GB2095694A - Tooth cleaning compositions - Google Patents
Tooth cleaning compositions Download PDFInfo
- Publication number
- GB2095694A GB2095694A GB8209360A GB8209360A GB2095694A GB 2095694 A GB2095694 A GB 2095694A GB 8209360 A GB8209360 A GB 8209360A GB 8209360 A GB8209360 A GB 8209360A GB 2095694 A GB2095694 A GB 2095694A
- Authority
- GB
- United Kingdom
- Prior art keywords
- composition according
- composition
- oxygen
- compositions
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 45
- 238000004140 cleaning Methods 0.000 title abstract description 11
- 150000001875 compounds Chemical class 0.000 claims abstract description 14
- 150000003839 salts Chemical class 0.000 claims abstract description 12
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000001301 oxygen Substances 0.000 claims abstract description 11
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- XQRLCLUYWUNEEH-UHFFFAOYSA-N diphosphonic acid Chemical compound OP(=O)OP(O)=O XQRLCLUYWUNEEH-UHFFFAOYSA-N 0.000 claims abstract description 6
- GFHPUWTUBQEWGA-UHFFFAOYSA-N C(C)(=O)P(=O)(O)OP(=O)O Chemical compound C(C)(=O)P(=O)(O)OP(=O)O GFHPUWTUBQEWGA-UHFFFAOYSA-N 0.000 claims description 5
- 229910052783 alkali metal Inorganic materials 0.000 claims description 5
- -1 alkali metal salt Chemical class 0.000 claims description 3
- 239000008247 solid mixture Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 abstract description 3
- 239000007787 solid Substances 0.000 abstract description 2
- 239000000463 material Substances 0.000 description 6
- 208000006558 Dental Calculus Diseases 0.000 description 5
- XSVSPKKXQGNHMD-UHFFFAOYSA-N 5-bromo-3-methyl-1,2-thiazole Chemical compound CC=1C=C(Br)SN=1 XSVSPKKXQGNHMD-UHFFFAOYSA-N 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 2
- DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 description 2
- 150000001340 alkali metals Chemical class 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 159000000007 calcium salts Chemical group 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 239000003352 sequestering agent Substances 0.000 description 2
- 229960001922 sodium perborate Drugs 0.000 description 2
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 239000004141 Sodium laurylsulphate Substances 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 229910001514 alkali metal chloride Inorganic materials 0.000 description 1
- 230000002272 anti-calculus Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 238000004061 bleaching Methods 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000004067 bulking agent Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- NASFKTWZWDYFER-UHFFFAOYSA-N sodium;hydrate Chemical compound O.[Na] NASFKTWZWDYFER-UHFFFAOYSA-N 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0052—Gas evolving or heat producing compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/36—Organic compounds containing phosphorus
- C11D3/361—Phosphonates, phosphinates or phosphonites
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/39—Organic or inorganic per-compounds
- C11D3/3942—Inorganic per-compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/22—Gas releasing
- A61K2800/222—Effervescent
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
Solids compositions comprising a diphosphonic acid, or a salt thereof, and a compound which releases oxygen with effervescence on contact with water, can be formulated as powders or tablets for cleaning teeth and, in particular, dentures.
Description
SPECIFICATION
Tooth cleaning compositions This invention relates to compositions which can be used for cleaning teeth and, in particular, dentures.
Denture-cleaning compositions are often provided in tablet or powder form, for addition to water in which dentures are stored, e.g. overnight. Known denture-cleaning compositions may be alkaline or acidic. Known acidic compositions comprise, for example, potassium monopersulphate and sodium monohydrate perborate. Such composition are effective in removing tartar and plaque deposits.
However, the reaction of a monopersulphate with an alkali metal chloride causes the evolution of chlorine. The compositions may therefore leave an acidic or evolved chlorine after-taste, and may cause exposed metal parts to corrode, A further disadvantage of such compositions is that they may cause rapid restain.
Known alkaline denture-cleaning compositions comprise oxidising agents which effectively bleach stains and film which form on dentures, and components which provide active effervescent oxygen which agitates and sterilises the dentures. Such compositions may comprise, for example, an alkali
metal monohydrate perborate and an alkali metal orthophosphate. However, such compositions do not readily dissolve tartar and plaque deposits.
It is known to add sequestering agents to alkaline compositions of the type described. Calgon (registered Trade Mark) and ethylenediaminetetraacetic acid and its salts have been used for this purpose. Such agents have the advantage that they render the composition clear when added to water.
This may make the compositions more acceptable to consumers, and may prevent deposition of calcium salts, but the known sequestering agents do not generally dissolve such salts.
British Patent Specification No. 1,1 10,987 discloses ethane-1 -hydroxy-1 ,1 diphosphonic acid as an anti-calculus agent. British Patent Specification Nos. 1,160,640 and 1,263,934 disclose other diphosphonic acids, and salts thereof, for use in tooth cleaning, i.e. toothpaste, compositions.
Ethane-1-hydroxy-1,1-diphosphonic acid (also known as acetyldiphosphonic acid) and its salts have been used, in solution, to remove lime scale from boilers and pipes. US Federal Drug
Administration (tDA) regulations may allow the use of such compounds in live steam for contact with foodstuffs. However, there has been no previous indication that such compounds could be successfully used In solid form for cleaning dentures, nor has there been any denture cleaning composition which satisfactorily removes the predominantly calcium phosphate-containing plaque/tartar/calculus on dentures, which is usually mixed in a crystal-type latice with desquamated epithelial cells, food debris and microorganisms.
A solid composition according to the present invention comprises a diphosphonic acid, or a salt thereof, and a compound which releases oxygen with effervescence on contact with water,
The compositions of the invention may be formulated, for example, as tablets or powders. On addition to water, oxygen is evolved with effervescence, causing bleaching of stains and films on dentures in the water and the diphosphonic acid of its salt provides tartar/plaque removal. The effervescence promotes rapid dissolution of soluble ingredients in the composition and rapid and uniform distribution of dissolved materials in water. If the composition is in tablet form, the tablet disintegrates quickly. The evolved oxygen has beneficial bactericidal proprties. The compositions are usually alkaline and this assists their bactericidal properties.
The diphosphonic acid, or salt thereof, may be any of those described in British Patent
Specifications Nos, 1,1 10,987, 1,160,640 and 1,263,934. Preferably, acetyldiphosphonic acid, or an alkali metal, e.g. the sodium, salt, thereof, is used. The amount of this component in a composition of the invention is usually from 1 to 50, and more preferably from 2 to 30, e.g. about 10, 96 by weight.
The oxygen-releasing compound may be of the type which has previously been used in alkaline denture-cleaning compositions. This compound preferably comprises a perborate. Hydrated perborates, suitably of alkali metals, e.g. sodium perborate monohydrate, may suitably be used. However, if an anhydrous perborate is included in the composition, then this will react and break up faster in an aqueous environment, providing more rapid dispersal of the disphonate. Most preferably, the oxygenreleasing compound comprises a mixture of hydrated and anhydrous perborate, e.g. sodium perborate monohydrate and anhydrous sodium perborate.
The weight of the oxygen-releasing compound or compounds in the composition is usually from 30 to 90, and most preferably from 40 to 85, 96 by weight of the composition. The amount of anhydrous perborate is usually from 20 to 100, and preferably from 30 to 60, 96 by weight of the total perborate content.
A composition of the invention is preferably such that it can provide a pH of at least 9, e.g. 10 to 12, when dissolved in water. The recommended amount of the composition for such purpose may be from 5 to 30 g/l, and this may comprise one or two tablets of the composition. It has been found that the disodium salt of acetyl-diphosphonic acid actively attacks calcium salts at a pH of 10 to 12, e.g. 1 g of the salt dissolves 0.8 g calcium carbonate. It is this property which causes marked dissolution and softening of tartar/plaque build-up on contaminated dentures. This effect allows, not only actual dissolution, but easier removal on light brushing and rinsing, owing to softening.
A composition of the invention may comprise materials further to those described above. Such additional materials may be, for example, buffers to ensure long-term storage stability and/or bulking agents. A suitable material which serves both purposes is tri-sodium orthophosphate. Such a material may be included in the composition of the invention in an amount of, for example, 5 to 6 96 by weight.
P articularly when a composition of the invention is provided in tablet form, the composition may comprise a binding agent. Suitable binding agents are talc and mineral oil. The total amount of such a material will not usually exceed 5 % by weight; the amount may be, for example, 1 96 by weight
The following Example illustrates a table formulation of the present invention.
% w/w Trisodium Orthophosphate 34.00 Sodium Perborate Anhydrous 20.0
Sodium Perborate Monohydrate 32.0
Sodium Lauryl Sulphate 0.14
Sodium Carbonate Anhydrous 2.12
Disodium Salt of Acetyldiphosphonic acid 9.74
Colour 0.025
Flavour 0.10
Pressing Aids 1.875
The given compounds were compounded into tablets.
Claims (9)
1. A solid composition which comprises a diphosphonic acid, or a salt thereof, and a compound.
which releases oxygen with effervescence on contact with water.
2. A composition according to claim 1 which comprises acetyldiphosphonic acid or an alkali metal salt thereof.
3. A composition according to claim 1 or claim 2, which comprises from 1 to 50 96 by weight of the diphosphonic acid or salt.
4. A composition according to any preceding claim, in which the oxygen-releasing compound is a perborate.
5. A composition according to claim 4, in which the oxygen-releasing compound comprises a mixture of hydrated and anhydrous perborates.
6. A composition according to any preceding claim, which comprises from 30 to 90 96 by weight of the oxygen-releasing compound.
7. A composition according to any preceding claim, which, when dissolved in water provides a pH of at least 9.
8. A composition according to any preceding claim, in tablet form.
9. A composition according to claim 1, substantially as described in the Example.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8209360A GB2095694B (en) | 1981-03-31 | 1982-03-30 | Tooth cleaning compositions |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8109977 | 1981-03-31 | ||
| GB8209360A GB2095694B (en) | 1981-03-31 | 1982-03-30 | Tooth cleaning compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB2095694A true GB2095694A (en) | 1982-10-06 |
| GB2095694B GB2095694B (en) | 1984-08-01 |
Family
ID=26278945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8209360A Expired GB2095694B (en) | 1981-03-31 | 1982-03-30 | Tooth cleaning compositions |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2095694B (en) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0123525A3 (en) * | 1983-04-22 | 1985-10-30 | Warner-Lambert Company | A cleansing composition and method of preparation thereof |
| US4657758A (en) * | 1984-01-27 | 1987-04-14 | Oral Research Laboratories, Inc. | Dental rinse |
| US4666708A (en) * | 1984-01-27 | 1987-05-19 | Oral Research Laboratories, Inc. | Dental rinse |
| EP0225658A1 (en) * | 1985-11-12 | 1987-06-16 | Douwe Egberts Koninklijke Tabaksfabriek- Koffiebranderijen-Theehandel N.V. | Shaped cleansing composition |
| GB2191500A (en) * | 1986-06-11 | 1987-12-16 | G C Dental Ind Corp | Compositions for cleaning and dissolving tartar on removable oral prostheses |
| WO1988000463A1 (en) * | 1986-07-11 | 1988-01-28 | Oral Research Laboratories, Inc. | Compositions for the prolonged action of anti-plaque agents |
| USRE32771E (en) * | 1983-04-22 | 1988-10-25 | Warner-Lambert Company | Denture cleaner having improved dissolution time and clarity and method of preparation |
| DE3931129A1 (en) * | 1988-04-16 | 1991-03-28 | Reckitt Gmbh | Tablet for cleaning artificial teeth - formed by pressing powder components without pre-granulation contg. organic phosphonic acid and spray dried sorbitol |
| WO1994017660A1 (en) * | 1993-02-10 | 1994-08-18 | E.I. Du Pont De Nemours And Company | Effervescent pesticide tablet with metal perborate |
| US5384062A (en) * | 1993-12-01 | 1995-01-24 | Warner-Lambert Company | Perborate persulfate: protease denture cleanser tablet composition |
| US6974885B2 (en) * | 2000-09-28 | 2005-12-13 | Schering Ag | Method for isolating pharmaceutically exploitable etidronate disodium |
| WO2005123007A1 (en) * | 2004-06-15 | 2005-12-29 | Universität Zürich | Phosphonate for mechanical dental treatment |
| EP3284456A1 (en) * | 2016-08-15 | 2018-02-21 | smartodont GmbH | Solid phosphonate salts as an add-on in endodontics |
-
1982
- 1982-03-30 GB GB8209360A patent/GB2095694B/en not_active Expired
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE32771E (en) * | 1983-04-22 | 1988-10-25 | Warner-Lambert Company | Denture cleaner having improved dissolution time and clarity and method of preparation |
| EP0123525A3 (en) * | 1983-04-22 | 1985-10-30 | Warner-Lambert Company | A cleansing composition and method of preparation thereof |
| US4657758A (en) * | 1984-01-27 | 1987-04-14 | Oral Research Laboratories, Inc. | Dental rinse |
| US4666708A (en) * | 1984-01-27 | 1987-05-19 | Oral Research Laboratories, Inc. | Dental rinse |
| EP0225658A1 (en) * | 1985-11-12 | 1987-06-16 | Douwe Egberts Koninklijke Tabaksfabriek- Koffiebranderijen-Theehandel N.V. | Shaped cleansing composition |
| GB2191500B (en) * | 1986-06-11 | 1991-02-27 | G C Dental Ind Corp | Agents for cleaning and dissolving tartar of removable oral prostheses |
| US4851146A (en) * | 1986-06-11 | 1989-07-25 | G-C Dental Industrial Corp. | Phosphonic acid derivative based agents for cleaning and dissolving tartar of removable oral prostheses |
| GB2191500A (en) * | 1986-06-11 | 1987-12-16 | G C Dental Ind Corp | Compositions for cleaning and dissolving tartar on removable oral prostheses |
| WO1988000463A1 (en) * | 1986-07-11 | 1988-01-28 | Oral Research Laboratories, Inc. | Compositions for the prolonged action of anti-plaque agents |
| DE3931129A1 (en) * | 1988-04-16 | 1991-03-28 | Reckitt Gmbh | Tablet for cleaning artificial teeth - formed by pressing powder components without pre-granulation contg. organic phosphonic acid and spray dried sorbitol |
| WO1994017660A1 (en) * | 1993-02-10 | 1994-08-18 | E.I. Du Pont De Nemours And Company | Effervescent pesticide tablet with metal perborate |
| US5384062A (en) * | 1993-12-01 | 1995-01-24 | Warner-Lambert Company | Perborate persulfate: protease denture cleanser tablet composition |
| US6974885B2 (en) * | 2000-09-28 | 2005-12-13 | Schering Ag | Method for isolating pharmaceutically exploitable etidronate disodium |
| WO2005123007A1 (en) * | 2004-06-15 | 2005-12-29 | Universität Zürich | Phosphonate for mechanical dental treatment |
| EP3284456A1 (en) * | 2016-08-15 | 2018-02-21 | smartodont GmbH | Solid phosphonate salts as an add-on in endodontics |
| US10434038B2 (en) | 2016-08-15 | 2019-10-08 | smartodont GmbH | Solid phosphonate salts as an add-on in endodontics |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2095694B (en) | 1984-08-01 |
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| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19970330 |