GB2044614B - Therapeutic compositions with a cytostatic action - Google Patents
Therapeutic compositions with a cytostatic actionInfo
- Publication number
- GB2044614B GB2044614B GB8006109A GB8006109A GB2044614B GB 2044614 B GB2044614 B GB 2044614B GB 8006109 A GB8006109 A GB 8006109A GB 8006109 A GB8006109 A GB 8006109A GB 2044614 B GB2044614 B GB 2044614B
- Authority
- GB
- United Kingdom
- Prior art keywords
- therapeutic compositions
- cytostatic action
- cytostatic
- action
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000001085 cytostatic effect Effects 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- SNKDCTFPQUHAPR-UHFFFAOYSA-N 1-fluoropyrimidine-2,4-dione Chemical compound FN1C=CC(=O)NC1=O SNKDCTFPQUHAPR-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000002152 alkylating effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- ZFSLODLOARCGLH-UHFFFAOYSA-N isocyanuric acid Chemical compound OC1=NC(O)=NC(O)=N1 ZFSLODLOARCGLH-UHFFFAOYSA-N 0.000 abstract 1
- HAWPXGHAZFHHAD-UHFFFAOYSA-N mechlorethamine Chemical class ClCCN(C)CCCl HAWPXGHAZFHHAD-UHFFFAOYSA-N 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A therapeutic composition with cytostatic action comprising an isocyanurate having the formula I <IMAGE> in which R, R', and R'' which may be the same or different represent hydrogen or alkyl having from 1 to 4 carbon atoms, preferably hydrogen or methyl in an inert pharmaceutically acceptable diluent, carrier or vehicle. The compositions may also contain other alkylating substances such as derivatives of nitrogen mustard or fluoruracil.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2907349A DE2907349C2 (en) | 1979-02-24 | 1979-02-24 | Medicines with cytostatic activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB2044614A GB2044614A (en) | 1980-10-22 |
| GB2044614B true GB2044614B (en) | 1983-01-26 |
Family
ID=6063886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8006109A Expired GB2044614B (en) | 1979-02-24 | 1980-02-22 | Therapeutic compositions with a cytostatic action |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0014981B1 (en) |
| JP (1) | JPS55118484A (en) |
| AT (1) | ATE716T1 (en) |
| AU (1) | AU536270B2 (en) |
| BE (1) | BE881834A (en) |
| CA (1) | CA1123740A (en) |
| CH (1) | CH645893A5 (en) |
| DE (1) | DE2907349C2 (en) |
| FR (1) | FR2449451A1 (en) |
| GB (1) | GB2044614B (en) |
| IE (1) | IE49274B1 (en) |
| IL (1) | IL59453A (en) |
| IT (1) | IT1147330B (en) |
| LU (1) | LU82190A1 (en) |
| NL (1) | NL8001100A (en) |
| NZ (1) | NZ192945A (en) |
| SE (1) | SE8001425L (en) |
| ZA (1) | ZA801017B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT371816B (en) * | 1979-10-08 | 1983-08-10 | Henkel Kgaa | METHOD FOR PRODUCING NEW ISOCYANURS [UREDERIVATIVES |
| EP0033503B1 (en) * | 1980-01-31 | 1986-09-10 | Henkel Kommanditgesellschaft auf Aktien | Medicaments with cytostatic activity and use of cyclic compounds, in which the heterocyclic n-ring atoms are substituted by several glycidyl groups, in pharmaceutical compositions |
| AT372382B (en) * | 1980-08-14 | 1983-09-26 | Henkel Kgaa | METHOD FOR PRODUCING NEW OXIRANYLISOCYANURIC ACID COMPOUNDS |
| DE3131365A1 (en) * | 1981-08-07 | 1983-02-24 | Henkel KGaA, 4000 Düsseldorf | NEW DIGLYCIDYL-SUBSTITUTED HETEROCYCLIC COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN PHARMACEUTICAL PREPARATIONS WITH CYTOSTATIC EFFECTIVENESS |
| DE3131396A1 (en) * | 1981-08-07 | 1983-03-24 | Henkel KGaA, 4000 Düsseldorf | "NEW DIGLYCIDYL-PTERIDINE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICINAL PRODUCTS WITH A CYTOSTATIC EFFECT" |
| DE3133077A1 (en) * | 1981-08-21 | 1983-03-10 | Henkel KGaA, 4000 Düsseldorf | NEW 1,3,2-OXAZAPHOSPHORINE COMPOUNDS CONTAINING NEW CYTOSTATICALLY EFFECTIVE EPOXY GROUPS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN PHARMACEUTICAL PREPARATIONS |
| TWI243169B (en) * | 1998-03-02 | 2005-11-11 | Nissan Chemical Ind Ltd | Optically active epoxy compound |
-
1979
- 1979-02-24 DE DE2907349A patent/DE2907349C2/en not_active Expired
-
1980
- 1980-02-18 AT AT80100806T patent/ATE716T1/en not_active IP Right Cessation
- 1980-02-18 EP EP80100806A patent/EP0014981B1/en not_active Expired
- 1980-02-21 BE BE0/199482A patent/BE881834A/en not_active IP Right Cessation
- 1980-02-22 AU AU55830/80A patent/AU536270B2/en not_active Ceased
- 1980-02-22 ZA ZA00801017A patent/ZA801017B/en unknown
- 1980-02-22 NL NL8001100A patent/NL8001100A/en not_active Application Discontinuation
- 1980-02-22 LU LU82190A patent/LU82190A1/en unknown
- 1980-02-22 GB GB8006109A patent/GB2044614B/en not_active Expired
- 1980-02-22 IE IE362/80A patent/IE49274B1/en unknown
- 1980-02-22 CH CH143980A patent/CH645893A5/en not_active IP Right Cessation
- 1980-02-22 FR FR8003962A patent/FR2449451A1/en active Granted
- 1980-02-22 NZ NZ192945A patent/NZ192945A/en unknown
- 1980-02-22 IT IT20100/80A patent/IT1147330B/en active
- 1980-02-22 SE SE8001425A patent/SE8001425L/en not_active Application Discontinuation
- 1980-02-22 IL IL59453A patent/IL59453A/en unknown
- 1980-02-23 JP JP2214580A patent/JPS55118484A/en active Granted
- 1980-02-25 CA CA346,385A patent/CA1123740A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IL59453A0 (en) | 1980-05-30 |
| ZA801017B (en) | 1981-02-25 |
| EP0014981A2 (en) | 1980-09-03 |
| DE2907349A1 (en) | 1980-08-28 |
| JPS6354688B2 (en) | 1988-10-28 |
| JPS55118484A (en) | 1980-09-11 |
| IT8020100A0 (en) | 1980-02-22 |
| CH645893A5 (en) | 1984-10-31 |
| DE2907349C2 (en) | 1982-09-16 |
| SE8001425L (en) | 1980-08-25 |
| FR2449451A1 (en) | 1980-09-19 |
| IL59453A (en) | 1984-02-29 |
| GB2044614A (en) | 1980-10-22 |
| ATE716T1 (en) | 1982-03-15 |
| IE49274B1 (en) | 1985-09-04 |
| LU82190A1 (en) | 1980-09-24 |
| BE881834A (en) | 1980-08-21 |
| NZ192945A (en) | 1984-05-31 |
| NL8001100A (en) | 1980-08-26 |
| AU536270B2 (en) | 1984-05-03 |
| AU5583080A (en) | 1980-09-04 |
| CA1123740A (en) | 1982-05-18 |
| EP0014981A3 (en) | 1981-02-11 |
| FR2449451B1 (en) | 1982-12-10 |
| IT1147330B (en) | 1986-11-19 |
| IE800362L (en) | 1980-08-24 |
| EP0014981B1 (en) | 1982-02-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |