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GB2056859A - Insecticidal cleaning compositions and their use in combatting insects - Google Patents

Insecticidal cleaning compositions and their use in combatting insects Download PDF

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Publication number
GB2056859A
GB2056859A GB8026632A GB8026632A GB2056859A GB 2056859 A GB2056859 A GB 2056859A GB 8026632 A GB8026632 A GB 8026632A GB 8026632 A GB8026632 A GB 8026632A GB 2056859 A GB2056859 A GB 2056859A
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Prior art keywords
composition
formula
cyano
group
compound
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GB8026632A
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GB2056859B (en
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Sanofi Aventis France
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Roussel Uclaf SA
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
    • A01N37/38Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N53/00Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof

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  • Life Sciences & Earth Sciences (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)

Abstract

An insecticidal cleaning composition comprises a cleaning agent and at least one compound of formula (I): <IMAGE> wherein the alcohol moiety is of the (S) configuration and in which Y represents a group of formula (IA> <IMAGE> [in which Z represents a group of formula <IMAGE> (wherein X1 and X2, which may be the same or different, each represents a chlorine or bromine atom) or a group of formula <IMAGE> (wherein X3, X4 and X5 which may be the same or different, each represents a chlorine or bromine atom)], the group of formula (IA) being of cis or trans configuration and optically active; or a group of formula (IB> <IMAGE> [in which Y' represents a hydrogen, chlorine or bromine atom, an alkyl radical containing from 1 to 4 carbon atoms or an alkoxy radical containing from 1 to 4 carbon atoms and n is 0, 1, 2 or 3].

Description

SPECIFICATION Insecticidal cleaning compositions and their use in combatting insects This invention relates to surface cleaning insecticidal compositions and their use in combatting insects.
Amongst known insecticidal compounds there are included compounds of general formula (I):
wherein the alcohol moiety is of the (S) configuration and in which Y represents a group of formula (IA)
[in which Z represents a group of formula
(wherein X1 and X2, which may be the same or different, each represents a chlorine or bromine atom) or a group of formula
(wherein X3, X4 and X5, which may be the same or different, each represents a chlorine or bromine atom the group of formula (IA) being of cis or trans configuration and optically active; or a group of formula (1B)
[in which Y' represents a hydrogen, chlorine or bromine atom, an alkyl radical containing from 1 to 4 carbon atoms or an alkoxy radical contain from 1 to 4 carbon atoms and n is O, 1, 2 or 3].
Thus the compounds of general formula (I) are described in French Patent Specification Nos.
2,185,612 and 2,375,161 as well as in Belgian Patent Specification Nos. 873,798 and 858,894 and include for example (S)-a-cyano-3-phenoxybenzyl (1 R,cis)-2,2-dimethyl-3-(2,2-di- bromovinyl)-cyclopropane-1-carboxylate (denoted herein as compound A).
However it is known that these compounds, although endowed with a high lethal insecticidal activity, exhibit a reduced activity as knock-down agents of insects, and notably of domestic insects.
We have now found that a very intense and very durable knock-down effect can be obtained on domestic insects such as e.g. flies and mosquitoes, associated with a good lethal effect, using extremely weak doses of a compound of formula (I) if the compound of formula (I) is applied in the form of a cleaning composition to a surface upon which the insects may alight.
Thus, according to one feature of the present invention there is provided an insecticidal cleaning composition comprising a cleaning agent and at least one compound of formula (I) as hereinbefore defined.
According to a further feature of the present invention there is provided a method of combatting insects which comprises applying to a surface upon which insects may alight, a cleaning composition as defined above.
The advantages of the compositions and method according to the invention, are of an entirely unexpected character.
After cleaning a surface and particularly after cleaning a glazed surface until transparent, the quantity of the product remaining on the surface is extremely small and theoretically ought to be endowed with only a weak insecticidal activity. One would have therefore thought that the very small quantities of the compound of formula (I) remaining on the surface and particularly on a glazed surfaces exposed to light and to solar heat would undergo a rapid degradation, causing loss of insecticidal activity. On the contrary, however, we have established that a strong knockdown effect and lethal effect remain. Another unexpected effect is that the compounds of general formula (I) and in particular the compound A after deposition on a surface according to the invention possess a strong and lasting knock-down activity.Hitherto compound A was known as possessing only a medium knock-down power when used conventionally.
The compositions and methods according to the invention are of particular use against winged insects but are also useful against wingless insects. A particular advantage of the present invention is that it permits, in a single operation, the cleaning of a surface as well as the control of insects in the vicinity. In addition, the control of insects and in particular, flies has a consequence that surfaces and particularly windows are less soiled by the excretions of insects and thus cleaning is required less frequently.
Using the compositions and methods according to the invention a lasting knock-down and lethal effect may be obtained within an enclosed area, e.g. a room by cleaning one or more surfaces.
The compositions according to the invention may, for example, be used for cleaning floors, walls and, more especially glass e.g. windows. They may, for example be in the form of solutions, creams or aerosols. In the cleaning of windows, compositions in the form of aerosols are particularly preferred.
The compositions may, for example, contain from 1 to 50 g, preferably 2,5 g to 25 g of compound of formula (I) per 100 ml of the composition.
Particularly preferred compounds of general formula (I) which may be present include (5)-ci- cyano-3-phenoxybenzyl (1 R,cis)-2,2-dimethyl-3-(2,2-dibromovinyl)-cyclopropane- 1 -carboxylate, (S)-a-cyano-3-phenoxybenzyl (1 R, cis)-2, 2-d imethyl-3-(2, 2-dichlorovinyl)cyclopropane- 1 -carboxylate and (S)-a-cyano-3-phenoxybenzyl "D" 2-chlorophenyl-2-isopropyl-acetate as well as cyano-3-phenoxybenzyl (1 R,cis)-2,2-dimethyl-3-(1 ,2,2,2-tetrabromoethyl)-cyclopropane-l -car- boxylate, tS)-a-cyano-3-phenoxybenzyl (1 R, cis)-2, 2-dimethyl-3-(2,2-dichloro- 1,2-dibromoethyl) cyclopropane- 1 -carboxylate and (S)-a-cyano-3-phenoxybenzyl (1 R, trans)-2,2-dimethyl-3-(2,2- dich loro- 1 , 2-d ibromoethyl)-cyclopropane- 1 -carboxylate.
Using the methods according to the invention, the insects alight on and thus come into contact with the cleaned and toxically rendered surfaces. In particular, winged insects are attracted by glazed surfaces lit by day-light and will tend to be in contact with these toxically rendered surfaces much longer than with walls and floors.
Thus according to a particularly preferred method of the invention a composition according to the invention in the form of an aerosol is atomized onto window-glass, and then the glass is wiped, preferably by rubbing with a soft cloth until the glass is transparent.
The compositions of the invention may also, however be applied to walls and/or floors, the walls and/or floors subsequently being wiped.
The compositions according to the invention are preferably applied so as to obtain a concentration of 0.05 to 2.5 mg most preferably from 0.1 25 to 1 mg of compound of formula (I) per square metre of surface to be cleaned. When the composition is in the form of an aerosol, e.g. for use in cleaning window-panes, atomization of the composition onto the surface is preferably effected under a pressure of 1 to 5 bars and at a rate of 1 to 10 ml per square metre.
The cleaning agent for use in compositions of the invention may be any product conventionally used commercially for this purpose or a specially prepared mixture of surface-active agents.
The cleaning compositions according to the invention preferably have a pH near to 7, in order to conserve the maximum efficacy of the insecticidally active ingredient of formula (I).
The activity of the compositions according to the invention may be illustrated as follows: Study of the insecticidal properties on flies of compositions of the invention containing (S)-a- cyano-3-phenoxybenzyl (1 A, (1R, cis)-2,2-dimethyl-3-(2,2-dibromovinyl)-cyclopropane-1-carboxylate of (compound A) and a cleaning agent for windows.
(1) Methods of test The enclosed space chosen for carrying out the tests is a room 3 m wide, 3 m high and 4 m long, having a large glazed surface of 3.3 m2. Compound A (decamethrine) is added to a cleaning product and the window panes are cleaned in conventional domestic manner, that is to say, that after atomization of the cleaning product, the panes are rubbed with a soft cloth until the glass is perfectly transparent.
A first series of tests enabled the necessary volume for a good atomization to be assessed.
The volume determined was of the order of 5 ml/m2 under a pressure of 3 bars with a gaseous output of 10 I/minute. Infestation was carried out with 1 00 females of the species of Musca Domestica, 1 hour after cleaning. Checks were carried out every hour for 4 hours, then at 24 and 48 hours. To permit survival, the flies had available water and food spread on the floor of the room.
In parallel with the above test of leaving the flies in a room with treated windows, a forced contact test was carried out with flies kept in an enclosure of the Petri box type placed against the glass itself.
After 48 hours the flies were removed and new infestations were carried out after 3, 7 and 14 days.
(2) Experimental results obtained.
(a) Composition containing compound A at 0.25 mg/mg2 in solution in product B; a wellknown commercial window-glass cleaning product such as AJAX VITRE, the composition having a pH of 7.
The experimental results are summarized in the following table: *The flies are released into the room.
**20 flies are kept in a cylindrical box, 12 cm in diameter and 3.5 high, placed against the treated glazed surface.
***Up to 5 hours, knock-down. At 24 and 48 hours, mortality.
Percentage KD and mortality at Relative Concentrations Nature of Temperature Humidity Infestations mg/m contact 1h 2h 3h 4h 5h 24h 48h C % *** *** Day 0 0.25 normal* 18 70 65 65 62 65 64 22#1 67#7 forced** 90 90 80 90 90 100 100 22#1 67#7 Day 3 0.25 normal 6 40 46 40 37 55 62 22.5#1.5 74#10 forced 75 75 90 100 100 100 100 22.5#1.5 74#10 Day 7 0.25 normal 13 53 53 48 46 54 63 22.5#0.5 72#8 forced 5 40 30 55 25 45 75 22.5#0.5 72#8 Day 14 0.25 normal 18 30 44 40 34 50 54 22.6#1.5 78#10 forced 45 35 25 25 25 30 55 22.6#1.5 78#10 Conclusion: A high percentage of knock-down and mortality is reached rapidly, over several hours. These percentages vary little up to the 7th day. At the 14th day they still remain notable, but show a reduction.
(b) Composition containing compound A at 0.50 mg/m2 in solution in product B, a wellknown commercial window-glass cleaning product such as AJAX VITRE, the composition having a pH of 7.
The experimental results are summarized in the following table: Percentage KD and mortality at Relative Concentrations Nature of Temperature humidity Infestations mg/m2 contact 1h 2h 3h 4h 5h 24h 48h C % Day 0 0.50 normal 43.3 60 4.1 75.5 77.8 72.2 88.8 20-23 54-70 forced 100 100 95.2 85.7 80.9 100 95.2 20-23 54-70 Day 3 0.50 normal 16.5 31 54.9 60.5 67.6 63.4 70.4 21-22 66-78 forced 100 100 90 85 85 100 100 21-22 66-78 Day 7 0.50 normal 22.2 44.4 53.3 52.2 55.6 68.9 77.8 22-23 79#5 forced 85 90 60 80 85 90 90 22-23 79#5 Day 14 0.50 normal 7.1 30 41.4 45.7 47.1 50 61.4 22-24 58-76 forced 22 59.1 63.6 86.4 86.4 90.9 100 22-24 58-76 Conclusion: Up to the 14th day the knock-down and mortality percentages remain high.At the 7th day, in normal use, the mortality is still near to 80%, which shows clearly that the compound A used in this manner possesses a truly exceptional insecticidal activity at very weak doses. The trials with forced contact show furthermore that at the 14th day, the treated glass surface is still impregnated with a sufficient quantity of the compound A to cause a mortality rate of 100% in 48 hours.
The following non-limiting Examples serve to illustrate the present invention Example 1: Composition according to the invention.
An aerosol was prepared corresponding to the formulation: (S)-a-cyano-3-phenoxybenzyl (1 R, cis)-2,2 dimethyl-3-(2, 2-dibromovinyl)-cyclopropane- 1-carboxylate 0.02 g -tergital M P X (non-ionic surface active agent) 0.98 g -isopropyl alcohol 10 g -acetone 5 g -propellent gas 23 g -demineralized water 61 g Example 2: Composition according to the invention.
A solution was prepared corresponding to the formulation: (S)-a-cyano-3-phenoxybenzyl (1 R, cis)-2,2 di methyl-3-(2, 2-di bromovi nyl)-cyclopropane 1-carboxylate 0.01 g --poloyoxyethylene lauryl ether 0.40 g -ethanol 3.00 g --ethylcellosolve 2.00 g -morpholine 0.50 g -polydimethylsiloxane 0.07 g -tetrasodium salt of ethylene diamine tetracetate 0.005 g -butane-propane 5.00 g -perfume 0.10 g water 88.91 g

Claims (21)

1. An insecticidal cleaning composition comprising a cleaning agent and at least one compound of formula (I):
wherein the alcohol moiety is of the (S) configuration and in which Y represents a group of formula (IA)
[in which Z represents a group of formula
(wherein X1 and X2, which may be the same or different, each represents a chlorine or bromine atom) or a group of formula
(wherein X3, X4 and X5 which may be the same or different, each represents a chlorine or bromine atom)], the group of formula (IA) being of cis or trans configuration and optically active; or a group of formula (1B)
[in which Y' represents a hydrogen, chlorine or bromine atom, an alkyl radical containing from 1 to 4 carbon atoms or an alkoxy radical containing from 1 to 4 carbon atoms and n is 0, 1, 2 or 3].
2. A composition as claimed in claim 1 wherein the cleaning agent is a cleaning agent for glass.
3. A composition as claimed in claim 1 wherein the cleaning agent is a cleaning agent for floors and/or walls.
4. A composition as claimed in any preceding claim in the form of a solution, cream or aerosol.
5. A composition as claimed in any preceding claim containing from 1 to 50 g of compound of formula (I) per 100 ml of the composition.
6. A composition as claimed in claim 5 containing from 2.5 g to 25 g of compound of formula (I) per 100 ml of the composition.
7. A composition as claimed in any preceding claim containing (S)-a-cyano-3-phenoxybenzyl (1 R, cis)-2, 2-dimethyl-3-(2, 2-dibromovinyl)cyclopropane- 1 -carboxylate.
8. A composition as claimed in any one of claims 1 to 6 containing (S)-a-cyano-3phenoxybenzyl (1 R, cis)-2, 2-dimethyl-3-(2, 2-dichlorovinyl)-cyclopropane- 1 -carboxylate.
9. A composition as claimed in any one of claims 1 to 6 containing (S)-a-cyano-3phenoxybenzyl ' ' D" ' 2- chlorophenyl-2-isopropyl-acetate.
10. A composition as claimed in any one of claims 1 to 6 containing one or more compounds selected from (S)-a-cyano-3-phenoxybenzyl (1 R, cis)-2,2-dimethyl-3-( 1,2,2,2-tetra- bromoethyl)-cyclopropane- 1 -carboxylate, (S)-a-cyano-3-phenoxybenzyl (1 R, cis)-2, 2-dimethyl-3 (2, 2-dich loro- 1 , 2-dibromoethyl)-cyclopropane- 1 -carboxylate and (S)-a-cyano-3-phenoxybenzyl (1 R, trans)-2,2-dimethyl-3-(2,2-d ichloro- 1 , 2-dibromoethyl)-cyclopropane- 1 -carboxylate.
11. An insecticidal cleaning composition as claimed in claim 1 substantially as herein described.
1 2. An insecticidal cleaning composition substantially as herein described in Example 1 or Example 2.
1 3. A method of combatting insects which comprises applying to a surface upon which insects may alight a cleaning composition as claimed in any one of claims 1 to 1 2.
14. A method as claimed in claim 13 wherein the composition is in the form of an aerosol and is atomized onto window-glass and then the glass is wiped.
15. A method as claimed in claim 14 wherein the glass is wiped, after atomization, by rubbing with a soft cloth until the glass is transparent.
16. A method as claimed in claim 13 wherein the composition is applied to walls and/or floors and then the walls and/or floors are wiped.
17. A method as claimed in any one of claims 13 to 16 wherein application of the composition is effected so as to obtain a concentration of 0.05 to 2.5 mg of compound of formula (I) per square metre of surface to be cleaned.
1 8. A method as claimed in claim 1 7 wherein application is effected so as to obtain a concentration of 0.125 to 1 mg of compound of formula (I) per square metre of surface to be cleaned.
1 9. A method as claimed in any one of claims 1 3 to 18 wherein the composition is in the form of an aerosol and atomization is effected under a pressure of from 1 to 5 bars and at a rate of 1 to 10 ml per square metre.
20. A method of combatting insects as claimed in claim 13 substantially as herein described.
21. Each and every novel method, process, composition and product herein disclosed.
GB8026632A 1979-08-17 1980-08-15 Insecticidal cleaning compositions and their use in combating insects Expired GB2056859B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7920841A FR2463584A1 (en) 1979-08-17 1979-08-17 WASTE INSECTICIDE COMPOSITIONS AND THEIR APPLICATION TO THE FIGHT AGAINST WELL INSECTS IN PREMISES

Publications (2)

Publication Number Publication Date
GB2056859A true GB2056859A (en) 1981-03-25
GB2056859B GB2056859B (en) 1983-03-02

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GB8026632A Expired GB2056859B (en) 1979-08-17 1980-08-15 Insecticidal cleaning compositions and their use in combating insects

Country Status (16)

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JP (1) JPS5663908A (en)
BE (1) BE884795A (en)
BR (1) BR8005194A (en)
CA (1) CA1150146A (en)
CH (1) CH644734A5 (en)
DE (1) DE3031148A1 (en)
DK (1) DK352480A (en)
FR (1) FR2463584A1 (en)
GB (1) GB2056859B (en)
GR (1) GR70217B (en)
IE (1) IE50428B1 (en)
IT (1) IT1145383B (en)
LU (1) LU82712A1 (en)
NL (1) NL8004663A (en)
PT (1) PT71701B (en)
SE (1) SE447328B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6019855A (en) * 1995-05-11 2000-02-01 Home & Personal Care Usa Perfumed compositions comprising polymer and nonionic surfactant
GB2351737A (en) * 1999-07-06 2001-01-10 Helen Dolisznyj Insecticidal cleaner
WO2006092570A1 (en) * 2005-03-02 2006-09-08 Reckitt Benckiser (Australia) Pty Limited Insect expellant floor cleaner additive comprising a synthetic pyrethroid

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE470768A (en) * 1947-01-29
US4024163A (en) * 1972-05-25 1977-05-17 National Research Development Corporation Insecticides
FR2398041A2 (en) * 1977-07-19 1979-02-16 Roussel Uclaf CYCLOPROPANE CARBOXYLIC ACID ESTERS CONTAINING A POLYHALOGENIC SUBSTITUTE, PROCESS FOR PREPARATION AND THEIR APPLICATION AS INSECTICIDES, ACARICIDES, NEMATICIDES AND AS VETERINARY MEDICINAL PRODUCTS
GB1594462A (en) * 1977-02-09 1981-07-30 Shell Int Research Pesticidal composition

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6019855A (en) * 1995-05-11 2000-02-01 Home & Personal Care Usa Perfumed compositions comprising polymer and nonionic surfactant
GB2351737A (en) * 1999-07-06 2001-01-10 Helen Dolisznyj Insecticidal cleaner
WO2001002525A1 (en) * 1999-07-06 2001-01-11 Helen Dolisznyj An insecticidal cleaner
GB2351737B (en) * 1999-07-06 2003-11-05 Helen Dolisznyj An insecticidal cleaner
WO2006092570A1 (en) * 2005-03-02 2006-09-08 Reckitt Benckiser (Australia) Pty Limited Insect expellant floor cleaner additive comprising a synthetic pyrethroid
AU2006219778B2 (en) * 2005-03-02 2012-05-24 Reckitt Benckiser (Australia) Pty Limited Insect expellant floor cleaner additive comprising a synthetic pyrethroid

Also Published As

Publication number Publication date
GB2056859B (en) 1983-03-02
DE3031148A1 (en) 1981-03-26
CA1150146A (en) 1983-07-19
JPS5663908A (en) 1981-05-30
LU82712A1 (en) 1981-03-24
SE8005310L (en) 1981-02-18
IT1145383B (en) 1986-11-05
GR70217B (en) 1982-08-31
IT8049508A0 (en) 1980-08-14
PT71701B (en) 1982-01-26
BR8005194A (en) 1981-03-04
SE447328B (en) 1986-11-10
PT71701A (en) 1980-09-01
FR2463584A1 (en) 1981-02-27
NL8004663A (en) 1981-02-19
IE50428B1 (en) 1986-04-16
DK352480A (en) 1981-02-18
BE884795A (en) 1981-02-16
IE801736L (en) 1981-02-17
FR2463584B1 (en) 1981-12-24
CH644734A5 (en) 1984-08-31

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