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GB1524318A - Polypeptide - Google Patents

Polypeptide

Info

Publication number
GB1524318A
GB1524318A GB2564276A GB2564276A GB1524318A GB 1524318 A GB1524318 A GB 1524318A GB 2564276 A GB2564276 A GB 2564276A GB 2564276 A GB2564276 A GB 2564276A GB 1524318 A GB1524318 A GB 1524318A
Authority
GB
United Kingdom
Prior art keywords
lys
leu
ala
thr
phe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2564276A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB2564276A priority Critical patent/GB1524318A/en
Priority to US05/799,938 priority patent/US4320117A/en
Priority to FR7718847A priority patent/FR2355803A1/en
Priority to JP7379377A priority patent/JPS52156861A/en
Priority to DE19772727846 priority patent/DE2727846A1/en
Publication of GB1524318A publication Critical patent/GB1524318A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/675—Beta-endorphins
    • C07K14/6755—Beta-endorphins with at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1524318 Polypeptide IMPERIAL CHEMICAL INDUSTRIES Ltd 12 May 1977 [21 June 1976 28 Oct 1976] 25642/76 and 44839/76 Heading C3H A polypeptide of the Formula (I) H-Tyr-AGly - Phe - B - Thr - Ser - Glu - Lys - Ser - Gln- Thr - Pro - Leu - Val - Thr - Leu - Phe - Lys- Asn - Ala - Ile - E - Lys - Asn - Ala - F - Lys- Lys-G-K, wherein D-Ala, D-Ser or D-Met; B is Leu or Met; E is Val or Ile; F is His or Tyr; G is Gly-Gln, Gly-Glu or a direct bond; K is OH, NH2 or O(C1-C5 alkyl); and the pharmaceutically-acceptable acid addition salts thereof, and, where the said polypeptide contains a carboxyl group, the pharmaceutically-acceptable base addition salts thereof. The polypeptide (I) exemplified is: H-Tyr- D - Ala - Gly - Phe - Leu - Thr - Ser - Glu - Lys- Ser - Gln - Thr - Pro - Leu - Val - Thr - Leu- Phe - Lys - Asn - Ala - Ile - Val - Lys - Asn - Ala- His - Lys - Lys - Gly - Gln - OH. Peptide intermediates isolated are: TRIACONTAPEPTIDE: Boc - Tyr(But) - D - Ala - Gly Phe - Leu - Thr(Bzl) - Ser(Bzl) - Glu(OBzl) - Lys(2,4 - DiClZ) - Ser(Bzl) - Gln- Thr(Bzl) - Pro - Leu - Val - Thr(Bzl) - Leu - Phe- Lys(2,4 - DiClZ) - Asn - Ala - Ile - Val - Lys- (2,4 - DiClZ) - Asn Ala - His(Tas) - Lys(2,4 - DiClZ) - Lys(2,4 - DiClZ) - Gly - Gln - polystyrene which is prepared by solid phase synthesis. PENTAPEPTIDES: Boc - Tyr(But) D - Ala- Gly - Phe - Leu - OMe and OH. TETRAPEPTIDES: Z and H-D-Ala-Gly-Phe- Leu-OMe. Pharmaceutical compositions, which may be in a form of parenteral administration, in association with a non-toxic, pharmaceuticallyacceptable carrier therefor.
GB2564276A 1976-06-21 1976-06-21 Polypeptide Expired GB1524318A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GB2564276A GB1524318A (en) 1976-06-21 1976-06-21 Polypeptide
US05/799,938 US4320117A (en) 1976-06-21 1977-05-24 Polypeptide
FR7718847A FR2355803A1 (en) 1976-06-21 1977-06-20 NEW POLYPEPTIDE, ITS PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITION CONTAINING IT
JP7379377A JPS52156861A (en) 1976-06-21 1977-06-21 Polipeptde* its preparation and analgesic anodyne composition containing same
DE19772727846 DE2727846A1 (en) 1976-06-21 1977-06-21 POLYPEPTIDE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2564276A GB1524318A (en) 1976-06-21 1976-06-21 Polypeptide

Publications (1)

Publication Number Publication Date
GB1524318A true GB1524318A (en) 1978-09-13

Family

ID=10230992

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2564276A Expired GB1524318A (en) 1976-06-21 1976-06-21 Polypeptide

Country Status (1)

Country Link
GB (1) GB1524318A (en)

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee