GB2012790A - Process for the Recovery of Heparin - Google Patents
Process for the Recovery of HeparinInfo
- Publication number
- GB2012790A GB2012790A GB79457A GB7900457A GB2012790A GB 2012790 A GB2012790 A GB 2012790A GB 79457 A GB79457 A GB 79457A GB 7900457 A GB7900457 A GB 7900457A GB 2012790 A GB2012790 A GB 2012790A
- Authority
- GB
- United Kingdom
- Prior art keywords
- heparin
- recovered
- sodium chloride
- recovery
- intestinal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title abstract 4
- 229960002897 heparin Drugs 0.000 title abstract 4
- 229920000669 heparin Polymers 0.000 title abstract 4
- 238000000034 method Methods 0.000 title 1
- 238000011084 recovery Methods 0.000 title 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 4
- 230000000968 intestinal effect Effects 0.000 abstract 2
- 239000011780 sodium chloride Substances 0.000 abstract 2
- 239000012267 brine Substances 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 210000000936 intestine Anatomy 0.000 abstract 1
- 210000003097 mucus Anatomy 0.000 abstract 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Heparin is recovered from intestinal brine formed by treatment, with aqueous sodium chloride solution or solid sodium chloride in the presence of water, of animal intestines from which intestinal mucus has been removed. The heparin recovered is almost completely free of by-products, and heparin of good quality is obtained.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2800943A DE2800943C2 (en) | 1978-01-06 | 1978-01-06 | Use of intestinal brine to obtain pure heparin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB2012790A true GB2012790A (en) | 1979-08-01 |
| GB2012790B GB2012790B (en) | 1983-03-30 |
Family
ID=6029250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB79457A Expired GB2012790B (en) | 1978-01-06 | 1979-01-05 | Process for the recovery of heparin |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS5943042B2 (en) |
| AR (1) | AR220734A1 (en) |
| AT (1) | AT365073B (en) |
| AU (1) | AU526459B2 (en) |
| BE (1) | BE873327A (en) |
| BR (1) | BR7900056A (en) |
| CA (1) | CA1132904A (en) |
| CH (1) | CH638818A5 (en) |
| CS (1) | CS216189B2 (en) |
| DD (1) | DD141311A5 (en) |
| DE (1) | DE2800943C2 (en) |
| DK (1) | DK163063C (en) |
| ES (1) | ES476623A1 (en) |
| FI (1) | FI65073C (en) |
| FR (1) | FR2414055A1 (en) |
| GB (1) | GB2012790B (en) |
| GR (1) | GR72952B (en) |
| HU (1) | HU179594B (en) |
| IT (1) | IT1109918B (en) |
| LU (1) | LU80755A1 (en) |
| NL (1) | NL187070C (en) |
| PL (1) | PL117279B3 (en) |
| RO (1) | RO78606A (en) |
| SE (1) | SE439109B (en) |
| YU (1) | YU301878A (en) |
| ZA (1) | ZA787305B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0066908B1 (en) * | 1981-05-21 | 1985-08-28 | Akzo N.V. | New anti-thromboticum based on polysacharides, method for its preparation and pharmaceutical compositions |
| CN103601821B (en) * | 2013-11-15 | 2016-01-06 | 重庆三腾食品有限公司 | A kind of enzymolysis processing method and corresponding heparin sodium working method |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1156938B (en) * | 1957-09-23 | 1963-11-07 | Upjohn Company Eine Ges Nach D | Method for obtaining heparin |
| GB889010A (en) * | 1957-11-06 | 1962-02-07 | Crinos Industria Farmaco | A new heparin-like compound |
| DE2652272C2 (en) * | 1976-11-12 | 1979-02-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Process for the production of heparin |
| DE2660052A1 (en) * | 1976-11-12 | 1979-01-25 | Schering Ag | Pure anticoagulant heparin prodn. - using salt lakes obtd. from mucus-free animal intestines by sprinkling with salt |
-
1978
- 1978-01-06 DE DE2800943A patent/DE2800943C2/en not_active Expired
- 1978-12-19 FI FI783904A patent/FI65073C/en not_active IP Right Cessation
- 1978-12-21 YU YU03018/78A patent/YU301878A/en unknown
- 1978-12-27 ZA ZA00787305A patent/ZA787305B/en unknown
- 1978-12-27 RO RO7896066A patent/RO78606A/en unknown
- 1978-12-27 DK DK582878A patent/DK163063C/en not_active IP Right Cessation
- 1978-12-28 JP JP53161328A patent/JPS5943042B2/en not_active Expired
- 1978-12-28 NL NLAANVRAGE7812621,A patent/NL187070C/en not_active IP Right Cessation
-
1979
- 1979-01-03 LU LU80755A patent/LU80755A1/en unknown
- 1979-01-04 CS CS79133A patent/CS216189B2/en unknown
- 1979-01-04 CA CA319,121A patent/CA1132904A/en not_active Expired
- 1979-01-04 AT AT0006879A patent/AT365073B/en not_active IP Right Cessation
- 1979-01-04 SE SE7900077A patent/SE439109B/en not_active IP Right Cessation
- 1979-01-04 PL PL1979212596A patent/PL117279B3/en unknown
- 1979-01-05 GR GR58030A patent/GR72952B/el unknown
- 1979-01-05 HU HU79SCHE667A patent/HU179594B/en unknown
- 1979-01-05 AR AR275072A patent/AR220734A1/en active
- 1979-01-05 IT IT19085/79A patent/IT1109918B/en active
- 1979-01-05 GB GB79457A patent/GB2012790B/en not_active Expired
- 1979-01-05 BR BR7900056A patent/BR7900056A/en unknown
- 1979-01-05 BE BE0/192777A patent/BE873327A/en not_active IP Right Cessation
- 1979-01-05 DD DD79210359A patent/DD141311A5/en unknown
- 1979-01-05 CH CH10279A patent/CH638818A5/en not_active IP Right Cessation
- 1979-01-05 ES ES476623A patent/ES476623A1/en not_active Expired
- 1979-01-08 FR FR7900295A patent/FR2414055A1/en active Granted
- 1979-01-08 AU AU43181/79A patent/AU526459B2/en not_active Ceased
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |