GB2012276A - Producing cephalosporins - Google Patents
Producing cephalosporinsInfo
- Publication number
- GB2012276A GB2012276A GB79312A GB7900312A GB2012276A GB 2012276 A GB2012276 A GB 2012276A GB 79312 A GB79312 A GB 79312A GB 7900312 A GB7900312 A GB 7900312A GB 2012276 A GB2012276 A GB 2012276A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- image
- amino
- salt
- cephalosporin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940124587 cephalosporin Drugs 0.000 title abstract 4
- 229930186147 Cephalosporin Natural products 0.000 title abstract 3
- 150000001780 cephalosporins Chemical class 0.000 title abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 2
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000000269 nucleophilic effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 239000000376 reactant Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A 7-[2-(2-aminothiazol-4-yl)-2- (syn)-alkoxy- iminoacetamido]cephalosporin derivative of the formula: <IMAGE> wherein R3 represents -CH2R5 (R5 is a hydrogen atom or the residue of a nucleophilic compound), a halogen atom, an alkoxyl group, thiol group, amino group or <IMAGE> (Z is hydrogen atom or hydroxyl, amino, thiol or a hydrocarbon group which may be substituted), -COOR4 represents a carboxylic group which may be esterified and R6 represents an alkyl group, or a salt thereof is prepared by reacting a novel 7-(4-halogeno-3-oxo-2- alkoxyiminobutyrylamino) cephalosporin derivative of the formula: <IMAGE> wherein X represents a halogen atom and other symbols have the same meanings as defined above, or a salt thereof with thiourea; the halo reactant is made by acylating the corresponding 7-amino-cephalosporin.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP303278A JPS5498795A (en) | 1978-01-13 | 1978-01-13 | Cephalosporin derivative and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB2012276A true GB2012276A (en) | 1979-07-25 |
| GB2012276B GB2012276B (en) | 1982-05-06 |
Family
ID=11545964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB79312A Expired GB2012276B (en) | 1978-01-13 | 1979-01-04 | Producing cephalosporins |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS5498795A (en) |
| CH (1) | CH642662A5 (en) |
| DE (1) | DE2900961A1 (en) |
| FR (1) | FR2414508A1 (en) |
| GB (1) | GB2012276B (en) |
| IT (1) | IT1111686B (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0036510A3 (en) * | 1980-03-06 | 1981-12-02 | Fujisawa Pharmaceutical Co., Ltd. | Synisomer cephalosporin compounds, processes for their preparation; intermediates and their preparation |
| GB2131799A (en) * | 1982-11-05 | 1984-06-27 | Toshiyasu Ishimaru | Cephalosporin compounds |
| EP0160563A3 (en) * | 1984-04-30 | 1986-11-26 | Glaxo Group Limited | Process for preparing cephalosporin compounds |
| US4845257A (en) * | 1986-05-21 | 1989-07-04 | Takeda Chemical Industries, Ltd. | 4-halogeno-2-oxyimino-3-oxobutyric acids and derivatives |
| EP0257275A3 (en) * | 1986-07-28 | 1990-05-23 | American Cyanamid Company | Cephalosporin and penicillin derivatives |
| EP0325183A3 (en) * | 1988-01-18 | 1990-12-19 | Takeda Chemical Industries, Ltd. | Method for the production of 2-oxyimino-3-oxobutyric acids |
| EP0324418A3 (en) * | 1988-01-14 | 1991-09-11 | Takeda Chemical Industries, Ltd. | Method for production of t-butyl- 3-oxobutyrates and their use |
| US6846952B2 (en) | 2001-11-26 | 2005-01-25 | Lupin Limited | Process for manufacture of a 4-bromo-2-oxyimino butyric acid and its derivatives |
| WO2005019227A1 (en) * | 2003-08-22 | 2005-03-03 | Orchid Chemicals & Pharmaceuticals Ltd | Process for the preparation of cephalosporin antibiotic |
| US7071329B2 (en) | 2003-12-02 | 2006-07-04 | Acs Dobfar S.P.A. | Process for preparing cephalosporins with salified intermediate |
| US8263675B2 (en) | 2007-09-04 | 2012-09-11 | Cheil Industries Inc. | Photosensitive resin composition for color filter and color filter made using the same |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2967053D1 (en) * | 1978-09-12 | 1984-07-19 | Fujisawa Pharmaceutical Co | Starting compounds for preparing cephem compounds and processes for their preparation |
| FI67385C (en) * | 1979-11-21 | 1985-03-11 | Hoffmann La Roche | PROCEDURE FOR FRAMSTATION OF AV (6R 7R) -7- (2- (2-AMINO-4-THIAZOLYL) -2- (Z-METHOXYIMINO) ACETAMIDO) -3-CEFEM-4-CARBOXYL SYRATER DERIVATIVES |
| IT8026945A0 (en) * | 1980-12-24 | 1980-12-24 | Isf Spa | KETOHYDROXYIMININOCEPHALOSPORINS. |
| JPS60260583A (en) * | 1985-05-14 | 1985-12-23 | Sankyo Co Ltd | Preparation of cephalosporin derivative |
| WO1987003585A1 (en) * | 1985-12-06 | 1987-06-18 | Mect Corporation | 4-halo-2-hydroxyimino-3-oxobutyronitriles and process for their preparation |
| DE3809845A1 (en) * | 1988-03-24 | 1989-10-12 | Hoechst Ag | METHOD FOR PRODUCING 4-HALO-3-OXO-2-ALKOXYIMINOBUTTERIC ACID ESTERS |
| JPH0393762A (en) * | 1989-09-04 | 1991-04-18 | Wako Pure Chem Ind Ltd | Production of 4-halogeno-2-alkoxyimino-3-oxofatty acid |
| WO2004083216A1 (en) * | 2003-03-20 | 2004-09-30 | Orchid Chemicals & Pharmaceuticals Ltd | A process for the preparation of cephalosporins |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE440655B (en) * | 1976-01-23 | 1985-08-12 | Roussel Uclaf | SET TO MAKE NEW OXIME DERIVATIVES OF 7-AMINO-THIAZOLYL-ACETAMIDO-CEPHALOSPORANIC ACID |
| FR2345153A1 (en) * | 1976-03-25 | 1977-10-21 | Roussel Uclaf | NEW ALCOYLOXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
| GB1576625A (en) * | 1976-04-12 | 1980-10-08 | Fujisawa Pharmaceutical Co | Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof |
| DK162391C (en) * | 1976-04-12 | 1992-03-09 | Fujisawa Pharmaceutical Co | ANALOGY PROCEDURE FOR PREPARING SYN-ISOMERS OF 3,7-DISUBSTITUTED 3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS |
| DE2715385A1 (en) * | 1976-04-14 | 1977-11-10 | Takeda Chemical Industries Ltd | CEPHALOSPORIN DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THEM |
| FI771866A7 (en) * | 1976-06-28 | 1977-12-29 | Fujisawa Pharmaceutical Co | |
| PH17188A (en) * | 1977-03-14 | 1984-06-14 | Fujisawa Pharmaceutical Co | New cephem and cepham compounds and their pharmaceutical compositions and method of use |
-
1978
- 1978-01-13 JP JP303278A patent/JPS5498795A/en active Granted
-
1979
- 1979-01-04 GB GB79312A patent/GB2012276B/en not_active Expired
- 1979-01-09 CH CH15179A patent/CH642662A5/en not_active IP Right Cessation
- 1979-01-11 FR FR7900655A patent/FR2414508A1/en active Granted
- 1979-01-11 DE DE19792900961 patent/DE2900961A1/en not_active Ceased
- 1979-01-12 IT IT19262/79A patent/IT1111686B/en active
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0036510A3 (en) * | 1980-03-06 | 1981-12-02 | Fujisawa Pharmaceutical Co., Ltd. | Synisomer cephalosporin compounds, processes for their preparation; intermediates and their preparation |
| GB2131799A (en) * | 1982-11-05 | 1984-06-27 | Toshiyasu Ishimaru | Cephalosporin compounds |
| EP0160563A3 (en) * | 1984-04-30 | 1986-11-26 | Glaxo Group Limited | Process for preparing cephalosporin compounds |
| US4845257A (en) * | 1986-05-21 | 1989-07-04 | Takeda Chemical Industries, Ltd. | 4-halogeno-2-oxyimino-3-oxobutyric acids and derivatives |
| EP0257275A3 (en) * | 1986-07-28 | 1990-05-23 | American Cyanamid Company | Cephalosporin and penicillin derivatives |
| EP0324418A3 (en) * | 1988-01-14 | 1991-09-11 | Takeda Chemical Industries, Ltd. | Method for production of t-butyl- 3-oxobutyrates and their use |
| US5109131A (en) * | 1988-01-14 | 1992-04-28 | Takeda Chemical Industries, Ltd. | Method for production of t-butyl 3-oxobutyrates and their use |
| US5183929A (en) * | 1988-01-14 | 1993-02-02 | Takeda Chemical Industries, Ltd. | Method for production of T-butyl 3-oxobutyrates and their use |
| EP0325183A3 (en) * | 1988-01-18 | 1990-12-19 | Takeda Chemical Industries, Ltd. | Method for the production of 2-oxyimino-3-oxobutyric acids |
| US6846952B2 (en) | 2001-11-26 | 2005-01-25 | Lupin Limited | Process for manufacture of a 4-bromo-2-oxyimino butyric acid and its derivatives |
| WO2005019227A1 (en) * | 2003-08-22 | 2005-03-03 | Orchid Chemicals & Pharmaceuticals Ltd | Process for the preparation of cephalosporin antibiotic |
| US7339055B2 (en) | 2003-08-22 | 2008-03-04 | Orchid Chemicals & Pharmaceuticals Ltd. | Process for the preparation of cephalosporin antibiotic |
| US7345169B2 (en) | 2003-08-22 | 2008-03-18 | Orchid Chemicals & Pharmaceuticals Ltd. | Process for the preparation of cephalosporin antibiotic |
| US7071329B2 (en) | 2003-12-02 | 2006-07-04 | Acs Dobfar S.P.A. | Process for preparing cephalosporins with salified intermediate |
| US8263675B2 (en) | 2007-09-04 | 2012-09-11 | Cheil Industries Inc. | Photosensitive resin composition for color filter and color filter made using the same |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2900961A1 (en) | 1979-07-19 |
| JPS5498795A (en) | 1979-08-03 |
| IT7919262A0 (en) | 1979-01-12 |
| GB2012276B (en) | 1982-05-06 |
| CH642662A5 (en) | 1984-04-30 |
| FR2414508A1 (en) | 1979-08-10 |
| JPH0142955B2 (en) | 1989-09-18 |
| FR2414508B1 (en) | 1983-05-27 |
| IT1111686B (en) | 1986-01-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB2012276A (en) | Producing cephalosporins | |
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| GB2022090A (en) | 7-[2-(2-amino-4-thiazolyl)-2- methoxyimino-acetamido]-3- heterocyclyl(thiomethyl)-cephems | |
| IL71772A (en) | Process for the preparation of 7-(2-(aminothiazolyl or aminothiadiazolyl)-2-hydroxyiminoacetamido)-3-(ammoniomethyl)-ceph-3-em-4-carboxylate derivatives | |
| PT69950A (en) | Process for preparing novel oxadiazolopyrimidine derivatives | |
| JPS55129287A (en) | Imidazole-dicarboxylic acid derivative | |
| IL69210A (en) | 7-(2-(2-amino 4-thiazolyl)-2-carboxyalkyloxyimino)acetamido)-3-(uronium thiomethyl)3-cephem 4-carboxylic acid derivatives,their preparation and antibiotic pharmaceutical compositions containing them | |
| DE3173642D1 (en) | Cephalosporin derivatives, process for their preparation, pharmaceutical compositions containing them and intermediates for their preparation | |
| PT69939A (en) | Process for preparing cephalosporin derivatives | |
| NO872502D0 (en) | PROCEDURE FOR 7-SUBSTITUTED CEPHALOSPORINES. | |
| DE3169296D1 (en) | Cephalosporin derivatives and their preparation | |
| ES455922A1 (en) | A procedure for the preparation of cephalosporine derivatives (Machine-translation by Google Translate, not legally binding) | |
| KR830000697A (en) | Method for producing cephalosporins | |
| JPS5283864A (en) | Cephalosporin derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PE20 | Patent expired after termination of 20 years |
Effective date: 19990103 |