GB2093874A - Absorbable surgical threads and method of making such threads - Google Patents
Absorbable surgical threads and method of making such threads Download PDFInfo
- Publication number
- GB2093874A GB2093874A GB8106674A GB8106674A GB2093874A GB 2093874 A GB2093874 A GB 2093874A GB 8106674 A GB8106674 A GB 8106674A GB 8106674 A GB8106674 A GB 8106674A GB 2093874 A GB2093874 A GB 2093874A
- Authority
- GB
- United Kingdom
- Prior art keywords
- threads
- oxidized
- absorbable surgical
- ratio
- treated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 8
- MWUXSHHQAYIFBG-UHFFFAOYSA-N nitrogen oxide Inorganic materials O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000002904 solvent Substances 0.000 claims abstract description 13
- 229920002678 cellulose Polymers 0.000 claims abstract description 12
- 239000001913 cellulose Substances 0.000 claims abstract description 12
- 230000008961 swelling Effects 0.000 claims description 19
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 9
- 229920000297 Rayon Polymers 0.000 claims description 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 8
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000000600 sorbitol Substances 0.000 claims description 6
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 239000008121 dextrose Substances 0.000 claims description 4
- 239000008103 glucose Substances 0.000 claims description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 3
- 229930195725 Mannitol Natural products 0.000 claims description 3
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 3
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 claims description 3
- 239000001639 calcium acetate Substances 0.000 claims description 3
- 229960005147 calcium acetate Drugs 0.000 claims description 3
- 235000011092 calcium acetate Nutrition 0.000 claims description 3
- 239000001110 calcium chloride Substances 0.000 claims description 3
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 3
- 229940113088 dimethylacetamide Drugs 0.000 claims description 3
- 239000000594 mannitol Substances 0.000 claims description 3
- 235000010355 mannitol Nutrition 0.000 claims description 3
- 239000003960 organic solvent Substances 0.000 claims description 3
- -1 pentaerytritol Chemical compound 0.000 claims description 3
- 150000005846 sugar alcohols Polymers 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 230000001590 oxidative effect Effects 0.000 claims 1
- 150000003388 sodium compounds Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 229920002201 Oxidized cellulose Polymers 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 235000013681 dietary sucrose Nutrition 0.000 description 3
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 229940107304 oxidized cellulose Drugs 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 229960004793 sucrose Drugs 0.000 description 3
- 230000002522 swelling effect Effects 0.000 description 3
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 235000001727 glucose Nutrition 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 235000010356 sorbitol Nutrition 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 150000003462 sulfoxides Chemical class 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 1
- 241000208202 Linaceae Species 0.000 description 1
- 235000004431 Linum usitatissimum Nutrition 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
Classifications
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M11/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising
- D06M11/58—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising with nitrogen or compounds thereof, e.g. with nitrides
- D06M11/64—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising with nitrogen or compounds thereof, e.g. with nitrides with nitrogen oxides; with oxyacids of nitrogen or their salts
Landscapes
- Engineering & Computer Science (AREA)
- Textile Engineering (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention relates to a method of making absorbable surgical threads. The method of making absorbable surgical threads consists in treating cellulose threads with nitrogen oxides, then treating the cellulose threads with a protophilic solvent for 1 to 2 hours at room temperature and holding the cellulose threads at a temperature of 70 to 90 DEG C for 1 to 2 hours. The absorbable surgical threads produced in accordance with the present invention are intended to be used in medicine, biology and veterinary science.
Description
SPECIFICATION
Absorbable surgical threads and method of making such threads
The present invention relates to a method of making absorbable surgical threads and can be used in medicine, biology and veterinary science.
At present absorbable threads are widely used in medical practice. They do not require to be removed and they ensure that cicatrices resulting from surgical operations are cosmetically pleasing.
In order to be successfully used, the absorbable threads should possess a sufficient strength.
However, conventional absorbable threads have inadequate mechanical strength. Therefore efforts are constantly undertaken to develop novel methods of making absorbable threads based on cellulose which have a higher mechanical strength than the mechanical strength of known threads.
The invention sets out to provide a method of making abscrbable surgical threads which makes it possible, by strengthening the supermolecular structure of the oxidied threads, to upgrade their quality i.e. to improve their mechanical strength and to reduce their swelling property both in water and in biological media.
According to the invention there is provided a method of making absorbable surgical threads
comprising treating cellulose threads with nitrogen oxides, wherein, according to the invention, the threads treated with the nitrogen oxides are further treated with a protophilic solvent for 1 to 2 hours at
room temperature and then held at a temperature of 70 to 900C for 1 to 2 hours.
The above treatment of the oxidized cellulose threads allows a high degree of ordering of their
supermolecular structure, a large amount of hydrogen bonds between macromolecules of the oxidized cellulose as well as between the latter and water bonded with cellulose. As a result, the mechanical strength of the oxidized threads improves and the swel!ing property of the oxidized threads in water and biological media decreases.
It is expedient to use as the protophilic solvent a 2 to~ 10% water solution of ionogenic compound selected from the group consisting of sodium chlonde, calcium chloride, calcium acetate and acetic acid: a 2 to 10% aqueous solution of an amphiprotonic polyhydric alcohol selected from the group consisting of glycerol, pentaerytritol, mannitol, sorbitol, glucose, saccharose and dextrose; an organic solvent selected from the group consisting of dimethyl formamide, dimethyl sulfoxide and dimethyl acetamide.
Absorbable surgical sutures according to the invention were produced in the following way.
Ceilulose threads are oxidized with nitrogen oxides in a conventional manner. The cellulose threads can be made from cotton, flax, viscose, high-module viscose, polynose etc. having a wide thickness range and various levels of additions.
The oxidized threads are thoroughly washed with water, whereupon wet threads are placed in a stainless steel reaction vessel having a capacity of 20 litres and filled with a pre-prepared protophilic solvent. The threads are held in this reaction vessel for 1 to 2 hours.
The protophilic solvent can be a 2 to 10% water solution of ionogenic compounds such as sodium chloride, calcium chloride, calcium acetate and acetic acid; a 2 to 10% aquaous solution of an amphiprotonic polyhydric alcohol such as glycerol, pentaerytritol, mannitol, sorbitol, glucose,
saccharose and dextrose as well as an organic solvent such as dimethyl formamide, dimethyl sulfoxide, or dimethyl acetamide.
The threads are then withdrawn from the reaction vessel and placed in a stainless steel chamber having a capacity of 20 litres and blown through with air heated up to a temperature of 70 to 900 C. The threads are held for 1 to 2 hours in this chamber.
The method of the present invention makes it possible to produce absorbable surgical threads whose mechanical strength is 83-to 105% of cellulose threads before oxidation.
The swelling property of the sutures produced according to the invention is reduced down to 20 to 60% of the swelling property of the initial non-oxidized cellulose threads.
The Examples set out hereinafter relate to embodiments of the present invention, or illustrate individual steps which may be used in putting the invention into practice.
EXAMPLE 1
Absorbable surgical sutures were produced according to the invention in the following way.
2.4 kg of complex viscose threads having a size of 60/18 and a tensile strength of 4.75 kg were oxidized with nitrogen oxides in a conventional manner. The oxidized threads were thoroughly washed with water and then tested to determine the content of carboxyls, the content of fixed nitrogen, relative humidity, tensile strength, and degree of swelling in water.
The results of the testing were the following:
content of carboxyls, % 6.5
content of fixed nitrogen, % 0.12
relative humidity, % 12.8
tensile strength, kg 3.35
degree of swelling in water, % 59.5
The wet threads were then placed in a reaction vessel having a capacity of 20 litres and filled with a 1 0% of an aqueous solution of sorbitol in an amount of 15 litres. The threads were held in the reaction vessel for 2 hours. They were then withdrawn from the reaction vessel, and placed in a chamber blown through with air heated to a temperature of 800 C. The threads were held for 1.5 hours in the chamber.
The treated threads were then tested to determine the tensile strength and degree of swelling.
The results of the testing are given below:
tensile strength, kg 5.0
degree of swelling, % 31.1
The ratio between the value of the tensile strength of the oxidized treated threads to the value of
the tensile strength of the oxidized non-treated threads was 149.3%, and the ratio between the value of
the degree of swelling of the oxidized treated threads to the value of the degree of swelling of the
oxidized non-treated threads was 52.3%.
The ratio between the value of the tensile strength of the oxidized treated threads to the value of
the tensile strength of the initial viscose threads was 1 05.3%.
EXAMPLES 2. 3
Absorbable surgical threads according to the invention were produced in the following way.
Complex viscose threads having initial properties simiiar to those described in Example 1 where
subjected to oxidation and then to treatment according to the procedure described in Example 1.
The properties of the oxidized non-treated threads are similar to those of Example 1.
TREATMENT CONDITIONS
Time of Temperature Duration ilo, of Protophilic holding1 of treatment of treatment, Example l solvent hours oc hours 1 2 3 4 5 2 2% sodium 2 80 1.5 chloride 1 2 3 1 4 1 5 3 2% calcium 2 80 chloride PROPERTIES OF THE OXIDIZED TREATED THREADS
Ratio between the values of Ratio between the oxidized treated threads and value of the tensile the values of oxidized strength of oxidized non-treated threads treated threads and the value of the tensile strength Tensile Degree of Tensile Degree of of initial No. of Strength, swelling. strength, swelling, threads. % Example kg 2 4.95 36.0 147.8 60.5 104-2 3 4.60 36u0 137.3 60.5 96C8 EXAMPLES 91 12 Absorbable surgical threads according to the invention were produced in the following way.
2.4 kg of viscose threads having a size of 60/18 and a tensile strength of 4.75 kg were oxidized and further treated in accordance with the procedure described in Example 1.
The properties of the oxidized non-treated threads are similar to those of Example 1.
TREATMENT CONDITIONS
Time of Temperature Duration No. of Protophilic holding, of treatment, of treatment, Example solvent hours C hours 4 6% sodium 1.5 80 1.9 chloride
5 10% calcium 1.0 70 2.0
chloride
6 6% glycerol 1.5 80 1.5
7 6% pentaerytritol 1.5 80 1.9 8 2% sorbitol 2*0 90 1.0
9 10% sorbitol 1.0 70 2.0 10 2% glucose 2.0 90 1.0 11 6% saccharose 1.9 80 1.5 12 10% dextrose 1.0 70 2.0
PROPERTIES OF THE OXIDIZED TREATED THREADS
Ratio between the values @ Ratio between the of or oxidized treated threads value of the tensile and the values of oxidized strength of oxidized non-treated threads treated threads and the value of the tensile strength Tensile Degree of Tensile Degree of of initial No. of strength, swelling, strength, swelling, threads, % Example kg % % % 1 2 3 4 5 6 4 4.95 35.5 147.8 59.7 104.2
5 4.70 36;0 104.3 60.5 98.9
6 4,t5 42.9 123.9 71.4 87.4
7 4,t5 43.0 123.9 72.3 87.4
8 5.0 31e1t 149.3 52.3 105.3
9 5.0 31.2 149.3 52.4 105.3
10 4.5 44.5 134.3 74.8 94,7 11 4.3 42.0 128.4 70.6 90.5
12 4.2 42.5 125.4 71.4 88.4 EXAMPLE 13
Absorbable surgical threads according to the invention were produced in the following way.
2.4 kg of complex viscose threads having a size of 60/18 and a tensile strength of 5.95 kg were oxidized and further treated in accordance with the procedure described in Example 1.
Properties of the oxidized non-treated threads:
content of carboxyls, /O 9.0
content of fixed nitrogen, % 0.1 relative hu,nidity, % 9.0
tensile strength, kg 4.05
degree of swelling in water,% /O 57.6
The conditions of the treatment were as follows:
protophilic solvent 4% acetic acid
time of holding, hours 2
temperature of heat treatment, 0C 80
time of heat treatment, hours 1.5
The properties of the oxidized treated threads were as follows::
tensile strength, kg 5.35
degree of swelling, % 45.0
ratio between the value of the tensile
strength of the oxidized treated threads
to the value of the tensile strength of the
oxidized non-treated threads, % 132.1
ratio between the value of the degree of
swelling of the oxidized treated threads
to the value of the degree of swelling of
the oxidized non-treated threads, % 78.1
ratio between the value of the tensile
strength of the oxidized treated threads
to the value of the tensile strength of the
initial threads, % 89.9
EXAMPLES 14-23 Absorbable surgical threads were produced according to the method of the present invention.
2.5 kg of high-module viscose having a size of 20/6 and a tensile strength of 5.60 kg were oxidized and further treated in accordance with the procedure described in Example 1.
The properties of the oxidized non-treated threads were the following:
content of carboxyls, % 5.5
content of fixed nitrogen, % 0.1
relative humidity, % 7.6
tensile strength, kg 4.45
degree of swelling in water, % 61.0
TREATMENT CONDITIONS
Time of Temperature Duration No. of Protophilic holding. of treatment, of treatment, Example solvent hours C hours 1 2 3 4 5 14 dimethyl 2.0 80 2.0
sulfoxide
15 dimethvl 2.0 90 1.0
formamide 16 - " - 1.9 80 1.5 17 - " - 1.0 70 2.0 18 dimethyl 2.0 90 1.0
sulfoxide 19 - ,, - 1.B 80 1.5 20 - " - 1.0 70 2.0 21 dimethyl 2.0 90 1.0
acetamide 22 - " - 1.5 80 1.5 23 - " - 1.0 70 2.0
PROPERTIES OF THE OXIDIZED TREATED THREADS
Ratio between the values Ratio between the of oxidized treated threads value of the tensile and the values of oxidized strength of oxidized non-treated threads treated threads and the tensile strength of initial threads, Tensile Degree of Tensile Degree of % No. of strength, swelling, strength, swelling, Example kg % % % 1 2 3 4 5 6 14 5.85 38.0 131.5 62.3 104.5
15 5.2 42.0 116.9 68.9 92.9
16 5.3 42.0 119.1 68.9 94.6
17 5.25 43.0 117.9 70.5 93.8
18 5.85 38.0 131.5 62.3 104.6 19 5.8 38.5 130.3 63.1 103.6
20 5.85 38.0 131.5 62.3 104.5
21 5.25 42.0 117.9 68.9 93.8
22 5.4 40.0 121.4 65.6 96.4
23 5.3 41.5 119.1 68.0 94.7
While particular embodiments of the invention have been shown and described, various modifications thereof will be apparent to those skilled in the art and therefore it is not intended that the invention be limited to the disclosed embodiments or to the details thereof and the departures may be made therefrom within the scope of the invention as defined in the claims.
Claims (12)
1. A method of making absorbable surgical threads comprising oxidizing cellulose threads with nitrogen oxides, treating the cellulose threads with nitrogen oxides, treating the cellulose threads with a protophilic solvent for 1 to 2 hours at room temperature and holding the cellulose threads at a temperature of 70 to 900C for 1 to 2 hours.
2. A method according to claim 1, wherein the protophilic solvent is a 2 to 10% aqueous solution of an ionogenic compound selected from the group consisting of sodium compound selected from the group consisting of sodium chloride, calcium chloride, calcium acetate and acetic acid.
3. A method according to claim 1, wherein the protophilic solvent is a 2 to 1 0% aqueous solution of an amphiprotonic polyhydric alcohol selected from the group consisting of glycerol, pentaerytritol, mannitol, sorbitol, glucose, sacdharose and dextrose.
4. A method according to claim 1, wherein the protophilic solvent is an organic solvent selected from the group consisting of dimethyl formamide, dimethyl sulfoxide and dimethyl acetamide.
5. A method substantially as hereinbefore described with reference to any one of the preceding claims in accordance with any one of the accompanying Examples.
6. An absorbable surgical thread made from any of the preceding claims, wherein the ratio between the value of the tensile strength of the oxidized treated threads to the value of the tensile strength of the oxidized non-treated threads is in the range from 110 to 1 60.
7. An absorbable surgical thread as claimed in claim 6, wherein the ratio is in the range from 116.9 to 149.3.
8. An absorbable surgical thread made from any of claims 1 to 5, wherein the ratio between the value of the degree of swelling of the oxidized treated threads to the value of the degree of swelling of the oxidized non-treated threads is in the range from 50 to 80.
9. An absorbable surgical thread as claimed in claim 8, wherein the ratio is in the range from 52.3 to 78.1
10. An absorbable surgical thread made from any of claims 1 to 5, wherein the ratio of the tensile strength of the oxidized treated threads to the value of the tensile strength of the initial viscose threads is in the range from 80 to 110.
1 An absorbable surgical thread as claimed in claim 9, wherein the ratio is in the range from 87.4 to 105.3.
12. An absorbable surgical thread as claimed in any one of claims 6 to 8 and substantially as herein described with reference to the accompanying Examples.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8106674A GB2093874B (en) | 1981-03-03 | 1981-03-03 | Absorbable surgical threads and method of making such threads |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8106674A GB2093874B (en) | 1981-03-03 | 1981-03-03 | Absorbable surgical threads and method of making such threads |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB2093874A true GB2093874A (en) | 1982-09-08 |
| GB2093874B GB2093874B (en) | 1985-01-16 |
Family
ID=10520110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8106674A Expired GB2093874B (en) | 1981-03-03 | 1981-03-03 | Absorbable surgical threads and method of making such threads |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2093874B (en) |
-
1981
- 1981-03-03 GB GB8106674A patent/GB2093874B/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB2093874B (en) | 1985-01-16 |
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| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |