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GB2010675A - Method of treating hypertension and medicaments therefor - Google Patents

Method of treating hypertension and medicaments therefor

Info

Publication number
GB2010675A
GB2010675A GB7849703A GB7849703A GB2010675A GB 2010675 A GB2010675 A GB 2010675A GB 7849703 A GB7849703 A GB 7849703A GB 7849703 A GB7849703 A GB 7849703A GB 2010675 A GB2010675 A GB 2010675A
Authority
GB
United Kingdom
Prior art keywords
alkyl
treating hypertension
phenyl
medicaments therefor
medicaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7849703A
Other versions
GB2010675B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25343256&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB2010675(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of GB2010675A publication Critical patent/GB2010675A/en
Application granted granted Critical
Publication of GB2010675B publication Critical patent/GB2010675B/en
Priority to MYPI87003001A priority Critical patent/MY102991A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A method for reducing blood pressure comprises administering a combination of a diuretic compound (specified) and a compound having the general formula <IMAGE> R = OH1 alkoxy or NH2 R1 & R4 = H1 alkyl or phenyl alkyl R2 = H or R5CO R3 = H1 OH or alkyl R5 = alkyl, phenyl, or phenyl alkyl n = 0 - 2.a
GB7849703A 1977-12-27 1978-12-21 Treating hypertension and medicaments therefor Expired GB2010675B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MYPI87003001A MY102991A (en) 1977-12-27 1987-10-31 Medicaments for treating hypertension.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86442877A 1977-12-27 1977-12-27

Publications (2)

Publication Number Publication Date
GB2010675A true GB2010675A (en) 1979-07-04
GB2010675B GB2010675B (en) 1982-06-16

Family

ID=25343256

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7849703A Expired GB2010675B (en) 1977-12-27 1978-12-21 Treating hypertension and medicaments therefor

Country Status (30)

Country Link
JP (1) JPS54110333A (en)
AR (1) AR230378A1 (en)
AU (1) AU526239B2 (en)
BE (1) BE873092A (en)
CA (1) CA1120400A (en)
CH (1) CH642542A5 (en)
DE (1) DE2854316C3 (en)
DK (1) DK578778A (en)
EG (1) EG14178A (en)
FI (1) FI783991A7 (en)
FR (1) FR2413089A1 (en)
GB (1) GB2010675B (en)
GR (1) GR72951B (en)
HK (1) HK45483A (en)
HU (1) HU178747B (en)
IE (1) IE48306B1 (en)
IL (1) IL56281A (en)
IT (1) IT1202811B (en)
KE (1) KE3235A (en)
LU (1) LU80709A1 (en)
MY (2) MY8300240A (en)
NL (2) NL192870C (en)
NO (1) NO784357L (en)
NZ (1) NZ189159A (en)
PH (1) PH22111A (en)
PL (1) PL212188A1 (en)
PT (1) PT68983A (en)
SE (1) SE445173B (en)
SG (1) SG41482G (en)
ZA (1) ZA786948B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450275A (en) * 1978-10-05 1984-05-22 Yoshitomi Pharmaceutical Industries, Ltd. Cyclic iminocarboxylic acid derivatives
EP0154009A1 (en) * 1983-12-09 1985-09-11 Euro-Celtique S.A. Use of a thiazide diuretic for the manufacture of a non-diuretic antihypertensive medicament
US4552889A (en) * 1983-06-09 1985-11-12 Eli Lilly And Company 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension
US5686451A (en) * 1992-03-11 1997-11-11 Merck & Co Inc Combination of an ace inhibitor and a diuretic

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4350704A (en) 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
US4482725A (en) * 1980-04-03 1984-11-13 E. R. Squibb & Sons, Inc. S-Acylation products of mercaptoacyl amino acids and carboxyl group containing diuretics
US4344949A (en) 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
DE3532036A1 (en) * 1985-09-09 1987-03-26 Hoechst Ag PHARMACEUTICAL PREPARATION FOR TREATING HIGH PRESSURE
AU4777896A (en) * 1995-02-10 1996-08-27 G.D. Searle & Co. Use of low dose amount of spironolactone for treatment of cardiovascular disease

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450275A (en) * 1978-10-05 1984-05-22 Yoshitomi Pharmaceutical Industries, Ltd. Cyclic iminocarboxylic acid derivatives
US4552889A (en) * 1983-06-09 1985-11-12 Eli Lilly And Company 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension
EP0154009A1 (en) * 1983-12-09 1985-09-11 Euro-Celtique S.A. Use of a thiazide diuretic for the manufacture of a non-diuretic antihypertensive medicament
US5686451A (en) * 1992-03-11 1997-11-11 Merck & Co Inc Combination of an ace inhibitor and a diuretic

Also Published As

Publication number Publication date
FR2413089A1 (en) 1979-07-27
DE2854316A1 (en) 1979-07-05
GB2010675B (en) 1982-06-16
NL192870C (en) 1998-04-02
BE873092A (en) 1979-06-27
DE2854316C3 (en) 1994-12-22
FI783991A7 (en) 1979-06-28
FR2413089B1 (en) 1980-12-26
IT1202811B (en) 1989-02-09
PH22111A (en) 1988-06-01
MY102991A (en) 1993-03-31
NL7812164A (en) 1979-06-29
NZ189159A (en) 1984-12-14
AR230378A1 (en) 1984-04-30
NO784357L (en) 1979-06-28
SE7813277L (en) 1979-06-28
ZA786948B (en) 1980-04-30
DE2854316C2 (en) 1989-08-10
IT7831266A0 (en) 1978-12-22
CH642542A5 (en) 1984-04-30
IE48306B1 (en) 1984-12-12
HK45483A (en) 1983-10-28
JPS647045B2 (en) 1989-02-07
IE782413L (en) 1979-06-27
PT68983A (en) 1979-01-01
PL212188A1 (en) 1980-02-11
NL980017I1 (en) 1998-07-01
JPS54110333A (en) 1979-08-29
HU178747B (en) 1982-06-28
IL56281A (en) 1983-05-15
NL192870B (en) 1997-12-01
DK578778A (en) 1979-06-28
LU80709A1 (en) 1979-04-13
EG14178A (en) 1984-06-30
KE3235A (en) 1982-11-05
CA1120400A (en) 1982-03-23
IL56281A0 (en) 1979-03-12
MY8300240A (en) 1983-12-31
AU526239B2 (en) 1982-12-23
SE445173B (en) 1986-06-09
SG41482G (en) 1985-01-11
AU4204178A (en) 1979-07-05
GR72951B (en) 1984-01-17

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Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Effective date: 19981220