GB201114733D0 - Detection of neurodegenerative disease - Google Patents
Detection of neurodegenerative diseaseInfo
- Publication number
- GB201114733D0 GB201114733D0 GB201114733A GB201114733A GB201114733D0 GB 201114733 D0 GB201114733 D0 GB 201114733D0 GB 201114733 A GB201114733 A GB 201114733A GB 201114733 A GB201114733 A GB 201114733A GB 201114733 D0 GB201114733 D0 GB 201114733D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- cell
- magnet
- proteins
- detection
- neurodegenerative disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 230000004770 neurodegeneration Effects 0.000 title abstract 2
- 208000015122 neurodegenerative disease Diseases 0.000 title abstract 2
- 238000001514 detection method Methods 0.000 title 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 4
- 210000004027 cell Anatomy 0.000 abstract 3
- 210000001175 cerebrospinal fluid Anatomy 0.000 abstract 2
- 229910052742 iron Inorganic materials 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000008857 Ferritin Human genes 0.000 abstract 1
- 108050000784 Ferritin Proteins 0.000 abstract 1
- 238000008416 Ferritin Methods 0.000 abstract 1
- -1 Parkinson's Diseases 0.000 abstract 1
- 102000004338 Transferrin Human genes 0.000 abstract 1
- 108090000901 Transferrin Proteins 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 230000005540 biological transmission Effects 0.000 abstract 1
- 239000000090 biomarker Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000013632 homeostatic process Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 239000012581 transferrin Substances 0.000 abstract 1
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The application is directed to apparatus and methods for detecting iron containing proteins, eg. ferritin, transferrin etc., in bodily fluids, eg. whole blood, serum, cerebrospinal fluid (CSF), using a magneto-optic technique, especially based on the Cotton-Mouton effect. These proteins serve as sensitive biomarkers for disruption of iron homeostasis and neurodegenerative diseases, such as Alzheimer's, Parkinson's, ALS etc. In one embodiment, an apparatus for transmission measurements (10) comprises a light source (12), a polariser (14), and a sample cell (16) for containing a liquid sample under analysis. A photodetector (18) is positioned near the rear face of the cell to detect light transmitted through the cell. The output of the detector is analysed by a computer or microprocessor (20) as a function of a modulating magnet field generated by magnet (22).
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201114733A GB201114733D0 (en) | 2011-08-26 | 2011-08-26 | Detection of neurodegenerative disease |
| PCT/GB2012/052064 WO2013030542A1 (en) | 2011-08-26 | 2012-08-23 | Detection of neurodegenerative disease |
| GB1403183.5A GB2507705A (en) | 2011-08-26 | 2012-08-23 | Detection of neurodegenerative disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201114733A GB201114733D0 (en) | 2011-08-26 | 2011-08-26 | Detection of neurodegenerative disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB201114733D0 true GB201114733D0 (en) | 2011-10-12 |
Family
ID=44838732
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB201114733A Ceased GB201114733D0 (en) | 2011-08-26 | 2011-08-26 | Detection of neurodegenerative disease |
| GB1403183.5A Withdrawn GB2507705A (en) | 2011-08-26 | 2012-08-23 | Detection of neurodegenerative disease |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1403183.5A Withdrawn GB2507705A (en) | 2011-08-26 | 2012-08-23 | Detection of neurodegenerative disease |
Country Status (2)
| Country | Link |
|---|---|
| GB (2) | GB201114733D0 (en) |
| WO (1) | WO2013030542A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2566995B (en) * | 2017-09-29 | 2023-01-18 | Cotton Mouton Diagnostics Ltd | A method of detection |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2608398T3 (en) * | 2003-05-30 | 2017-04-10 | Nls-1 Pharma Ag | Use of iron for the treatment of attention deficit / hyperactivity disorder in children |
| WO2011141766A1 (en) * | 2010-05-11 | 2011-11-17 | University Of Calcutta | Ferritin biosensor and methods of using the same |
-
2011
- 2011-08-26 GB GB201114733A patent/GB201114733D0/en not_active Ceased
-
2012
- 2012-08-23 GB GB1403183.5A patent/GB2507705A/en not_active Withdrawn
- 2012-08-23 WO PCT/GB2012/052064 patent/WO2013030542A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| GB201403183D0 (en) | 2014-04-09 |
| WO2013030542A1 (en) | 2013-03-07 |
| GB2507705A (en) | 2014-05-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AT | Applications terminated before publication under section 16(1) |