012101678A external-priority patent/AU2012101678B4/en
Priority claimed from DE201320000688 external-priority patent/DE202013000688U1/en
Application filed by Novartis AG filed Critical Novartis AG
Publication of GB201301368D0 publication Critical patent/GB201301368D0/en
Publication of GB2500092A publication Critical patent/GB2500092A/en
Application granted granted Critical
Publication of GB2500092B publication Critical patent/GB2500092B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31513—Piston constructions to improve sealing or sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/20—Gaseous substances, e.g. vapours
    • A61L2/206—Ethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/20—Gaseous substances, e.g. vapours
    • A61L2/208—Hydrogen peroxide
    • A61L2103/15—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3104—Caps for syringes without needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M5/3137—Specially designed finger grip means, e.g. for easy manipulation of the syringe rod
    • A61M2005/3139—Finger grips not integrally formed with the syringe barrel, e.g. using adapter with finger grips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A61M2005/31508—Means for blocking or restricting the movement of the rod or piston provided on the piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A61M5/31505—Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Anesthesiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A pre-filled syringe 1, the syringe 1 comprising a glass body 2, a stopper 10 and a plunger 4, the body comprising an outlet 12 at an outlet end 14 and the stopper 10 being arranged within the body 2 such that a front surface of the stopper 10 and the body 2 define a variable volume chamber 18 from which a fluid can be expelled through the outlet 12. The plunger 4 comprising a plunger contact surface 22 at a first end and a rod 26 extending between the plunger contact surface 22 and a rear portion 25, the plunger contact surface 22 arranged to contact the stopper 10 such, that the plunger 4 can be used to force the stopper 10 towards the outlet end 14 of the body 2, reducing the volume of the variable volume chamber 18. Characterised in that the fluid is an ophthalmic solution which comprises a VEGF antagonist. The syringe 1 has a nominal maximum fill volume between about 0.5ml and about 1ml. The syringe 1 is filled a dosage volume of between about 0.5ml and about 1ml. The syringe barrel 2 comprises less than about 500µg silicon oil. The VEGF antagonist solution comprises no more than 2 particles ¥50µm in diameter per ml.
GB1301368.5A 2012-07-03 2013-01-25 Syringe Active GB2500092B (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
EP12174860 2012-07-03
EP12189649 2012-10-23
AU2012101678A AU2012101678B4 (en) 2012-07-03 2012-11-16 Use of device
DE202012011016U DE202012011016U1 (en) 2012-07-03 2012-11-16 Aflibercept syringe
AU2012101677A AU2012101677B4 (en) 2012-07-03 2012-11-16 Device
DE202012011260U DE202012011260U1 (en) 2012-07-03 2012-11-23 Ranibizumab Injection
DE202012011259U DE202012011259U1 (en) 2012-07-03 2012-11-23 Bevacizumab syringe
EP12195360 2012-12-03
AU2013100070A AU2013100070B4 (en) 2012-07-03 2013-01-23 Use of device
DE201320000688 DE202013000688U1 (en) 2012-07-03 2013-01-23 Glass syringe
AU2013100071A AU2013100071C4 (en) 2012-07-03 2013-01-23 Device

Publications (3)

Publication Number Publication Date
GB201301368D0 true GB201301368D0 (en) 2013-03-13
GB2500092A GB2500092A (en) 2013-09-11
GB2500092B GB2500092B (en) 2014-02-12

Family

ID=47790686

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1301368.5A Active GB2500092B (en) 2012-07-03 2013-01-25 Syringe

Country Status (2)

Country Link
AU (5) AU2013100071C4 (en)
GB (1) GB2500092B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10780228B2 (en) 2012-05-07 2020-09-22 Medline Industries, Inc. Prefilled container systems
JOP20200175A1 (en) 2012-07-03 2017-06-16 Novartis Ag Syringe
US20170232199A1 (en) * 2014-05-12 2017-08-17 Formycon Ag Pre-Filled Plastic Syringe Containing a VEGF Antagonist
KR102354198B1 (en) 2015-11-18 2022-01-20 에스아이오2 메디컬 프로덕츠, 인크. Pre-filled pharmaceutical package comprising a liquid formulation of a VEGF-antagonist
CN108883057A (en) 2015-11-18 2018-11-23 Sio2医药产品公司 Pharmaceutical packaging for ophthalmic preparations
US20170349313A1 (en) 2016-06-01 2017-12-07 Centurion Medical Products Corporation Methods for manufacturing non-glass prefilled syringes
WO2018217995A1 (en) * 2017-05-24 2018-11-29 Formycon Ag Sterilizable pre-filled pharmaceutical packages comprising a liquid formulation of a vegf-antagonist
BR112022001812A2 (en) * 2019-08-01 2022-03-29 Gennova Biopharmaceuticals Ltd Ophthalmic composition of bevacizumab
US20230010593A1 (en) * 2019-12-05 2023-01-12 Hoffmann-La Roche Inc. Syringe and tightness testing method
EP4255530B1 (en) * 2020-12-01 2025-10-08 Boehringer Ingelheim International GmbH Administration device for in particular intravitreal administration of a fluid
JP2025529049A (en) * 2022-08-30 2025-09-04 アムジエン・インコーポレーテツド Systems and methods for limiting sub-visible particles in syringes

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6243938B1 (en) * 1998-03-17 2001-06-12 Becton, Dickinson And Company Low silicone plastic prefillable syringe
TWI260327B (en) * 2001-11-09 2006-08-21 Osi Eyetech Inc Pharmaceutical compositions for treating ocular neovascular diseases
US20050043220A1 (en) * 2002-11-08 2005-02-24 Guyer David R. Methods and compositions for treating macular degeneration
CA2536912C (en) * 2003-08-27 2015-03-31 Eyetech Pharmaceuticals, Inc. Combination therapy for the treatment of ocular neovascular disorders
US20080027113A1 (en) * 2003-09-23 2008-01-31 Zeldis Jerome B Methods of Using and Compositions Comprising Immunomodulatory Compounds for Treatment and Management of Macular Degeneration
US20060182783A1 (en) * 2004-04-30 2006-08-17 Allergan, Inc. Sustained release intraocular drug delivery systems
EP2324848A3 (en) * 2004-10-21 2011-09-14 Genentech, Inc. Method for treating intraocular neovascular diseases
WO2006088650A2 (en) * 2005-02-02 2006-08-24 Regeneron Pharmaceuticals, Inc. Method of treating eye injury with local administration of a vegf inhibitor
WO2006128564A1 (en) * 2005-05-31 2006-12-07 Baxter International Inc. Polypropylene hollow barrel with sliding coated rubber piston
WO2007035621A1 (en) * 2005-09-16 2007-03-29 (Osi) Eyetech, Inc. Ophthalmic syringe
US20070071756A1 (en) * 2005-09-26 2007-03-29 Peyman Gholam A Delivery of an agent to ameliorate inflammation
US8168584B2 (en) * 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
SI2364691T1 (en) * 2006-06-16 2013-08-30 Regeneron Pharmaceuticals, Inc. VEGF antagonist formulations suitable for intravitreal administration
AU2012202859C1 (en) * 2006-06-16 2025-08-07 Regeneron Pharmaceuticals, Inc. VEGF antagonist formulations suitable for intravitreal administration
US20080070855A1 (en) * 2006-09-20 2008-03-20 James Pitzer Gills Treatment with anti-VEGF agents to prevent postoperative inflammation and angiogenesis in normal and diseased eyes
EP2186528B1 (en) * 2007-08-06 2014-03-19 Senju Pharmaceutical Co., Ltd. Pharmaceutical containing hif-1 alpha and hif-2 alpha expression inhibitor
BRPI0921469B1 (en) * 2008-11-03 2022-01-18 Molecular Partners Ag BINDING PROTEINS THAT INHIBIT INTERACTION WITH THE VEGF-A RECEPTOR, PHARMACEUTICAL COMPOSITION
WO2010064667A1 (en) * 2008-12-03 2010-06-10 電気化学工業株式会社 Syringe
JP2012525415A (en) * 2009-05-01 2012-10-22 オプソテツク・コーポレイシヨン Methods for treating or preventing ophthalmic diseases
AU2010251966A1 (en) * 2009-05-28 2011-12-22 Glaxo Group Limited Combination of a TNF-alpha antagonist and a VEGF antagonist for use in the treatment or prevention of diseases of the eye.
KR20120129904A (en) * 2010-01-14 2012-11-28 공립대학법인 나고야 시립대학 Pharmaceutical for preventing or treating disorders accompanied by ocular angiogenesis and/or elevated ocular vascular permeability
CN201578690U (en) * 2010-01-21 2010-09-15 王建友 Syringe
US9408746B2 (en) * 2010-03-31 2016-08-09 Ocuject, Llc Device and method for intraocular drug delivery
US20130012918A1 (en) * 2011-07-07 2013-01-10 Gary Foster Steady grip ophthalmic surgical syringe and method

Also Published As

Publication number Publication date
AU2013100145B4 (en) 2013-05-02
GB2500092A (en) 2013-09-11
AU2013100146B4 (en) 2013-04-18
GB2500092B (en) 2014-02-12
AU2013100070B4 (en) 2013-04-04
AU2013100145A4 (en) 2013-03-28
AU2013100147B4 (en) 2013-04-18
AU2013100146A4 (en) 2013-03-28
AU2013100147A4 (en) 2013-03-28
AU2013100070A4 (en) 2013-03-07
AU2013100071B4 (en) 2013-03-28
AU2013100071C4 (en) 2013-05-02
AU2013100071A4 (en) 2013-03-07

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