GB2001061A - alpha -Vinyl Amino Acids - Google Patents
alpha -Vinyl Amino AcidsInfo
- Publication number
- GB2001061A GB2001061A GB7828005A GB7828005A GB2001061A GB 2001061 A GB2001061 A GB 2001061A GB 7828005 A GB7828005 A GB 7828005A GB 7828005 A GB7828005 A GB 7828005A GB 2001061 A GB2001061 A GB 2001061A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydrogen
- carbon atoms
- carbonyl
- alkyl
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920002554 vinyl polymer Polymers 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 150000002431 hydrogen Chemical group 0.000 abstract 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000003143 4-hydroxybenzyl group Chemical group [H]C([*])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Pharmaceutically useful compounds have the formula <IMAGE> and pharmaceutically acceptable salts and individual optical isomers thereof, wherein R1 is hydrogen, (C1-4alkyl) carbonyl (C1-4alkoxy) carbonyl or CO-CHNH2-R17 wherein R17 is hydrogen, alkyl of 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; R is hydroxy, alkoxy of 1 to 8 carbon atoms, -NR7R8 wherein R7 and R8 are the same or different and are each hydrogen or alkyl or 1 to 4 carbon atoms or -NH-CHR9COOH wherein R9 is hydrogen, alkyl of 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; and R2, R3, R4, R5 and R6 are certain combinations of hydrogen, methyl, ethyl, tert-butyl, chlorine, fluorine and OR10 wherein R10 is hydrogen, alkyl of 1 to 8 carbon atoms, (C1-6alkyl) carbonyl, benzoyl or phenyl(C1-6alkyl)-carbonyl.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81226477A | 1977-07-01 | 1977-07-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB2001061A true GB2001061A (en) | 1979-01-24 |
| GB2001061B GB2001061B (en) | 1982-02-24 |
Family
ID=25209049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7828005A Expired GB2001061B (en) | 1977-07-01 | 1978-06-27 | -vincly amino acids |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS5416443A (en) |
| BE (1) | BE868593A (en) |
| CA (1) | CA1157030A (en) |
| DE (1) | DE2827805A1 (en) |
| FR (1) | FR2395984A1 (en) |
| GB (1) | GB2001061B (en) |
| ZA (1) | ZA783275B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0007615A3 (en) * | 1978-07-24 | 1980-05-28 | Merck & Co. Inc. | Process for preparing amino acids and esters, and intermediates therefor |
| GB2188047A (en) * | 1986-03-04 | 1987-09-23 | Toyo Jozo Kk | Aldose reductase inhibitors |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK309679A (en) * | 1978-07-24 | 1980-02-22 | Merck & Co Inc | PROCESS FOR THE PREPARATION OF ALFAVINYLAMINO ACIDS AND ESTERS THEREOF |
| NL2028208B1 (en) | 2021-05-12 | 2022-11-30 | Flint Group Germany Gmbh | Flexographic printing element precursor with high melt flow index |
| NL2028207B1 (en) | 2021-05-12 | 2022-11-30 | Flint Group Germany Gmbh | A relief precursor with vegetable oils as plasticizers suitable for printing plates |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3960927A (en) * | 1975-03-18 | 1976-06-01 | Richardson-Merrell Inc. | Olefinic derivatives of amino acids |
| US4401676A (en) * | 1977-06-01 | 1983-08-30 | Merck & Co., Inc. | Novel α-amino acids |
-
1978
- 1978-06-06 CA CA000304898A patent/CA1157030A/en not_active Expired
- 1978-06-07 ZA ZA00783275A patent/ZA783275B/en unknown
- 1978-06-24 DE DE19782827805 patent/DE2827805A1/en not_active Withdrawn
- 1978-06-27 GB GB7828005A patent/GB2001061B/en not_active Expired
- 1978-06-28 FR FR7819352A patent/FR2395984A1/en active Granted
- 1978-06-29 BE BE188953A patent/BE868593A/en not_active IP Right Cessation
- 1978-07-01 JP JP7927278A patent/JPS5416443A/en active Granted
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0007615A3 (en) * | 1978-07-24 | 1980-05-28 | Merck & Co. Inc. | Process for preparing amino acids and esters, and intermediates therefor |
| GB2188047A (en) * | 1986-03-04 | 1987-09-23 | Toyo Jozo Kk | Aldose reductase inhibitors |
| US4749571A (en) * | 1986-03-04 | 1988-06-07 | Toyo Jozo Co., Ltd. | Physiologically-active novel substance "Aldostatin" and production method thereof |
| GB2188047B (en) * | 1986-03-04 | 1989-12-28 | Toyo Jozo Kk | Aldose reductase inhibitor |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA783275B (en) | 1979-06-27 |
| JPS5416443A (en) | 1979-02-07 |
| BE868593A (en) | 1978-10-16 |
| JPS6338345B2 (en) | 1988-07-29 |
| DE2827805A1 (en) | 1979-01-18 |
| CA1157030A (en) | 1983-11-15 |
| GB2001061B (en) | 1982-02-24 |
| FR2395984A1 (en) | 1979-01-26 |
| FR2395984B1 (en) | 1981-09-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19940627 |