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GB1538479A - Imidazobenzoxazines - Google Patents

Imidazobenzoxazines

Info

Publication number
GB1538479A
GB1538479A GB21111/76A GB2111176A GB1538479A GB 1538479 A GB1538479 A GB 1538479A GB 21111/76 A GB21111/76 A GB 21111/76A GB 2111176 A GB2111176 A GB 2111176A GB 1538479 A GB1538479 A GB 1538479A
Authority
GB
United Kingdom
Prior art keywords
compound
hydrolysed
converted
carboxylic acid
reduced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB21111/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roussel Laboratories Ltd
Original Assignee
Roussel Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Laboratories Ltd filed Critical Roussel Laboratories Ltd
Priority to GB21111/76A priority Critical patent/GB1538479A/en
Priority to DK216977A priority patent/DK216977A/en
Priority to FR7715294A priority patent/FR2351980A1/en
Priority to DE19772722772 priority patent/DE2722772A1/en
Priority to BE177750A priority patent/BE854850A/en
Priority to NL7705614A priority patent/NL7705614A/en
Priority to JP52057812A priority patent/JPS6045199B2/en
Priority to CA278,863A priority patent/CA1100963A/en
Priority to CH623277A priority patent/CH624118A5/en
Priority to IE1052/77A priority patent/IE44905B1/en
Priority to US05/820,836 priority patent/US4145419A/en
Publication of GB1538479A publication Critical patent/GB1538479A/en
Priority to CH666280A priority patent/CH623053A5/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Compounds of formula: <IMAGE> in which R3 represents a C1-C5 alkyl are prepared by decarboxylation of a corresponding alkyl ester carrying a carboxyl in position 1, followed by a nitration. The compound IB can be reduced to an amino ester (IC), can be hydrolysed to the carboxylic acid (IE) or can be reduced and then hydrolysed. The amine compound IC can be converted by acylation into the acylamino compound, and the carboxylic acid IE can be esterified or converted to the amide. The compounds mentioned above and their salts have antiallergic and bronchodilatory properties; they can be used, especially, in the treatment of allergic asthma.
GB21111/76A 1976-05-21 1976-05-21 Imidazobenzoxazines Expired GB1538479A (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
GB21111/76A GB1538479A (en) 1976-05-21 1976-05-21 Imidazobenzoxazines
DK216977A DK216977A (en) 1976-05-21 1977-05-18 PROCEDURE FOR THE PREPARATION OF IMIDAZOBENZOXAZINES
FR7715294A FR2351980A1 (en) 1976-05-21 1977-05-18 NEW IMIDAZOBENZOXAZINES AND THEIR SALTS, METHOD OF PREPARATION AND APPLICATION AS MEDICINAL PRODUCTS
NL7705614A NL7705614A (en) 1976-05-21 1977-05-20 PROCESS FOR THE PREPARATION OF NEW IMIDAZO BENZOXAZINS.
BE177750A BE854850A (en) 1976-05-21 1977-05-20 NEW IMIDAZOBENZOXAZINES AND THEIR SALTS, METHOD OF PREPARATION AND PHARMACEUTICAL COMPOSITIONS
DE19772722772 DE2722772A1 (en) 1976-05-21 1977-05-20 NEW IMIDAZOBENZOXAZINE DERIVATIVES, THEIR SALT, PROCESS FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS
JP52057812A JPS6045199B2 (en) 1976-05-21 1977-05-20 Novel imidazobenzoxazines and pharmaceutical compositions containing them
CA278,863A CA1100963A (en) 1976-05-21 1977-05-20 No translation available
CH623277A CH624118A5 (en) 1976-05-21 1977-05-20 Processes for the preparation of new imidazobenzoxazines
IE1052/77A IE44905B1 (en) 1976-05-21 1977-05-23 Imidazobenzoxazines
US05/820,836 US4145419A (en) 1976-05-21 1977-08-01 Novel imidazobenzoxazines
CH666280A CH623053A5 (en) 1976-05-21 1980-09-04 Processes for the preparation of new imidazobenzoxazines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB21111/76A GB1538479A (en) 1976-05-21 1976-05-21 Imidazobenzoxazines

Publications (1)

Publication Number Publication Date
GB1538479A true GB1538479A (en) 1979-01-17

Family

ID=10157418

Family Applications (1)

Application Number Title Priority Date Filing Date
GB21111/76A Expired GB1538479A (en) 1976-05-21 1976-05-21 Imidazobenzoxazines

Country Status (10)

Country Link
JP (1) JPS6045199B2 (en)
BE (1) BE854850A (en)
CA (1) CA1100963A (en)
CH (2) CH624118A5 (en)
DE (1) DE2722772A1 (en)
DK (1) DK216977A (en)
FR (1) FR2351980A1 (en)
GB (1) GB1538479A (en)
IE (1) IE44905B1 (en)
NL (1) NL7705614A (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049422A (en) * 1976-03-29 1977-09-20 United States Borax & Chemical Corporation Herbicidal morpholinobenzimidazoles
SE444319B (en) * 1977-11-18 1986-04-07 Roussel Uclaf NEW IMIDAZOBENOXAZINE DERIVATIVES, PROCEDURES FOR PREPARING THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE ASSOCIATIONS
SE439308B (en) * 1978-08-02 1985-06-10 Roussel Uclaf IMIDAZO (1,2-A) KINOXALINES AND PHARMACEUTICAL COMPOSITIONS THEREOF
IL59104A (en) * 1979-02-09 1984-02-29 Roussel Uclaf Heterotricyclic derivatives,process for their preparation and pharmaceutical compositions incorporating them
US5329012A (en) * 1987-10-29 1994-07-12 The Research Foundation Of State University Of New York Bis(acyloxmethyl)imidazole compounds
GB9212486D0 (en) * 1992-06-12 1992-07-22 Erba Carlo Spa Derivatives of substituted imidazo benzoxazin-1-one and process for their preparation
JP6705262B2 (en) * 2016-04-04 2020-06-03 三菱ケミカル株式会社 Curing agent for anion-curable compound, curable composition, and cured product

Also Published As

Publication number Publication date
DE2722772A1 (en) 1977-12-08
JPS6045199B2 (en) 1985-10-08
CA1100963A (en) 1981-05-12
CH623053A5 (en) 1981-05-15
BE854850A (en) 1977-11-21
DK216977A (en) 1977-11-22
CH624118A5 (en) 1981-07-15
FR2351980B1 (en) 1980-03-07
NL7705614A (en) 1977-11-23
JPS52156899A (en) 1977-12-27
IE44905L (en) 1982-05-05
FR2351980A1 (en) 1977-12-16
IE44905B1 (en) 1982-05-05

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee