GB2080285A - Process for the Preparation of Cyclopropylmethyl-n-Propylamine - Google Patents
Process for the Preparation of Cyclopropylmethyl-n-Propylamine Download PDFInfo
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- GB2080285A GB2080285A GB8024039A GB8024039A GB2080285A GB 2080285 A GB2080285 A GB 2080285A GB 8024039 A GB8024039 A GB 8024039A GB 8024039 A GB8024039 A GB 8024039A GB 2080285 A GB2080285 A GB 2080285A
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- platinum
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- 238000000034 method Methods 0.000 title claims abstract description 33
- 230000008569 process Effects 0.000 title claims abstract description 32
- MAVLRJDQJZJTQP-UHFFFAOYSA-N n-(cyclopropylmethyl)propan-1-amine Chemical compound CCCNCC1CC1 MAVLRJDQJZJTQP-UHFFFAOYSA-N 0.000 title claims abstract description 11
- 238000002360 preparation method Methods 0.000 title description 3
- 239000003054 catalyst Substances 0.000 claims abstract description 45
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims abstract description 45
- FVSKHRXBFJPNKK-UHFFFAOYSA-N propionitrile Chemical compound CCC#N FVSKHRXBFJPNKK-UHFFFAOYSA-N 0.000 claims abstract description 21
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 claims abstract description 21
- IGSKHXTUVXSOMB-UHFFFAOYSA-N cyclopropylmethanamine Chemical compound NCC1CC1 IGSKHXTUVXSOMB-UHFFFAOYSA-N 0.000 claims abstract description 19
- 238000006243 chemical reaction Methods 0.000 claims abstract description 14
- 239000000203 mixture Substances 0.000 claims abstract description 14
- 238000004519 manufacturing process Methods 0.000 claims abstract description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 24
- 229910052799 carbon Inorganic materials 0.000 claims description 24
- 229910052697 platinum Inorganic materials 0.000 claims description 19
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 18
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 18
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 18
- 239000001257 hydrogen Substances 0.000 claims description 18
- 229910052739 hydrogen Inorganic materials 0.000 claims description 18
- 229910052703 rhodium Inorganic materials 0.000 claims description 15
- 239000010948 rhodium Substances 0.000 claims description 15
- 229910052751 metal Inorganic materials 0.000 claims description 7
- 239000002184 metal Substances 0.000 claims description 7
- 229910052763 palladium Inorganic materials 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000006227 byproduct Substances 0.000 abstract description 4
- 238000005984 hydrogenation reaction Methods 0.000 abstract description 4
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 14
- AUQDITHEDVOTCU-UHFFFAOYSA-N cyclopropyl cyanide Chemical compound N#CC1CC1 AUQDITHEDVOTCU-UHFFFAOYSA-N 0.000 description 7
- 229910052757 nitrogen Inorganic materials 0.000 description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 230000035484 reaction time Effects 0.000 description 3
- 238000007086 side reaction Methods 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 239000005909 Kieselgur Substances 0.000 description 1
- 239000007868 Raney catalyst Substances 0.000 description 1
- NPXOKRUENSOPAO-UHFFFAOYSA-N Raney nickel Chemical compound [Al].[Ni] NPXOKRUENSOPAO-UHFFFAOYSA-N 0.000 description 1
- 229910000564 Raney nickel Inorganic materials 0.000 description 1
- AEJRNONYXDAILM-UHFFFAOYSA-N [Ba+2].[O-][Cr]([O-])=O Chemical compound [Ba+2].[O-][Cr]([O-])=O AEJRNONYXDAILM-UHFFFAOYSA-N 0.000 description 1
- QXZUUHYBWMWJHK-UHFFFAOYSA-N [Co].[Ni] Chemical compound [Co].[Ni] QXZUUHYBWMWJHK-UHFFFAOYSA-N 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- AYJRCSIUFZENHW-DEQYMQKBSA-L barium(2+);oxomethanediolate Chemical compound [Ba+2].[O-][14C]([O-])=O AYJRCSIUFZENHW-DEQYMQKBSA-L 0.000 description 1
- 229910001570 bauxite Inorganic materials 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- JGDFBJMWFLXCLJ-UHFFFAOYSA-N copper chromite Chemical compound [Cu]=O.[Cu]=O.O=[Cr]O[Cr]=O JGDFBJMWFLXCLJ-UHFFFAOYSA-N 0.000 description 1
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000008570 general process Effects 0.000 description 1
- 239000004009 herbicide Substances 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- HFFBUTJCQGSVLC-UHFFFAOYSA-N n-methyl-n-propylcyclopropanamine Chemical compound CCCN(C)C1CC1 HFFBUTJCQGSVLC-UHFFFAOYSA-N 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 231100000989 no adverse effect Toxicity 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229910052573 porcelain Inorganic materials 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 239000011819 refractory material Substances 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- ZCUFMDLYAMJYST-UHFFFAOYSA-N thorium dioxide Chemical compound O=[Th]=O ZCUFMDLYAMJYST-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
A process for preparing cyclopropylmethyl-n-propylamine from the reaction of cyclopropylmethylamine with propionitrile is described. The reaction takes place in the presence of a hydrogenation catalyst, preferably a mixture of rhodium on carbon and platinum on carbon. The process is particularly useful as it consumes the cyclopropylmethylamine by-product from another scheme for the synthesis of cyclopropylmethyl-n-propylamine.
Description
SPECIFICATION
Process for the Preparation of Cyclopropylmethyl-n-propylamine
This invention relates to a process for preparing cyclopropylmethyl-n-propyiamine. More particularly the invention relates to reacting cyclopropylmethyamine (CPMA) with propionitrile (PN) in the presence of hydrogen and a hydrogenation catalyst, rhodium, palladium or platinum supported on carbon, and a mixture of rhodium supported on carbon and platinum supported on carbon.
In U.S. Patent No. 3,739,025, U.S. Patent No. 3,847,984 and U.S. Patent No. 3,847,985, methods for preparing cyclopropylmethyl-alkyl-amines are described including reacting cyclopropylmethylamine (CPMA) with ketones, aldehydes or alcohols in the presence of hydrogen and a metal hydrogenation catalyst or compound thereof. A representative equation is as follows:
The catalytic materials can be in pure form but preferably are deposited on a carrier, such as carbon, alumina, silica gel, barium sulfate, calcium carbonate, barium carbonate, kieselguhr, zirconia, thoria, magnesia, titania, montmorillonite clay, bauxite, diatomaceous earth, course porcelain or any other refractory material which has no adverse effect on the reaction.
Useful catalysts for these reactions are selected from the group consisting of rhodium on carbon, platinum on carbon, palladium on carbon, Raney nickel or nickel-cobalt, copper on a siliceous support, copper on alumina, or unsupported copper chromite which may contain 150% barium chromite.
It has now been found that by reacting cyclopropyl-methyiamine with propionitrile, a good yield of cyclopropyl-methyl-n-propylamine can be obtained according to the following equation:
The catalyst is selected from the group consisting of rhodium supported on carbon; platinum supported on carbon; palladium supported on carbon, and a mixture of rhodium supported on carbon and platinum supported on carbon. Very high yields of cyclopropylmethyl-n-propylamine (CMPA) are obtained amounting to 90%-i 00% based on the weight of cyclopropylmethylamine (CPMA).
In the mixed catalyst, which is preferred, the weight of platinum, based on the total weight of metal present in the catalyst, can be in the range of up to about 99%, advantageously in the range of about 25 to 75%, preferably in the range 50 to 67%, most preferably in the range of about 60 to 67%, optimally at about 60%. A mixed catalyst suitable for the process of this invention consists of a mixture of rhodium on carbon, with rhodium accounting for 1 to 12% by weight. The preferred mixed catalyst consists of a mixture of about 5% platinum on carbon in a 4:6 weight ratio. Other suitable catalysts are rhodium on carbon, palladium on carbon or platinum on carbon with the metal accounting for 1 to 12% by weight, preferably about 5% by weight of the catalyst. The weight of the catalyst used preferably amounts to about 0.5 to 0.6% by weight based on the weight of propionitrile.
The mole ratio in the reaction of cyclopropylmethylamine to propionitrile is in the range of about 5:1 to 1:1 preferably about 3:1 to 2:1 and optimally 2.35:1 to 3.0:1.
The reaction is carried out in hydrogen and under pressures of about 40 to 300 psig., preferably about 1 50 psig.
The reaction proceeds satisfactorily at temperatures in the range of O to 800C and especially at 400C.
The reaction takes place in a mutual solvent for the amine and nitrile. Alkanols such as methanol are suitable solvents. The reaction also proceeds in the absence of a solvent. The latter condition is presently preferred.
The choice of the preferred catalyst is governed by the speed of the reaction, specificity of yield and overall yield as evidenced by the data in Table 1:
Table 1
400C Yield Yield
Catalyst Reaction Time Based on PN Based on CPMA
5% Pd/C 2.3 Hours 53.5% 98.8%
5% Pt/C 6.9 Hours (incomplete) 36.4%
5% RH/C 3.75 Hours 58.9% 61.8%
5% Pd/C 6.25 Hours 64.1% 88.1% (60%), 5% Rh/C (40%), 5% Pt/C 5.0 Hours 65.3% 95.3%
The specific catalyst was chosen based on the data in Table 2 below::
Table 2 5O0C Yield Yield
%Rh % Pt Reaction Time Based on PN Based on CMPA
60 40 1.8 Hours 60.1% 97.3%
50 50 1.4 Hours 61.6% 98.9%
40 60 1.5 Hours 60.5% 98.2%
33 67 1.3 Hours 61.5% 98.8%
25 75 2.0 Hours 61.1% 96.0%
From Table 2 it wili be seen that the mixed catalysts containing 50 to 67% platinum provided the fastest reaction times and highest yields, substantially equivalent within experimental error. As the 60% platinum 40% rhodium mixture is less expensive it is the preferred catalyst.
The starting cyclopropylmethylamine is a by-product from the process for the preparation of cycloproylmethyl-n-propylamine from cyclopropyl cyanide, also known as cyclopropylnitrile (CPN). This is an intermediate for the manufacture of certain herbicides. The major process proceeds is according to equation Ill:
but a side reaction provides cyclopropylmethylamine (CPMA) according to equation IV:
This side reaction accounts for about 10 to 1 2% of the cyclopropyl cyanide (CPN) consumed in the general process of equation III.
The conversion of this by-product to the desired end product by the process of this invention thus provides an economically desirable utility particularly since it is more than 90% efficient based on the amount of the by-product processed.
Example 1
57.4 g (96%/1 mole) of propionitrile, 6.35 g of 5% rhodium supported on carbon, 232.2 g (90.17%, 7.4% H20) of cyclopropylmethylamine and 151.1 g of methanol are fed into a 1-liter Parr hydrogenation apparatus. The reaction mixture is hydrogenated at about 400 C. Hydrogen is introduced under 145-1 50 psig hydrogen pressure. When the hydrogen is no longer absorbed, the temperature is increased to 600C and held about 1 hour 1 5 minutes. After cooling to room temperature, the mixture is filtered to remove the catalyst and to yield 429.4 g of filtrate, containing 16.1% (61.2% yield based on propionitrile) of cyclopropylmethyl-n-propylamine in methanol. This is recovered by distillation.BP 135-1 480C. The yield, based on the amount of cyclopropylmethylamine used, is 92.7%.
Example 2 (Pilot Plant)
A 30 gallon jacketed stainless steel pressure vessel fitted with 5 gallon catalyst drop tank is purged with nitrogen and charged with 126 Ibs (17.6 gallons) of a 55% solution of cyclopropylmethylamine in methanol recovered from a cyclopropyl cyanide (CPN) catalytic hydrogenation. To this is added 48.5 Ibs of methanol (7.4 gallons) and the temperature is controlled to the range 200--250C.
The nitrogen-purged drop tank is charged with 12.5 Ibs of a 60--40 mixture of 5% Pt/C and 5%
Rh/C catalyst and 13 Ibs (2 gallons) of propionitrile (96% pure). The catalyst is slurried by agitation and dropped into the main vessel. An additional 11 Ibs (17 gal) of propionitrile is used to flush any slurry residue into the vessel which is then purged of p2 with nitrogen. The mole ratio of propionitrile to cyclopropylmethylamine is 1 :2.35. When the 02 level is below 0.5%, the vessel is pressurized to 1 50 psig with hydrogen. The vessel temperature is maintained at 500+20C and additional hydrogen is added as consumed to maintain the pressure. When the hydrogen uptake ceases, the reaction mixture is heated to 600C and held there for 2 hours. The mixture is then cooled to 200 C, the hydrogen is carefully vented and the vessel is flushed with nitrogen. The reaction mass is filtered to remove the catalyst and the filtrate is distilled. 28.1 Ibs of cyclopropylmethyl-n-propylamine is recovered in 90% yield, based on the cyclopropylmethylamine content of the starting material and 60% yield based on propionitrile.
Example 3-Plant A 3000 gallon stainless steel reactor assembly fitted with a 500 gallon drop tank purged with nitrogen. The drop tank is charged with 50 Ibs of 5% rhodium on carbon catalyst and 75 Ibs of 5% platinum on carbon catalyst, and 200 gallons (1,288 Ibs) of propionitrle (99.9%). This mixture is agitated for 10 minutes.
The reactor is meanwhile charged with 2,200 gallons (15,380 Ibs) of cyclopropylmethylamine (7172% purity recovered from the production process according to equation Ill and formed by side reaction IV). The cyclopropylmethylamine in the reactor is agitated and its temperature stabilized to 1 80C. The residual purge nitrogen is vented and the slurry from the drop tank is introduced into the reactor. An additional 242 gallons (1,560 Ibs) of propionitrile is used to flush the residual catalyst from the drop tank into the reactor. The reactor is then again purged with nitrogen until the oxygen content of the flushed gas is below 0.5 volume %.
The reactor is then pressurized with hydrogen to 1 50 psig. The hydrogen feed is continued to maintain the 1 50 psig until hydrogen uptake ceases, while maintaining the temperature within the reactor at about 50--600C. The hydrogen uptake ceases after about 7 to 8 hours. The hydrogen feed is shut off and the reactor temperature is held at 600C for two hours.
The hydrogen pressure is then reduced to 5 psig. The residual hydrogen is purged from the reactor by a flow of nitrogen.
The contents from the reactor are then filtered to remove the catalyst residue and the filtrate is worked up by distillation.
Yield: Total cyclopropylmethylpropylamine (3,512 Ibs).
60% cyclopropylmethylpropylamine based on propionitrile
90% cyclopropylmethylpropylamine based on cyclopropylmethylamine.
Claims (23)
1. A process for preparing cyclopropylmethyl-n-propylamine comprising the step of reacting cyclopropylmethylamine with propionitrile in the presence of hydrogen and a catalyst selected from the group consisting of rhodium supported on carbon, palladium supported on carbon, platinum supported on carbon, or a mixture of rhodium supported on carbon and platinum supported on carbon.
2. The process according to claim 1, wherein a catalyst consisting of a mixture of rhodium supported on carbon and platinum supported on carbon is employed, said catalyst containing 25 to 75% by weight of platinum based on the total weight of metal in the catalyst.
3. The process according to claim 2, wherein the catalyst contains 50 to 67% by weight of platinum based on the total weight of metal present in the catalyst.
4. The process according to claim 3, wherein the catalyst contains 60 to 67% by weight of platinum based on the total weight of metal present in the catalyst.
5. The process according to claim 4, wherein the catalyst contains 60% by weight of platinum based on the total weight of metal present in the catalyst.
6. The process according to claim 1, wherein a catalyst consisting of a mixture of 1-1 2% by weight of platinum supported on carbon and 112% rhodium supported on carbon is employed.
7. The process according to claim 6, wherein a catalyst consisting of a mixture of 5% by weight of platinum supported on carbon and 5% of rhodium supported on carbon is employed.
8. The process according to any preceding claim, wherein the mole ratio of cyclopropylmethylamine to propionitrile is in the range about 5:1 to 2:1.
9. The process according to claim 8, wherein the mole ratio of cyclopropylmethylamine to propionitrile is substantially 2.35:1 to 3.0:1.
1 0. The process according to any preceding claim wherein the catalyst amounts to about 0.5 to 0.6% by weight based on the weight of propionitrile.
11. The process according to any preceding claim, wherein the reaction is carried out at a pressure range of about 40 to 300 psig.
12. The process according to claim 11 , wherein the reaction is carried out at a pressure of about 1 50 psig.
13. The process according to any preceding claim, wherein the process is carried out at a temperature of about 10 to 800C.
14. The process according to claim 13 wherein the process is carried out at a temperature of about 500 C.
1 5. The process according to claim 1 wherein the catalyst consists of rhodium.
1 6. The process according to claim 1 5 wherein the catalyst consists of 5% rhodium supported on carbon.
1 7. The process according to claim 1 wherein the catalyst consists of platinum.
1 8. The process according to claim 1 7 wherein the catalyst consists of 5% platinum supported on carbon.
19. The process according to claim 1 wherein the catalyst consists of palladium.
20. The process according to claim 1 9 wherein the catalyst consists of 5% palladium supported on carbon.
21. The process according to any preceding claim, wherein the process is carried out in a mutual solvent of the cyclopropylmethylamine and the propionitrile.
22. The process according to claim 20, wherein the solvent is methanol.
23. The process according to claim 1, substantially as hereinbefore described, with reference to any of the foregoing Examples.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8024039A GB2080285B (en) | 1980-07-23 | 1980-07-23 | Process for the preparation of cyclopropylmethyl-n-propylamine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8024039A GB2080285B (en) | 1980-07-23 | 1980-07-23 | Process for the preparation of cyclopropylmethyl-n-propylamine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB2080285A true GB2080285A (en) | 1982-02-03 |
| GB2080285B GB2080285B (en) | 1984-08-15 |
Family
ID=10514961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8024039A Expired GB2080285B (en) | 1980-07-23 | 1980-07-23 | Process for the preparation of cyclopropylmethyl-n-propylamine |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2080285B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0167887A1 (en) * | 1984-06-19 | 1986-01-15 | Union Carbide Corporation | Process for the preparation of N-substituted aminoalkylsilanes |
-
1980
- 1980-07-23 GB GB8024039A patent/GB2080285B/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0167887A1 (en) * | 1984-06-19 | 1986-01-15 | Union Carbide Corporation | Process for the preparation of N-substituted aminoalkylsilanes |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2080285B (en) | 1984-08-15 |
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| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |