GB1529564A - Pharmaceutical compositions - Google Patents
Pharmaceutical compositionsInfo
- Publication number
- GB1529564A GB1529564A GB1915774A GB1915774A GB1529564A GB 1529564 A GB1529564 A GB 1529564A GB 1915774 A GB1915774 A GB 1915774A GB 1915774 A GB1915774 A GB 1915774A GB 1529564 A GB1529564 A GB 1529564A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- lower alkyl
- phenyl
- alkyl
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 12
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- -1 methylene, hydroxymethylene Chemical group 0.000 abstract 3
- 125000005036 alkoxyphenyl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000005037 alkyl phenyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004802 cyanophenyl group Chemical group 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005059 halophenyl group Chemical group 0.000 abstract 1
- 229960000890 hydrocortisone Drugs 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004464 hydroxyphenyl group Chemical group 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000006501 nitrophenyl group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/53—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
1529564 Pharmaceutical compositions A LAWSON and A F AL-SAYYAB 22 April 1975 [1 May 1974] 19157/74 Heading A5B A pharmaceutical composition comprises a diluent or carrier and a compound of the formula: in which R<SP>1</SP> is a hydrogen atom or a lower alkyl group; R<SP>2</SP> and R<SP>3</SP> are the same or are different and each is a hydrogen or halogen atom or a hydroxy or lower alkoxy group (provided that neither of R<SP>2</SP> and R<SP>3</SP> is a lower alkoxy group when R' is a lower alkyl group), or R<SP>2</SP> and R<SP>3</SP> are attached to adjacent carbon atoms of benzene nucleus A and together represent a carbocyclic ring fused to benzene nucleus A; R<SP>4</SP> is a hydrogen atom or a lower alkyl, phenyllower alkyl, phenyl, hydroxy phenyl or lower alkoxy phenyl group; R<SP>5</SP> is a hydrogen atom or a lower alkyl or hydroxy lower alkyl group; R<SP>6</SP> is a methylene, hydroxymethylene or mercaptomethylene group or is absent; R<SP>7</SP> is a hydrogen atom or a lower alkyl, hydroxy-lower alkyl, lower alkyl-thiolower alkyl, or amino-lower alkyl, or an aryl or heterocyclic group selected from phenyl, lower alkyl-phenyl, lower alkoxy-phenyl, halophenyl, nitrophenyl, cyanophenyl, methylenedioxyphenyl, pyridyl, imidazolyl, indolyl and morpholyl groups, or a lower alkyl group substituted with such an aryl or heterocyclic group, or a group of the formula: (in which R<SP>1</SP>, R<SP>2</SP>, R<SP>3</SP> and R<SP>4</SP> have the meanings defined above and R<SP>8</SP> is a lower alkylene group), and X is an oxygen or sulphur atom; the term "lower" as applied to an alkyl, alkylene or alkoxy group indicating that it contains from 1 to 6 carbon atoms). The compositions may also contain hydrocortisone.
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1915774A GB1529564A (en) | 1974-05-01 | 1974-05-01 | Pharmaceutical compositions |
| EG25475A EG12028A (en) | 1974-05-01 | 1975-04-26 | Process for preparing of pharmaceutical compositions containing certain schiff bases |
| BE155898A BE828530A (en) | 1974-05-01 | 1975-04-29 | PHARMACEUTICAL PRODUCT AND PROCESS FOR ITS MANUFACTURING |
| DE19752519193 DE2519193A1 (en) | 1974-05-01 | 1975-04-30 | PHARMACEUTICAL PRODUCTS |
| ES437363A ES437363A1 (en) | 1974-05-01 | 1975-04-30 | Pharmaceutical compositions |
| CA225,873A CA1060438A (en) | 1974-05-01 | 1975-04-30 | Pharmaceutical compositions |
| FR7513529A FR2282870A1 (en) | 1974-05-01 | 1975-04-30 | PHARMACEUTICAL PRODUCT AND PROCESS FOR ITS MANUFACTURING |
| JP5308975A JPS5112933A (en) | 1974-05-01 | 1975-05-01 | GOSEIYAKUZAIN OSEIZOHO |
| AU80721/75A AU502579B2 (en) | 1974-05-01 | 1975-05-01 | Pharmaceutical compositions containing schiff bases |
| NL7505174A NL7505174A (en) | 1974-05-01 | 1975-05-01 | PHARMACEUTICAL MIXTURES. |
| NZ17738475A NZ177384A (en) | 1974-05-01 | 1975-05-01 | N-substituted benzimines and pharmaceutical compositons |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1915774A GB1529564A (en) | 1974-05-01 | 1974-05-01 | Pharmaceutical compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1529564A true GB1529564A (en) | 1978-10-25 |
Family
ID=10124714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1915774A Expired GB1529564A (en) | 1974-05-01 | 1974-05-01 | Pharmaceutical compositions |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS5112933A (en) |
| AU (1) | AU502579B2 (en) |
| BE (1) | BE828530A (en) |
| CA (1) | CA1060438A (en) |
| DE (1) | DE2519193A1 (en) |
| EG (1) | EG12028A (en) |
| ES (1) | ES437363A1 (en) |
| FR (1) | FR2282870A1 (en) |
| GB (1) | GB1529564A (en) |
| NL (1) | NL7505174A (en) |
| NZ (1) | NZ177384A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4564636A (en) * | 1983-04-14 | 1986-01-14 | Synthelabo | Diphenylazomethines and pharmaceutical compositions containing them |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2418222A2 (en) * | 1975-08-01 | 1979-09-21 | Synthelabo | Alpha-phenyl 2-hydroxy-benzylidene amino-alkanoic acid derivs. - and novel di:phenyl-ketone intermediates, useful as anticonvulsants for treating epilepsy |
| JPS52159599U (en) * | 1976-05-27 | 1977-12-03 | ||
| JPS5812993Y2 (en) * | 1978-07-19 | 1983-03-12 | 日本鋼管株式会社 | Suspended opening/closing scaffolding device |
| FR2475543A1 (en) * | 1980-02-12 | 1981-08-14 | Synthelabo | BENZYLIDENIC DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
| NO940195L (en) * | 1993-01-25 | 1994-07-26 | Norsk Hydro As | New connections |
-
1974
- 1974-05-01 GB GB1915774A patent/GB1529564A/en not_active Expired
-
1975
- 1975-04-26 EG EG25475A patent/EG12028A/en active
- 1975-04-29 BE BE155898A patent/BE828530A/en unknown
- 1975-04-30 ES ES437363A patent/ES437363A1/en not_active Expired
- 1975-04-30 CA CA225,873A patent/CA1060438A/en not_active Expired
- 1975-04-30 FR FR7513529A patent/FR2282870A1/en active Granted
- 1975-04-30 DE DE19752519193 patent/DE2519193A1/en active Pending
- 1975-05-01 AU AU80721/75A patent/AU502579B2/en not_active Expired
- 1975-05-01 NZ NZ17738475A patent/NZ177384A/en unknown
- 1975-05-01 NL NL7505174A patent/NL7505174A/en not_active Application Discontinuation
- 1975-05-01 JP JP5308975A patent/JPS5112933A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4564636A (en) * | 1983-04-14 | 1986-01-14 | Synthelabo | Diphenylazomethines and pharmaceutical compositions containing them |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2282870A1 (en) | 1976-03-26 |
| NL7505174A (en) | 1975-11-04 |
| AU8072175A (en) | 1976-11-04 |
| CA1060438A (en) | 1979-08-14 |
| NZ177384A (en) | 1978-03-06 |
| DE2519193A1 (en) | 1975-11-20 |
| ES437363A1 (en) | 1977-05-16 |
| EG12028A (en) | 1978-06-30 |
| JPS5112933A (en) | 1976-01-31 |
| AU502579B2 (en) | 1979-08-02 |
| FR2282870B1 (en) | 1978-11-10 |
| BE828530A (en) | 1975-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |